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Review

Pharmacological and dietary agents for colorectal cancer chemoprevention: Effects on polyamine metabolism (Review)

  • Authors:
    • Michele Linsalata
    • Antonella Orlando
    • Francesco Russo
  • View Affiliations / Copyright

    Affiliations: Laboratory of Nutritional Pathophysiology, National Institute for Digestive Diseases, I.R.C.C.S. ‘S. de Bellis’ Via Turi 27, Castellana Grotte (Ba), I-70013, Italy
  • Pages: 1802-1812
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    Published online on: August 14, 2014
       https://doi.org/10.3892/ijo.2014.2597
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Abstract

Chemoprevention is the long-term use of different chemical agents, both synthetic and natural, to prevent or delay the onset of disease. Since colorectal cancer has a significant environmental component, it is an ideal disease in which to evaluate the potential benefits of chemopreventive agents. The polyamines, spermine, spermidine and putrescine have been involved in almost all the steps of colorectal tumorigenesis. Consequently, polyamine biosynthesis and catabolism can be considered as promising targets for cancer chemoprevention. A variety of drug formulations have been tested for their efficacy in affecting polyamines in a strategy of colorectal cancer prevention. Different molecules, such as biosynthesis inhibitors and catabolism inducers, have been proposed alone or in combination with other drugs proved to diminish the colorectal cancer risk. Interestingly, also diet can play a role in cancer prevention by affecting polyamines. Several dietary components, such as probiotics or flavonoids, have been shown to affect the polyamine metabolic pathway in colorectal neoplastic tissue. On the other hand, the polyamines ingested with diet might contrast the above cited effects shown by both drugs and nutritional factors. It is, therefore, fundamental to acquire more data also on these aspects in view of an innovative approach to colorectal oncology. This review summarizes data on the role of polyamine metabolism in neoplastic transformation of colorectal mucosa and as possible target for colorectal cancer chemoprevention. Attention will be focused on the influence of drugs and nutritional factors on polyamine metabolism, as well as the role played by dietary polyamines.
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1 

Surh YJ: Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer. 3:768–780. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Casero RA Jr and Marton LJ: Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases. Nat Rev Drug Discov. 6:373–390. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Ramani D, De Bandt JP and Cynober L: Aliphatic polyamines in physiology and diseases. Clin Nutr. 33:14–22. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Thomas T and Thomas TJ: Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications. Cell Mol Life Sci. 58:244–258. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Rothenburg S, Koch-Nolte F, Rich A and Haag F: A polymorphic dinucleotide repeat in the rat nucleolin gene forms Z-DNA and inhibits promoter activity. Proc Natl Acad Sci USA. 98:8985–8990. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Iacomino G, Picariello G and D’Agostino L: DNA and nuclear aggregates of polyamines. Biochim Biophys Acta. 1823:1745–1755. 2012. View Article : Google Scholar

7 

Igarashi K and Kashiwagi K: Modulation of cellular function by polyamines. Int J Biochem Cell Biol. 42:39–51. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Pegg AE and Casero RA Jr: Current status of the polyamine research field. Methods Mol Biol. 720:3–35. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Pegg AE: Mammalian polyamine metabolism and function. IUBMB Life. 61:880–894. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Coffino P: Regulation of cellular polyamines by antizyme. Nat Rev Mol Cell Biol. 2:188–194. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Bachrach U: Polyamines and cancer: minireview article. Amino Acids. 26:307–309. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Linsalata M, Caruso MG, Leo S, Guerra V, D’Attoma B and Di Leo A: Prognostic value of tissue polyamine levels in human colorectal carcinoma. Anticancer Res. 22:2465–2469. 2002.PubMed/NCBI

13 

Linsalata M, Giannini R, Notarnicola M and Cavallini A: Peroxisome proliferator-activated receptor gamma and spermidine/spermine N1-acetyltransferase gene expressions are significantly correlated in human colorectal cancer. BMC Cancer. 6:1912006. View Article : Google Scholar

