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Article

Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo

  • Authors:
    • Wenkai Xiao
    • Yajie Jiang
    • Qiuxu Men
    • Ling Yuan
    • Zebo Huang
    • Ting Liu
    • Wenhua Li
    • Xin Liu
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei 430071, P.R. China, School of Life Science, Wuhan University, Wuhan, Hubei 430071, P.R. China
  • Pages: 360-368
    |
    Published online on: October 29, 2014
       https://doi.org/10.3892/ijo.2014.2735
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Abstract

Tetrandrine, a bisbenzylisoquinoline alkaloid, is known to inhibit tumor cell proliferation and induce apoptosis in cancer models in vitro and in vivo. In the present study, tetrandrine significantly inhibited the proliferation of mouse endothelial cells (EOMA cell) and induced G1/S arrest in EOMA cells, in which the expressions of cyclin D and cyclin E and CDKs were downregulated. Tetrandrine treatment also caused intracellular accumulation of reactive oxygen species (ROS). Pretreatment with NAC, which is a ROS inhibitor, blocked G1/S cell arrest and cyclin regulation induced by tetrandrine, implying that ROS generation plays an important role in tetrandrine-induced cell cycle arrest. Furthermore, a decreased phospho-Akt protein level after tetrandrine treatment was reversible with the removal of the intracellular ROS by NAC. Notably, overexpression of Akt decreased tetrandrine-induced G1/S arrest. Finally, we verified the antiangiogenic effects of tetrandrine in vivo in a liver cancer xenograft model in nude mice. In conclusion, tetrandrine inhibits EOMA cell growth through the ROS/Akt pathway, and it could be a promising compound for cancer therapy as an inhibitor of tumor vascular growth.
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1 

Gerald D, Chintharlapalli S, Augustin HG and Benjamin LE: Angiopoietin-2: an attractive target for improved antiangiogenic tumor therapy. Cancer Res. 73:1649–1657. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Turley RS, Fontanella AN, Padussis JC, et al: Bevacizumab-induced alterations in vascular permeability and drug delivery: a novel approach to augment regional chemotherapy for in-transit melanoma. Clin Cancer Res. 18:3328–3339. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Peng F, Xu Z, Wang J, et al: Recombinant human endostatin normalizes tumor vasculature and enhances radiation response in xenografted human nasopharyngeal carcinoma models. PLoS One. 7:e346462012. View Article : Google Scholar

4 

Sagar SM, Yance D and Wong RK: Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer - Part 2. Curr Oncol. 13:99–107. 2006.

5 

Li SY, Ling LH, Teh BS, Seow WK and Thong YH: Anti-inflammatory and immunosuppressive properties of the bis-benzylisoquinolines: in vitro comparisons of tetrandrine and berbamine. Int J Immunopharmacol. 11:395–401. 1989. View Article : Google Scholar : PubMed/NCBI

6 

Chen Y, Chen JC and Tseng SH: Tetrandrine suppresses tumor growth and angiogenesis of gliomas in rats. Int J Cancer. 124:2260–2269. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Lai JH: Immunomodulatory effects and mechanisms of plant alkaloid tetrandrine in autoimmune diseases. Acta Pharmacol Sin. 23:1093–1101. 2002.PubMed/NCBI

8 

Wang G, Lemos JR and Iadecola C: Herbal alkaloid tetrandrine: fron an ion channel blocker to inhibitor of tumor proliferation. Trends Pharmacol Sci. 25:120–123. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Liu C, Gong K, Mao X and Li W: Tetrandrine induces apoptosis by activating reactive oxygen species and repressing Akt activity in human hepatocellular carcinoma. Int J Cancer. 129:1519–1531. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Lee JH, Kang GH, Kim KC, et al: Tetrandrine-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells. Int J Oncol. 21:1239–1244. 2002.PubMed/NCBI

11 

Li X, Su B, Liu R, Wu D and He D: Tetrandrine induces apoptosis and triggers caspase cascade in human bladder cancer cells. J Surg Res. 166:e45–51. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Wu JM, Chen Y, Chen JC, Lin TY and Tseng SH: Tetrandrine induces apoptosis and growth suppression of colon cancer cells in mice. Cancer Lett. 287:187–195. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Gong K, Chen C, Zhan Y, Chen Y, Huang Z and Li W: Autophagy-related gene 7 (ATG7) and reactive oxygen species/extracellular signal-regulated kinase regulate tetrandrine-induced autophagy in human hepatocellular carcinoma. J Biol Chem. 287:35576–35588. 2012. View Article : Google Scholar

