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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Importance of circulating tumor cells in newly diagnosed colorectal cancer

  • Authors:
    • Guus van Dalum
    • Gerrit-Jan Stam
    • Loes F.A. Scholten
    • Walter J.B. Mastboom
    • Istvan Vermes
    • Arjan G.J. Tibbe
    • Marco R. De Groot
    • Leon W.M.M. Terstappen
  • View Affiliations / Copyright

    Affiliations: Department of Medical Cell BioPhysics, University of Twente, Enschede, The Netherlands, Department of Internal Medicine, Medisch Spectrum Twente, Enschede, The Netherlands, Department of Surgery, Medisch Spectrum Twente, Enschede, The Netherlands, Department of Laboratory Medicine, Medisch Spectrum Twente, Enschede, The Netherlands
  • Pages: 1361-1368
    |
    Published online on: January 9, 2015
       https://doi.org/10.3892/ijo.2015.2824
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Abstract

Presence of circulating tumor cells (CTC) is associated with poor prognosis in patients with metastatic colorectal cancer (CRC). The present study was conducted to determine if the presence of CTC prior to surgery and during follow‑up in patients with newly diagnosed non-metastatic CRC can identify patients at risk for disease recurrence. In a prospective single center study 183 patients with newly diagnosed non-disseminated CRC, scheduled for surgery, were enrolled and followed-up for a median of 5.1 years. CTC were enumerated with the CellSearch system in 4 aliquots of 7.5 ml of blood before surgery and at several time-points during follow-up after surgery. The results showed that ≥1 CTC/30 ml of blood were detected in 44 (24%) patients before surgery. Patients with CTC before surgery had a significant decrease in recurrence-free survival (RFS, log-rank test p=0.014) and colon cancer related survival (CCRS, p=0.002). The 5-year RFS dropped from 75 to 61% and the 5-year CCRS from 83 to 69% for patients with CTC before surgery. The presence of CTC and positive lymph nodes remained significant factors in multivariate analysis for recurrence-free survival (RFS). Surprisingly, the presence of CTC weeks after surgery was not significantly associated with RFS and CCRD whereas CTC 2-3 years after surgery was again significantly associated with RFS and CCRD. The presence of CTC in patients with stage I-III CRC before surgery is associated with a significant reduction in RFS and CCRS. These findings suggest a role of CTC detection to assess which patients need adjuvant treatment.
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Copy and paste a formatted citation
Spandidos Publications style
van Dalum G, Stam G, Scholten LF, Mastboom WJ, Vermes I, Tibbe AG, De Groot MR and Terstappen LW: Importance of circulating tumor cells in newly diagnosed colorectal cancer. Int J Oncol 46: 1361-1368, 2015.
APA
van Dalum, G., Stam, G., Scholten, L.F., Mastboom, W.J., Vermes, I., Tibbe, A.G. ... Terstappen, L.W. (2015). Importance of circulating tumor cells in newly diagnosed colorectal cancer. International Journal of Oncology, 46, 1361-1368. https://doi.org/10.3892/ijo.2015.2824
MLA
van Dalum, G., Stam, G., Scholten, L. F., Mastboom, W. J., Vermes, I., Tibbe, A. G., De Groot, M. R., Terstappen, L. W."Importance of circulating tumor cells in newly diagnosed colorectal cancer". International Journal of Oncology 46.3 (2015): 1361-1368.
Chicago
van Dalum, G., Stam, G., Scholten, L. F., Mastboom, W. J., Vermes, I., Tibbe, A. G., De Groot, M. R., Terstappen, L. W."Importance of circulating tumor cells in newly diagnosed colorectal cancer". International Journal of Oncology 46, no. 3 (2015): 1361-1368. https://doi.org/10.3892/ijo.2015.2824
Copy and paste a formatted citation
x
Spandidos Publications style
van Dalum G, Stam G, Scholten LF, Mastboom WJ, Vermes I, Tibbe AG, De Groot MR and Terstappen LW: Importance of circulating tumor cells in newly diagnosed colorectal cancer. Int J Oncol 46: 1361-1368, 2015.
APA
van Dalum, G., Stam, G., Scholten, L.F., Mastboom, W.J., Vermes, I., Tibbe, A.G. ... Terstappen, L.W. (2015). Importance of circulating tumor cells in newly diagnosed colorectal cancer. International Journal of Oncology, 46, 1361-1368. https://doi.org/10.3892/ijo.2015.2824
MLA
van Dalum, G., Stam, G., Scholten, L. F., Mastboom, W. J., Vermes, I., Tibbe, A. G., De Groot, M. R., Terstappen, L. W."Importance of circulating tumor cells in newly diagnosed colorectal cancer". International Journal of Oncology 46.3 (2015): 1361-1368.
Chicago
van Dalum, G., Stam, G., Scholten, L. F., Mastboom, W. J., Vermes, I., Tibbe, A. G., De Groot, M. R., Terstappen, L. W."Importance of circulating tumor cells in newly diagnosed colorectal cancer". International Journal of Oncology 46, no. 3 (2015): 1361-1368. https://doi.org/10.3892/ijo.2015.2824
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