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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Article

Combined treatment with tamoxifen and a fusicoccin derivative (ISIR-042) to overcome resistance to therapy and to enhance the antitumor activity of 5-fluorouracil and gemcitabine in pancreatic cancer cells

  • Authors:
    • Takaaki Miyake
    • Yoshio Honma
    • Takeshi Urano
    • Nobuo Kato
    • Junji Suzumiya
  • View Affiliations / Copyright

    Affiliations: Department of Oncology/Hematology, School of Medicine, Shimane University, Izumo, Shimane 693-8501, Japan, Department of Biochemistry, School of Medicine, Shimane University, Izumo, Shimane 693-8501, Japan, The Institute of Scientific and Industrial Research, Osaka University, Osaka 567-0047, Japan
  • Pages: 315-324
    |
    Published online on: April 30, 2015
       https://doi.org/10.3892/ijo.2015.2979
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Abstract

Although progress has been made in chemotherapeutic strategies against pancreatic cancer, overall survival has not significantly improved over the past decade. Thus, the development of better therapeutic regimens remains a high priority. Pancreatic cancer cell lines were treated with tamoxifen, a novel antitumor fusicoccin derivative (ISIR-042), and anticancer drugs, and their effects on cell growth, signaling and gene expression were determined. Xenografts of Panc-1 cells were treated with tamoxifen, ISIR-042 and 5-fluorouracil (5FU) to determine the effects on tumor growth. The inhibition of the growth of pancreatic cancer cells induced by tamoxifen was effectively reduced by α-tocopherol, a membrane stabilizer. ISIR-042 produced synergistic effects with tamoxifen in inhibiting cell growth. Tamoxifen elevated lipid peroxidation and the release of cytochrome c, and these effects of tamoxifen were reduced by α-tocopherol. ISIR-042 significantly inhibited colony formation and the expression of stemness-related genes of pancreatic cancer cells. The triple combination of tamoxifen, ISIR-042, and 5FU or gemcitabine was effective at inhibiting cell growth and the appearance of drug-resistant cells. This combined treatment significantly inhibited the growth of Panc-1 cells as xenografts without apparent adverse effects. The triple combination of tamoxifen and ISIR-042 with 5FU or gemcitabine may be highly effective against pancreatic cancer by overcoming resistance to therapy.
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1 

Evance DB, Abbruzzes JL and Rich TA: Cancer of the pancreas. Cancer, Principles and Practice of Oncology. DeVita VT Jr, Hellman S and Rosenberg SA: J.B. Lippincott Co; Philadelphia: pp. 1054–1087. 1997

2 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Conroy T, Desseigne F, Ychou M, Bouché O, Guimbaud R, Bécouarn Y, Adenis A, Raoul JL, Gourgou-Bourgade S, de la Fouchardière C, et al; Groupe Tumeurs Digestives of Unicancer; PRODIGE Intergroup. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 364:1817–1825. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Bozic I, Reiter JG, Allen B, Antal T, Chatterjee K, Shah P, Moon YS, Yaqubie A, Kelly N, Le DT, et al: Evolutionary dynamics of cancer in response to targeted combination therapy. eLife. 2:e007472013. View Article : Google Scholar : PubMed/NCBI

5 

Kawakami K, Hattori M, Inoue T, Maruyama Y, Ohkanda J, Kato N, Tongu M, Yamada T, Akimoto M, Takenaga K, et al: A novel fusicoccin derivative preferentially targets hypoxic tumor cells and inhibits tumor growth in xenografts. Anticancer Agents Med Chem. 12:791–800. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Mandlekar S and Kong ANT: Mechanisms of tamoxifen-induced apoptosis. Apoptosis. 6:469–477. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Avgeropoulos NG and Batchelor TT: New treatment strategies for malignant gliomas. Oncologist. 4:209–224. 1999.PubMed/NCBI

8 

Chou TC and Talalay P: Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul. 22:27–55. 1984. View Article : Google Scholar : PubMed/NCBI

9 

Buege JA and Aust SD: Microsomal lipid peroxidation. Methods Enzymol. 52:302–310. 1978. View Article : Google Scholar : PubMed/NCBI

10 

Tian Y, Ding W, Wang Y, Ji T, Sun S, Mo Q, Chen P, Fang Y, Liu J, Wang B, et al: Ubiquitin B in cervical cancer: Critical for the maintenance of cancer stem-like cell characters. PLoS One. 8:e844572013. View Article : Google Scholar : PubMed/NCBI

11 

Hattori M, Kawakami K, Akimoto M, Takenaga K, Suzumiya J and Honma Y: Antitumor effect of Japanese apricot extract (MK615) on human cancer cells in vitro and in vivo through a reactive oxygen species-dependent mechanism. Tumori. 99:239–248. 2013.PubMed/NCBI

