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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Gene expression profile for predicting survival of patients with meningioma

  • Authors:
    • Feng Chen
    • Chun-Xiang Xiang
    • Yi Zhou
    • Xiang-Sheng Ao
    • Da-Quan Zhou
    • Peng Peng
    • Hai-Quan Zhang
    • Han-Dong Liu
    • Xing Huang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Xiangyang Central Hospital, Hubei University of Arts and Science, Xiangyang, Hubei 441021, P.R. China, Department of Pathology, Wuhan Central Hospital, Wuhan, Hubei 430014, P.R. China
  • Pages: 791-797
    |
    Published online on: November 25, 2014
       https://doi.org/10.3892/ijo.2014.2779
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Abstract

Current staging methods are inadequate for predicting the overall survival of meningioma. DNA microarray technologies improve the understanding of tumour progression. We analysed genome wide expression profiles of 119 meningioma samples from two previous published DNA microarray studies. The Cox proportional hazards regression models were applied to identify overall survival related gene signature. A total of 449 genes (109 upregulated and 340 downregulated) were identified as differentially expressed in meningioma. Among these differentially expressed genes, 37 genes were identified to be related to meningioma overall survival. Our 37-gene signature is closely associated with overall survival among patients with meningioma. This gene expression profile could provide an optimization of the clinical management and development of new therapeutic strategies for meningioma.
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Copy and paste a formatted citation
Spandidos Publications style
Chen F, Xiang C, Zhou Y, Ao X, Zhou D, Peng P, Zhang H, Liu H and Huang X: Gene expression profile for predicting survival of patients with meningioma. Int J Oncol 46: 791-797, 2015.
APA
Chen, F., Xiang, C., Zhou, Y., Ao, X., Zhou, D., Peng, P. ... Huang, X. (2015). Gene expression profile for predicting survival of patients with meningioma. International Journal of Oncology, 46, 791-797. https://doi.org/10.3892/ijo.2014.2779
MLA
Chen, F., Xiang, C., Zhou, Y., Ao, X., Zhou, D., Peng, P., Zhang, H., Liu, H., Huang, X."Gene expression profile for predicting survival of patients with meningioma". International Journal of Oncology 46.2 (2015): 791-797.
Chicago
Chen, F., Xiang, C., Zhou, Y., Ao, X., Zhou, D., Peng, P., Zhang, H., Liu, H., Huang, X."Gene expression profile for predicting survival of patients with meningioma". International Journal of Oncology 46, no. 2 (2015): 791-797. https://doi.org/10.3892/ijo.2014.2779
Copy and paste a formatted citation
x
Spandidos Publications style
Chen F, Xiang C, Zhou Y, Ao X, Zhou D, Peng P, Zhang H, Liu H and Huang X: Gene expression profile for predicting survival of patients with meningioma. Int J Oncol 46: 791-797, 2015.
APA
Chen, F., Xiang, C., Zhou, Y., Ao, X., Zhou, D., Peng, P. ... Huang, X. (2015). Gene expression profile for predicting survival of patients with meningioma. International Journal of Oncology, 46, 791-797. https://doi.org/10.3892/ijo.2014.2779
MLA
Chen, F., Xiang, C., Zhou, Y., Ao, X., Zhou, D., Peng, P., Zhang, H., Liu, H., Huang, X."Gene expression profile for predicting survival of patients with meningioma". International Journal of Oncology 46.2 (2015): 791-797.
Chicago
Chen, F., Xiang, C., Zhou, Y., Ao, X., Zhou, D., Peng, P., Zhang, H., Liu, H., Huang, X."Gene expression profile for predicting survival of patients with meningioma". International Journal of Oncology 46, no. 2 (2015): 791-797. https://doi.org/10.3892/ijo.2014.2779
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