Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
November-2014 Volume 45 Issue 5

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2014 Volume 45 Issue 5

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Naringin inhibits growth and induces apoptosis by a mechanism dependent on reduced activation of NF‑κB/COX‑2‑caspase-1 pathway in HeLa cervical cancer cells

  • Authors:
    • Lan Zeng
    • Yulan Zhen
    • Yiming Chen
    • Lin Zou
    • Ying Zhang
    • Fen Hu
    • Jianqiang Feng
    • Jianhua Shen
    • Bing Wei
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Liwan Chinese Traditional Medicine Hospital, Guangzhou, Guangdong 510140, P.R. China, Department of Oncology, The Affiliated Hospital, Guangdong Medical College, Zhanjiang 524001, P.R. China, Department of Reproductive Medical Center, The Affiliated Hospital, Guangdong Medical College, Zhanjiang 524001, P.R. China, Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China, Department of Physiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China
  • Pages: 1929-1936
    |
    Published online on: August 22, 2014
       https://doi.org/10.3892/ijo.2014.2617
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Naringin (NRG), a bioflavonoid found in citrus fruit extracts, has been pharmacologically evaluated as a potential anticancer agent. This study confirmed a novel mechanism of the anticancer effects of NRG in the human cervical cancer HeLa cell line (HeLa cells). Exposure of HeLa cells to NRG resulted in growth inhibition, as evidenced by a decrease in cell viability. In addition, NRG treatment induced apoptosis, as indicated by the increased apoptotic percentage and the cleaved caspase-3 expression. Importantly, exposure of the cells to NRG attenuated the expression levels of phosphorylated (p) nuclear factor κB (NF-κB) p65 subunit, cyclooxygenase-2 (COX-2) and cysteinyl aspartate proteinase-1 (caspase-1). Treatment with PDTC (an inhibitor of NF-κB) or NS-398 (an inhibitor of COX-2) or SC-3069 (an inhibitor of caspase-1) markedly induced growth inhibition and apoptosis. Treatment with PDTC or NS-398 also reduced caspase-1 expression. Interestingly, PDTC treatment blocked the expression of COX-2 and NS-398 reduced the p-NF-κB p65 expression. Taken together, this study provides novel evidence that NRG induces growth inhibition and apoptosis by inhibiting the NF-κB/COX-2-caspase-1 pathway and that a positive interaction between NF-κB and COX-2 pathway contributes to the growth and antiapoptotic effect in HeLa cells.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Münger K, Baldwin A, Edwards KM, et al: Mechanisms of human papillomavirus-induced oncogenesis. J Virol. 78:11451–11460. 2004.

2 

Karin M and Greten FR: NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 5:749–759. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Baldwin AS Jr: The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol. 14:649–683. 1996. View Article : Google Scholar : PubMed/NCBI

4 

Yang C, Ling H, Zhang M, et al: Oxidative stress mediates chemical hypoxia-induced injury and inflammation by activating NF-κb-COX-2 pathway in HaCaT cells. Mol Cells. 31:531–538. 2011.PubMed/NCBI

5 

Yang C, Yang Z, Zhang M, et al: Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. PLoS One. 6:e219712011.PubMed/NCBI

6 

Guo RM, Xu WM, Lin JC, et al: Activation of the p38 MAPK/NF-κB pathway contributes to doxorubicin-induced inflammation and cytotoxicity in H9c2 cardiac cells. Mol Med Rep. 8:603–608. 2013.

7 

Lu H, Ouyang W and Huang C: Inflammation, a key event in cancer development. Mol Cancer Res. 4:221–233. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Pollard JW: Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer. 4:71–78. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Kim SH, Oh JM, No JH, Bang YJ, Juhnn YS and Song YS: Involvement of NF-kappaB and AP-1 in COX-2 upregulation by human papillomavirus 16 E5 oncoprotein. Carcinogenesis. 30:753–757. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Li J, Jia H, Xie L, et al: Association of constitutive nuclear factor-kappaB activation with aggressive aspects and poor prognosis in cervical cancer. Int J Gynecol Cancer. 19:1421–1426. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Wu Z, Peng X, Li J, Zhang Y and Hu L: Constitutive activation of nuclear factor κB contributes to cystic fibrosis transmembrane conductance regulator expression and promotes human cervical cancer progression and poor prognosis. Int J Gynecol Cancer. 23:906–915. 2013.

