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Article

PJ34, a poly(ADP-ribose) polymerase (PARP) inhibitor, reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R

  • Authors:
    • Ting Xiong
    • Heng Wei
    • Xiaoqiong Chen
    • Hui Xiao
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China
  • Pages: 223-232
    |
    Published online on: October 23, 2014
       https://doi.org/10.3892/ijo.2014.2726
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Abstract

There is still no ideal treatment for multidrug resistant multiple myeloma, looking for drugs which can reverse chemotherapy resistance and enhance curative effects of chemotherapy drugs becomes a problem that needs to be solved urgently. Poly(ADP-ribose) polymerase inhibitors appear to be an important tool for medical therapy of several malignancies. In the present study, we investigated the potential of the PARP-1 inhibitor PJ34, in vitro, to further enhance the efficacy of the traditional chemotherapy drug melphalan in the multidrug-resistant multiple myeloma cell line RPMI8226/R. The effects of different concentrations of PJ34 and melphalan on cell proliferation were determined by the CCK-8 assay. The expressions of FA/BRCA pathway-related factors were detected by western blotting and RT-PCR. The percentage of cell apoptosis was measured with flow cytometry. DNA double-strand break (DSB) repair was quantified by γH2AX immunofluorescence. In addition, DNA damage repair at the level of the individual cell was determined by comet assay. Co-administration of PJ34 and melphalan had synergistic inhibitory effects on the proliferation of RPMI8226/R cells, suggesting more powerful antitumor activities. The apoptosis percentage also was increased more obviously by the treatment of melphalan plus PJ34. The activation of FA/BRCA pathway was inhibited by downregulation of related factors including FANCD2, BRCA2 and Rad51. PJ34 significantly increased the ratio of γH2AX-positive cells and the number of foci/cells. The comet tail rate of cells, tail length, tail moment and Olive tail moment all increased after PJ34 treatment in RPMI8226/R cells. These results indicate that PJ34 combined treatment with melphalan produces synergistic effects and reverses multidrug resistance of RPMI8226/R cells effectively. PJ34 cannot induce DNA damage directly, but it may increase the DNA damage induced by melphalan through inhibiting DNA damage repair. The suppression of FA/BRCA pathway may be the mechanism. Therefore, we suggest that PARP inhibitors may deserve future investigations as tools for medical treatment of multidrug resistant multiple myeloma.
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1 

Spanswick VJ, Lowe HL, Newton C, et al: Evidence for different mechanisms of ‘unhooking’ for melphalan and cisplatin-induced DNA interstrand cross-links in vitro and in clinical acquired resistant tumour samples. BMC Cancer. 12:4362012. View Article : Google Scholar

2 

Bouwman P and Jonker J: The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance. Nat Rev Cancer. 12:587–598. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Altieri F, Grillo C, Maceroni M, et al: DNA damage and repair: from molecular mechanisms to health implications. Antioxid Redox Signal. 10:891–937. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Hlavin EM, Smeaton MB and Miller PS: Initiation of DNA interstrand cross-link repair in mammalian cells. Environ Mol Mutagen. 51:604–624. 2010.PubMed/NCBI

5 

Bessho T: Induction of DNA replication-mediated double strand breaks by psoralen DNA interstrandcross-links. J Biol Chem. 278:5250–5254. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Sczepanski JT, Jacobs AC, Van Houten B, et al: Double-strand break formation during nucleotide excision repair of a DNA interstrand cross-link. Biochemistry. 48:7565–7567. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Kim H and D’Andrea AD: Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes Dev. 26:1393–1408. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Mouw KW and D’Andrea AD: Crosstalk between the nucleotide excision repair and Fanconi anemia/BRCA pathways. DNA Repair. 19:130–134. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Levitus M, Joenje H and de Winter JP: The Fanconi anemia pathway of genomic maintenance. Cell Oncol. 28:3–29. 2006.PubMed/NCBI

10 

Cohn MA and D’Andrea AD: Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways. Mol Cell. 32:306–312. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Rodríguez A, Sosa D, Torres L, et al: A Boolean network model of the FA/BRCA pathway. Bioinformatics. 28:858–866. 2012.

