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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Multiple roles of extracellular fibroblast growth factors in lung cancer cells

  • Authors:
    • Takahiro Suzuki
    • Hiroyuki Yasuda
    • Koji Funaishi
    • Daisuke Arai
    • Kota Ishioka
    • Keiko Ohgino
    • Tetsuo Tani
    • Junko Hamamoto
    • Ayano Ohashi
    • Katsuhiko Naoki
    • Tomoko Betsuyaku
    • Kenzo Soejima
  • View Affiliations / Copyright

    Affiliations: Keio University School of Medicine, Tokyo 160-8582, Japan, Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan, Keio Cancer Center, Keio University Hospital, Shinjuku-ku, Tokyo 160-8582, Japan
  • Pages: 423-429
    |
    Published online on: October 21, 2014
       https://doi.org/10.3892/ijo.2014.2718
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Abstract

Cancer cells are surrounded by the extracellular fluid, matrix, and stroma cells. Little is known about how extracellular components such as growth factor ligands affect the biology of lung cancer cells. The objective of this study was to determine whether extracellular fibroblast growth factors (FGFs) can affect the biology of lung cancer cells and to understand how extracellular FGFs affect the biology of lung cancer cells, including non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells. Out of the 23 reported FGFs, we focused on FGF2, FGF9 and FGF10. We examined the effect of FGFs on proliferation, treatment sensitivity, and apoptosis of NSCLC (PC9) and SCLC (H69, H82 and H146) cells in vitro. To determine which FGF was the most clinically relevant, we also examined FGF2 and FGF9 concentrations in the serum of patients with lung cancer. We found that extracellular FGFs can affect proliferation, treatment sensitivity, and apoptosis of lung cancer cells in a cell-specific manner. Our results indicate that extracellular FGFs affect the biology of lung cancer cells through multiple functions.
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Copy and paste a formatted citation
Spandidos Publications style
Suzuki T, Yasuda H, Funaishi K, Arai D, Ishioka K, Ohgino K, Tani T, Hamamoto J, Ohashi A, Naoki K, Naoki K, et al: Multiple roles of extracellular fibroblast growth factors in lung cancer cells. Int J Oncol 46: 423-429, 2015.
APA
Suzuki, T., Yasuda, H., Funaishi, K., Arai, D., Ishioka, K., Ohgino, K. ... Soejima, K. (2015). Multiple roles of extracellular fibroblast growth factors in lung cancer cells. International Journal of Oncology, 46, 423-429. https://doi.org/10.3892/ijo.2014.2718
MLA
Suzuki, T., Yasuda, H., Funaishi, K., Arai, D., Ishioka, K., Ohgino, K., Tani, T., Hamamoto, J., Ohashi, A., Naoki, K., Betsuyaku, T., Soejima, K."Multiple roles of extracellular fibroblast growth factors in lung cancer cells". International Journal of Oncology 46.1 (2015): 423-429.
Chicago
Suzuki, T., Yasuda, H., Funaishi, K., Arai, D., Ishioka, K., Ohgino, K., Tani, T., Hamamoto, J., Ohashi, A., Naoki, K., Betsuyaku, T., Soejima, K."Multiple roles of extracellular fibroblast growth factors in lung cancer cells". International Journal of Oncology 46, no. 1 (2015): 423-429. https://doi.org/10.3892/ijo.2014.2718
Copy and paste a formatted citation
x
Spandidos Publications style
Suzuki T, Yasuda H, Funaishi K, Arai D, Ishioka K, Ohgino K, Tani T, Hamamoto J, Ohashi A, Naoki K, Naoki K, et al: Multiple roles of extracellular fibroblast growth factors in lung cancer cells. Int J Oncol 46: 423-429, 2015.
APA
Suzuki, T., Yasuda, H., Funaishi, K., Arai, D., Ishioka, K., Ohgino, K. ... Soejima, K. (2015). Multiple roles of extracellular fibroblast growth factors in lung cancer cells. International Journal of Oncology, 46, 423-429. https://doi.org/10.3892/ijo.2014.2718
MLA
Suzuki, T., Yasuda, H., Funaishi, K., Arai, D., Ishioka, K., Ohgino, K., Tani, T., Hamamoto, J., Ohashi, A., Naoki, K., Betsuyaku, T., Soejima, K."Multiple roles of extracellular fibroblast growth factors in lung cancer cells". International Journal of Oncology 46.1 (2015): 423-429.
Chicago
Suzuki, T., Yasuda, H., Funaishi, K., Arai, D., Ishioka, K., Ohgino, K., Tani, T., Hamamoto, J., Ohashi, A., Naoki, K., Betsuyaku, T., Soejima, K."Multiple roles of extracellular fibroblast growth factors in lung cancer cells". International Journal of Oncology 46, no. 1 (2015): 423-429. https://doi.org/10.3892/ijo.2014.2718
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