12 

Agarwal B, Rao CV, Bhendwal S, Ramey WR, Shirin H, Reddy BS and Holt PR: Lovastatin augments sulindac-induced apoptosis in colon cancer cells and potentiates chemopreventive effects of sulindac. Gastroenterology. 117:838–847. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Vane JR, Bakhle YS and Botting RM: Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol. 38:97–120. 1998. View Article : Google Scholar

14 

Bae SH, Jung ES, Park YM, Kim BS, Kim BK, Kim DG and Ryu WS: Expression of cyclooxygenase-2 (COX-2) in hepato-cellular carcinoma and growth inhibition of hepatoma cell lines by a COX-2 inhibitor, NS-398. Clin Cancer Res. 7:1410–1418. 2001.PubMed/NCBI

15 

Dubois RN: Review article: cyclooxygenase - a target for colon cancer prevention. Aliment Pharmacol Ther. 14(Suppl 1): 64–67. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Hsu AL, Ching TT, Wang DS, Song X, Rangnekar VM and Chen CS: The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2. J Biol Chem. 275:11397–11403. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Grossman EM, Longo WE, Panesar N, Mazuski JE and Kaminski DL: The role of cyclooxygenase enzymes in the growth of human gall bladder cancer cells. Carcinogenesis. 21:1403–1409. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Khuri FR, Wu H, Lee JJ, et al: Cyclooxygenase-2 overexpression is a marker of poor prognosis in stage I non-small cell lung cancer. Clin Cancer Res. 7:861–867. 2001.PubMed/NCBI

19 

Higashi Y, Kanekura T and Kanzaki T: Enhanced expression of cyclooxygenase (COX)-2 in human skin epidermal cancer cells: evidence for growth suppression by inhibiting COX-2 expression. Int J Cancer. 86:667–671. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Kulkarni S, Rader JS, Zhang F, et al: Cyclooxygenase-2 is overexpressed in human cervical cancer. Clin Cancer Res. 7:429–434. 2001.PubMed/NCBI

21 

Ferrandina G, Lauriola L, Distefano MG, et al: Increased cyclooxygenase-2 expression is associated with chemotherapy resistance and poor survival in cervical cancer patients. J Clin Oncol. 20:973–981. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Ryu HS, Chang KH, Yang HW, Kim MS, Kwon HC and Oh KS: High cyclooxygenase-2 expression in stage IB cervical cancer with lymph node metastasis or parametrial invasion. Gynecol Oncol. 76:320–325. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Gaffney DK, Holden J, Davis M, Zempolich K, Murphy KJ and Dodson M: Elevated cyclooxygenase-2 expression correlates with diminished survival in carcinoma of the cervix treated with radiotherapy. Int J Radiat Oncol Biol Phys. 49:1213–1217. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Weppelmann B and Mönkemeier D: The influence of prostaglandin antagonists on radiation therapy of carcinoma of the cervix. Gynecol Oncol. 17:196–199. 1984. View Article : Google Scholar : PubMed/NCBI

25 

Wang AH, Tian XY, Yu JJ, Mi JQ, Liu H and Wang RF: Celecoxib radiosensitizes the human cervical cancer HeLa cell line via a mechanism dependent on reduced cyclo-oxygenase-2 and vascular endothelial growth factor C expression. J Int Med Res. 40:56–66. 2012. View Article : Google Scholar

26 

Kang YJ, Wingerd BA, Arakawa T and Smith WL: Cyclooxygenase-2 gene transcription in a macrophage model of inflammation. J Immunol. 177:8111–8122. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Liu W, Reinmuth N, Stoeltzing O, et al: Cyclooxygenase-2 is up-regulated by interleukin-1 beta in human colorectal cancer cells via multiple signaling pathways. Cancer Res. 63:3632–3636. 2003.PubMed/NCBI

28 

Thornberry NA, Bull HG, Calaycay JR, et al: A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature. 356:768–774. 1992. View Article : Google Scholar : PubMed/NCBI