12 

Karanja KK, Cox SW, Duxin JP, et al: DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network. Cell Cycle. 11:3983–3996. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Stecklein SR and Jensen RA: Identifying and exploiting defects in the Fanconi anemia/BRCA pathway in oncology. Transl Res. 160:178–197. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Jacquemont C, Simon JA, D’Andrea AD, et al: Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin. Mol Cancer. 11:262012. View Article : Google Scholar : PubMed/NCBI

15 

Chirnomas D, Taniguchi T, de la Vega M, et al: Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway. Mol Cancer Ther. 5:952–961. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Taniguchi T and D’Andrea AD: Molecular pathogenesis of Fanconi anemia: recent progress. Blood. 107:4223–4233. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Mori R, Yoshida K, Tanahashi T, et al: Decreased FANCJ caused by 5FU contributes to the increased sensitivity to oxaliplatin in gastric cancer cells. Gastric Cancer. 16:345–354. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Deans AJ and West SC: DNA interstrand crosslink repair and cancer. Nat Rev Cancer. 11:467–480. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Hegi ME, Sciuscio D, Murat A, et al: Epigenetic deregulation of DNA repair and its potential for therapy. Clin Cancer Res. 15:5026–5031. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Palagyi A, Neveling K, Plinninger U, et al: Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents. Mol Cancer. 9:1272010. View Article : Google Scholar

21 

Burkitt K and Ljungman M: Phenylbutyrate interferes with the Fanconi anemia and BRCA pathway and sensitizes head and neck cancer cells to cisplatin. Mol Cancer. 7:242008. View Article : Google Scholar : PubMed/NCBI

22 

Kondo N, Takahashi A, Mori E, et al: FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ. PLoS One. 6:e196592011. View Article : Google Scholar : PubMed/NCBI

23 

Yarde DN, Oliveira V, Mathews L, et al: Targeting the Fanconi anemia/BRCA pathway circumvents drug resistance in multiple myeloma. Cancer Res. 69:9367–9375. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Adhikari S, Choudhury S, Mitra PS, et al: Targeting base excision repair for chemosensitization. Anticancer Agents Med Chem. 8:351–357. 2008. View Article : Google Scholar : PubMed/NCBI

25 

David KK, Andrabi SA, Dawson TM, et al: Parthanatos, a messenger of death. Front Biosci. 14:1116–1128. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Wang Y, Dawson VL and Dawson TM: Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos. Exp Neurol. 218:193–202. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Bryant HE, Petermann E, Schultz N, et al: PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination. EMBO J. 28:2601–2615. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Krishnakumar R and Kraus WL: The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets. Mol Cell. 39:8–24. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Węsierska-Gądek J, Zulehner N, Ferk F, et al: PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells. Biochem Pharmacol. 84:1318–1331. 2012.PubMed/NCBI

30 

Lavarone E, Puppin C, Passon N, et al: The PARP inhibitor PJ34 modifies proliferation, NIS expression and epigenetic marks in thyroid cancer cell lines. Mol Cell Endocrinol. 365:1–10. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Davidson D, Wang Y, Aloyz R, et al: The PARP inhibitor ABT-888 synergizes irinotecan treatment of colon cancer cell lines. Invest New Drugs. 31:461–468. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Cheng H, Zhang Z, Borczuk A, et al: PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells. Carcinogenesis. 34:739–749. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Cavallo F, Graziani G, Antinozzi C, et al: Reduced proficiency in homologous recombination underlies the high sensitivity of embryonal carcinoma testicular germ cell tumors to cisplatin and poly (ADP-ribose) polymerase inhibition. PLoS One. 7:e515632012. View Article : Google Scholar

34 

Donawho CK, Luo Y, Luo Y, et al: ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin Cancer Res. 13:2728–2737. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Ahel I, Ahel D, Matsusaka T, et al: Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. Nature. 451:81–85. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Pyriochou A, Olah G, Deitch EA, et al: Inhibition of angiogenesis by the poly(ADP-ribose) polymerase inhibitor PJ-34. Int J Mol Med. 22:113–118. 2008.PubMed/NCBI