14 

Shantz LM and Levin VA: Regulation of ornithine decarboxylase during oncogenic transformation: mechanisms and therapeutic potential. Amino Acids. 33:213–223. 2007. View Article : Google Scholar

15 

Erdman SH, Ignatenko NA, Powell MB, et al: APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse. Carcinogenesis. 20:1709–1713. 1999. View Article : Google Scholar

16 

Casero RA and Pegg AE: Polyamine catabolism and disease. Biochem J. 421:323–338. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Palmer AJ and Wallace HM: The polyamine transport system as a target for anticancer drug development. Amino Acids. 38:415–422. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Thompson PA and Gerner EW: Current concepts in colorectal cancer prevention. Expert Rev Gastroenterol Hepatol. 3:369–382. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Pegg AE: Regulation of ornithine decarboxylase. J Biol Chem. 281:14529–14532. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Xiao L and Wang J-Y: Posttranscriptional regulation of gene expression in epithelial cells by polyamines. Methods Mol Biol. 720:67–79. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Ignatenko NA, Babbar N, Mehta D, Casero RA Jr and Gerner EW: Suppression of polyamine catabolism by activated Ki-ras in human colon cancer cells. Mol Carcinog. 39:91–102. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Linsalata M, Notarnicola M, Caruso MG, Di Leo A, Guerra V and Russo F: Polyamine biosynthesis in relation to K-ras and p-53 mutations in colorectal carcinoma. Scand J Gastroenterol. 39:470–477. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Notarnicola M, Linsalata M, Caruso MG, et al: Genetic and biochemical changes in colorectal carcinoma in relation to morphologic characteristics. Oncol Rep. 10:1987–1991. 2003.PubMed/NCBI

24 

Babbar N and Gerner EW: Targeting polyamines and inflammation for cancer prevention. Recent Results Cancer Res. 188:49–64. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Seiler N: Thirty years of polyamine-related approaches to cancer therapy. Retrospect and prospect Part 1 Selective enzyme inhibitors. Curr Drug Targets. 4:537–564. 2003.

26 

Laukaitis CM and Gerner EW: DFMO: targeted risk reduction therapy for colorectal neoplasia. Best Pract Res Clin Gastroenterol. 25:495–506. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Gerner EW and Meyskens FL Jr: Polyamines and cancer: old molecules, new understanding. Nat Rev Cancer. 4:781–792. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Love RR, Carbone PP, Verma AK, et al: Randomized phase I chemoprevention dose-seeking study of alpha-difluoromethylornithine. J Natl Cancer Inst. 85:732–737. 1993. View Article : Google Scholar : PubMed/NCBI

29 

Levin VA, Uhm JH, Jaeckle KA, et al: Phase III randomized study of postradiotherapy chemotherapy with alpha-difluoromethylornithine-procarbazine, N-(2-chloroethyl)-N′-cyclohexyl-N-nitrosurea, vincristine (DFMO-PCV) versus PCV for glioblastoma multiforme. Clin Cancer Res. 6:3878–3884. 2000.PubMed/NCBI

30 

Leveque J, Burtin F, Catros-Quemener V, Havouis R and Moulinoux JP: The gastrointestinal polyamine source depletion enhances DFMO induced polyamine depletion in MCF-7 human breast cancer cells in vivo. Anticancer Res. 18:2663–2668. 1998.PubMed/NCBI

31 

Meyskens FL Jr and Gerner EW: Development of difluoromethylornithine (DFMO) as a chemoprevention agent. Clin Cancer Res. 5:945–951. 1999.PubMed/NCBI

32 

Gerner EW: Cancer chemoprevention locks onto a new polyamine metabolic target. Cancer Prev Res (Phila). 3:125–127. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Love RR, Jacoby R, Newton MA, et al: A randomized, placebo-controlled trial of low-dose alpha-difluoromethylornithine in individuals at risk for colorectal cancer. Cancer Epidemiol Biomarkers Prev. 7:989–992. 1998.PubMed/NCBI

