Dlx-2 is implicated in TGF-β- and Wnt-induced epithelial-mesenchymal, glycolytic switch, and mitochondrial repression by Snail activation

Lee,Su Yeon; Jeon,Hyun Min; Ju,Min Kyung; Jeong,Eui Kyong; Kim,Cho Hee; Yoo,Mi-Ae; Park,Hye Gyeong; Han,Song Iy; Kang,Ho Sung

doi:10.3892/ijo.2015.2874

April-2015 Volume 46 Issue 4

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April-2015 Volume 46 Issue 4

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Article

Dlx-2 is implicated in TGF-β- and Wnt-induced epithelial-mesenchymal, glycolytic switch, and mitochondrial repression by Snail activation

Authors:
- Su Yeon Lee
- Hyun Min Jeon
- Min Kyung Ju
- Eui Kyong Jeong
- Cho Hee Kim
- Mi-Ae Yoo
- Hye Gyeong Park
- Song Iy Han
- Ho Sung Kang
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Affiliations: Department of Molecular Biology, College of Natural Sciences, Pusan National University, Pusan 609-735, Republic of Korea, Nanobiotechnology Center, Pusan National University, Pusan 609-735, Republic of Korea, The Division of Natural Medical Sciences, College of Health Science, Chosun University, Gwangju 501-759, Republic of Korea
Pages: 1768-1780
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Published online on: February 4, 2015

https://doi.org/10.3892/ijo.2015.2874
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Abstract

Epithelial-mesenchymal transition (EMT) and oncogenic metabolism (including glycolytic switch) are important for tumor development and progression. Here, we show that Dlx-2, one of distal-less (Dlx) homeobox genes, induces EMT and glycolytic switch by activation of Snail. In addition, it was induced by TGF-β and Wnt and regulates TGF-β- and Wnt-induced EMT and glycolytic switch by activating Snail. We also found that TGF-β/Wnt suppressed cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, in a Dlx-2/Snail-dependent manner. TGF-β/Wnt appeared to downregulate the expression of various COX subunits including COXVIc, COXVIIa and COXVIIc; among these COX subunits, COXVIc was a common target of TGF-β, Wnt, Dlx-2 and Snail, indicating that COXVIc downregulation plays an important role(s) in TGF-β/Wnt-induced COX inhibition. Taken together, our results showed that Dlx-2 is involved in TGF-β- and Wnt-induced EMT, glycolytic switch, and mitochondrial repression by Snail activation.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Dlx-2 is implicated in TGF-β- and Wnt-induced epithelial-mesenchymal, glycolytic switch, and mitochondrial repression by Snail activation

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