|
1
|
Jemal A, Bray F, Center MM, Ferlay J, Ward
E and Forman D: Global cancer statistics. CA Cancer J Clin.
61:69–90. 2011. View Article : Google Scholar
|
|
2
|
Mann J: Natural products in cancer
chemotherapy: past, present and future. Nat Rev Cancer. 2:143–148.
2002. View
Article : Google Scholar : PubMed/NCBI
|
|
3
|
Crowell JA: The chemopreventive agent
development research program in the Division of Cancer Prevention
of the US National Cancer Institute: an overview. Eur J Cancer.
41:1889–1910. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Cragg GM, Newman DJ and Snader KM: Natural
products in drug discovery and development. J Nat Prod. 60:52–60.
1997. View Article : Google Scholar
|
|
5
|
Harvey AL: Natural products in drug
discovery. Drug Discov Today. 13:894–901. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Sha WC: Regulation of immune responses by
NF-kappa B/Rel transcription factor. J Exp Med. 187:143–146. 1998.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Xiao G and Fu J: NF-κB and cancer: a
paradigm of Yin-Yang. Am J Cancer Res. 1:192–221. 2011.
|
|
8
|
Basseres DS and Baldwin AS: Nuclear
factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic
initiation and progression. Oncogene. 25:6817–6830. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Bours V, Bonizzi G, Bentires-Alj M, et al:
NF-kappaB activation in response to toxical and therapeutical
agents: role in inflammation and cancer treatment. Toxicology.
153:27–38. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Huang CY, Fong YC, Lee CY, et al: CCL5
increases lung cancer migration via PI3K, Akt and NF-kappaB
pathways. Biochem Pharmacol. 77:794–803. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Nottingham LK, Yan CH, Yang X, et al:
Aberrant IKKα and IKKβ cooperatively activate NF-κB and induce
EGFR/AP1 signaling to promote survival and migration of head and
neck cancer. Oncogene. 33:1135–1147. 2014.
|
|
12
|
Zhang W, Tan W, Wu X, et al: A NIK-IKKα
module expands ErbB2-induced tumor-initiating cells by stimulating
nuclear export of p27/Kip1. Cancer Cell. 23:647–659. 2013.
|
|
13
|
Shaffer AL, Rosenwald A and Staudt LM:
Lymphoid malignancies: the dark side of B-cell differentiation. Nat
Rev Immunol. 2:920–932. 2002. View
Article : Google Scholar : PubMed/NCBI
|
|
14
|
Panwalkar A, Verstovsek S and Giles F:
Nuclear factor-kappaB modulation as a therapeutic approach in
hematologic malignancies. Cancer. 100:1578–1589. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Orlowski RZ and Baldwin AS Jr: NF-kappaB
as a therapeutic target in cancer. Trends Mol Med. 8:385–389. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Singh NP, Singh UP, Hegde VL, et al:
Resveratrol (trans-3,5,4′-trihydroxystilbene) suppresses EL4 tumor
growth by induction of apoptosis involving reciprocal regulation of
SIRT1 and NF-κB. Mol Nutr Food Res. 55:1207–1218. 2011.
|
|
17
|
Kumar A and Sharma SS: NF-kappaB
inhibitory action of resveratrol: a probable mechanism of
neuroprotection in experimental diabetic neuropathy. Biochem
Biophys Res Commun. 394:360–365. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Youn J, Lee JS, Na HK, Kundu JK and Surh
YJ: Resveratrol and piceatannol inhibit iNOS expression and
NF-kappaB activation in dextran sulfate sodium-induced mouse
colitis. Nutr Cancer. 61:847–854. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Chhunchha B, Fatma N, Kubo E, Rai P, Singh
SP and Singh DP: Curcumin abates hypoxia-induced oxidative stress
based-ER stress-mediated cell death in mouse hippocampal cells
(HT22) by controlling Prdx6 and NF-κB regulation. Am J Physiol Cell
Physiol. 304:C636–C655. 2013.PubMed/NCBI
|
|
20
|
Leclercq IA, Farrell GC, Sempoux C, dela
Pena A and Horsmans Y: Curcumin inhibits NF-kappaB activation and
reduces the severity of experimental steatohepatitis in mice. J
Hepatol. 41:926–934. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Lin SY, Chang YT, Liu JD, et al: Molecular
mechanisms of apoptosis induced by magnolol in colon and liver
cancer cells. Mol Carcinog. 32:73–83. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Ikeda K, Sakai Y and Nagase H: Inhibitory
effect of magnolol on tumour metastasis in mice. Phytother Res.
17:933–937. 2003. View
Article : Google Scholar : PubMed/NCBI
|
|
23
|
Yang SE, Hsieh MT, Tsai TH and Hsu SL:
Effector mechanism of magnolol-induced apoptosis in human lung
squamous carcinoma CH27 cells. Br J Pharmacol. 138:193–201. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Hsu YF, Lee TS, Lin SY, et al: Involvement
of Ras/Raf-1/ERK actions in the magnolol-induced upregulation of
p21 and cellcycle arrest in colon cancer cells. Mol Carcinog.
