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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December-2014 Volume 45 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Silencing HIWI suppresses the growth, invasion and migration of glioma cells

  • Authors:
    • Xiuyu Wang
    • Xiaoguang Tong
    • Hongmei Gao
    • Xiaoling Yan
    • Xinnv Xu
    • Shupeng Sun
    • Qiong Wang
    • Jinhuan Wang
  • View Affiliations / Copyright

    Affiliations: The Graduate School, Tianjin Medical University, Tianjin 300070, P.R. China, Tianjin Neurosurgery Institute, Tianjin Cerebral Vascular and Neural Degenerative Disease Key Laboratory, Tianjin Huanhu Hospital, Tianjin 300060, P.R. China, Department of Critical Care Medicine, Tianjin First Central Hospital, Tianjin 300192, P.R. China
  • Pages: 2385-2392
    |
    Published online on: September 25, 2014
       https://doi.org/10.3892/ijo.2014.2673
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Abstract

The HIWI gene is one of the members of the PIWI gene family that is important for stem cell self‑renewal and expressed highly in certain human tumors. Some studies have demonstrated that HIWI plays a key role in the development of tumors in cervical, colon and liver cancer. Previous studies have demonstrated that HIWI is associated with prognosis of patients with glioma. However, there is no report on the analysis of HIWI in the biological characteristics of glioma cells. The aim of the study was to investigate whether HIWI plays an important role in the progress of glioma. Silencing HIWI inhibited cell proliferation by promoting apoptosis and increased cell cycle arrest. The expression of proteins related to apoptosis and the cell cycle, including p21, cyclin D1, Bcl‑2, and Bax was significantly altered. Moreover, knockdown of HIWI inhibited the migration and invasion of glioma cells by reducing the expression of MMP‑2 and MMP‑9. Furthermore, we found that reduction of HIWI inhibited tumor growth in vivo. These findings suggest that HIWI is an oncogene involved in the progression of glioma.
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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Tong X, Gao H, Yan X, Xu X, Sun S, Wang Q and Wang J: Silencing HIWI suppresses the growth, invasion and migration of glioma cells. Int J Oncol 45: 2385-2392, 2014.
APA
Wang, X., Tong, X., Gao, H., Yan, X., Xu, X., Sun, S. ... Wang, J. (2014). Silencing HIWI suppresses the growth, invasion and migration of glioma cells. International Journal of Oncology, 45, 2385-2392. https://doi.org/10.3892/ijo.2014.2673
MLA
Wang, X., Tong, X., Gao, H., Yan, X., Xu, X., Sun, S., Wang, Q., Wang, J."Silencing HIWI suppresses the growth, invasion and migration of glioma cells". International Journal of Oncology 45.6 (2014): 2385-2392.
Chicago
Wang, X., Tong, X., Gao, H., Yan, X., Xu, X., Sun, S., Wang, Q., Wang, J."Silencing HIWI suppresses the growth, invasion and migration of glioma cells". International Journal of Oncology 45, no. 6 (2014): 2385-2392. https://doi.org/10.3892/ijo.2014.2673
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Tong X, Gao H, Yan X, Xu X, Sun S, Wang Q and Wang J: Silencing HIWI suppresses the growth, invasion and migration of glioma cells. Int J Oncol 45: 2385-2392, 2014.
APA
Wang, X., Tong, X., Gao, H., Yan, X., Xu, X., Sun, S. ... Wang, J. (2014). Silencing HIWI suppresses the growth, invasion and migration of glioma cells. International Journal of Oncology, 45, 2385-2392. https://doi.org/10.3892/ijo.2014.2673
MLA
Wang, X., Tong, X., Gao, H., Yan, X., Xu, X., Sun, S., Wang, Q., Wang, J."Silencing HIWI suppresses the growth, invasion and migration of glioma cells". International Journal of Oncology 45.6 (2014): 2385-2392.
Chicago
Wang, X., Tong, X., Gao, H., Yan, X., Xu, X., Sun, S., Wang, Q., Wang, J."Silencing HIWI suppresses the growth, invasion and migration of glioma cells". International Journal of Oncology 45, no. 6 (2014): 2385-2392. https://doi.org/10.3892/ijo.2014.2673
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