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Article

Celecoxib exerts antitumor effects in canine mammary tumor cells via COX‑2‑independent mechanisms

  • Authors:
    • Dai Tamura
    • Teruyoshi Saito
    • Kanae Murata
    • Masafumi Kawashima
    • Ryuji Asano
  • View Affiliations / Copyright

    Affiliations: Laboratory of Veterinary Pharmacology, Nihon University College of Bioresource Sciences, Fujisawa, Kanagawa 252‑8510, Japan
  • Pages: 1393-1404
    |
    Published online on: January 8, 2015
       https://doi.org/10.3892/ijo.2015.2820
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Abstract

Celecoxib plays antitumor roles via multiple mechanisms in a variety of human cancers. The aim of this study was to clarify the mechanism of action of celecoxib in canine mammary tumors. We examined the antitumor effects of celecoxib in AZACB canine mammary tumor cells expressing low levels of cyclooxygenase‑2 (COX‑2) to minimize the effect of COX‑2 on its activity. Our data revealed that celecoxib inhibited cell proliferation mainly via COX‑2‑independent mechanisms. Specifically, celecoxib decreased the proportion of cells in S phase and increased G2/M arrest, which was associated with increased expression of the cyclin‑dependent kinase inhibitors (CDKIs) p21 and p27. In addition, treatment with celecoxib downregulated COX‑2 expression, and induced apoptosis via both the intrinsic and extrinsic pathways. These findings suggest that celecoxib might be a useful agent for the treatment of canine mammary tumors, regardless of COX‑2 expression. In the future, it might be possible to use a combination of celecoxib and other antitumor agents to treat canine mammary tumors.
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1 

Hawkey CJ: COX-2 inhibitors. Lancet. 353:307–314. 1999. View Article : Google Scholar : PubMed/NCBI

2 

Chandrasekharan NV, Dai H, Roos KL, Evanson NK, Tomsik J, Elton TS and Simmons DL: COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci USA. 99:13926–13931. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Tsujii M and DuBois RN: Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell. 83:493–501. 1995. View Article : Google Scholar : PubMed/NCBI

4 

Tsujii M, Kawano S and DuBois RN: Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc Natl Acad Sci USA. 94:3336–3340. 1997. View Article : Google Scholar : PubMed/NCBI

5 

Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M and DuBois RN: Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell. 93:705–716. 1998. View Article : Google Scholar : PubMed/NCBI

6 

Sheng H, Shao J, Morrow JD, Beauchamp RD and DuBois RN: Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res. 58:362–366. 1998.PubMed/NCBI

7 

Saikawa Y, Sugiura T, Toriumi F, Kubota T, Suganuma K, Isshiki S, Otani Y, Kumai K and Kitajima M: Cyclooxygenase-2 gene induction causes CDDP resistance in colon cancer cell line, HCT-15. Anticancer Res. 24:2723–2728. 2004.PubMed/NCBI

8 

Liu B, Qu L and Tao H: Cyclo-oxygenase 2 up-regulates the effect of multidrug resistance. Cell Biol Int. 34:21–25. 2009.PubMed/NCBI

9 

Rolle CE, Sengupta S and Lesniak MS: Mechanisms of immune evasion by gliomas. Adv Exp Med Biol. 746:53–76. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Goldschmidt M, Peña L, Rasotto R and Zappulli V: Classification and grading of canine mammary tumors. Vet Pathol. 48:117–131. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Spugnini EP, Porrello A, Citro G and Baldi A: COX-2 over-expression in canine tumors: potential therapeutic targets in oncology. Histol Histopathol. 20:1309–1312. 2005.PubMed/NCBI

12 

Klopfleisch R, von Euler H, Sarli G, Pinho SS, Gärtner F and Gruber AD: Molecular carcinogenesis of canine mammary tumors: news from an old disease. Vet Pathol. 48:98–116. 2011. View Article : Google Scholar

13 

Doré M: Cyclooxygenase-2 expression in animal cancers. Vet Pathol. 48:254–265. 2011. View Article : Google Scholar

14 

Pinho SS, Carvalho S, Cabral J, Reis CA and Gärtner F: Canine tumors: a spontaneous animal model of human carcinogenesis. Transl Res. 159:165–172. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Howe LR: Inflammation and breast cancer. Cyclooxygenase/prostaglandin signaling and breast cancer. Breast Cancer Res. 9:2102007. View Article : Google Scholar : PubMed/NCBI

16 

Doré M, Lanthier I and Sirois J: Cyclooxygenase-2 expression in canine mammary tumors. Vet Pathol. 40:207–212. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Queiroga FL, Pires I, Parente M, Gregório H and Lopes CS: COX-2 over-expression correlates with VEGF and tumour angiogenesis in canine mammary cancer. Vet J. 189:77–82. 2011. View Article : Google Scholar

18 

Saito T, Tamura D and Asano R: Usefulness of selective COX-2 inhibitors as therapeutic agents against canine mammary tumors. Oncol Rep. 31:1637–1644. 2014.PubMed/NCBI