29 

Lamkanfi M, Kalai M, Saelens X, Declercq W and Vandenabeele P: Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity. J Biol Chem. 279:24785–24793. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Sarkar A, Duncan M, Hart J, Hertlein E, Guttridge DC and Wewers MD: ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions. J Immunol. 176:4979–4986. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Zhang WH, Wang X, Narayanan M, Zhang Y, Huo C, Reed JC and Friedlander RM: Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death. Proc Natl Acad Sci USA. 100:16012–16017. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Feng Q, Li P, Salamanca C, Huntsman D, Leung PC and Auersperg N: Caspase-1alpha is down-regulated in human ovarian cancer cells and the overexpression of caspase-1alpha induces apoptosis. Cancer Res. 65:8591–8596. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Winter RN, Rhee JG and Kyprianou N: Caspase-1 enhances the apoptotic response of prostate cancer cells to ionizing radiation. Anticancer Res. 24:1377–1386. 2004.PubMed/NCBI

34 

Schlosser S, Gansauge F, Ramadani M, Beger HG and Gansauge S: Inhibition of caspase-1 induces cell death in pancreatic carcinoma cells and potentially modulates expression levels of bcl-2 family proteins. FEBS Lett. 491:104–108. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Chen J, Guo R, Yan H, et al: Naringin inhibits ROS-activated MAPK pathway in high glucose-induced injuries in H9c2 cardiac cells. Basic Clin Pharmacol Toxicol. 114:293–304. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Mahmoud AM, Ashour MB, Abdel-Moneim A and Ahmed OM: Hesperidin and naringin attenuate hyper-glycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats. J Diabetes Complications. 26:483–490. 2012. View Article : Google Scholar

37 

Nie YC, Wu H, Li PB, et al: Anti-inflammatory effects of naringin in chronic pulmonary neutrophilic inflammation in cigarette smoke-exposed rats. J Med Food. 15:894–900. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Huang H and Wu K, You Q, Huang R, Li S and Wu K: Naringin inhibits high glucose-induced cardiomyocyte apoptosis by attenuating mitochondrial dysfunction and modulating the activation of the p38 signaling pathway. Int J Mol Med. 32:396–402. 2013.

39 

Chen J, Mo H, Guo R, You Q, Huang R and Wu K: Inhibition of the leptin-induced activation of the p38 MAPK pathway contributes to the protective effects of naringin against high glucose-induced injury in H9c2 cardiac cells. Int J Mol Med. 33:605–612. 2014.PubMed/NCBI

40 

Kaul TN, Middleton E Jr and Ogra PL: Antiviral effect of flavonoids on human viruses. J Med Virol. 15:71–79. 1985. View Article : Google Scholar : PubMed/NCBI

41 

So FV, Guthrie N, Chambers AF, Moussa M and Carroll KK: Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr Cancer. 26:167–181. 1996. View Article : Google Scholar : PubMed/NCBI

42 

Le Marchand L, Murphy SP, Hankin JH, Wilkens LR and Kolonel LN: Intake of flavonoids and lung cancer. J Natl Cancer Inst. 92:154–160. 2000.PubMed/NCBI

43 

Vanamala J, Leonardi T, Patil BS, et al: Suppression of colon carcinogenesis by bioactive compounds in grapefruit. Carcinogenesis. 27:1257–1265. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Kim DI, Lee SJ, Lee SB, Park K, Kim WJ and Moon SK: Requirement for Ras/Raf/ERK pathway in naringin-induced G1-cell-cycle arrest via p21WAF1 expression. Carcinogenesis. 29:1701–1709. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Schindler R and Mentlein R: Flavonoids and vitamin E reduce the release of the angiogenic peptide vascular endothelial growth factor from human tumor cells. J Nutr. 136:1477–1482. 2006.PubMed/NCBI

46 

Ramesh E and Alshatwi AA: Naringin induces death receptor and mitochondria-mediated apoptosis in human cervical cancer (SiHa) cells. Food Chem Toxicol. 51:97–105. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Choi JS and Ryter SW: Inflammasomes: Molecular Regulation and Implications for Metabolic and Cognitive Diseases. Mol Cells. May 19–2014.(Epub ahead of print).

