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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

p62/SQSTM1 is involved in cisplatin resistance in human ovarian cancer cells via the Keap1-Nrf2-ARE system

  • Authors:
    • Meihui Xia
    • Huimei Yu
    • Shuang Gu
    • Ye Xu
    • Jing Su
    • Hongyan Li
    • Jinsong Kang
    • Manhua Cui
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China, Department of Pathophysiology, School of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China, Department of Thoracic Surgery, The People's Hospital of Jilin Province, Changchun, Jilin 130021, P.R. China, Medical Research Lab, Jilin Medical College, Jilin 132013, P.R. China
  • Pages: 2341-2348
    |
    Published online on: September 24, 2014
       https://doi.org/10.3892/ijo.2014.2669
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Abstract

The mechanisms underlying cisplatin resistance in tumors are not fully understood. Previous studies have reported that cellular resistance to oxidative stress is accompanied by resistance to cisplatin. However, the relationship between the resistance to oxidative stress and cisplatin drug resistance in human ovarian cancer cells (HOCCs) is not clear. Here, we reveal a critical role for the multifunctional protein p62/SQSTM1 in cisplatin resistance in human ovarian cancer cells (HOCCs). p62/SQSTM1 (sequestosome 1) plays important roles in cell differentiation, proliferation and as an antiapoptotic molecule. We found that cisplatin-resistant SKOV3/DDP cells express much higher levels of p62 than do cisplatin-sensitive SKOV3 cells. The protein p62 can activate the Keap1-Nrf2-ARE signaling pathway and induce the expression of antioxidant genes in SKOV3/DDP cells. Knockdown of p62 resensitizes SKOV3/DDP cells to cisplatin. Collectively, our data indicate that cisplatin resistance in HOCCs is partially attributable to their high expression of p62, which plays an important role in preventing ROS stress-induced apoptosis by regulating the Keap1-Nrf2-ARE signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Xia M, Yu H, Gu S, Xu Y, Su J, Li H, Kang J and Cui M: p62/SQSTM1 is involved in cisplatin resistance in human ovarian cancer cells via the Keap1-Nrf2-ARE system. Int J Oncol 45: 2341-2348, 2014.
APA
Xia, M., Yu, H., Gu, S., Xu, Y., Su, J., Li, H. ... Cui, M. (2014). p62/SQSTM1 is involved in cisplatin resistance in human ovarian cancer cells via the Keap1-Nrf2-ARE system. International Journal of Oncology, 45, 2341-2348. https://doi.org/10.3892/ijo.2014.2669
MLA
Xia, M., Yu, H., Gu, S., Xu, Y., Su, J., Li, H., Kang, J., Cui, M."p62/SQSTM1 is involved in cisplatin resistance in human ovarian cancer cells via the Keap1-Nrf2-ARE system". International Journal of Oncology 45.6 (2014): 2341-2348.
Chicago
Xia, M., Yu, H., Gu, S., Xu, Y., Su, J., Li, H., Kang, J., Cui, M."p62/SQSTM1 is involved in cisplatin resistance in human ovarian cancer cells via the Keap1-Nrf2-ARE system". International Journal of Oncology 45, no. 6 (2014): 2341-2348. https://doi.org/10.3892/ijo.2014.2669
Copy and paste a formatted citation
x
Spandidos Publications style
Xia M, Yu H, Gu S, Xu Y, Su J, Li H, Kang J and Cui M: p62/SQSTM1 is involved in cisplatin resistance in human ovarian cancer cells via the Keap1-Nrf2-ARE system. Int J Oncol 45: 2341-2348, 2014.
APA
Xia, M., Yu, H., Gu, S., Xu, Y., Su, J., Li, H. ... Cui, M. (2014). p62/SQSTM1 is involved in cisplatin resistance in human ovarian cancer cells via the Keap1-Nrf2-ARE system. International Journal of Oncology, 45, 2341-2348. https://doi.org/10.3892/ijo.2014.2669
MLA
Xia, M., Yu, H., Gu, S., Xu, Y., Su, J., Li, H., Kang, J., Cui, M."p62/SQSTM1 is involved in cisplatin resistance in human ovarian cancer cells via the Keap1-Nrf2-ARE system". International Journal of Oncology 45.6 (2014): 2341-2348.
Chicago
Xia, M., Yu, H., Gu, S., Xu, Y., Su, J., Li, H., Kang, J., Cui, M."p62/SQSTM1 is involved in cisplatin resistance in human ovarian cancer cells via the Keap1-Nrf2-ARE system". International Journal of Oncology 45, no. 6 (2014): 2341-2348. https://doi.org/10.3892/ijo.2014.2669
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