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International Journal of Oncology
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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

HIF-1α decoy oligodeoxynucleotides inhibit HIF-1α signaling and breast cancer proliferation

  • Authors:
    • Xuhong Zhu
    • Qin Li
    • Shuang Li
    • Bote Chen
    • Haidong Zou
  • View Affiliations / Copyright

    Affiliations: Outpatient Department, Gansu Provincial Hospital, Lanzhou 730000, P.R. China, Department of Plastic Surgery, General Hospital of Guangzhou Military Command, Guangzhou 510010, P.R. China, Department of Urology, General Hospital of Guangzhou Military Command, Guangzhou 510010, P.R. China, Department of Obstetrics and Gynecology, General Hospital of Guangzhou Military Command, Guangzhou 510010, P.R. China
  • Pages: 215-222
    |
    Published online on: October 21, 2014
       https://doi.org/10.3892/ijo.2014.2715
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Abstract

Although HIF-1α is considered an attractive target for the development of cancer therapies, like other transcriptional factors, it has been regarded as ‘undruggable’. The decoy approach is a new class of antigene strategy that can be used to modulate the function of endogenous transcriptional factors. Here, we designed a decoy oligodeoxynucleotide (ODN) and tested its effect on the function of HIF-1α. We found the HIF-1α decoy ODN could efficiently enter into cells. Furthermore, these decoy ODNs can significantly block the expression of VEGFA, a known targeted gene of HIF-1α suggesting that the HIF-1α decoy ODNs can inhibit the function of HIF-1α. More importantly, the HIF-1α decoy ODN induced apoptosis and cell cycle arrest in MDA-MB-231 breast cancer cells. In summary, HIF-1α decoy ODNs can inhibit the function of HIF-1α and induce cancer cell apoptosis. Therefore, HIF-1α decoy ODNs should be further modified to improve their biological activity in vivo.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu X, Li Q, Li S, Chen B and Zou H: HIF-1α decoy oligodeoxynucleotides inhibit HIF-1α signaling and breast cancer proliferation. Int J Oncol 46: 215-222, 2015.
APA
Zhu, X., Li, Q., Li, S., Chen, B., & Zou, H. (2015). HIF-1α decoy oligodeoxynucleotides inhibit HIF-1α signaling and breast cancer proliferation. International Journal of Oncology, 46, 215-222. https://doi.org/10.3892/ijo.2014.2715
MLA
Zhu, X., Li, Q., Li, S., Chen, B., Zou, H."HIF-1α decoy oligodeoxynucleotides inhibit HIF-1α signaling and breast cancer proliferation". International Journal of Oncology 46.1 (2015): 215-222.
Chicago
Zhu, X., Li, Q., Li, S., Chen, B., Zou, H."HIF-1α decoy oligodeoxynucleotides inhibit HIF-1α signaling and breast cancer proliferation". International Journal of Oncology 46, no. 1 (2015): 215-222. https://doi.org/10.3892/ijo.2014.2715
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu X, Li Q, Li S, Chen B and Zou H: HIF-1α decoy oligodeoxynucleotides inhibit HIF-1α signaling and breast cancer proliferation. Int J Oncol 46: 215-222, 2015.
APA
Zhu, X., Li, Q., Li, S., Chen, B., & Zou, H. (2015). HIF-1α decoy oligodeoxynucleotides inhibit HIF-1α signaling and breast cancer proliferation. International Journal of Oncology, 46, 215-222. https://doi.org/10.3892/ijo.2014.2715
MLA
Zhu, X., Li, Q., Li, S., Chen, B., Zou, H."HIF-1α decoy oligodeoxynucleotides inhibit HIF-1α signaling and breast cancer proliferation". International Journal of Oncology 46.1 (2015): 215-222.
Chicago
Zhu, X., Li, Q., Li, S., Chen, B., Zou, H."HIF-1α decoy oligodeoxynucleotides inhibit HIF-1α signaling and breast cancer proliferation". International Journal of Oncology 46, no. 1 (2015): 215-222. https://doi.org/10.3892/ijo.2014.2715
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