MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1

Retraction in: /10.3892/ijo.2023.5525

  • Authors:
    • Hongyi Zhang
    • Zhiqiang Feng
    • Rui Huang
    • Zhenglin Xia
    • Guoan Xiang
    • Jinqian Zhang
  • View Affiliations

  • Published online on: August 13, 2014     https://doi.org/10.3892/ijo.2014.2596
  • Pages: 2143-2152
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Abstract

MicroRNA (miRNA or miR) inhibition of oncogenic related pathways has been shown to be a promising therapeutic approach for cancer. SIRT1 might be a promoter factor on tumorigenesis of hepatocellular carcinoma (HCC). However, the mechanism is unknown. We investigated whether miRNAs regulate the SIRT1 and its downstream SREBP-lipogenesis-cholesterogenesis metabolic pathway in hepatoma cells. Human hepatoma cells were transfected with miR-449 mimics and inhibitors, and the effects of miR-449 on cell proliferation was assessed. We identified the miRNAs, miR-449, that control lipogenesis and cholesterogenesis in hepatoma cells by inhibiting SIRT1 and SREBP-1c expression and downregulating their targeted genes, including fatty acid synthase (FASN) and 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR). MiR-449 repressed DNA synthesis, mitotic entry and proliferation of hepatoma cells. Restoration of miR-449 led to suppression of SIRT1 expression and liver tumorigenesis. The newly identified miRNAs, miR-449 represents a novel targeting mechanism for HCC therapy.
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November-2014
Volume 45 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Zhang H, Feng Z, Huang R, Xia Z, Xiang G and Zhang J: MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1 Retraction in /10.3892/ijo.2023.5525. Int J Oncol 45: 2143-2152, 2014.
APA
Zhang, H., Feng, Z., Huang, R., Xia, Z., Xiang, G., & Zhang, J. (2014). MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1 Retraction in /10.3892/ijo.2023.5525. International Journal of Oncology, 45, 2143-2152. https://doi.org/10.3892/ijo.2014.2596
MLA
Zhang, H., Feng, Z., Huang, R., Xia, Z., Xiang, G., Zhang, J."MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1 Retraction in /10.3892/ijo.2023.5525". International Journal of Oncology 45.5 (2014): 2143-2152.
Chicago
Zhang, H., Feng, Z., Huang, R., Xia, Z., Xiang, G., Zhang, J."MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1 Retraction in /10.3892/ijo.2023.5525". International Journal of Oncology 45, no. 5 (2014): 2143-2152. https://doi.org/10.3892/ijo.2014.2596