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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November-2014 Volume 45 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November-2014 Volume 45 Issue 5

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Article

MicroRNA-135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin

  • Authors:
    • Wei-Guo Xu
    • Ying-Lie Shang
    • Xian-Rui Cong
    • Xia Bian
    • Zhen Yuan
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Shanxian County Dongda Hospital, Shanxian, Heze, Shandong 274300, P.R. China, Department of Orthopedics, The 2nd People's Hospital of Dongying, Dawang Town, Dongying, Shandong 257335, P.R. China, Department of Oncology, The People's Hospital of Dongying, Dongying District, Dongying, Shandong 257091, P.R. China, Department of Orthopedics, Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China
  • Pages: 2024-2032
    |
    Published online on: September 4, 2014
       https://doi.org/10.3892/ijo.2014.2641
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Abstract

MicroRNA-135b (miR‑135b) functions as an oncogene in malignant tumors suggesting that it might be a target for malignant tumor therapy, but its role in osteosarcoma has not been investigated to date. In this study, we found that myocardin expression is specifically attenuated in MG63 osteosarcoma cells. Silencing miR‑135b restores the expression of myocardin and miR‑135b inhibits the expression of myocardin by targeting its 3'UTR in MG63 osteosarcoma cells. In additional experiments, we found that miR‑135b was highly expressed in osteosarcoma tissues and it promoted MG63 cell proliferation, migration and invasion. Myocardin had the opposite effects of miR‑135b, which suppressed proliferation, migration and invasion in MG63 cells. Thus, it is probably that miR‑135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin.
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Copy and paste a formatted citation
Spandidos Publications style
Xu W, Shang Y, Cong X, Bian X and Yuan Z: MicroRNA-135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin. Int J Oncol 45: 2024-2032, 2014.
APA
Xu, W., Shang, Y., Cong, X., Bian, X., & Yuan, Z. (2014). MicroRNA-135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin. International Journal of Oncology, 45, 2024-2032. https://doi.org/10.3892/ijo.2014.2641
MLA
Xu, W., Shang, Y., Cong, X., Bian, X., Yuan, Z."MicroRNA-135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin". International Journal of Oncology 45.5 (2014): 2024-2032.
Chicago
Xu, W., Shang, Y., Cong, X., Bian, X., Yuan, Z."MicroRNA-135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin". International Journal of Oncology 45, no. 5 (2014): 2024-2032. https://doi.org/10.3892/ijo.2014.2641
Copy and paste a formatted citation
x
Spandidos Publications style
Xu W, Shang Y, Cong X, Bian X and Yuan Z: MicroRNA-135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin. Int J Oncol 45: 2024-2032, 2014.
APA
Xu, W., Shang, Y., Cong, X., Bian, X., & Yuan, Z. (2014). MicroRNA-135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin. International Journal of Oncology, 45, 2024-2032. https://doi.org/10.3892/ijo.2014.2641
MLA
Xu, W., Shang, Y., Cong, X., Bian, X., Yuan, Z."MicroRNA-135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin". International Journal of Oncology 45.5 (2014): 2024-2032.
Chicago
Xu, W., Shang, Y., Cong, X., Bian, X., Yuan, Z."MicroRNA-135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin". International Journal of Oncology 45, no. 5 (2014): 2024-2032. https://doi.org/10.3892/ijo.2014.2641
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