34 

Meyskens FL Jr, Gerner EW, Emerson S, et al: Effect of alpha-difluoromethylornithine on rectal mucosal levels of polyamines in a randomized, double-blinded trial for colon cancer prevention. J Natl Cancer Inst. 90:1212–1218. 1998. View Article : Google Scholar

35 

Flossmann E and Rothwell PM: Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies. Lancet. 369:1603–1613. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Lawson KR, Ignatenko NA, Piazza GA, Cui H and Gerner EW: Influence of K-ras activation on the survival responses of Caco-2 cells to the chemopreventive agents sulindac and difluoromethylornithine. Cancer Epidemiol Biomarkers Prev. 9:1155–1162. 2000.PubMed/NCBI

37 

Gerner EW and Meyskens FL Jr: Combination chemoprevention for colon cancer targeting polyamine synthesis and inflammation. Clin Cancer Res. 15:758–761. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Jacoby RF, Cole CE, Tutsch K, et al: Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos. Cancer Res. 60:1864–1870. 2000.

39 

Ignatenko NA, Besselsen DG, Stringer DE, Blohm-Mangone KA, Cui H and Gerner EW: Combination chemoprevention of intestinal carcinogenesis in a murine model of familial adenomatous polyposis. Nutr Cancer. 60(Suppl 1): 30–35. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Thompson PA, Wertheim BC, Zell JA, et al: Levels of rectal mucosal polyamines and prostaglandin E2 predict ability of DFMO and sulindac to prevent colorectal adenoma. Gastroenterology. 139:797–805. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Meyskens FL Jr, McLaren CE, Pelot D, et al: Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial. Cancer Prev Res (Phila). 1:32–38. 2008. View Article : Google Scholar

42 

Zell JA, Pelot D, Chen WP, McLaren CE, Gerner EW and Meyskens FL: Risk of cardiovascular events in a randomized placebo-controlled, double-blind trial of difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas. Cancer Prev Res (Phila). 2:209–212. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Zell JA, Ziogas A, Ignatenko N, et al: Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival. Clin Cancer Res. 15:6208–6216. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Martinez ME, O’Brien TG, Fultz KE, et al: Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene. Proc Natl Acad Sci USA. 100:7859–7864. 2003. View Article : Google Scholar

45 

Hubner RA, Muir KR, Liu JF, Logan RF, Grainge MJ and Houlston RS: Ornithine decarboxylase G316A genotype is prognostic for colorectal adenoma recurrence and predicts efficacy of aspirin chemoprevention. Clin Cancer Res. 14:2303–2309. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Jell J, Merali S, Hensen ML, et al: Genetically altered expression of spermidine/spermine N1-acetyltransferase affects fat metabolism in mice via acetyl-CoA. J Biol Chem. 282:8404–8413. 2007. View Article : Google Scholar : PubMed/NCBI

47 

Jacobs ET, Ahnen DJ, Ashbeck EL, et al: Association between body mass index and colorectal neoplasia at follow-up colonoscopy: a pooling study. Am J Epidemiol. 169:657–666. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Zell JA, Lin BS, Madson N, McLaren CE, Gerner EW and Meyskens FL: Role of obesity in a randomized placebo-controlled trial of difluoromethylornithine (DFMO) + sulindac for the prevention of sporadic colorectal adenomas. Cancer Causes Control. 23:1739–1744. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Wallace HM and Fraser AV: Inhibitors of polyamine metabolism: review article. Amino Acids. 26:353–365. 2004. View Article : Google Scholar : PubMed/NCBI

50 

Niiranen K, Pietila M, Pirttila TJ, et al: Targeted disruption of spermidine/spermine N1-acetyltransferase gene in mouse embryonic stem cells. Effects on polyamine homeostasis and sensitivity to polyamine analogues. J Biol Chem. 277:25323–25328. 2002. View Article : Google Scholar : PubMed/NCBI

51 

Battaglia V, DeStefano Shields C, Murray-Stewart T and Casero RA Jr: Polyamine catabolism in carcinogenesis: potential targets for chemotherapy and chemoprevention. Amino Acids. 46:511–519. 2014. View Article : Google Scholar : PubMed/NCBI

