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Article

Geographical and anatomical influences on human papillomavirus prevalence diversity in head and neck squamous cell carcinoma in Germany

  • Authors:
    • Elgar Susanne Quabius
    • Jochen Haag
    • André Kühnel
    • Hannes Henry
    • Anna Sophie Hoffmann
    • Tibor Görögh
    • Jürgen Hedderich
    • Matthias Evert
    • Achim G. Beule
    • Steffen Maune
    • Rainald Knecht
    • Attila Óvári
    • Martin Durisin
    • Florian Hoppe
    • Silke Tribius
    • Christoph Röcken
    • Petra Ambrosch
    • Markus Hoffmann
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University Kiel, D-24105 Kiel, Germany, Institute for Pathology, Christian-Albrechts-University Kiel, D-24105 Kiel, Germany, Department of Otorhinolaryngology, University of Schleswig-Holstein, Campus Lübeck, D-23538 Lübeck, Germany, Institute for Medical Informatics and Statistics, Christian-Albrechts-University Kiel, D-24105 Kiel, Germany, Institute for Pathology, Ernst-Moritz-Arndt-University of Greifswald, D-17487 Greifswald, Germany, Department of Otorhinolaryngology, Head and Neck Surgery, Ernst-Moritz-Arndt-University of Greifswald, D-17475 Greifswald, Germany, Department of Otorhinolaryngology, Hospitals of the City of Cologne, Cologne, D-51067 Köln, Germany, Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University Medical Centre Hamburg-Eppendorf, D-20246 Hamburg, Germany, Department of Otorhinolaryngology, Head and Neck Surgery, University of Rostock, D-18057 Rostock, Germany, Department of Otorhinolaryngology, Medical University of Hannover, D-30625 Hannover, Germany, Department of Otorhinolaryngology-Head and Neck Surgery, Klinikum Oldenburg, D-26133 Oldenburg, Germany, Department of Radiation Oncology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany
  • Pages: 414-422
    |
    Published online on: October 7, 2014
       https://doi.org/10.3892/ijo.2014.2697
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Abstract

The increased knowledge regarding HPV-infections in head and neck squamous cell carcinoma (HNSCC) has unexpectedly contributed to several uncertainties related to i) prevalence diversities depending on tumour site and geographical origin of the patients, ii) proportion of HPV-driven tumours among HPV-DNA-positive cases, and iii) identification of patients with HPV-attributed survival benefit. To investigate this heterogeneity, we analysed 307 HNSCC cases (tonsillar, n=135; non-tonsillar, n=172) from eight health care centers mostly from Northern Germany and determined HPV-DNA/mRNA and p16INK4A-status and combined results with the patient outcome. Overall HPV-DNA prevalence rate was 23.5% (72/307); attributed to: 43.7% (59/135) and 7.6% (13/172) tonsillar and non-tonsillar cases, respectively. Among these, 96.6% tonsillar and 38.5% non-tonsillar SCC were HPV-mRNA-positive. Although the study cohort was composed of patients from regions of rather close proximity, prevalence rates showed diversities of up to 40% in HNSCC subsite analysis with the lowest prevalence for tonsillar SCC in metropolitan areas (22.2%) vs. 50.9% in rural areas. Survival analysis identified p16INK4A alone as strongest predictor, followed by HPV-DNA-status alone or in combination with p16INK4A. This survival benefit was shown for tonsillar and non-tonsillar cases. Smoking significantly correlated with HPV-status, however, it does not influence survival when stratified for HPV. In conclusion, the data emphasize the urge for further data on HPV-infection in HNSCC to, e.g. clarify to what extent survival benefits of p16INK4A-positive patients are truly attributed to HPV-infections.
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1 

Fakhry C, Westra WH, Li S, et al: Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst. 100:261–269. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Gillison ML, Koch WM, Capone RB, et al: Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst. 92:709–720. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Klussmann JP, Weissenborn SJ, Wieland U, et al: Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas. Cancer. 92:2875–2884. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Kreimer AR, Clifford GM, Boyle P, et al: Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev. 14:467–475. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Ang KK, Harris J, Wheeler R, et al: Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 363:24–35. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Smith EM, Ritchie JM, Summersgill KF, et al: Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers. Int J Cancer. 108:766–772. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Holzinger D, Schmitt M, Dyckhoff G, et al: Viral RNA patterns and high viral load reliably define oropharynx carcinomas with active HPV16 involvement. Cancer Res. 72:4993–5003. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Hoffmann M, Ihloff AS, Görögh T, et al: p16(INK4a) over-expression predicts translational active human papillomavirus infection in tonsillar cancer. Int J Cancer. 127:1595–1602. 2910. View Article : Google Scholar : PubMed/NCBI

