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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January-2015 Volume 46 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Selective anticancer effects and protection from chemotherapy by the botanical compound LCS101: Implications for cancer treatment

  • Authors:
    • Zoya Cohen
    • Yair Maimon
    • Merav Yoeli-Lerner
    • Peiying Yang
    • Noah Samuels
    • Raanan Berger
  • View Affiliations / Copyright

    Affiliations: Tal Center for Integrative Medicine, Institute of Oncology, Sheba Medical Center, Tel Hashomer, Israel, Department of General Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA, Institute of Oncology, Sheba Medical Center, Tel Hashomer, Israel
  • Pages: 308-316
    |
    Published online on: October 17, 2014
       https://doi.org/10.3892/ijo.2014.2711
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Abstract

There is a need for new options for reducing the side effects of cancer treatment, without compromising efficacy, enabling patients to complete treatment regimens. The botanical compound LCS101 exhibits inhibitory effects on cancer cell growth, and reduces chemotherapy-induced hematological toxicities. The aim of the present study is to examine the selectivity of the effects of the compound, alone and in conjunction with conventional chemotherapy agents, on cancer cell proliferation. The effects of LCS101 were tested on a number of cancer cell lines (breast, MCF7, MDA-MB‑231; colorectal, HCT116; prostate, PC-3, DU-145) and on non-tumorigenic normal human epithelial cells (breast, MCF10A; prostate, EP#2). Cell viability was analyzed using an XTT assay and observed by light microscopy. Necrosis and apoptosis were examined using FACS analysis and immunoblotting. LCS101 selectively induced cell death in breast, colon and prostate cancer cell lines, as measured by XTT assay. Light microscopy and FACS analysis showed changes indicative of a necrotic process. LCS101 was also found to induce PARP-1 reduction in breast cancer cells, with no effect on non-tumorigenic breast epithelial cells. While LCS101 increased cell death in cancer cells exposed to doxorubicin and 5-FU, it showed a protective effect on non-tumorigenic human epithelial cells from chemotherapy-induced cell death. A similar selective effect was observed with apoptosis-associated PARP-1 cleavage. The findings demonstrate that the anti-proliferative effects exhibited by the botanical compound LCS101 are selective to cancer cells, and offer protection to non-tumorigenic normal epithelial cells from chemotherapy agents.
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Copy and paste a formatted citation
Spandidos Publications style
Cohen Z, Maimon Y, Yoeli-Lerner M, Yang P, Samuels N and Berger R: Selective anticancer effects and protection from chemotherapy by the botanical compound LCS101: Implications for cancer treatment. Int J Oncol 46: 308-316, 2015.
APA
Cohen, Z., Maimon, Y., Yoeli-Lerner, M., Yang, P., Samuels, N., & Berger, R. (2015). Selective anticancer effects and protection from chemotherapy by the botanical compound LCS101: Implications for cancer treatment. International Journal of Oncology, 46, 308-316. https://doi.org/10.3892/ijo.2014.2711
MLA
Cohen, Z., Maimon, Y., Yoeli-Lerner, M., Yang, P., Samuels, N., Berger, R."Selective anticancer effects and protection from chemotherapy by the botanical compound LCS101: Implications for cancer treatment". International Journal of Oncology 46.1 (2015): 308-316.
Chicago
Cohen, Z., Maimon, Y., Yoeli-Lerner, M., Yang, P., Samuels, N., Berger, R."Selective anticancer effects and protection from chemotherapy by the botanical compound LCS101: Implications for cancer treatment". International Journal of Oncology 46, no. 1 (2015): 308-316. https://doi.org/10.3892/ijo.2014.2711
Copy and paste a formatted citation
x
Spandidos Publications style
Cohen Z, Maimon Y, Yoeli-Lerner M, Yang P, Samuels N and Berger R: Selective anticancer effects and protection from chemotherapy by the botanical compound LCS101: Implications for cancer treatment. Int J Oncol 46: 308-316, 2015.
APA
Cohen, Z., Maimon, Y., Yoeli-Lerner, M., Yang, P., Samuels, N., & Berger, R. (2015). Selective anticancer effects and protection from chemotherapy by the botanical compound LCS101: Implications for cancer treatment. International Journal of Oncology, 46, 308-316. https://doi.org/10.3892/ijo.2014.2711
MLA
Cohen, Z., Maimon, Y., Yoeli-Lerner, M., Yang, P., Samuels, N., Berger, R."Selective anticancer effects and protection from chemotherapy by the botanical compound LCS101: Implications for cancer treatment". International Journal of Oncology 46.1 (2015): 308-316.
Chicago
Cohen, Z., Maimon, Y., Yoeli-Lerner, M., Yang, P., Samuels, N., Berger, R."Selective anticancer effects and protection from chemotherapy by the botanical compound LCS101: Implications for cancer treatment". International Journal of Oncology 46, no. 1 (2015): 308-316. https://doi.org/10.3892/ijo.2014.2711
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