|
1
|
Brenner H, Rothenbacher D and Arndt V:
Epidemiology of stomach cancer. Methods Mol Biol. 472:467–477.
2009. View Article : Google Scholar
|
|
2
|
Ridley AJ: Rho GTPases and actin dynamics
in membrane protrusions and vesicle trafficking. Trends Cell Biol.
16:522–529. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Karpel-Massler G, Westhoff MA, Zhou S, et
al: Combined inhibition of HER1/EGFR and RAC1 results in a
synergistic antiproliferative effect on established and primary
cultured human glioblastoma cells. Mol Cancer Ther. 12:1783–1795.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Menard L, Parker PJ and Kermorgant S:
Receptor tyrosine kinase c-Met controls the cytoskeleton from
different endosomes via different pathways. Nat Commun. 5:39072014.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Kumar R, Gururaj AE and Barnes CJ:
p21-activated kinases in cancer. Nat Rev Cancer. 6:459–471. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Valente AJ, Yoshida T, Clark RA,
Delafontaine P, Siebenlist U and Chandrasekar B: Advanced oxidation
protein products induce cardiomyocyte death via
Nox2/Rac1/superoxide-dependent TRAF3IP2/JNK signaling. Free Radic
Biol Med. 60:125–135. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Shepelev MV, Chernoff J and Korobko IV:
Rho family GTPase Chp/RhoV induces PC12 apoptotic cell death via
JNK activation. Small GTPases. 2:17–26. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Foldynova-Trantirkova S, Sekyrova P,
Tmejova K, et al: Breast cancer-specific mutations in CK1epsilon
inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT
pathways to decrease cell adhesion and promote cell migration.
Breast Cancer Res. 12:R302010. View
Article : Google Scholar : PubMed/NCBI
|
|
9
|
Wang X, Zhang F, Chen F, et al: MEKK3
regulates IFN-gamma production in T cells through the
Rac1/2-dependent MAPK cascades. J Immunol. 186:5791–5800. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Esufali S and Bapat B: Cross-talk between
Rac1 GTPase and dysregulated Wnt signaling pathway leads to
cellular redistribution of beta-catenin and TCF/LEF-mediated
transcriptional activation. Oncogene. 23:8260–8271. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Goc A, Abdalla M, Al-Azayzih A and
Somanath PR: Rac1 activation driven by 14-3-3zeta dimerization
promotes prostate cancer cell-matrix interactions, motility and
transendothelial migration. PLoS One. 7:e405942012. View Article : Google Scholar
|
|
12
|
Vader P, van der Meel R, Symons MH, et al:
Examining the role of Rac1 in tumor angiogenesis and growth: a
clinically relevant RNAi-mediated approach. Angiogenesis.
14:457–466. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Ma J, Xue Y, Liu W, et al: Role of
activated rac1/cdc42 in mediating endothelial cell proliferation
and tumor angiogenesis in breast cancer. PLoS One. 8:e662752013.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Lin KT, Gong J, Li CF, et al: Vav3-rac1
signaling regulates prostate cancer metastasis with elevated Vav3
expression correlating with prostate cancer progression and
posttreatment recurrence. Cancer Res. 72:3000–3009. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Lin CW, Sun MS, Liao MY, et al:
Podocalyxin-like 1 promotes invadopodia formation and metastasis
through activation of Rac1/Cdc42/cortactin signaling in breast
cancer cells. Carcinogenesis. 35:2425–2435. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Schnelzer A, Prechtel D, Knaus U, et al:
Rac1 in human breast cancer: overexpression, mutation analysis, and
characterization of a new isoform, Rac1b. Oncogene. 19:3013–3020.
2000. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Fritz G, Just I and Kaina B: Rho GTPases
are over-expressed in human tumors. Int J Cancer. 81:682–687. 1999.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Zhu G, Wang Y, Huang B, et al: A Rac1/PAK1
cascade controls beta-catenin activation in colon cancer cells.
Oncogene. 31:1001–1012. 2012. View Article : Google Scholar
|
|
19
|
Kamai T, Shirataki H, Nakanishi K, et al:
Increased Rac1 activity and Pak1 overexpression are associated with
lymphovascular invasion and lymph node metastasis of upper urinary
tract cancer. BMC Cancer. 10:1642010. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Zhan H, Liang H, Liu X, Deng J, Wang B and
Hao X: Expression of Rac1, HIF-1alpha, and VEGF in gastric
carcinoma: correlation with angiogenesis and prognosis. Onkologie.
36:102–107. 2013. View Article : Google Scholar
|
|
21
|
Wu YJ, Tang Y, Li ZF, et al: Expression
and significance of Rac1, Pak1 and Rock1 in gastric carcinoma. Asia
Pac J Clin Oncol. 10:e33–e39. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Kato T, Kawai K, Egami Y, Kakehi Y and
Araki N: Rac1-dependent lamellipodial motility in prostate cancer
PC-3 cells revealed by optogenetic control of Rac1 activity. PLoS
One. 9:e977492014. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Bauer NN, Chen YW, Samant RS, Shevde LA
and Fodstad O: Rac1 activity regulates proliferation of aggressive
metastatic melanoma. Exp Cell Res. 313:3832–3839. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Jun Cho H, Kim IK, Park SM, et al: VEGF-C
mediates RhoGDI2-induced gastric cancer cell metastasis and
cisplatin resistance. Int J Cancer. 135:1553–1563. 2014. View Article : Google Scholar
|
|
25
|
Zeng W, Fu K, Quintanilla-Fend L, Lim M,
Ondrejka S and Hsi ED: Cyclin D1-negative blastoid mantle cell
lymphoma identified by SOX11 expression. Am J Surg Pathol.
