Journal Articles
Review
Update on Epstein-Barr virus and gastric cancer (Review)
Aya Shinozaki-Ushiku, Akiko Kunita, Masashi Fukayama
Pages: 1421-1434 Published online on: 28 January 2015
Review
Molecular basis of carcinogenesis in diabetic patients (Review)
Artur Matyszewski, Anna M. Czarnecka, Wojciech Solarek, Piotr Korzeń, Ilan J. Safir, Wojciech Kukwa, Cezary Szczylik
Pages: 1435-1443 Published online on: 03 February 2015
Review
YAP/TAZ for cancer therapy: Opportunities and challenges (Review)
Liwen Guo, Lisong Teng
Pages: 1444-1452 Published online on: 05 February 2015
Article
γ‑tocotrienol prevents 5‑FU‑induced reactive oxygen species production in human oral keratinocytes through the stabilization of 5‑FU‑induced activation of Nrf2
Hideyuki Takano, Yukihiro Momota, Kouichi Kani, Keiko Aota, Yoshiko Yamamura, Tomoko Yamanoi, Masayuki Azuma
Pages: 1453-1460 Published online on: 26 January 2015
Article
Slug contributes to cancer progression by direct regulation of ERα signaling pathway
Youqiang Li, Yanyuan Wu, Thomas C. Abbatiello, Warren L. Wu, Ju Ri Kim, Marianna Sarkissyan, Suren Sarkissyan, Seyung S. Chung, Yahya Elshimali, Jaydutt V. Vadgama
Pages: 1461-1472 Published online on: 05 February 2015
Article
A novel point-of-care system for high-speed real-time polymerase chain reaction testing for epidermal growth factor receptor mutations in bronchial lavage fluids after transbronchial biopsy in patients with non-small cell lung cancer
Tomohiro Sakamoto, Masahiro Kodani, Miyako Takata, Hiroki Chikumi, Masaki Nakamoto, Shizuka Nishii-Ito, Yasuto Ueda, Hiroki Izumi, Haruhiko Makino, Hirokazu Touge, Kenichi Takeda, Akira Yamasaki, Masaaki Yanai, Natsumi Tanaka, Tadashi Igishi, Eiji Shimizu
Pages: 1473-1480 Published online on: 04 February 2015
Article
New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulvestrant treatment and cross-resistance between letrozole and exemestane
Stine Hole, Astrid M. Pedersen, Susanne K. Hansen, Johan Lundqvist, Christina W. Yde, Anne E. Lykkesfeldt
Pages: 1481-1490 Published online on: 26 January 2015
Article
Gallic acid exerts a protective or an anti-proliferative effect on glioma T98G cells via dose-dependent epigenetic regulation mediated by miRNAs
Alessandro Paolini, Valeria Curti, Francesca Pasi, Giuliano Mazzini, Rosanna Nano, Enrica Capelli
Pages: 1491-1497 Published online on: 02 February 2015
Article
Aurora kinase A has a significant role as a therapeutic target and clinical biomarker in endometrial cancer
Kiyoko Umene, Megumi Yanokura, Kouji Banno, Haruko Irie, Masataka Adachi, Miho Iida, Kanako Nakamura, Yuya Nogami, Kenta Masuda, Yusuke Kobayashi, Eiichiro Tominaga, Daisuke Aoki
Pages: 1498-1506 Published online on: 22 January 2015
Article
(-)-Epigallocatechingallate induces apoptosis in B lymphoma cells via caspase-dependent pathway and Bcl-2 family protein modulation
Jiangyan Wang, Yu'an Xie, Yan Feng, Litu Zhang, Xinping Huang, Xiaoyun Shen, Xiaoling Luo
Pages: 1507-1515 Published online on: 03 February 2015
Article
Antimicrobial peptide FF/CAP18 induces apoptotic cell death in HCT116 colon cancer cells via changes in the metabolic profile
Kengo Kuroda, Tomokazu Fukuda, Hiroshi Isogai, Kazuhiko Okumura, Marija Krstic-Demonacos, Emiko Isogai
Pages: 1516-1526 Published online on: 10 February 2015
Article
Significance of SALL4 as a drug‑resistant factor in lung cancer
Nozomi Yanagihara, Daisuke Kobayashi, Kageaki Kuribayashi, Maki Tanaka, Tadashi Hasegawa, Naoki Watanabe
