Dlx-2 is implicated in TGF-β- and Wnt-induced epithelial-mesenchymal, glycolytic switch, and mitochondrial repression by Snail activation

  • Authors:
    • Su Yeon Lee
    • Hyun Min Jeon
    • Min Kyung Ju
    • Eui Kyong Jeong
    • Cho Hee Kim
    • Mi-Ae Yoo
    • Hye Gyeong Park
    • Song Iy Han
    • Ho Sung Kang
  • View Affiliations

  • Published online on: February 4, 2015     https://doi.org/10.3892/ijo.2015.2874
  • Pages: 1768-1780
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Abstract

Epithelial-mesenchymal transition (EMT) and oncogenic metabolism (including glycolytic switch) are important for tumor development and progression. Here, we show that Dlx-2, one of distal-less (Dlx) homeobox genes, induces EMT and glycolytic switch by activation of Snail. In addition, it was induced by TGF-β and Wnt and regulates TGF-β- and Wnt-induced EMT and glycolytic switch by activating Snail. We also found that TGF-β/Wnt suppressed cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, in a Dlx-2/Snail-dependent manner. TGF-β/Wnt appeared to downregulate the expression of various COX subunits including COXVIc, COXVIIa and COXVIIc; among these COX subunits, COXVIc was a common target of TGF-β, Wnt, Dlx-2 and Snail, indicating that COXVIc downregulation plays an important role(s) in TGF-β/Wnt-induced COX inhibition. Taken together, our results showed that Dlx-2 is involved in TGF-β- and Wnt-induced EMT, glycolytic switch, and mitochondrial repression by Snail activation.
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April-2015
Volume 46 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Lee SY, Jeon HM, Ju MK, Jeong EK, Kim CH, Yoo M, Park HG, Han SI and Kang HS: Dlx-2 is implicated in TGF-β- and Wnt-induced epithelial-mesenchymal, glycolytic switch, and mitochondrial repression by Snail activation. Int J Oncol 46: 1768-1780, 2015
APA
Lee, S.Y., Jeon, H.M., Ju, M.K., Jeong, E.K., Kim, C.H., Yoo, M. ... Kang, H.S. (2015). Dlx-2 is implicated in TGF-β- and Wnt-induced epithelial-mesenchymal, glycolytic switch, and mitochondrial repression by Snail activation. International Journal of Oncology, 46, 1768-1780. https://doi.org/10.3892/ijo.2015.2874
MLA
Lee, S. Y., Jeon, H. M., Ju, M. K., Jeong, E. K., Kim, C. H., Yoo, M., Park, H. G., Han, S. I., Kang, H. S."Dlx-2 is implicated in TGF-β- and Wnt-induced epithelial-mesenchymal, glycolytic switch, and mitochondrial repression by Snail activation". International Journal of Oncology 46.4 (2015): 1768-1780.
Chicago
Lee, S. Y., Jeon, H. M., Ju, M. K., Jeong, E. K., Kim, C. H., Yoo, M., Park, H. G., Han, S. I., Kang, H. S."Dlx-2 is implicated in TGF-β- and Wnt-induced epithelial-mesenchymal, glycolytic switch, and mitochondrial repression by Snail activation". International Journal of Oncology 46, no. 4 (2015): 1768-1780. https://doi.org/10.3892/ijo.2015.2874