19 

Kato M, Nishida S, Kitasato H, Sakata N and Kawai S: Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes. J Pharm Pharmacol. 53:1679–1685. 2001. View Article : Google Scholar

20 

Sanderson RO, Beata C, Flipo RM, Genevois JP, Macias C, Tacke S, Vezzoni A and Innes JF: Systematic review of the management of canine osteoarthritis. Vet Rec. 164:418–424. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Saito T, Dai T and Asano R: The hyaluronan synthesis inhibitor 4-methylumbelliferone exhibits antitumor effects against mesenchymal-like canine mammary tumor cells. Oncol Lett. 5:1068–1074. 2013.PubMed/NCBI

22 

Saito T, Tamura D, Nakamura T, Makita Y, Ariyama H, Komiyama K, Yoshihara T and Asano R: 4-Methylumbelliferone leads to growth arrest and apoptosis in canine mammary tumor cells. Oncol Rep. 29:335–342. 2013.

23 

Saito T, Kawana H, Azuma K, Toyoda A, Fujita H, Kitagawa M and Harigaya K: Fragmented hyaluronan is an autocrine chemo-kinetic motility factor supported by the HAS2-HYAL2/CD44 system on the plasma membrane. Int J Oncol. 39:1311–1320. 2011.PubMed/NCBI

24 

Gurpinar E, Grizzle WE and Piazza GA: COX-independent mechanisms of cancer chemoprevention by anti-inflammatory drugs. Front Oncol. 3:1812013. View Article : Google Scholar : PubMed/NCBI

25 

Kardosh A, Wang W, Uddin J, Petasis NA, Hofman FM, Chen TC and Schönthal AH: Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt’s lymphoma in vitro and in vivo. Cancer Biol Ther. 4:571–582. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Luque I and Gélinas C: Rel/NF-kappa B factors in oncogenesis. Semin Cancer Biol. 8:103–111. 1997. View Article : Google Scholar : PubMed/NCBI

27 

Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK and Lee SS: Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res. 480–481:243–268. 2001. View Article : Google Scholar

28 

Takada Y, Bhardwaj A, Potdar P and Aggarwal BB: Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene. 23:9247–9258. 2004.PubMed/NCBI

29 

Baeuerle PA and Baltimore D: I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science. 242:540–546. 1988. View Article : Google Scholar : PubMed/NCBI

30 

Tait SW and Green DR: Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol. 11:621–632. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Darzynkiewicz Z, Bruno S, Del Bino G, Gorczyca W, Hotz MA, Lassota P and Traganos F: Features of apoptotic cells measured by flow cytometry. Cytometry. 13:795–808. 1992. View Article : Google Scholar : PubMed/NCBI

32 

Hengartner MO: The biochemistry of apoptosis. Nature. 407:770–776. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Ola MS, Nawaz M and Ahsan H: Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. Mol Cell Biochem. 351:41–58. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Igney FH and Krammer PH: Death and anti-death: tumour resistance to apoptosis. Nat Rev Cancer. 2:277–288. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES and Wang X: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 91:479–489. 1997. View Article : Google Scholar : PubMed/NCBI

36 

Menter DG, Schilsky RL and DuBois RN: Cyclooxygenase-2 and cancer treatment: understanding the risk should be worth the reward. Clin Cancer Res. 16:1384–1390. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Holmes MD, Chen WY, Li L, Hertzmark E, Spiegelman D and Hankinson SE: Aspirin intake and survival after breast cancer. J Clin Oncol. 28:1467–1472. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Howe LR, Subbaramaiah K, Brown AM and Dannenberg AJ: Cyclooxygenase-2: a target for the prevention and treatment of breast cancer. Endocr Relat Cancer. 8:97–114. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Ristimäki A, Sivula A, Lundin J, Lundin M, Salminen T, Haglund C, Joensuu H and Isola J: Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. Cancer Res. 62:632–635. 2002.PubMed/NCBI

40 

Ranger GS, Thomas V, Jewell A and Mokbel K: Elevated cyclooxygenase-2 expression correlates with distant metastases in breast cancer. Anticancer Res. 24:2349–2351. 2004.PubMed/NCBI

41 

Reader J, Holt D and Fulton A: Prostaglandin E2 EP receptors as therapeutic targets in breast cancer. Cancer Metastasis Rev. 30:449–463. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Queiroga FL, Pires I, Lobo L and Lopes CS: The role of Cox-2 expression in the prognosis of dogs with malignant mammary tumours. Res Vet Sci. 88:441–445. 2010. View Article : Google Scholar

43 

Queiroga FL, Perez-Alenza MD, Silvan G, Peña L, Lopes C and Illera JC: Cox-2 levels in canine mammary tumors, including inf lammatory mammary carcinoma: clinicopathological features and prognostic significance. Anticancer Res. 25:4269–4275. 2005.PubMed/NCBI

44 

Müller AC, Handrick R, Elsaesser SJ, Rudner J, Henke G, Ganswindt U, Belka C and Jendrossek V: Importance of Bak for celecoxib-induced apoptosis. Biochem Pharmacol. 76:1082–1096. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Jendrossek V, Handrick R and Belka C: Celecoxib activates a novel mitochondrial apoptosis signaling pathway. FASEB J. 17:1547–1549. 2003.PubMed/NCBI