37 

Xiao H, Xiao Q, Zhang K, et al: Reversal of multidrug resistance by curcumin through FA/BRCA pathway in multiple myeloma cell line MOLP-2/R. Ann Hematol. 89:399–404. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Vinod BS, Maliekal TT and Anto RJ: Phytochemicals as chemosensitizers: from molecular mechanism to clinical significance. Antioxid Redox Signal. 18:1307–1348. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Tomicic MT and Kaina B: Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors. Biochim Biophys Acta. 1835:11–27. 2013.PubMed/NCBI

40 

Liu X, Luo X, Shi Y, et al: Poly (ADP-ribose) polymerase activity regulates apoptosis in HeLa cells after alkylating DNA damage. Cancer Biol Ther. 7:934–941. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Gambi N, Tramontano F and Quesada P: Poly(ADPR) polymerase inhibition and apoptosis induction in cDDP-treated human carcinoma cell lines. Biochem Pharmacol. 75:2356–2363. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Yang YG, Cortes U, Patnaik S, et al: Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks. Oncogene. 23:3872–3882. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Mah LJ, Orlowski C, Ververis K, et al: Utility of γH2AX as a molecular marker of DNA double-strand breaks in nuclear medicine: applications to radionuclide therapy employing auger electron-emitting isotopes. Curr Radiopharm. 4:59–67. 2011. View Article : Google Scholar

44 

Richardson C: RAD51, genomic stability, and tumorigenesis. Cancer Lett. 218:127–139. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Klein HL: The consequences of Rad51 overexpression for normal and tumor cells. DNA Repair. 7:686–693. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Qiao GB, Wu YL, Yang XN, et al: High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients. Br J Cancer. 93:137–143. 2005. View Article : Google Scholar : PubMed/NCBI

47 

Luoto KR, Meng AX, Wasylishen AR, et al: Tumor cell kill by c-MYC depletion: role of MYC-regulated genes that control DNA double-strand break repair. Cancer Res. 70:8748–8759. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xiong T, Wei H, Chen X and Xiao H: PJ34, a poly(ADP-ribose) polymerase (PARP) inhibitor, reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R. Int J Oncol 46: 223-232, 2015.
APA
Xiong, T., Wei, H., Chen, X., & Xiao, H. (2015). PJ34, a poly(ADP-ribose) polymerase (PARP) inhibitor, reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R. International Journal of Oncology, 46, 223-232. https://doi.org/10.3892/ijo.2014.2726
MLA
Xiong, T., Wei, H., Chen, X., Xiao, H."PJ34, a poly(ADP-ribose) polymerase (PARP) inhibitor, reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R". International Journal of Oncology 46.1 (2015): 223-232.
Chicago
Xiong, T., Wei, H., Chen, X., Xiao, H."PJ34, a poly(ADP-ribose) polymerase (PARP) inhibitor, reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R". International Journal of Oncology 46, no. 1 (2015): 223-232. https://doi.org/10.3892/ijo.2014.2726
Copy and paste a formatted citation
x
Spandidos Publications style
Xiong T, Wei H, Chen X and Xiao H: PJ34, a poly(ADP-ribose) polymerase (PARP) inhibitor, reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R. Int J Oncol 46: 223-232, 2015.
APA
Xiong, T., Wei, H., Chen, X., & Xiao, H. (2015). PJ34, a poly(ADP-ribose) polymerase (PARP) inhibitor, reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R. International Journal of Oncology, 46, 223-232. https://doi.org/10.3892/ijo.2014.2726
MLA
Xiong, T., Wei, H., Chen, X., Xiao, H."PJ34, a poly(ADP-ribose) polymerase (PARP) inhibitor, reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R". International Journal of Oncology 46.1 (2015): 223-232.
Chicago
Xiong, T., Wei, H., Chen, X., Xiao, H."PJ34, a poly(ADP-ribose) polymerase (PARP) inhibitor, reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R". International Journal of Oncology 46, no. 1 (2015): 223-232. https://doi.org/10.3892/ijo.2014.2726
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