Open Access

Death-associated protein kinase: A molecule with functional antagonistic duality and a potential role in inflammatory bowel disease (Review)

  • Authors:
    • Sara Steinmann
    • Kristina Scheibe
    • Katharina Erlenbach-Wuensch
    • Clemens Neufert
    • Regine Schneider-Stock
  • View Affiliations

  • Published online on: May 11, 2015     https://doi.org/10.3892/ijo.2015.2998
  • Pages: 5-15
  • Copyright: © Steinmann et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

The cytoskeleton-associated serine/threonine kinase death-associated protein kinase (DAPK) has been described as a cancer gene chameleon with functional antagonistic duality in a cell type and context specific manner. The broad range of interaction partners and substrates link DAPK to inflammatory processes especially in the gut. Herein we summarize our knowledge on the role of DAPK in different cell types that play a role under inflammatory conditions in the gut. Besides some promising experimental data suggesting DAPK as an interesting drug target in inflammatory bowel disease there are many open questions regarding direct evidence for a role of DAPK in intestinal inflammation.
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July-2015
Volume 47 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Steinmann S, Scheibe K, Erlenbach-Wuensch K, Neufert C and Schneider-Stock R: Death-associated protein kinase: A molecule with functional antagonistic duality and a potential role in inflammatory bowel disease (Review). Int J Oncol 47: 5-15, 2015
APA
Steinmann, S., Scheibe, K., Erlenbach-Wuensch, K., Neufert, C., & Schneider-Stock, R. (2015). Death-associated protein kinase: A molecule with functional antagonistic duality and a potential role in inflammatory bowel disease (Review). International Journal of Oncology, 47, 5-15. https://doi.org/10.3892/ijo.2015.2998
MLA
Steinmann, S., Scheibe, K., Erlenbach-Wuensch, K., Neufert, C., Schneider-Stock, R."Death-associated protein kinase: A molecule with functional antagonistic duality and a potential role in inflammatory bowel disease (Review)". International Journal of Oncology 47.1 (2015): 5-15.
Chicago
Steinmann, S., Scheibe, K., Erlenbach-Wuensch, K., Neufert, C., Schneider-Stock, R."Death-associated protein kinase: A molecule with functional antagonistic duality and a potential role in inflammatory bowel disease (Review)". International Journal of Oncology 47, no. 1 (2015): 5-15. https://doi.org/10.3892/ijo.2015.2998