Pages: 1527-1534 Published online on: 03 February 2015
Article
Long‑term exposure to leptin enhances the growth of prostate cancer cells
Terutaka Noda, Tadahiko Kikugawa, Nozomu Tanji, Noriyoshi Miura, Seiji Asai, Shigeki Higashiyama, Masayoshi Yokoyama
Pages: 1535-1542 Published online on: 23 January 2015
Article
Tumor-suppressive microRNA-let-7a inhibits cell proliferation via targeting of E2F2 in osteosarcoma cells
Tatsuya Iwasaki, Kazuhiro Tanaka, Masanori Kawano, Ichiro Itonaga, Hiroshi Tsumura
Pages: 1543-1550 Published online on: 03 February 2015
Article
The effectiveness of an anti-human IL-6 receptor monoclonal antibody combined with chemotherapy to target colon cancer stem-like cells
Jin Ying, Masahiko Tsujii, Jumpei Kondo, Yoshito Hayashi, Motohiko Kato, Tomofumi Akasaka, Takuta Inoue, Eri Shiraishi, Tahahiro Inoue, Satoshi Hiyama, Yoshiki Tsujii, Akira Maekawa, Shoichiro Kawai, Tetsuji Fujinaga, Maekawa Araki, Shinichiro Shinzaki, Kenji Watabe, Tsutomu Nishida, Hideki Iijima, Tetsuo Takehara
Pages: 1551-1559 Published online on: 26 January 2015
Article
CH5137291, an androgen receptor nuclear translocation-inhibiting compound, inhibits the growth of castration-resistant prostate cancer cells
Nobuyuki Ishikura, Hiromitsu Kawata, Ayako Nishimoto, Ryo Nakamura, Toshiaki Tsunenari, Miho Watanabe, Kazutaka Tachibana, Takuya Shiraishi, Hitoshi Yoshino, Akie Honma, Takashi Emura, Masateru Ohta, Toshito Nakagawa, Takao Houjo, Eva Corey, Robert L. Vessella, Yuko Aoki, Haruhiko Sato
Pages: 1560-1572 Published online on: 30 January 2015
Article
Cystatin B as a potential diagnostic biomarker in ovarian clear cell carcinoma
Akane Takaya, Wei‑Xia Peng, Kousuke Ishino, Mitsuhiro Kudo, Tetsushi Yamamoto, Ryuichi Wada, Toshiyuki Takeshita, Zenya Naito
Pages: 1573-1581 Published online on: 28 January 2015
Article
Colon cancer stem cell markers CD44 and CD133 in patients with colorectal cancer and synchronous hepatic metastases
Feifeng Jing, Hun Jin Kim, Chang Hyun Kim, Young Jin Kim, Jae Hyuk Lee, Hyeong Rok Kim
Pages: 1582-1588 Published online on: 23 January 2015
Article
Combination treatment with doxorubicin and microRNA-21 inhibitor synergistically augments anticancer activity through upregulation of tumor suppressing genes
Shanshan Zhang, Lei Han, Jianwei Wei, Zhendong Shi, Peiyu Pu, Jianning Zhang, Xubo Yuan, Chunsheng Kang
Pages: 1589-1600 Published online on: 22 January 2015
Article
miR‑27a suppresses the clonogenic growth and migration of human glioblastoma multiforme cells by targeting BTG2
Wei-Qing Li, Hong-Yu Yu, Nan-Zhe Zhong, Li-Jun Hou, Yi-Ming Li, Jin He, Hui-Min Liu, Chun-Yan Xia, Yi-Cheng Lu
Pages: 1601-1608 Published online on: 22 January 2015
Article
Activation of PKC‑δ in HTLV‑1‑infected T cells
Naoki Mori, Chie Ishikawa, Masachika Senba
Pages: 1609-1618 Published online on: 26 January 2015
Article
The anthraquinone derivative Emodin inhibits angiogenesis and metastasis through downregulating Runx2 activity in breast cancer
Junchao Ma, Hong Lu, Shan Wang, Bin Chen, Zhaojie Liu, Xiaoqin Ke, Ting Liu, Jianjiang Fu
Pages: 1619-1628 Published online on: 10 February 2015
Article
Pro‑apoptotic effects of pycnogenol on HT1080 human fibrosarcoma cells
Kamran Harati, Pawel Slodnik, Ansgar Michael Chromik, Björn Behr, Ole Goertz, Tobias Hirsch, Nicolai Kapalschinski, Ludger Klein‑Hitpass, Jonas Kolbenschlag, Waldemar Uhl, Marcus Lehnhardt, Adrien Daigeler
Pages: 1629-1636 Published online on: 27 January 2015
Article