46 

Liu X, Yue P, Zhou Z, Khuri FR and Sun SY: Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst. 96:1769–1780. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Liu X, Yue P, Schönthal AH, Khuri FR and Sun SY: Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells. Cancer Res. 66:11115–11119. 2006. View Article : Google Scholar : PubMed/NCBI

48 

Reginato MJ, Mills KR, Paulus JK, Lynch DK, Sgroi DC, Debnath J, Muthuswamy SK and Brugge JS: Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol. 5:733–740. 2003. View Article : Google Scholar : PubMed/NCBI

49 

Sun Y, Tang XM, Half E, Kuo MT and Sinicrope FA: Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. Cancer Res. 62:6323–6328. 2002.PubMed/NCBI

50 

He Q, Luo X, Huang Y and Sheikh MS: Apo2L/TRAIL differentially modulates the apoptotic effects of sulindac and a COX-2 selective non-steroidal anti-inflammatory agent in Bax-deficient cells. Oncogene. 21:6032–6040. 2002. View Article : Google Scholar : PubMed/NCBI

51 

Shao J, Evers BM and Sheng H: Prostaglandin E2 synergistically enhances receptor tyrosine kinase-dependent signaling system in colon cancer cells. J Biol Chem. 279:14287–14293. 2004. View Article : Google Scholar : PubMed/NCBI

52 

Sonoshita M, Takaku K, Sasaki N, Sugimoto Y, Ushikubi F, Narumiya S, Oshima M and Taketo MM: Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice. Nat Med. 7:1048–1051. 2001. View Article : Google Scholar : PubMed/NCBI

53 

Nagatsuka I, Yamada N, Shimizu S, Ohira M, Nishino H, Seki S and Hirakawa K: Inhibitory effect of a selective cyclooxygenase-2 inhibitor on liver metastasis of colon cancer. Int J Cancer. 100:515–519. 2002. View Article : Google Scholar : PubMed/NCBI

54 

Timoshenko AV, Xu G, Chakrabarti S, Lala PK and Chakraborty C: Role of prostaglandin E2 receptors in migration of murine and human breast cancer cells. Exp Cell Res. 289:265–274. 2003. View Article : Google Scholar : PubMed/NCBI

55 

Chen Z, Hagler J, Palombella VJ, Melandri F, Scherer D, Ballard D and Maniatis T: Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. Genes Dev. 9:1586–1597. 1995. View Article : Google Scholar : PubMed/NCBI

56 

Seo KW, Coh YR, Rebhun RB, Ahn JO, Han SM, Lee HW and Youn HY: Antitumor effects of celecoxib in COX-2 expressing and non-expressing canine melanoma cell lines. Res Vet Sci. 96:482–486. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tamura D, Saito T, Murata K, Kawashima M and Asano R: Celecoxib exerts antitumor effects in canine mammary tumor cells via COX‑2‑independent mechanisms. Int J Oncol 46: 1393-1404, 2015.
APA
Tamura, D., Saito, T., Murata, K., Kawashima, M., & Asano, R. (2015). Celecoxib exerts antitumor effects in canine mammary tumor cells via COX‑2‑independent mechanisms. International Journal of Oncology, 46, 1393-1404. https://doi.org/10.3892/ijo.2015.2820
MLA
Tamura, D., Saito, T., Murata, K., Kawashima, M., Asano, R."Celecoxib exerts antitumor effects in canine mammary tumor cells via COX‑2‑independent mechanisms". International Journal of Oncology 46.3 (2015): 1393-1404.
Chicago
Tamura, D., Saito, T., Murata, K., Kawashima, M., Asano, R."Celecoxib exerts antitumor effects in canine mammary tumor cells via COX‑2‑independent mechanisms". International Journal of Oncology 46, no. 3 (2015): 1393-1404. https://doi.org/10.3892/ijo.2015.2820
Copy and paste a formatted citation
x
Spandidos Publications style
Tamura D, Saito T, Murata K, Kawashima M and Asano R: Celecoxib exerts antitumor effects in canine mammary tumor cells via COX‑2‑independent mechanisms. Int J Oncol 46: 1393-1404, 2015.
APA
Tamura, D., Saito, T., Murata, K., Kawashima, M., & Asano, R. (2015). Celecoxib exerts antitumor effects in canine mammary tumor cells via COX‑2‑independent mechanisms. International Journal of Oncology, 46, 1393-1404. https://doi.org/10.3892/ijo.2015.2820
MLA
Tamura, D., Saito, T., Murata, K., Kawashima, M., Asano, R."Celecoxib exerts antitumor effects in canine mammary tumor cells via COX‑2‑independent mechanisms". International Journal of Oncology 46.3 (2015): 1393-1404.
Chicago
Tamura, D., Saito, T., Murata, K., Kawashima, M., Asano, R."Celecoxib exerts antitumor effects in canine mammary tumor cells via COX‑2‑independent mechanisms". International Journal of Oncology 46, no. 3 (2015): 1393-1404. https://doi.org/10.3892/ijo.2015.2820
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