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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2014 Volume 45 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Torilis japonica extract, a new potential EMT suppressor agent by regulation of EGFR signaling pathways

  • Authors:
    • Guen Tae Kim
    • Se Hee Lee
    • Young Min Kim
  • View Affiliations / Copyright

    Affiliations: Department of Biological Sciences, College of Life Science and Nano Technology, Hannam University, Yuseong-gu, Daejeon 305-811, Republic of Korea
  • Pages: 1673-1679
    |
    Published online on: July 17, 2014
       https://doi.org/10.3892/ijo.2014.2546
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Abstract

Abnormal metastasis of carcinoma is associated with the loss of epithelial features and the acquisition of a mesenchymal phenotype. The stimulation of cells with epidermal growth factor (EGF) resulted in morphological changes and induced epithelial-mesenchymal transition (EMT). EGF stimulation resulted in increased mobility along with upregulated actin polarization related proteins, E-cadherin regulators and the mesenchymal markers. Treatment with Torilis japonica extract (TJE) along with stimulation by EGF prevented changes in cell morphology, mobility, expression of actin polarization proteins and EMT markers. Using specific inhibitors and siEGFR, it was demonstrated that TJE suppressed EMT through EGFR inactivation and regulation of its downstream signaling pathways. We suggest that TJE is a new potential reagent for EGFR-targeted therapy and anti-abnormal metastasis in MCF-7 breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Kim GT, Lee SH and Kim YM: Torilis japonica extract, a new potential EMT suppressor agent by regulation of EGFR signaling pathways. Int J Oncol 45: 1673-1679, 2014.
APA
Kim, G.T., Lee, S.H., & Kim, Y.M. (2014). Torilis japonica extract, a new potential EMT suppressor agent by regulation of EGFR signaling pathways. International Journal of Oncology, 45, 1673-1679. https://doi.org/10.3892/ijo.2014.2546
MLA
Kim, G. T., Lee, S. H., Kim, Y. M."Torilis japonica extract, a new potential EMT suppressor agent by regulation of EGFR signaling pathways". International Journal of Oncology 45.4 (2014): 1673-1679.
Chicago
Kim, G. T., Lee, S. H., Kim, Y. M."Torilis japonica extract, a new potential EMT suppressor agent by regulation of EGFR signaling pathways". International Journal of Oncology 45, no. 4 (2014): 1673-1679. https://doi.org/10.3892/ijo.2014.2546
Copy and paste a formatted citation
x
Spandidos Publications style
Kim GT, Lee SH and Kim YM: Torilis japonica extract, a new potential EMT suppressor agent by regulation of EGFR signaling pathways. Int J Oncol 45: 1673-1679, 2014.
APA
Kim, G.T., Lee, S.H., & Kim, Y.M. (2014). Torilis japonica extract, a new potential EMT suppressor agent by regulation of EGFR signaling pathways. International Journal of Oncology, 45, 1673-1679. https://doi.org/10.3892/ijo.2014.2546
MLA
Kim, G. T., Lee, S. H., Kim, Y. M."Torilis japonica extract, a new potential EMT suppressor agent by regulation of EGFR signaling pathways". International Journal of Oncology 45.4 (2014): 1673-1679.
Chicago
Kim, G. T., Lee, S. H., Kim, Y. M."Torilis japonica extract, a new potential EMT suppressor agent by regulation of EGFR signaling pathways". International Journal of Oncology 45, no. 4 (2014): 1673-1679. https://doi.org/10.3892/ijo.2014.2546
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