48 

Man SM, Tourlomousis P, Hopkins L, Monie TP, Fitzgerald KA and Bryant CE: Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1β production. J Immunol. 191:5239–5246. 2013. View Article : Google Scholar

49 

Yusup G, Akutsu Y, Mutallip M, et al: A COX-2 inhibitor enhances the antitumor effects of chemotherapy and radiotherapy for esophageal squamous cell carcinoma. Int J Oncol. 44:1146–1152. 2014.PubMed/NCBI

50 

Jarry A, Vallette G, Cassagnau E, et al: Interleukin 1 and interleukin 1beta converting enzyme (caspase 1) expression in the human colonic epithelial barrier. Caspase 1 downregulation in colon cancer. Gut. 45:246–251. 1999. View Article : Google Scholar : PubMed/NCBI

51 

Ueki T, Takeuchi T, Nishimatsu H, et al: Silencing of the caspase-1 gene occurs in murine and human renal cancer cells and causes solid tumor growth in vivo. Int J Cancer. 91:673–679. 2001. View Article : Google Scholar

52 

Alnemri ES, Fernandes-Alnemri T and Litwack G: Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities. J Biol Chem. 270:4312–4317. 1995. View Article : Google Scholar : PubMed/NCBI

53 

Chen YC, Shen SC, Chow JM, Ko CH and Tseng SW: Flavone inhibition of tumor growth via apoptosis in vitro and in vivo. Int J Oncol. 25:661–670. 2004.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zeng L, Zhen Y, Chen Y, Zou L, Zhang Y, Hu F, Feng J, Shen J and Wei B: Naringin inhibits growth and induces apoptosis by a mechanism dependent on reduced activation of NF‑κB/COX‑2‑caspase-1 pathway in HeLa cervical cancer cells. Int J Oncol 45: 1929-1936, 2014.
APA
Zeng, L., Zhen, Y., Chen, Y., Zou, L., Zhang, Y., Hu, F. ... Wei, B. (2014). Naringin inhibits growth and induces apoptosis by a mechanism dependent on reduced activation of NF‑κB/COX‑2‑caspase-1 pathway in HeLa cervical cancer cells. International Journal of Oncology, 45, 1929-1936. https://doi.org/10.3892/ijo.2014.2617
MLA
Zeng, L., Zhen, Y., Chen, Y., Zou, L., Zhang, Y., Hu, F., Feng, J., Shen, J., Wei, B."Naringin inhibits growth and induces apoptosis by a mechanism dependent on reduced activation of NF‑κB/COX‑2‑caspase-1 pathway in HeLa cervical cancer cells". International Journal of Oncology 45.5 (2014): 1929-1936.
Chicago
Zeng, L., Zhen, Y., Chen, Y., Zou, L., Zhang, Y., Hu, F., Feng, J., Shen, J., Wei, B."Naringin inhibits growth and induces apoptosis by a mechanism dependent on reduced activation of NF‑κB/COX‑2‑caspase-1 pathway in HeLa cervical cancer cells". International Journal of Oncology 45, no. 5 (2014): 1929-1936. https://doi.org/10.3892/ijo.2014.2617
Copy and paste a formatted citation
x
Spandidos Publications style
Zeng L, Zhen Y, Chen Y, Zou L, Zhang Y, Hu F, Feng J, Shen J and Wei B: Naringin inhibits growth and induces apoptosis by a mechanism dependent on reduced activation of NF‑κB/COX‑2‑caspase-1 pathway in HeLa cervical cancer cells. Int J Oncol 45: 1929-1936, 2014.
APA
Zeng, L., Zhen, Y., Chen, Y., Zou, L., Zhang, Y., Hu, F. ... Wei, B. (2014). Naringin inhibits growth and induces apoptosis by a mechanism dependent on reduced activation of NF‑κB/COX‑2‑caspase-1 pathway in HeLa cervical cancer cells. International Journal of Oncology, 45, 1929-1936. https://doi.org/10.3892/ijo.2014.2617
MLA
Zeng, L., Zhen, Y., Chen, Y., Zou, L., Zhang, Y., Hu, F., Feng, J., Shen, J., Wei, B."Naringin inhibits growth and induces apoptosis by a mechanism dependent on reduced activation of NF‑κB/COX‑2‑caspase-1 pathway in HeLa cervical cancer cells". International Journal of Oncology 45.5 (2014): 1929-1936.
Chicago
Zeng, L., Zhen, Y., Chen, Y., Zou, L., Zhang, Y., Hu, F., Feng, J., Shen, J., Wei, B."Naringin inhibits growth and induces apoptosis by a mechanism dependent on reduced activation of NF‑κB/COX‑2‑caspase-1 pathway in HeLa cervical cancer cells". International Journal of Oncology 45, no. 5 (2014): 1929-1936. https://doi.org/10.3892/ijo.2014.2617
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team