Prevalence of chromosomal rearrangements involving non-ETS genes in prostate cancer
Martina Kluth, Rami Galal, Antje Krohn, Joachim Weischenfeldt, Christina Tsourlakis, Lisa Paustian, Ramin Ahrary, Malik Ahmed, Sekander Scherzai, Anne Meyer, Hüseyin Sirma, Jan Korbel, Guido Sauter, Thorsten Schlomm, Ronald Simon, Sarah Minner
Pages: 1637-1642 Published online on: 27 January 2015
Article
β-catenin knockdown inhibits pituitary adenoma cell proliferation and invasion via interfering with AKT and gelatinases expression
Chengcheng Zhao, Meng Zhang, Wenlan Liu, Chuanfang Wang, Qiusheng Zhang, Weiping Li
Pages: 1643-1650 Published online on: 02 February 2015
Article
GDC-0152 attenuates the malignant progression of osteosarcoma promoted by ANGPTL2 via PI3K/AKT but not p38MAPK signaling pathway
Lin Yang, Taipengfei Shu, Yingjian Liang, Wenguang Gu, Chunlei Wang, Xuanhe Song, Changdong Fan, Wenbo Wang
Pages: 1651-1658 Published online on: 04 February 2015
Article
Naphthazarin enhances ionizing radiation-induced cell cycle arrest and apoptosis in human breast cancer cells
Min Young Kim, Seong-Joon Park, Jae Woong Shim, Kwangmo Yang, Ho Sung Kang, Kyu Heo
Pages: 1659-1666 Published online on: 28 January 2015
Article
Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/LeY expression
Xiu Shan, Faisal Aziz, Li Li Tian, Xiao Qi Wang, Qiu Yan, Ji Wei Liu
Pages: 1667-1676 Published online on: 10 February 2015
Article
Fra‑1 is downregulated in cervical cancer tissues and promotes cervical cancer cell apoptosis by p53 signaling pathway in vitro
Songshu Xiao, Yanhong Zhou, Wei Yi, Guijuan Luo, Bin Jiang, Qi Tian, Yueran Li, Min Xue
Pages: 1677-1684 Published online on: 04 February 2015
Article
Bleb formation is induced by alkaline but not acidic pH in estrogen receptor silenced breast cancer cells
Maitham A. Khajah, Princy M. Mathew, Nada S. Alam-Eldin, Yunus A. Luqmani
Pages: 1685-1698 Published online on: 09 February 2015
Article
Immune responses in patients with esophageal cancer treated with SART1 peptide‑pulsed dendritic cell vaccine
Miwako Narita, Tatsuo Kanda, Takashi Abe, Takayoshi Uchiyama, Minami Iwafuchi, Zhiyin Zheng, Aichun Liu, Tsutomu Kaifu, Shinichi Kosugi, Masahiro Minagawa, Kyogo Itoh, Masuhiro Takahashi
Pages: 1699-1709 Published online on: 23 January 2015
Article
RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMP9
Zhikui Liu, Changwei Dou, Yuli Jia, Qing Li, Xin Zheng, Yingmin Yao, Qingguang Liu, Tao Song
Pages: 1710-1720 Published online on: 26 January 2015
Article
EGF‑stimulated AKT activation is mediated by EGFR recycling via an early endocytic pathway in a gefitinib‑resistant human lung cancer cell line
Yukio Nishimura, Soichi Takiguchi, Shigeru Ito, Kazuyuki Itoh
Pages: 1721-1729 Published online on: 04 February 2015
Article
Ellagic acid induces cell cycle arrest and apoptosis through TGF-β/Smad3 signaling pathway in human breast cancer MCF-7 cells
Hong-Sheng Chen, Ming-Han Bai, Tao Zhang, Guo-Dong Li, Ming Liu
Pages: 1730-1738 Published online on: 03 February 2015
Article
Resveratrol inhibits glioma cell growth via targeting oncogenic microRNAs and multiple signaling pathways
Guangxiu Wang, Fang Dai, Kai Yu, Zhifan Jia, Anling Zhang, Qiang Huang, Chunsheng Kang, Hao Jiang, Peiyu Pu
Pages: 1739-1747 Published online on: 02 February 2015
Article
iTRAQ-based quantitative proteomic analysis of cervical cancer
Yibing Ding, Min Yang, Sha She, Haiyan Min, Xiaoming Xv, Xiaoping Ran, Yongzheng Wu, Wei Wang, Lei Wang, Long Yi, Yixuan Yang, Qian Gao