46:275–283. 2007. View
Article : Google Scholar : PubMed/NCBI
|
|
25
|
Huang SH, Chen Y, Tung PY, et al:
Mechanisms for the magnolol-induced cell death of CGTH W-2 thyroid
carcinoma cells. J Cell Biochem. 101:1011–1022. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Lee SJ, Cho YH, Park K, et al: Magnolol
elicits activation of the extracellular signal-regulated kinase
pathway by inducing p27KIP1-mediated G2/M-phase cell cycle arrest
in human urinary bladder cancer 5637 cells. Biochem Pharmacol.
75:2289–2300. 2008. View Article : Google Scholar
|
|
27
|
Tsai JR, Chong IW, Chen YH, et al:
Magnolol induces apoptosis via caspase-independent pathways in
non-small cell lung cancer cells. Arch Pharm Res. 37:548–557. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Chen MC, Lee CF, Huang WH and Chou TC:
Magnolol suppresses hypoxia-induced angiogenesis via inhibition of
HIF-1α/VEGF signaling pathway in human bladder cancer cells.
Biochem Pharmacol. 85:1278–1287. 2013.PubMed/NCBI
|
|
29
|
Rasul A, Yu B, Khan M, et al: Magnolol, a
natural compound, induces apoptosis of SGC-7901 human gastric
adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling
pathways. Int J Oncol. 40:1153–1161. 2012.PubMed/NCBI
|
|
30
|
Lee J, Jung E, Park J, et al:
Anti-inflammatory effects of magnolol and honokiol are mediated
through inhibition of the downstream pathway of MEKK-1 in NF-kappaB
activation signaling. Planta Med. 71:338–343. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Tse AK, Wan CK, Zhu GY, et al: Magnolol
suppresses NF-kappaB activation and NF-kappaB regulated gene
expression through inhibition of IkappaB kinase activation. Mol
Immunol. 44:2647–2658. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Chua HL, Bhat-Nakshatri P, Clare SE,
Morimiya A, Badve S and Nakshatri H: NF-kappaB represses E-cadherin
expression and enhances epithelial to mesenchymal transition of
mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2.
Oncogene. 26:711–724. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Yang J, Pan WH, Clawson GA and Richmond A:
Systemic targeting inhibitor of kappaB kinase inhibits melanoma
tumor growth. Cancer Res. 67:3127–3134. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Scartozzi M, Bearzi I, Pierantoni C, et
al: Nuclear factor-κB tumor expression predicts response and
survival in irinotecan-refractory metastatic colorectal cancer
treated with cetuximab-irinotecan therapy. J Clin Oncol.
25:3930–3935. 2007.
|
|
35
|
Keats JJ, Fonseca R, Chesi M, et al:
Promiscuous mutations activate the noncanonical NF-kappaB pathway
in multiple myeloma. Cancer Cell. 12:131–144. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Annunziata CM, Davis RE, Demchenko Y, et
al: Frequent engagement of the classical and alternative NF-kappaB
pathways by diverse genetic abnormalities in multiple myeloma.
Cancer Cell. 12:115–130. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Yeh CB, Hsieh MJ, Hsieh YH, Chien MH,
Chiou HL and Yang SF: Antimetastatic effects of norcantharidin on
hepatocellular carcinoma by transcriptional inhibition of MMP-9
through modulation of NF-κB activity. PLoS One.
7:e310552012.PubMed/NCBI
|
|
38
|
Lin TH, Tan TW, Tsai TH, et al: D-pinitol
inhibits prostate cancer metastasis through inhibition of αVβ3
integrin by modulating FAK, c-Src and NF-κB pathways. Int J Mol
Sci. 14:9790–9802. 2013.PubMed/NCBI
|
|
39
|
Chen YY, Lu HF, Hsu SC, et al: Bufalin
inhibits migration and invasion in human hepatocellular carcinoma
SK-Hep1 cells through the inhibitions of NF-κB and matrix
metalloproteinase-2/-9-signaling pathways. Environ Toxicol. Aug
16–2013.(Epub ahead of print).
|
|
40
|
Yang XC, Wang X, Luo L, et al: RNA
interference suppression of A100A4 reduces the growth and
metastatic phenotype of human renal cancer cells via
NF-κB-dependent MMP-2 and bcl-2 pathway. Eur Rev Med Pharmacol Sci.
17:1669–1680. 2013.PubMed/NCBI
|
|
41
|
Wu LX, Gu XF, Zhu YC and Zhu YZ:
Protective effects of novel single compound, Hirsutine on hypoxic
neonatal rat cardiomyocytes. Eur J Pharmacol. 650:290–297. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Horie S, Yano S, Aimi N, Sakai S and
Watanabe K: Effects of hirsutine, an antihypertensive indole
alkaloid from Uncaria rhynchophylla, on intracellular
calcium in rat thoracic aorta. Life Sci. 50:491–498. 1992.
View Article : Google Scholar : PubMed/NCBI
|