9 

Hoffmann M, Tribius S, Quabius ES, et al: HPV DNA, E6(*) I-mRNA expression and p16(INK4A) immunohistochemistry in head and neck cancer - How valid is p16(INK4A) as surrogate marker? Cancer Lett. 323:88–96. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Shi W, Kato H, Perez-Ordonez B, et al: Comparative prognostic value of HPV16 E6 mRNA compared with in situ hybridization for human oropharyngeal squamous carcinoma. J Clin Oncol. 27:6213–6221. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Smeets SJ, Hesselink AT, Speel E-JM, et al: A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen. Int J Cancer. 121:2465–2472. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Wiest T, Schwarz E, Enders C, et al: Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control. Oncogene. 21:1510–1517. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Attner P, Du J, Näsman A, et al: Human papillomavirus and survival in patients with base of tongue cancer. Int J Cancer. 128:2892–2897. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Tribius S, Ihloff AS, Rieckmann T, et al: Impact of HPV status on treatment of squamous cell cancer of the oropharynx: what we know and what we need to know. Cancer Lett. 304:71–79. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Hoffmann M, Görögh T, Gottschlich S, et al: Human papilloma-viruses in head and neck cancer: 8 year-survival-analysis of 73 patients. Cancer Lett. 218:199–206. 2005.PubMed/NCBI

16 

Straetmans JM, Olthof N, Mooren JJ, et al: Human papillomavirus reduces the prognostic value of nodal involvement in tonsillar squamous cell carcinomas. Laryngoscope. 119:1951–1957. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Hoffmann M, Kahn T, Mahnke CG, et al: Prevalence of human papillomavirus in squamous cell carcinoma of the head and neck determined by polymerase chain reaction and Southern blot hybridization: proposal for optimized diagnostic requirements. Acta Otolaryngol. 118:138–144. 1998. View Article : Google Scholar

18 

Näsman A, Attner P, Hammarstedt L, et al: Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: an epidemic of viral-induced carcinoma? Int J Cancer. 125:362–366. 2009.PubMed/NCBI

19 

Termine N, Panzarella V, Falaschini S, et al: HPV in oral squamous cell carcinoma vs. head and neck squamous cell carcinoma biopsies: a meta-analysis (1988–2007). Ann Oncol. 19:1681–1690. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Pannone G, Rodolico V, Santoro A, et al: Evaluation of a combined triple method to detect causative HPV in oral and oropharyngeal squamous cell carcinomas: p16 immunohisto-chemistry, consensus PCR HPV-DNA, and in situ hybridization. Infect Agent Cancer. 7:42012. View Article : Google Scholar

21 

Holzinger D, Flechtenmacher C, Henfling N, et al: Identification of oropharyngeal squamous cell carcinomas with active HPV16 involvement by immunohistochemical analysis of the retinoblastoma protein pathway. Int J Cancer. 133:1389–1400. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Kostareli E, Holzinger D, Bogatyrova O, et al: HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas. J Clin Invest. 123:2488–2501. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Reuschenbach M, Clad A, von Knebel Doeberitz C, et al: Performance of p16INK4a-cytology, HPV mRNA, and HPV DNA testing to identify high grade cervical dysplasia in women with abnormal screening results. Gynecol Oncol. 119:98–105. 2010. View Article : Google Scholar

24 

Reuschenbach M, Kansy K, Garbe K, et al: Lack of evidence of human papillomavirus-induced squamous cell carcinomas of the oral cavity in southern Germany. Oral Oncol. 49:937–942. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Remmerbach TW, Brinckmann UG, Hemprich A, et al: PCR detection of human papillomavirus of the mucosa: comparison between MY09/11 and GP5+/6+ primer sets. J Clin Virol. 30:302–208. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Quabius ES, Ossenkop L, Harder S and Kern M: Dental implants stimulate expression of Interleukin-8 and its receptor in human blood - An in vitro approach. J Biomed Mater Res B Appl Biomater. 100:1283–1288. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Halec G, Schmitt M, Dondog B, et al: Biological activity of probable/possible high-risk human papillomavirus types in cervical cancer. Int J Cancer. 132:63–71. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Klaes R, Friedrich T, Spitkovsky D, et al: Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer. 92:276–284. 2001. View Article : Google Scholar

29 

Gillison ML, D’Souza G, Westra W, et al: Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst. 100:407–420. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Weiss D, Koopmann M and Rudack C: Prevalence and impact on clinicopathological characteristics of human papillomavirus-16 DNA in cervical lymph node metastases of head and neck squamous cell carcinoma. Head Neck. 33:856–862. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Hoffmann M, Gottschlich S, Görögh T, et al: Human papilloma-viruses in lymph node neck metastases of head and neck cancers. Acta Otolaryngol. 125:415–4121. 2005.PubMed/NCBI

32 

Hoffmann M, Orlamünder A, Sucher J, et al: HPV16 DNA in histologically confirmed tumour-free neck lymph nodes of head and neck cancers. Anticancer Res. 26:663–670. 2006.PubMed/NCBI

33 

Hoffmann M, Klose N, Gottschlich S, Görögh T, Fazel A, Lohrey C, et al: Detection of human papillomavirus DNA in benign and malignant sinonasal neoplasms. Cancer Lett. 239:64–70. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Hoffmann M, Scheunemann D, Fazel A, et al: Human papillomavirus and p53 polymorphism in codon 72 in head and neck squamous cell carcinoma. Oncol Rep. 21:809–814. 2009.PubMed/NCBI