52 

Seiler N: Thirty years of polyamine-related approaches to cancer therapy. Retrospect and prospect Part 2 Structural analogues and derivatives. Curr Drug Targets. 4:565–585. 2003.PubMed/NCBI

53 

Wallace HM and Niiranen K: Polyamine analogues - an update. Amino Acids. 33:261–265. 2007. View Article : Google Scholar : PubMed/NCBI

54 

Belting M, Borsig L, Fuster MM, et al: Tumor attenuation by combined heparan sulfate and polyamine depletion. Proc Natl Acad Sci USA. 99:371–376. 2002. View Article : Google Scholar : PubMed/NCBI

55 

Bonithon-Kopp C, Kronborg O, Giacosa A, Rath U and Faivre J: Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial. European Cancer Prevention Organisation Study Group. Lancet. 356:1300–1306. 2000. View Article : Google Scholar : PubMed/NCBI

56 

Delzenne NM and Williams CM: Prebiotics and lipid metabolism. Curr Opin Lipidol. 13:61–67. 2002. View Article : Google Scholar : PubMed/NCBI

57 

Food and Agriculture Organization of the United Nations and World Health Organization. Probiotics in food: health and nutritional properties and guidelines for evaluation. Food and Agriculture Organization of the United Nations, World Health Organization; Rome: 2006

58 

Boesten RJ and de Vos WM: Interactomics in the human intestine: Lactobacilli and Bifidobacteria make a difference. J Clin Gastroenterol. 42(Suppl 3): S163–S167. 2008. View Article : Google Scholar

59 

Quigley EM: Gut bacteria in health and disease. Gastroenterol Hepatol (NY). 9:560–569. 2013.PubMed/NCBI

60 

Riezzo G, Orlando A, D’Attoma B, et al: Randomised clinical trial: efficacy of Lactobacillus paracasei-enriched artichokes in the treatment of patients with functional constipation - a double-blind, controlled, crossover study. Aliment Pharmacol Ther. 35:441–450. 2012.

61 

Valerio F, de Candia S, Lonigro SL, et al: Role of the probiotic strain Lactobacillus paracasei LMGP22043 carried by artichokes in influencing faecal bacteria and biochemical parameters in human subjects. J Appl Microbiol. 111:155–164. 2011.PubMed/NCBI

62 

Sisto A and Lavermicocca P: Suitability of a probiotic Lactobacillus paracasei strain as a starter culture in olive fermentation and development of the innovative patented product ‘probiotic table olives’. Front Microbiol. 3:1742012.

63 

Ishikawa H, Akedo I, Otani T, et al: Randomized trial of dietary fiber and Lactobacillus casei administration for prevention of colorectal tumors. Int J Cancer. 116:762–767. 2005. View Article : Google Scholar : PubMed/NCBI

64 

Zeng H, Lazarova DL and Bordonaro M: Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention. World J Gastrointest Oncol. 6:41–51. 2014. View Article : Google Scholar : PubMed/NCBI

65 

Kulkarni N and Reddy BS: Inhibitory effect of Bifidobacterium longum cultures on the azoxymethane-induced aberrant crypt foci formation and fecal bacterial beta-glucuronidase. Proc Soc Exp Biol Med. 207:278–283. 1994.

66 

Boleij A and Tjalsma H: Gut bacteria in health and disease: a survey on the interface between intestinal microbiology and colorectal cancer. Biol Rev Camb Philos Soc. 87:701–730. 2012. View Article : Google Scholar : PubMed/NCBI

67 

Singh J, Rivenson A, Tomita M, Shimamura S, Ishibashi N and Reddy BS: Bifidobacterium longum, a lactic acid-producing intestinal bacterium inhibits colon cancer and modulates the intermediate biomarkers of colon carcinogenesis. Carcinogenesis. 18:833–841. 1997. View Article : Google Scholar

68 

Di Marzio L, Russo FP, D’Alo S, et al: Apoptotic effects of selected strains of lactic acid bacteria on a human T leukemia cell line are associated with bacterial arginine deiminase and/or sphingomyelinase activities. Nutr Cancer. 40:185–196. 2001.

