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Article

The role of IGFBP-5 in mediating the anti-proliferation effect of tetrandrine in human colon cancer cells

Corrigendum in: /10.3892/ijo.2024.5681
  • Authors:
    • Ke Wu
    • Mi Zhou
    • Qiu-Xiang Wu
    • Shuang-Xu Yuan
    • Dong-Xu Wang
    • Jie-Li Jin
    • Jun Huang
    • Jun-Qin Yang
    • Wen-Juan Sun
    • Li-Hua Wan
    • Bai-Cheng He
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, P.R. China, Department of Forensic Medicine, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, P.R. China
  • Pages: 1205-1213
    |
    Published online on: December 17, 2014
       https://doi.org/10.3892/ijo.2014.2800
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Abstract

Colon cancer is one of the most common malignancies, causes considerable morbidity and mortality. The current treatment for colon cancer is more modest than had been hoped. There is an urgent clinical need to explore new agents or adjuvants for colon cancer treatment. Natural products and their derivates act as one of the major source for anticancer agent. In the present study, we investigated the anti-proliferation and chemoprevention effects of tetrandrine (Tet) on colon cancer cells to uncover the possible molecular basis of this effect. We found that Tet can inhibit proliferation and induce apoptosis in LoVo cells. With dimethylhydrazine (DMH) and dextran sodium sulfate (DSS) induced colon cancer model, we found that Tet can prevent or inhibit DMH plus DSS induced aberrant crypt foci (ACF) and colon cancer formation, as well as suppress tumor growth in the xenograft colon cancer model. Tet can downregulate the expression of IGFBP-5 in LoVo cells. Exogenous expression of IGFBP-5 can attenuate the anti-cancer activity of Tet, while IGFBP-5 knockdown potentiates this effect of Tet on LoVo cells. Tet can inhibit Wnt/β-catenin signaling transduction, which can be partly reversed by exogenous expression of IGFBP-5, but is enhanced by IGFBP-5 knockdown. Our results demonstrated that the anticancer activity of Tet in colon cancer cells may be mediated partly by downregulating the expression of IGFBP-5, thus inactivating Wnt/β-catenin signaling transduction.
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Copy and paste a formatted citation
Spandidos Publications style
Wu K, Zhou M, Wu Q, Yuan S, Wang D, Jin J, Huang J, Yang J, Sun W, Wan L, Wan L, et al: The role of IGFBP-5 in mediating the anti-proliferation effect of tetrandrine in human colon cancer cells Corrigendum in /10.3892/ijo.2024.5681. Int J Oncol 46: 1205-1213, 2015.
APA
Wu, K., Zhou, M., Wu, Q., Yuan, S., Wang, D., Jin, J. ... He, B. (2015). The role of IGFBP-5 in mediating the anti-proliferation effect of tetrandrine in human colon cancer cells Corrigendum in /10.3892/ijo.2024.5681. International Journal of Oncology, 46, 1205-1213. https://doi.org/10.3892/ijo.2014.2800
MLA
Wu, K., Zhou, M., Wu, Q., Yuan, S., Wang, D., Jin, J., Huang, J., Yang, J., Sun, W., Wan, L., He, B."The role of IGFBP-5 in mediating the anti-proliferation effect of tetrandrine in human colon cancer cells Corrigendum in /10.3892/ijo.2024.5681". International Journal of Oncology 46.3 (2015): 1205-1213.
Chicago
Wu, K., Zhou, M., Wu, Q., Yuan, S., Wang, D., Jin, J., Huang, J., Yang, J., Sun, W., Wan, L., He, B."The role of IGFBP-5 in mediating the anti-proliferation effect of tetrandrine in human colon cancer cells Corrigendum in /10.3892/ijo.2024.5681". International Journal of Oncology 46, no. 3 (2015): 1205-1213. https://doi.org/10.3892/ijo.2014.2800
Copy and paste a formatted citation
x
Spandidos Publications style
Wu K, Zhou M, Wu Q, Yuan S, Wang D, Jin J, Huang J, Yang J, Sun W, Wan L, Wan L, et al: The role of IGFBP-5 in mediating the anti-proliferation effect of tetrandrine in human colon cancer cells Corrigendum in /10.3892/ijo.2024.5681. Int J Oncol 46: 1205-1213, 2015.
APA
Wu, K., Zhou, M., Wu, Q., Yuan, S., Wang, D., Jin, J. ... He, B. (2015). The role of IGFBP-5 in mediating the anti-proliferation effect of tetrandrine in human colon cancer cells Corrigendum in /10.3892/ijo.2024.5681. International Journal of Oncology, 46, 1205-1213. https://doi.org/10.3892/ijo.2014.2800
MLA
Wu, K., Zhou, M., Wu, Q., Yuan, S., Wang, D., Jin, J., Huang, J., Yang, J., Sun, W., Wan, L., He, B."The role of IGFBP-5 in mediating the anti-proliferation effect of tetrandrine in human colon cancer cells Corrigendum in /10.3892/ijo.2024.5681". International Journal of Oncology 46.3 (2015): 1205-1213.
Chicago
Wu, K., Zhou, M., Wu, Q., Yuan, S., Wang, D., Jin, J., Huang, J., Yang, J., Sun, W., Wan, L., He, B."The role of IGFBP-5 in mediating the anti-proliferation effect of tetrandrine in human colon cancer cells Corrigendum in /10.3892/ijo.2024.5681". International Journal of Oncology 46, no. 3 (2015): 1205-1213. https://doi.org/10.3892/ijo.2014.2800
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