12 

Kohli L, Kaza N, Coric T, Byer SJ, Brossier NM, Klocke BJ, Bjornsti MA, Carroll SL and Roth KA: 4-Hydroxytamoxifen induces autophagic death through K-Ras degradation. Cancer Res. 73:4395–4405. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Morad SAF, Levin JC, Tan S-F, Fox TE, Feith DJ and Cabot MC: Novel off-target effect of tamoxifen - inhibition of acid ceramidase activity in cancer cells. Biochim Biophys Acta. 1831:1657–1664. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N and Depinho RA: Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev. 20:1218–1249. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Maccarrone M, Fantini C, Ranalli M, Melino G and Agrò AF: Activation of nitric oxide synthase is involved in tamoxifen-induced apoptosis of human erythroleukemia K562 cells. FEBS Lett. 434:421–424. 1998. View Article : Google Scholar : PubMed/NCBI

16 

Nazarewicz RR, Zenebe WJ, Parihar A, Larson SK, Alidema E, Choi J and Ghafourifar P: Tamoxifen induces oxidative stress and mitochondrial apoptosis via stimulating mitochondrial nitric oxide synthase. Cancer Res. 67:1282–1290. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Atkinson J, Harroun T, Wassall SR, Stillwell W and Katsaras J: The location and behavior of alpha-tocopherol in membranes. Mol Nutr Food Res. 54:641–651. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Ghafourifar P, Schenk U, Klein SD and Richter C: Mitochondrial nitric-oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation. J Biol Chem. 274:31185–31188. 1999. View Article : Google Scholar : PubMed/NCBI

19 

Radi R, Beckman JS, Bush KM and Freeman BA: Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide. Arch Biochem Biophys. 288:481–487. 1991. View Article : Google Scholar : PubMed/NCBI

20 

Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, Adsay V, Wicha M, Clarke MF and Simeone DM: Identification of pancreatic cancer stem cells. Cancer Res. 67:1030–1037. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Lee CJ, Li C and Simeone DM: Human pancreatic cancer stem cells: Implications for how we treat pancreatic cancer. Transl Oncol. 1:14–18. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Honma Y, Ishii Y, Yamamoto-Yamaguchi Y, Sassa T and Asahi K: Cotylenin A, a differentiation-inducing agent, and IFN-alpha cooperatively induce apoptosis and have an antitumor effect on human non-small cell lung carcinoma cells in nude mice. Cancer Res. 63:3659–3666. 2003.PubMed/NCBI

23 

Oecking C, Eckerskorn C and Weiler EW: The fusicoccin receptor of plants is a member of the 14-3-3 superfamily of eukaryotic regulatory proteins. FEBS Lett. 352:163–166. 1994. View Article : Google Scholar : PubMed/NCBI

24 

Seimiya H, Sawada H, Muramatsu Y, Shimizu M, Ohko K, Yamane K and Tsuruo T: Involvement of 14-3S3 proteins in nuclear localization of telomerase. EMBO J. 19:2652–2661. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Rittinger K, Budman J, Xu J, Volinia S, Cantley LC, Smerdon SJ, Gamblin SJ and Yaffe MB: Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding. Mol Cell. 4:153–166. 1999. View Article : Google Scholar : PubMed/NCBI

26 

Fujita N, Saito S and Tsuruo T: Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinase promotes its binding to 14-3-3 and cytoplasmic localization. J Biol Chem. 278:49254–49260. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Molzan M, Kasper S, Röglin L, Skwarczynska M, Sassa T, Inoue T, Breitenbuecher F, Ohkanda J, Kato N, Schuler M, et al: Stabilization of physical RAF/14-3-3 interaction by cotylenin A as treatment strategy for RAS mutant cancers. ACS Chem Biol. 8:1869–1875. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Lu Y, Zhu H, Shan H, Lu J, Chang X, Li X, Lu J, Fan X, Zhu S, Wang Y, et al: Knockdown of Oct4 and Nanog expression inhibits the stemness of pancreatic cancer cells. Cancer Lett. 340:113–123. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Herreros-Villanueva M, Bujanda L, Billadeau DD and Zhang J-S: Embryonic stem cell factors and pancreatic cancer. World J Gastroenterol. 20:2247–2254. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Greenway B, Iqbal MJ, Johnson PJ and Williams R: Oestrogen receptor proteins in malignant and fetal pancreas. Br Med J (Clin Res Ed). 283:751–753. 1981. View Article : Google Scholar

31 

Benz C, Hollander C and Miller B: Endocrine-responsive pancreatic carcinoma: Steroid binding and cytotoxicity studies in human tumor cell lines. Cancer Res. 46:2276–2281. 1986.PubMed/NCBI