14 

Yu J, Tian S, Metheny-Barlow L, et al: Modulation of endothelial cell growth arrest and apoptosis by vascular endothelial growth inhibitor. Circ Res. 89:1161–1167. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Kuo PL and Lin CC: Tetrandrine-induced cell cycle arrest and apoptosis in Hep G2 cells. Life Sci. 73:243–252. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Kobayashi S, Inaba K, Kimura I and Kimura M: Inhibitory effects of tetrandrine on angiogenesis in adjuvant-induced chronic inflammation and tube formation of vascular endothelial cells. Biol Pharm Bull. 21:346–349. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Gao JL, Ji X, He TC, et al: Tetrandrine suppresses cancer angio-genesis and metastasis in 4T1 tumor bearing mice. Evid Based Complement Alternat Med. 2013:2650612013.PubMed/NCBI

18 

Felbor U, Dreier L, Bryant RA, Ploegh HL, Olsen BR and Mothes W: Secreted cathepsin L generates endostatin from collagen XVIII. EMBO J. 19:1187–1194. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Wen W, Moses MA, Wiederschain D, Arbiser JL and Folkman J: The generation of endostatin is mediated by elastase. Cancer Res. 59:6052–6056. 1999.PubMed/NCBI

20 

Gordillo GM, Onat D, Stockinger M, et al: A key angiogenic role of monocyte chemoattractant protein-1 in hemangioendothelioma proliferation. Am J Physiol Cell Physiol. 287:C866–C873. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Obeso J, Weber J and Auerbach R: A hemangioendothelioma-derived cell line: its use as a model for the study of endothelial cell biology. Lab Invest. 63:259–269. 1990.PubMed/NCBI

22 

Lannutti BJ, Gately ST, Quevedo ME, Soff GA and Paller AS: Human angiostatin inhibits murine hemangioendothelioma tumor growth in vivo. Cancer Res. 57:5277–5280. 1997.PubMed/NCBI

23 

O’Reilly MS, Brem H and Folkman J: Treatment of murine hemangioendotheliomas with the angiogenesis inhibitor AGM-1470. J Pediatr Surg. 30:325–330. 1995.PubMed/NCBI

24 

O’Reilly MS, Boehm T, Shing Y, et al: Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell. 88:277–285. 1997.

25 

Koukourakis MI, Giatromanolaki A, Thorpe PE, et al: Vascular endothelial growth factor/KDR activated microvessel density versus CD31 standard microvessel density in non-small cell lung cancer. Cancer Res. 60:3088–3095. 2000.PubMed/NCBI

26 

Qin L, Zhao D, Liu X, et al: Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway. Mol Cancer Res. 4:811–820. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Davani S, Marandin A, Mersin N, et al: Mesenchymal progenitor cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a rat cellular cardiomyoplasty model. Circulation. 108(Suppl 1): II253–II258. 2003. View Article : Google Scholar

28 

Li X, Lu X, Xu H, et al: Paclitaxel/tetrandrine coloaded nanoparticles effectively promote the apoptosis of gastric cancer cells based on ‘oxidation therapy’. Mol Pharm. 9:222–229. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Heinzelmann S and Bauer G: Multiple protective functions of catalase against intercellular apoptosis-inducing ROS signaling of human tumor cells. Biol Chem. 391:675–693. 2010. View Article : Google Scholar

30 

Fatehi-Hassanabad Z, Chan CB and Furman BL: Reactive oxygen species and endothelial function in diabetes. Eur J Pharmacol. 636:8–17. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Ferreira AK, de-Sa-Junior PL, Pasqualoto KF, et al: Cytotoxic effects of dillapiole on MDA-MB-231 cells involve the induction of apoptosis through the mitochondrial pathway by inducing an oxidative stress while altering the cytoskeleton network. Biochimie. 99:195–207. 2013. View Article : Google Scholar