69 

Linsalata M, Russo F, Berloco P, et al: The influence of Lactobacillus brevis on ornithine decarboxylase activity and polyamine profiles in Helicobacter pylori-infected gastric mucosa. Helicobacter. 9:165–172. 2004.

70 

Famularo G, Perluigi M, Pieluigi M, Coccia R, Mastroiacovo P and De Simone C: Microecology, bacterial vaginosis and probiotics: perspectives for bacteriotherapy. Med Hypotheses. 56:421–430. 2001. View Article : Google Scholar : PubMed/NCBI

71 

Orlando A, Messa C, Linsalata M, Cavallini A and Russo F: Effects of Lactobacillus rhamnosus GG on proliferation and polyamine metabolism in HGC-27 human gastric and DLD-1 colonic cancer cell lines. Immunopharmacol Immunotoxicol. 31:108–116. 2009.

72 

Buts JP and De Keyser N: Effects of Saccharomyces boulardii on intestinal mucosa. Dig Dis Sci. 51:1485–1492. 2006.

73 

Linsalata M, Russo F, Berloco P, et al: Effects of probiotic bacteria (VSL#3) on the polyamine biosynthesis and cell proliferation of normal colonic mucosa of rats. In Vivo. 19:989–995. 2005.

74 

Matsumoto M and Benno Y: Consumption of Bifidobacterium lactis LKM512 yogurt reduces gut mutagenicity by increasing gut polyamine contents in healthy adult subjects. Mutat Res. 568:147–153. 2004.

75 

Cederroth CR and Nef S: Soy, phytoestrogens and metabolism: A review. Mol Cell Endocrinol. 304:30–42. 2009. View Article : Google Scholar : PubMed/NCBI

76 

Thompson LU, Robb P, Serraino M and Cheung F: Mammalian lignan production from various foods. Nutr Cancer. 16:43–52. 1991. View Article : Google Scholar : PubMed/NCBI

77 

Albini A, Rosano C, Angelini G, et al: Exogenous hormonal regulation in breast cancer cells by phytoestrogens and endocrine disruptors. Curr Med Chem. 21:1129–1145. 2014. View Article : Google Scholar : PubMed/NCBI

78 

Cassidy A: Potential risks and benefits of phytoestrogen-rich diets. Int J Vitam Nutr Res. 73:120–126. 2003. View Article : Google Scholar : PubMed/NCBI

79 

Cotterchio M, Boucher BA, Manno M, Gallinger S, Okey A and Harper P: Dietary phytoestrogen intake is associated with reduced colorectal cancer risk. J Nutr. 136:3046–3053. 2006.PubMed/NCBI

80 

Lechner D, Kállay E and Cross HS: Phytoestrogens and colorectal cancer prevention. Vitam Horm. 70:169–198. 2005. View Article : Google Scholar : PubMed/NCBI

81 

Hawrylewicz EJ, Zapata JJ and Blair WH: Soy and experimental cancer: animal studies. J Nutr. 125:698S–708S. 1995.PubMed/NCBI

82 

Linsalata M, Messa C, Russo F, Cavallini A and Di Leo A: Estrogen receptors and polyamine levels in human gastric carcinoma. Scand J Gastroenterol. 29:67–70. 1994. View Article : Google Scholar : PubMed/NCBI

83 

Russo F, Linsalata M, Messa C, et al: Polyamines and estrogen-receptor concentrations in human colorectal carcinomas. Ital J Gastroenterol. 24:8–12. 1992.PubMed/NCBI

84 

Cross HS, Kallay E, Lechner D, Gerdenitsch W, Adlercreutz H and Armbrecht HJ: Phytoestrogens and vitamin D metabolism: a new concept for the prevention and therapy of colorectal, prostate, and mammary carcinomas. J Nutr. 134:1207S–1212S. 2004.PubMed/NCBI