35 

Chaturvedi AK, Engels EA, Pfeiffer RM, et al: Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol. 29:4294–4301. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Chung CH and Gillison ML: Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications. Clin Cancer Res. 15:6758–6762. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Klussmann JP, Mooren JJ, Lehnen M, et al: Genetic signatures of HPV-related and unrelated oropharyngeal carcinoma and their prognostic implications. Clin Cancer Res. 15:1779–1786. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Liang C, Marsit CJ, McClean MD, et al: Biomarkers of HPV in head and neck squamous cell carcinoma. Cancer Res. 72:5004–5013. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Lassen P, Eriksen JG, Hamilton-Dutoit S, et al: Effect of HPV-associated p16INK4A expression on response to radio-therapy and survival in squamous cell carcinoma of the head and neck. J Clin Oncol. 27:1992–1998. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Lassen P, Eriksen JG, Hamilton-Dutoit S, Tramm T, et al: HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer. Radiother Oncol. 94:30–35. 2010. View Article : Google Scholar : PubMed/NCBI

41 

O’Sullivan B, Hui Huang S, Siu LL, et al: Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis. J Clin Oncol. 31:543–550. 2013.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Quabius ES, Haag J, Kühnel A, Henry H, Hoffmann AS, Görögh T, Hedderich J, Evert M, Beule AG, Maune S, Maune S, et al: Geographical and anatomical influences on human papillomavirus prevalence diversity in head and neck squamous cell carcinoma in Germany. Int J Oncol 46: 414-422, 2015.
APA
Quabius, E.S., Haag, J., Kühnel, A., Henry, H., Hoffmann, A.S., Görögh, T. ... Hoffmann, M. (2015). Geographical and anatomical influences on human papillomavirus prevalence diversity in head and neck squamous cell carcinoma in Germany. International Journal of Oncology, 46, 414-422. https://doi.org/10.3892/ijo.2014.2697
MLA
Quabius, E. S., Haag, J., Kühnel, A., Henry, H., Hoffmann, A. S., Görögh, T., Hedderich, J., Evert, M., Beule, A. G., Maune, S., Knecht, R., Óvári, A., Durisin, M., Hoppe, F., Tribius, S., Röcken, C., Ambrosch, P., Hoffmann, M."Geographical and anatomical influences on human papillomavirus prevalence diversity in head and neck squamous cell carcinoma in Germany". International Journal of Oncology 46.1 (2015): 414-422.
Chicago
Quabius, E. S., Haag, J., Kühnel, A., Henry, H., Hoffmann, A. S., Görögh, T., Hedderich, J., Evert, M., Beule, A. G., Maune, S., Knecht, R., Óvári, A., Durisin, M., Hoppe, F., Tribius, S., Röcken, C., Ambrosch, P., Hoffmann, M."Geographical and anatomical influences on human papillomavirus prevalence diversity in head and neck squamous cell carcinoma in Germany". International Journal of Oncology 46, no. 1 (2015): 414-422. https://doi.org/10.3892/ijo.2014.2697
Copy and paste a formatted citation
x
Spandidos Publications style
Quabius ES, Haag J, Kühnel A, Henry H, Hoffmann AS, Görögh T, Hedderich J, Evert M, Beule AG, Maune S, Maune S, et al: Geographical and anatomical influences on human papillomavirus prevalence diversity in head and neck squamous cell carcinoma in Germany. Int J Oncol 46: 414-422, 2015.
APA
Quabius, E.S., Haag, J., Kühnel, A., Henry, H., Hoffmann, A.S., Görögh, T. ... Hoffmann, M. (2015). Geographical and anatomical influences on human papillomavirus prevalence diversity in head and neck squamous cell carcinoma in Germany. International Journal of Oncology, 46, 414-422. https://doi.org/10.3892/ijo.2014.2697
MLA
Quabius, E. S., Haag, J., Kühnel, A., Henry, H., Hoffmann, A. S., Görögh, T., Hedderich, J., Evert, M., Beule, A. G., Maune, S., Knecht, R., Óvári, A., Durisin, M., Hoppe, F., Tribius, S., Röcken, C., Ambrosch, P., Hoffmann, M."Geographical and anatomical influences on human papillomavirus prevalence diversity in head and neck squamous cell carcinoma in Germany". International Journal of Oncology 46.1 (2015): 414-422.
Chicago
Quabius, E. S., Haag, J., Kühnel, A., Henry, H., Hoffmann, A. S., Görögh, T., Hedderich, J., Evert, M., Beule, A. G., Maune, S., Knecht, R., Óvári, A., Durisin, M., Hoppe, F., Tribius, S., Röcken, C., Ambrosch, P., Hoffmann, M."Geographical and anatomical influences on human papillomavirus prevalence diversity in head and neck squamous cell carcinoma in Germany". International Journal of Oncology 46, no. 1 (2015): 414-422. https://doi.org/10.3892/ijo.2014.2697
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