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Article

TM4SF1 as a prognostic marker of pancreatic ductal adenocarcinoma is involved in migration and invasion of cancer cells

  • Authors:
    • Biao Zheng
    • Kenoki Ohuchida
    • Lin Cui
    • Ming Zhao
    • Koji Shindo
    • Kenji Fujiwara
    • Tatsuya Manabe
    • Nobuhiro Torata
    • Taiki Moriyama
    • Yoshihiro Miyasaka
    • Takao Ohtsuka
    • Shunichi Takahata
    • Kazuhiro Mizumoto
    • Yoshinao Oda
    • Masao Tanaka
  • View Affiliations / Copyright

    Affiliations: Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
  • Pages: 490-498
    |
    Published online on: May 28, 2015
       https://doi.org/10.3892/ijo.2015.3022
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Abstract

The cell surface protein Transmembrane 4 L6 family member 1 (TM4SF1) has been detected in various tumors, and its expression on tumor cells is implicated in cancer cell metastasis and patient prognosis. The role of TM4SF1 in malignant tumors remains poorly understood, particularly in pancreatic cancer. We performed immunohistochemical staining to analyze the expression of TM4SF1 in resected pancreatic tissues and investigated the correlation between TM4SF1 expression and prognosis. The function of TM4SF1 in the invasion and migration of pancreatic cancer cells was analyzed in vitro using an RNA interference technique. In pancreatic cancer tissues, TM4SF1 expression was detected in cancer cells, and patients with high tumor levels of TM4SF1 showed longer survival times than those with low TM4SF1 levels (P=0.0332). In vitro, reduced TM4SF1 expression enhanced the migration (P<0.05) and invasion (P<0.05) of pancreatic cancer cells partially via decreased E-cadherin expression. TM4SF1 protein levels were also reduced after TGF-β1-induced epithelial-mesenchymal transition (EMT).TM4SF1 expression is associated with better prognosis in pancreatic cancer. Loss of TM4SF1 contributes to the invasion and migration of pancreatic cancer cells.
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Copy and paste a formatted citation
Spandidos Publications style
Zheng B, Ohuchida K, Cui L, Zhao M, Shindo K, Fujiwara K, Manabe T, Torata N, Moriyama T, Miyasaka Y, Miyasaka Y, et al: TM4SF1 as a prognostic marker of pancreatic ductal adenocarcinoma is involved in migration and invasion of cancer cells. Int J Oncol 47: 490-498, 2015.
APA
Zheng, B., Ohuchida, K., Cui, L., Zhao, M., Shindo, K., Fujiwara, K. ... Tanaka, M. (2015). TM4SF1 as a prognostic marker of pancreatic ductal adenocarcinoma is involved in migration and invasion of cancer cells. International Journal of Oncology, 47, 490-498. https://doi.org/10.3892/ijo.2015.3022
MLA
Zheng, B., Ohuchida, K., Cui, L., Zhao, M., Shindo, K., Fujiwara, K., Manabe, T., Torata, N., Moriyama, T., Miyasaka, Y., Ohtsuka, T., Takahata, S., Mizumoto, K., Oda, Y., Tanaka, M."TM4SF1 as a prognostic marker of pancreatic ductal adenocarcinoma is involved in migration and invasion of cancer cells". International Journal of Oncology 47.2 (2015): 490-498.
Chicago
Zheng, B., Ohuchida, K., Cui, L., Zhao, M., Shindo, K., Fujiwara, K., Manabe, T., Torata, N., Moriyama, T., Miyasaka, Y., Ohtsuka, T., Takahata, S., Mizumoto, K., Oda, Y., Tanaka, M."TM4SF1 as a prognostic marker of pancreatic ductal adenocarcinoma is involved in migration and invasion of cancer cells". International Journal of Oncology 47, no. 2 (2015): 490-498. https://doi.org/10.3892/ijo.2015.3022
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng B, Ohuchida K, Cui L, Zhao M, Shindo K, Fujiwara K, Manabe T, Torata N, Moriyama T, Miyasaka Y, Miyasaka Y, et al: TM4SF1 as a prognostic marker of pancreatic ductal adenocarcinoma is involved in migration and invasion of cancer cells. Int J Oncol 47: 490-498, 2015.
APA
Zheng, B., Ohuchida, K., Cui, L., Zhao, M., Shindo, K., Fujiwara, K. ... Tanaka, M. (2015). TM4SF1 as a prognostic marker of pancreatic ductal adenocarcinoma is involved in migration and invasion of cancer cells. International Journal of Oncology, 47, 490-498. https://doi.org/10.3892/ijo.2015.3022
MLA
Zheng, B., Ohuchida, K., Cui, L., Zhao, M., Shindo, K., Fujiwara, K., Manabe, T., Torata, N., Moriyama, T., Miyasaka, Y., Ohtsuka, T., Takahata, S., Mizumoto, K., Oda, Y., Tanaka, M."TM4SF1 as a prognostic marker of pancreatic ductal adenocarcinoma is involved in migration and invasion of cancer cells". International Journal of Oncology 47.2 (2015): 490-498.
Chicago
Zheng, B., Ohuchida, K., Cui, L., Zhao, M., Shindo, K., Fujiwara, K., Manabe, T., Torata, N., Moriyama, T., Miyasaka, Y., Ohtsuka, T., Takahata, S., Mizumoto, K., Oda, Y., Tanaka, M."TM4SF1 as a prognostic marker of pancreatic ductal adenocarcinoma is involved in migration and invasion of cancer cells". International Journal of Oncology 47, no. 2 (2015): 490-498. https://doi.org/10.3892/ijo.2015.3022
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