85 

Booth C, Hargreaves DF, Hadfield JA, McGown AT and Potten CS: Isoflavones inhibit intestinal epithelial cell proliferation and induce apoptosis in vitro. Br J Cancer. 80:1550–1557. 1999. View Article : Google Scholar : PubMed/NCBI

86 

Li HQ, Luo Y and Qiao CH: The mechanisms of anticancer agents by genistein and synthetic derivatives of isoflavone. Mini Rev Med Chem. 12:350–362. 2012. View Article : Google Scholar : PubMed/NCBI

87 

Shon YH, Park SD and Nam KS: Effective chemopreventive activity of genistein against human breast cancer cells. J Biochem Mol Biol. 39:448–451. 2006. View Article : Google Scholar : PubMed/NCBI

88 

Linsalata M, Russo F, Notarnicola M, et al: Effects of genistein on the polyamine metabolism and cell growth in DLD-1 human colon cancer cells. Nutr Cancer. 52:84–93. 2005. View Article : Google Scholar : PubMed/NCBI

89 

Tanaka T, Makita H, Kawabata K, et al: Chemoprevention of azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin. Carcinogenesis. 18:957–965. 1997. View Article : Google Scholar : PubMed/NCBI

90 

Au A, Li B, Wang W, Roy H, Koehler K and Birt D: Effect of dietary apigenin on colonic ornithine decarboxylase activity, aberrant crypt foci formation, and tumorigenesis in different experimental models. Nutr Cancer. 54:243–251. 2006. View Article : Google Scholar : PubMed/NCBI

91 

Linsalata M, Orlando A, Messa C, Refolo MG and Russo F: Quercetin inhibits human DLD-1 colon cancer cell growth and polyamine biosynthesis. Anticancer Res. 30:3501–3507. 2010.PubMed/NCBI

92 

Gosse F, Roussi S, Guyot S, et al: Potentiation of apple procyanidin-triggered apoptosis by the polyamine oxidase inactivator MDL 72527 in human colon cancer-derived metastatic cells. Int J Oncol. 29:423–428. 2006.

93 

Ibanez C, Simo C, Garcia-Canas V, Gomez-Martinez A, Ferragut JA and Cifuentes A: CE/LC-MS multiplatform for broad metabolomic analysis of dietary polyphenols effect on colon cancer cells proliferation. Electrophoresis. 33:2328–2336. 2012. View Article : Google Scholar : PubMed/NCBI

94 

Wallerath T, Deckert G, Ternes T, et al: Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation. 106:1652–1658. 2002. View Article : Google Scholar : PubMed/NCBI

95 

Sengottuvelan M, Senthilkumar R and Nalini N: Modulatory influence of dietary resveratrol during different phases of 1,2-dimethylhydrazine induced mucosal lipid-peroxidation, antioxidant status and aberrant crypt foci development in rat colon carcinogenesis. Biochim Biophys Acta. 1760:1175–1183. 2006. View Article : Google Scholar

96 

Wolter F and Stein J: Resveratrol enhances the differentiation induced by butyrate in caco-2 colon cancer cells. J Nutr. 132:2082–2086. 2002.PubMed/NCBI

97 

Schneider Y, Vincent F, Duranton B, et al: Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells. Cancer Lett. 158:85–91. 2000. View Article : Google Scholar : PubMed/NCBI

98 

Schneider Y, Duranton B, Gosse F, Schleiffer R, Seiler N and Raul F: Resveratrol inhibits intestinal tumorigenesis and modulates host-defense-related gene expression in an animal model of human familial adenomatous polyposis. Nutr Cancer. 39:102–107. 2001. View Article : Google Scholar : PubMed/NCBI

99 

Wolter F, Turchanowa L and Stein J: Resveratrol-induced modification of polyamine metabolism is accompanied by induction of c-Fos. Carcinogenesis. 24:469–474. 2003. View Article : Google Scholar : PubMed/NCBI

