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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November-2014 Volume 45 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Significance of serine threonine tyrosine kinase 1 as a drug resistance factor and therapeutic predictor in acute leukemia

  • Authors:
    • Shinya Nirasawa
    • Daisuke Kobayashi
    • Takashi Kondoh
    • Kageaki Kuribayashi
    • Maki Tanaka
    • Nozomi Yanagihara
    • Naoki Watanabe
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory Medicine, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan
  • Pages: 1867-1874
    |
    Published online on: September 3, 2014
       https://doi.org/10.3892/ijo.2014.2633
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Abstract

Alterations in the mRNA expression or the mutation of previously reported tyrosine kinases have been detected only in a limited number of patients with acute leukemia. In this study, we examined whether the widely expressed serine threonine tyrosine kinase 1 (STYK1)/novel oncogene with kinase domain (NOK) acts as a drug resistance factor in acute leukemia. The transfection of leukemic HL-60 cells with an STYK1 expression vector resulted in the resistance to doxorubicin and etoposide and decreased drug-induced caspase-3/7 activity and sub-G1 population. To investigate the mechanism of STYK1-induced drug resistance, microarray analysis was performed using HL-60 cells transfected with control or STYK1 expression vectors. Three tyrosine kinases (EphA4, FLT4 and STK31), two NF-κB inducers (MAPK4 and TNF-RSF11A), and two genes essential for stem cell replication (SALL4 and NOV) were identified as novel STYK1-induced genes. In addition to the data using cell line, a comparison of the leukemic patients who did and did not respond to therapy revealed that STYK1 expression before therapy was significantly higher in the non-responder group compared with the group that responded completely. These results suggest that STYK1 is a novel drug resistance factor and could be a predictor of the therapeutic response in acute leukemia.
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Copy and paste a formatted citation
Spandidos Publications style
Nirasawa S, Kobayashi D, Kondoh T, Kuribayashi K, Tanaka M, Yanagihara N and Watanabe N: Significance of serine threonine tyrosine kinase 1 as a drug resistance factor and therapeutic predictor in acute leukemia. Int J Oncol 45: 1867-1874, 2014.
APA
Nirasawa, S., Kobayashi, D., Kondoh, T., Kuribayashi, K., Tanaka, M., Yanagihara, N., & Watanabe, N. (2014). Significance of serine threonine tyrosine kinase 1 as a drug resistance factor and therapeutic predictor in acute leukemia. International Journal of Oncology, 45, 1867-1874. https://doi.org/10.3892/ijo.2014.2633
MLA
Nirasawa, S., Kobayashi, D., Kondoh, T., Kuribayashi, K., Tanaka, M., Yanagihara, N., Watanabe, N."Significance of serine threonine tyrosine kinase 1 as a drug resistance factor and therapeutic predictor in acute leukemia". International Journal of Oncology 45.5 (2014): 1867-1874.
Chicago
Nirasawa, S., Kobayashi, D., Kondoh, T., Kuribayashi, K., Tanaka, M., Yanagihara, N., Watanabe, N."Significance of serine threonine tyrosine kinase 1 as a drug resistance factor and therapeutic predictor in acute leukemia". International Journal of Oncology 45, no. 5 (2014): 1867-1874. https://doi.org/10.3892/ijo.2014.2633
Copy and paste a formatted citation
x
Spandidos Publications style
Nirasawa S, Kobayashi D, Kondoh T, Kuribayashi K, Tanaka M, Yanagihara N and Watanabe N: Significance of serine threonine tyrosine kinase 1 as a drug resistance factor and therapeutic predictor in acute leukemia. Int J Oncol 45: 1867-1874, 2014.
APA
Nirasawa, S., Kobayashi, D., Kondoh, T., Kuribayashi, K., Tanaka, M., Yanagihara, N., & Watanabe, N. (2014). Significance of serine threonine tyrosine kinase 1 as a drug resistance factor and therapeutic predictor in acute leukemia. International Journal of Oncology, 45, 1867-1874. https://doi.org/10.3892/ijo.2014.2633
MLA
Nirasawa, S., Kobayashi, D., Kondoh, T., Kuribayashi, K., Tanaka, M., Yanagihara, N., Watanabe, N."Significance of serine threonine tyrosine kinase 1 as a drug resistance factor and therapeutic predictor in acute leukemia". International Journal of Oncology 45.5 (2014): 1867-1874.
Chicago
Nirasawa, S., Kobayashi, D., Kondoh, T., Kuribayashi, K., Tanaka, M., Yanagihara, N., Watanabe, N."Significance of serine threonine tyrosine kinase 1 as a drug resistance factor and therapeutic predictor in acute leukemia". International Journal of Oncology 45, no. 5 (2014): 1867-1874. https://doi.org/10.3892/ijo.2014.2633
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