Pages: 1748-1758 Published online on: 29 January 2015
Article
Gene therapy for human colorectal cancer cell lines with recombinant adenovirus 5 based on loss of the insulin-like growth factor 2 imprinting
Huiling Sun, Yuqin Pan, Bangshun He, Qiwen Deng, Rui Li, Yeqiong Xu, Jie Chen, Tianyi Gao, Houqun Ying, Feng Wang, Xian Liu, Shukui Wang
Pages: 1759-1767 Published online on: 26 January 2015
Article
Dlx-2 is implicated in TGF-β- and Wnt-induced epithelial-mesenchymal, glycolytic switch, and mitochondrial repression by Snail activation
Su Yeon Lee, Hyun Min Jeon, Min Kyung Ju, Eui Kyong Jeong, Cho Hee Kim, Mi-Ae Yoo, Hye Gyeong Park, Song Iy Han, Ho Sung Kang
Pages: 1768-1780 Published online on: 04 February 2015
Article
A newly developed anti-Mucin 13 monoclonal antibody targets pancreatic ductal adenocarcinoma cells
Yukari Nishii, Miki Yamaguchi, Yasutoshi Kimura, Tadashi Hasegawa, Hiroyuki Aburatani, Hiroaki Uchida, Koichi Hirata, Yuji Sakuma
Pages: 1781-1787 Published online on: 05 February 2015
Article
Generation of an anti-EpCAM antibody and epigenetic regulation of EpCAM in colorectal cancer
Mei-Ying Liao, Mark Yen-Ping Kuo, Tung-Ying Lu, Yi-Ping Wang, Han-Chung Wu
Pages: 1788-1800 Published online on: 05 February 2015
Article
Synergistic combination therapy with cotylenin A and vincristine in multiple myeloma models
Tsutomu Takahashi, Yoshio Honma, Takaaki Miyake, Koji Adachi, Saki Takami, Masahiro Okada, Satoshi Kumanomidou, Fumiyoshi Ikejiri, Yumi Jo, Chie Onishi, Koshi Kawakami, Ichiro Moriyama, Masaya Inoue, Junko Tanaka, Junji Suzumiya
Pages: 1801-1809 Published online on: 09 February 2015
Article
Molecular response of 4T1-induced mouse mammary tumours and healthy tissues to zinc treatment
Marketa Sztalmachova, Jaromir Gumulec, Martina Raudenska, Hana Polanska, Monika Holubova, Jan Balvan, Kristyna Hudcova, Lucia Knopfova, Rene Kizek, Vojtech Adam, Petr Babula, Michal Masarik
Pages: 1810-1818 Published online on: 09 February 2015
Article
Trends and variations in breast and colorectal cancer incidence from 1995 to 2011: A comparative study between Texas Cancer Registry and National Cancer Institute's Surveillance, Epidemiology and End Results data
Zheyu Liu, Yefei Zhang, Luisa Franzin, Janice N. Cormier, Wenyaw Chan, Hua Xu, Xianglin L. Du
Pages: 1819-1826 Published online on: 06 February 2015
Article
Evaluation of ibuprofen loaded solid lipid nanoparticles and its combination regimens for pancreatic cancer chemoprevention
Arvind Thakkar, Sushma Chenreddy, Jeffrey Wang, Sunil Prabhu
Pages: 1827-1834 Published online on: 05 February 2015
Article
Chrysin inhibits cell invasion by inhibition of Recepteur d'origine Nantais via suppressing early growth response-1 and NF-κB transcription factor activities in gastric cancer cells
Yong Xia, Sen Lian, Pham Ngoc Khoi, Hyun Joong Yoon, Jae Young Han, Kee Oh Chay, Kyung Keun Kim, Young Do Jung
Pages: 1835-1843 Published online on: 23 January 2015
Article
Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small cell lung cancer
Masayoshi Toge, Satoru Yokoyama, Shinichiro Kato, Hiroaki Sakurai, Kazutaka Senda, Yoshinori Doki, Yoshihiro Hayakawa, Naoki Yoshimura, Ikuo Saiki
Pages: 1844-1848 Published online on: 30 January 2015
Article
Bitter melon juice targets molecular mechanisms underlying gemcitabine resistance in pancreatic cancer cells
Ranganatha R. Somasagara, Gagan Deep, Sangeeta Shrotriya, Manisha Patel, Chapla Agarwal, Rajesh Agarwal
Pages: 1849-1857 Published online on: 09 February 2015
Correction