32 

Singh S, Baker PR, Poulsom R, Wright NA, Sheppard MC, Langman MJ and Neoptolemos JP: Expression of oestrogen receptor and oestrogen-inducible genes in pancreatic cancer. Br J Surg. 84:1085–1089. 1997. View Article : Google Scholar : PubMed/NCBI

33 

Mikulski S: Tamoxifen in patients with advanced pancreatic adenocarcinoma. Oncol Rep. 3:17–19. 1996.PubMed/NCBI

34 

Horimi T, Takasaki M, Toki A, Nishimura W and Morita S: The beneficial effect of tamoxifen therapy in patients with resected adenocarcinoma of the pancreas. Hepatogastroenterology. 43:1225–1229. 1996.PubMed/NCBI

35 

Lamy R, Conroy T, Brunaud L and Bresler L: Tamoxifen for metastatic pancreatic adenocarcinoma: A complete response. Gastroenterol Clin Biol. 25:912–913. 2001.(In French).

36 

Eckel F, Lersch C, Lippl F, Assmann G and Schulte-Frohlinde E: Phase II trial of cyclophosphamide, leucovorin, 5-fluorouracil 24-hour infusion and tamoxifen in pancreatic cancer. J Exp Clin Cancer Res. 19:295–300. 2000.

37 

Tomao S, Romiti A, Massidda B, Ionta MT, Farris A, Zullo A, Brescia A, Santuari L and Frati L: A phase II study of gemcitabine and tamoxifen in advanced pancreatic cancer. Anticancer Res. 22:2361–2364. 2002.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Miyake T, Honma Y, Urano T, Kato N and Suzumiya J: Combined treatment with tamoxifen and a fusicoccin derivative (ISIR-042) to overcome resistance to therapy and to enhance the antitumor activity of 5-fluorouracil and gemcitabine in pancreatic cancer cells. Int J Oncol 47: 315-324, 2015.
APA
Miyake, T., Honma, Y., Urano, T., Kato, N., & Suzumiya, J. (2015). Combined treatment with tamoxifen and a fusicoccin derivative (ISIR-042) to overcome resistance to therapy and to enhance the antitumor activity of 5-fluorouracil and gemcitabine in pancreatic cancer cells. International Journal of Oncology, 47, 315-324. https://doi.org/10.3892/ijo.2015.2979
MLA
Miyake, T., Honma, Y., Urano, T., Kato, N., Suzumiya, J."Combined treatment with tamoxifen and a fusicoccin derivative (ISIR-042) to overcome resistance to therapy and to enhance the antitumor activity of 5-fluorouracil and gemcitabine in pancreatic cancer cells". International Journal of Oncology 47.1 (2015): 315-324.
Chicago
Miyake, T., Honma, Y., Urano, T., Kato, N., Suzumiya, J."Combined treatment with tamoxifen and a fusicoccin derivative (ISIR-042) to overcome resistance to therapy and to enhance the antitumor activity of 5-fluorouracil and gemcitabine in pancreatic cancer cells". International Journal of Oncology 47, no. 1 (2015): 315-324. https://doi.org/10.3892/ijo.2015.2979
Copy and paste a formatted citation
x
Spandidos Publications style
Miyake T, Honma Y, Urano T, Kato N and Suzumiya J: Combined treatment with tamoxifen and a fusicoccin derivative (ISIR-042) to overcome resistance to therapy and to enhance the antitumor activity of 5-fluorouracil and gemcitabine in pancreatic cancer cells. Int J Oncol 47: 315-324, 2015.
APA
Miyake, T., Honma, Y., Urano, T., Kato, N., & Suzumiya, J. (2015). Combined treatment with tamoxifen and a fusicoccin derivative (ISIR-042) to overcome resistance to therapy and to enhance the antitumor activity of 5-fluorouracil and gemcitabine in pancreatic cancer cells. International Journal of Oncology, 47, 315-324. https://doi.org/10.3892/ijo.2015.2979
MLA
Miyake, T., Honma, Y., Urano, T., Kato, N., Suzumiya, J."Combined treatment with tamoxifen and a fusicoccin derivative (ISIR-042) to overcome resistance to therapy and to enhance the antitumor activity of 5-fluorouracil and gemcitabine in pancreatic cancer cells". International Journal of Oncology 47.1 (2015): 315-324.
Chicago
Miyake, T., Honma, Y., Urano, T., Kato, N., Suzumiya, J."Combined treatment with tamoxifen and a fusicoccin derivative (ISIR-042) to overcome resistance to therapy and to enhance the antitumor activity of 5-fluorouracil and gemcitabine in pancreatic cancer cells". International Journal of Oncology 47, no. 1 (2015): 315-324. https://doi.org/10.3892/ijo.2015.2979
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