MicroRNA-135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin

  • Authors:
    • Wei-Guo Xu
    • Ying-Lie Shang
    • Xian-Rui Cong
    • Xia Bian
    • Zhen Yuan
  • View Affiliations

  • Published online on: September 4, 2014     https://doi.org/10.3892/ijo.2014.2641
  • Pages: 2024-2032
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Abstract

MicroRNA-135b (miR‑135b) functions as an oncogene in malignant tumors suggesting that it might be a target for malignant tumor therapy, but its role in osteosarcoma has not been investigated to date. In this study, we found that myocardin expression is specifically attenuated in MG63 osteosarcoma cells. Silencing miR‑135b restores the expression of myocardin and miR‑135b inhibits the expression of myocardin by targeting its 3'UTR in MG63 osteosarcoma cells. In additional experiments, we found that miR‑135b was highly expressed in osteosarcoma tissues and it promoted MG63 cell proliferation, migration and invasion. Myocardin had the opposite effects of miR‑135b, which suppressed proliferation, migration and invasion in MG63 cells. Thus, it is probably that miR‑135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin.
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November-2014
Volume 45 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Xu W, Shang Y, Cong X, Bian X and Yuan Z: MicroRNA-135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin. Int J Oncol 45: 2024-2032, 2014.
APA
Xu, W., Shang, Y., Cong, X., Bian, X., & Yuan, Z. (2014). MicroRNA-135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin. International Journal of Oncology, 45, 2024-2032. https://doi.org/10.3892/ijo.2014.2641
MLA
Xu, W., Shang, Y., Cong, X., Bian, X., Yuan, Z."MicroRNA-135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin". International Journal of Oncology 45.5 (2014): 2024-2032.
Chicago
Xu, W., Shang, Y., Cong, X., Bian, X., Yuan, Z."MicroRNA-135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin". International Journal of Oncology 45, no. 5 (2014): 2024-2032. https://doi.org/10.3892/ijo.2014.2641