32 

Gong K, Xie J, Yi H and Li W: CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells. Biochem J. 443:735–746. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Sheppard K, Kinross KM, Solomon B, Pearson RB and Phillips WA: Targeting PI3 kinase/AKT/mTOR signaling in cancer. Crit Rev Oncog. 17:69–95. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Janku F, McConkey DJ, Hong DS and Kurzrock R: Autophagy as a target for anticancer therapy. Nat Rev Clin Oncol. 8:528–539. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Song MS, Salmena L and Pandolfi PP: The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol. 13:283–296. 2012.PubMed/NCBI

36 

Liu P, Begley M, Michowski W, et al: Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 508:541–545. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Zhang Y, Wang C, Wang H, Wang K, Du Y and Zhang J: Combination of Tetrandrine with cisplatin enhances cytotoxicity through growth suppression and apoptosis in ovarian cancer in vitro and in vivo. Cancer Lett. 304:21–32. 2011. View Article : Google Scholar : PubMed/NCBI

38 

McCubrey JA, Basecke J, Cervello M, Martelli AM and Franklin RA: GSK-3beta is a critical mediator of tetrandrine induced cell cycle arrest and cytotoxicity. Cancer Biol Ther. 7:10792008. View Article : Google Scholar : PubMed/NCBI

39 

Lee HG, Lee YJ and Yang JH: Perfluorooctane sulfonate induces apoptosis of cerebellar granule cells via a ROS-dependent protein kinase C signaling pathway. Neurotoxicology. 33:314–320. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Lu CY, Yang YC, Li CC, Liu KL, Lii CK and Chen HW: Andrographolide inhibits TNFalpha-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt/AP-1 pathways in human endothelial cells. Biochem Pharmacol. 91:40–50. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Muniz-Feliciano L, Van Grol J, Portillo JA, et al: Toxoplasma gondii-induced activation of EGFR prevents autophagy protein-mediated killing of the parasite. PLoS Pathog. 9:e10038092013. View Article : Google Scholar : PubMed/NCBI

42 

Rodon J, Dienstmann R, Serra V and Tabernero J: Development of PI3K inhibitors: lessons learned from early clinical trials. Nat Rev Clin Oncol. 10:143–153. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Qin L, Zeng H and Zhao D: Requirement of protein kinase D tyrosine phosphorylation for VEGF-A165-induced angiogenesis through its interaction and regulation of phospholipase Cgamma phosphorylation. J Biol Chem. 281:32550–32558. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xiao W, Jiang Y, Men Q, Yuan L, Huang Z, Liu T, Li W and Liu X: Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo. Int J Oncol 46: 360-368, 2015.
APA
Xiao, W., Jiang, Y., Men, Q., Yuan, L., Huang, Z., Liu, T. ... Liu, X. (2015). Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo. International Journal of Oncology, 46, 360-368. https://doi.org/10.3892/ijo.2014.2735
MLA
Xiao, W., Jiang, Y., Men, Q., Yuan, L., Huang, Z., Liu, T., Li, W., Liu, X."Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo". International Journal of Oncology 46.1 (2015): 360-368.
Chicago
Xiao, W., Jiang, Y., Men, Q., Yuan, L., Huang, Z., Liu, T., Li, W., Liu, X."Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo". International Journal of Oncology 46, no. 1 (2015): 360-368. https://doi.org/10.3892/ijo.2014.2735
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao W, Jiang Y, Men Q, Yuan L, Huang Z, Liu T, Li W and Liu X: Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo. Int J Oncol 46: 360-368, 2015.
APA
Xiao, W., Jiang, Y., Men, Q., Yuan, L., Huang, Z., Liu, T. ... Liu, X. (2015). Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo. International Journal of Oncology, 46, 360-368. https://doi.org/10.3892/ijo.2014.2735
MLA
Xiao, W., Jiang, Y., Men, Q., Yuan, L., Huang, Z., Liu, T., Li, W., Liu, X."Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo". International Journal of Oncology 46.1 (2015): 360-368.
Chicago
Xiao, W., Jiang, Y., Men, Q., Yuan, L., Huang, Z., Liu, T., Li, W., Liu, X."Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo". International Journal of Oncology 46, no. 1 (2015): 360-368. https://doi.org/10.3892/ijo.2014.2735
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