100 

Ulrich S, Loitsch SM, Rau O, et al: Peroxisome proliferator-activated receptor gamma as a molecular target of resveratrol-induced modulation of polyamine metabolism. Cancer Res. 66:7348–7354. 2006. View Article : Google Scholar : PubMed/NCBI

101 

Wolter F, Ulrich S and Stein J: Molecular mechanisms of the chemopreventive effects of resveratrol and its analogs in colorectal cancer: key role of polyamines? J Nutr. 134:3219–3222. 2004.PubMed/NCBI

102 

Henning SM, Wang P, Abgaryan N, et al: Phenolic acid concentrations in plasma and urine from men consuming green or black tea and potential chemopreventive properties for colon cancer. Mol Nutr Food Res. 57:483–493. 2013. View Article : Google Scholar : PubMed/NCBI

103 

Yang CS, Li G, Yang Z, Guan F, Chen A and Ju J: Cancer prevention by tocopherols and tea polyphenols. Cancer Lett. Feb 8–2013.(Epub ahead of print).

104 

Kumazaki M, Noguchi S, Yasui Y, et al: Anti-cancer effects of naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells. J Nutr Biochem. 24:1849–1858. 2013. View Article : Google Scholar

105 

Melgarejo E, Urdiales JL, Sanchez-Jimenez F and Medina MA: Targeting polyamines and biogenic amines by green tea epigallocatechin-3-gallate. Amino Acids. 38:519–523. 2010. View Article : Google Scholar : PubMed/NCBI

106 

Bachrach U and Wang YC: Cancer therapy and prevention by green tea: role of ornithine decarboxylase. Amino Acids. 22:1–13. 2002. View Article : Google Scholar : PubMed/NCBI

107 

Paul B, Hayes CS, Kim A, Athar M and Gilmour SK: Elevated polyamines lead to selective induction of apoptosis and inhibition of tumorigenesis by (−)-epigallocatechin-3-gallate (EGCG) in ODC/Ras transgenic mice. Carcinogenesis. 26:119–124. 2005.PubMed/NCBI

108 

Chung JY, Huang C, Meng X, Dong Z and Yang CS: Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved. Cancer Res. 59:4610–4617. 1999.PubMed/NCBI

109 

Gupta S, Ahmad N, Marengo SR, MacLennan GT, Greenberg NM and Mukhtar H: Chemoprevention of prostate carcinogenesis by alpha-difluoromethylornithine in TRAMP mice. Cancer Res. 60:5125–5133. 2000.PubMed/NCBI

110 

Milovic V, Turchanowa L, Stein J and Caspary WF: Transepithelial transport of putrescine across monolayers of the human intestinal epithelial cell line, Caco-2. World J Gastroenterol. 7:193–197. 2001.PubMed/NCBI

111 

Zoumas-Morse C, Rock CL, Quintana EL, Neuhouser ML, Gerner EW and Meyskens FL Jr: Development of a polyamine database for assessing dietary intake. J Am Diet Assoc. 107:1024–1027. 2007. View Article : Google Scholar : PubMed/NCBI

112 

Loser C, Eisel A, Harms D and Folsch UR: Dietary polyamines are essential luminal growth factors for small intestinal and colonic mucosal growth and development. Gut. 44:12–16. 1999. View Article : Google Scholar : PubMed/NCBI

113 

Seiler N, Sarhan S, Grauffel C, Jones R, Knodgen B and Moulinoux JP: Endogenous and exogenous polyamines in support of tumor growth. Cancer Res. 50:5077–5083. 1990.PubMed/NCBI

114 

Muth A, Madan M, Archer JJ, Ocampo N, Rodriguez L and Phanstiel O: Polyamine transport inhibitors: design, synthesis, and combination therapies with difluoromethylornithine. J Med Chem. 57:348–363. 2014. View Article : Google Scholar : PubMed/NCBI

115 

Ignatenko NA, Besselsen DG, Roy UK, et al: Dietary putrescine reduces the intestinal anticarcinogenic activity of sulindac in a murine model of familial adenomatous polyposis. Nutr Cancer. 56:172–181. 2006. View Article : Google Scholar : PubMed/NCBI

