Hypermethylation of the tumor-suppressor cell adhesion molecule 1 in human papillomavirus-transformed cervical carcinoma cells

  • Authors:
    • Hyun Ju Woo
    • Sung Jin Kim
    • Kyung-Joo Song
    • Sung Soon Kim
    • Cheol-Hee Yoon
    • Byeong-Sun Choi
    • Jee Eun Rhee
  • View Affiliations

  • Published online on: April 1, 2015     https://doi.org/10.3892/ijo.2015.2945
  • Pages: 2656-2662
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Abstract

Epigenetic modification at CpG islands located on the promoter regions of tumor-suppressor genes has been associated with tumor development in many human cancers. Our study showed that the cell adhesion molecule 1 (CADM1) is downregulated in human papillomavirus (HPV)-infected cervical cancer cell lines via its hypermethylation and demethylation using 5-aza-2'-deoxycyticine (5-aza-dC) restored the expression of CADM1 protein. Overexpression of CADM1 inhibited cell proliferation. p53 was involved in the regulation of CADM1. Our results demonstrate that epigenetic alteration of CADM1 was more frequent in HPV-positive cervical cancers and that restoration of CADM1 expression may be a potential strategy for cervical cancer therapy.
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June-2015
Volume 46 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Woo HJ, Kim SJ, Song K, Kim SS, Yoon C, Choi B and Rhee JE: Hypermethylation of the tumor-suppressor cell adhesion molecule 1 in human papillomavirus-transformed cervical carcinoma cells. Int J Oncol 46: 2656-2662, 2015
APA
Woo, H.J., Kim, S.J., Song, K., Kim, S.S., Yoon, C., Choi, B., & Rhee, J.E. (2015). Hypermethylation of the tumor-suppressor cell adhesion molecule 1 in human papillomavirus-transformed cervical carcinoma cells. International Journal of Oncology, 46, 2656-2662. https://doi.org/10.3892/ijo.2015.2945
MLA
Woo, H. J., Kim, S. J., Song, K., Kim, S. S., Yoon, C., Choi, B., Rhee, J. E."Hypermethylation of the tumor-suppressor cell adhesion molecule 1 in human papillomavirus-transformed cervical carcinoma cells". International Journal of Oncology 46.6 (2015): 2656-2662.
Chicago
Woo, H. J., Kim, S. J., Song, K., Kim, S. S., Yoon, C., Choi, B., Rhee, J. E."Hypermethylation of the tumor-suppressor cell adhesion molecule 1 in human papillomavirus-transformed cervical carcinoma cells". International Journal of Oncology 46, no. 6 (2015): 2656-2662. https://doi.org/10.3892/ijo.2015.2945