36:214–219. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Subauste MC, Von Herrath M, Benard V, et
al: Rho family proteins modulate rapid apoptosis induced by
cytotoxic T lymphocytes and Fas. J Biol Chem. 275:9725–9733. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Wang X, Deng Y, Mao Z, et al: CCN1
promotes tumorigenicity through Rac1/Akt/NF-kappaB signaling
pathway in pancreatic cancer. Tumour Biol. 33:1745–1758. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Safina A, Vandette E and Bakin AV: ALK5
promotes tumor angiogenesis by upregulating matrix
metalloproteinase-9 in tumor cells. Oncogene. 26:2407–2422. 2007.
View Article : Google Scholar
|
|
29
|
Cho JY, Lim JY, Cheong JH, et al: Gene
expression signature-based prognostic risk score in gastric cancer.
Clin Cancer Res. 17:1850–1857. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Wang Q, Wen YG, Li DP, et al: Upregulated
INHBA expression is associated with poor survival in gastric
cancer. Med Oncol. 29:77–83. 2012. View Article : Google Scholar
|
|
31
|
D’Errico M, de Rinaldis E, Blasi MF, et
al: Genome-wide expression profile of sporadic gastric cancers with
microsatellite instability. Eur J Cancer. 45:461–469. 2009.
View Article : Google Scholar
|
|
32
|
Ooi CH, Ivanova T, Wu J, et al: Oncogenic
pathway combinations predict clinical prognosis in gastric cancer.
PLoS Genet. 5:e10006762009. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Forster S, Gretschel S, Jons T, Yashiro M
and Kemmner W: THBS4, a novel stromal molecule of diffuse-type
gastric adenocarcinomas, identified by transcriptome-wide
expression profiling. Mod Pathol. 24:1390–1403. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Gao Y, Dickerson JB, Guo F, Zheng J and
Zheng Y: Rational design and characterization of a Rac
GTPase-specific small molecule inhibitor. Proc Natl Acad Sci USA.
101:7618–7623. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Bid HK, Roberts RD, Manchanda PK and
Houghton PJ: RAC1: an emerging therapeutic option for targeting
cancer angiogenesis and metastasis. Mol Cancer Ther. 12:1925–1934.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Leve F and Morgado-Diaz JA: Rho GTPase
signaling in the development of colorectal cancer. J Cell Biochem.
113:2549–2559. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Oleinik NV, Helke KL, Kistner-Griffin E,
Krupenko NI and Krupenko SA: Rho GTPases RhoA and Rac1 mediate
effects of dietary folate on metastatic potential of A549 cancer
cells through the control of cofilin phosphorylation. J Biol Chem.
289:26383–26394. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Kaneto N, Yokoyama S, Hayakawa Y, Kato S,
Sakurai H and Saiki I: RAC1 inhibition as a therapeutic target for
gefitinib-resistant non-small-cell lung cancer. Cancer Sci.
105:788–794. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Elsayed HE, Akl MR, Ebrahim HY, et al:
Discovery, optimization, and pharmacophore modeling of oleanolic
acid and analogues as breast cancer cell migration and invasion
inhibitors through targeting Brk/Paxillin/Rac1 Axis. Chem Biol Drug
Des. Jun 20–2014. View Article : Google Scholar : (Epub ahead of
print). PubMed/NCBI
|
|
40
|
Baugher PJ, Krishnamoorthy L, Price JE and
Dharmawardhane SF: Rac1 and Rac3 isoform activation is involved in
the invasive and metastatic phenotype of human breast cancer cells.
Breast Cancer Res. 7:R965–R974. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Watson IR, Li L, Cabeceiras PK, et al: The
RAC1 P29S hotspot mutation in melanoma confers resistance to
pharmacological inhibition of RAF. Cancer Res. 74:4845–4852. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Fackler OT and Grosse R: Cell motility
through plasma membrane blebbing. J Cell Biol. 181:879–884. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Skvortsov S, Dudas J, Eichberger P, et al:
Rac1 as a potential therapeutic target for chemo-radioresistant
head and neck squamous cell carcinomas (HNSCC). Br J Cancer.
110:2677–2687. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Akunuru S, Palumbo J, Zhai QJ and Zheng Y:
Rac1 targeting suppresses human non-small cell lung adenocarcinoma
cancer stem cell activity. PLoS One. 6:e169512011. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Cardama GA, Comin MJ, Hornos L, et al:
Preclinical development of novel Rac1-GEF signaling inhibitors
using a rational design approach in highly aggressive breast cancer
cell lines. Anticancer Agents Med Chem. 14:840–851. 2014.
View Article : Google Scholar :
|