116 

Yerushalmi HF, Besselsen DG, Ignatenko NA, et al: Role of polyamines in arginine-dependent colon carcinogenesis in Apc(Min) (/+) mice. Mol Carcinog. 45:764–773. 2006. View Article : Google Scholar : PubMed/NCBI

117 

Gerner EW: Impact of dietary amino acids and polyamines on intestinal carcinogenesis and chemoprevention in mouse models. Biochem Soc Trans. 35:322–325. 2007. View Article : Google Scholar : PubMed/NCBI

118 

Ignatenko NA, Gerner EW and Besselsen DG: Defining the role of polyamines in colon carcinogenesis using mouse models. J Carcinog. 10:102011. View Article : Google Scholar : PubMed/NCBI

119 

Zell JA, Ignatenko NA, Yerushalmi HF, et al: Risk and risk reduction involving arginine intake and meat consumption in colorectal tumorigenesis and survival. Int J Cancer. 120:459–468. 2007. View Article : Google Scholar : PubMed/NCBI

120 

Vargas AJ, Wertheim BC, Gerner EW, Thomson CA, Rock CL and Thompson PA: Dietary polyamine intake and risk of colorectal adenomatous polyps. Am J Clin Nutr. 96:133–141. 2012. View Article : Google Scholar : PubMed/NCBI

121 

Raj KP, Zell JA, Rock CL, et al: Role of dietary polyamines in a phase III clinical trial of difluoromethylornithine (DFMO) and sulindac for prevention of sporadic colorectal adenomas. Br J Cancer. 108:512–518. 2013. View Article : Google Scholar : PubMed/NCBI

122 

Cipolla BG, Havouis R and Moulinoux JP: Polyamine reduced diet (PRD) nutrition therapy in hormone refractory prostate cancer patients. Biomed Pharmacother. 64:363–368. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Linsalata M, Orlando A and Russo F: Pharmacological and dietary agents for colorectal cancer chemoprevention: Effects on polyamine metabolism (Review). Int J Oncol 45: 1802-1812, 2014.
APA
Linsalata, M., Orlando, A., & Russo, F. (2014). Pharmacological and dietary agents for colorectal cancer chemoprevention: Effects on polyamine metabolism (Review). International Journal of Oncology, 45, 1802-1812. https://doi.org/10.3892/ijo.2014.2597
MLA
Linsalata, M., Orlando, A., Russo, F."Pharmacological and dietary agents for colorectal cancer chemoprevention: Effects on polyamine metabolism (Review)". International Journal of Oncology 45.5 (2014): 1802-1812.
Chicago
Linsalata, M., Orlando, A., Russo, F."Pharmacological and dietary agents for colorectal cancer chemoprevention: Effects on polyamine metabolism (Review)". International Journal of Oncology 45, no. 5 (2014): 1802-1812. https://doi.org/10.3892/ijo.2014.2597
Copy and paste a formatted citation
x
Spandidos Publications style
Linsalata M, Orlando A and Russo F: Pharmacological and dietary agents for colorectal cancer chemoprevention: Effects on polyamine metabolism (Review). Int J Oncol 45: 1802-1812, 2014.
APA
Linsalata, M., Orlando, A., & Russo, F. (2014). Pharmacological and dietary agents for colorectal cancer chemoprevention: Effects on polyamine metabolism (Review). International Journal of Oncology, 45, 1802-1812. https://doi.org/10.3892/ijo.2014.2597
MLA
Linsalata, M., Orlando, A., Russo, F."Pharmacological and dietary agents for colorectal cancer chemoprevention: Effects on polyamine metabolism (Review)". International Journal of Oncology 45.5 (2014): 1802-1812.
Chicago
Linsalata, M., Orlando, A., Russo, F."Pharmacological and dietary agents for colorectal cancer chemoprevention: Effects on polyamine metabolism (Review)". International Journal of Oncology 45, no. 5 (2014): 1802-1812. https://doi.org/10.3892/ijo.2014.2597
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