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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September-2015 Volume 47 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Circulating miR-103 and miR-720 as novel serum biomarkers for patients with colorectal cancer

  • Authors:
    • Ryoji Nonaka
    • Yuichiro Miyake
    • Taishi Hata
    • Yoshinori Kagawa
    • Takeshi Kato
    • Hideki Osawa
    • Junichi Nishimura
    • Masakazu Ikenaga
    • Kohei Murata
    • Mamoru Uemura
    • Daisuke Okuzaki
    • Ichiro Takemasa
    • Tsunekazu Mizushima
    • Hirofumi Yamamoto
    • Yuichiro Doki
    • Masaki Mori
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan, Department of Surgery, Kansai Rosai Hospital, Hyogo, Japan, Department of Surgery, Osaka Rosai Hospital, Osaka, Japan, Department of Surgery, Suita Municipal Hospital, Osaka, Japan, Special Research Facilities DNA-chip Development Center for Infectious Diseases, Research Institute for Microbial Disease, Osaka University, Osaka, Japan
  • Pages: 1097-1102
    |
    Published online on: June 26, 2015
       https://doi.org/10.3892/ijo.2015.3064
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Abstract

Circulating microRNAs (miRNAs) have been reported as a biomarker for human malignancies, including colorectal cancer (CRC). The purpose of this study was to identify a novel biomarker for CRC through examination of serum miRNAs from the patients with CRC. Microarray analysis of miRNA expression was performed using paired pre- and post-operative serum from 10 CRC patients. miR-103 and miR-720 decreased significantly in the post-operative serum when compared to pre-operative serum. With an extended scale validation by qRT-PCR (quantitative real-time polymerase chain reaction) in 30 CRC patients, we confirmed that serum miR-103 and miR-720 decreased significantly after surgery (P=0.0004, and P=0.0274, respectively). Next, we examined serum miR-103 and miR-720 levels in 32 non-cancer patients and 84 CRC patients, and we found that expression of these two miRNAs was significantly higher in CRC patients than non-cancer patients. Furthermore, clinical and pathological survey indicated that high expression of miR-103 was significantly associated with histological differentiation grade, and lymphatic invasion and high expression of miR-720 was significantly associated with male gender and lymph node metastasis. Our data suggest that circulating miR-103 and miR-720 show potential as novel serum biomarkers for CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Nonaka R, Miyake Y, Hata T, Kagawa Y, Kato T, Osawa H, Nishimura J, Ikenaga M, Murata K, Uemura M, Uemura M, et al: Circulating miR-103 and miR-720 as novel serum biomarkers for patients with colorectal cancer. Int J Oncol 47: 1097-1102, 2015.
APA
Nonaka, R., Miyake, Y., Hata, T., Kagawa, Y., Kato, T., Osawa, H. ... Mori, M. (2015). Circulating miR-103 and miR-720 as novel serum biomarkers for patients with colorectal cancer. International Journal of Oncology, 47, 1097-1102. https://doi.org/10.3892/ijo.2015.3064
MLA
Nonaka, R., Miyake, Y., Hata, T., Kagawa, Y., Kato, T., Osawa, H., Nishimura, J., Ikenaga, M., Murata, K., Uemura, M., Okuzaki, D., Takemasa, I., Mizushima, T., Yamamoto, H., Doki, Y., Mori, M."Circulating miR-103 and miR-720 as novel serum biomarkers for patients with colorectal cancer". International Journal of Oncology 47.3 (2015): 1097-1102.
Chicago
Nonaka, R., Miyake, Y., Hata, T., Kagawa, Y., Kato, T., Osawa, H., Nishimura, J., Ikenaga, M., Murata, K., Uemura, M., Okuzaki, D., Takemasa, I., Mizushima, T., Yamamoto, H., Doki, Y., Mori, M."Circulating miR-103 and miR-720 as novel serum biomarkers for patients with colorectal cancer". International Journal of Oncology 47, no. 3 (2015): 1097-1102. https://doi.org/10.3892/ijo.2015.3064
Copy and paste a formatted citation
x
Spandidos Publications style
Nonaka R, Miyake Y, Hata T, Kagawa Y, Kato T, Osawa H, Nishimura J, Ikenaga M, Murata K, Uemura M, Uemura M, et al: Circulating miR-103 and miR-720 as novel serum biomarkers for patients with colorectal cancer. Int J Oncol 47: 1097-1102, 2015.
APA
Nonaka, R., Miyake, Y., Hata, T., Kagawa, Y., Kato, T., Osawa, H. ... Mori, M. (2015). Circulating miR-103 and miR-720 as novel serum biomarkers for patients with colorectal cancer. International Journal of Oncology, 47, 1097-1102. https://doi.org/10.3892/ijo.2015.3064
MLA
Nonaka, R., Miyake, Y., Hata, T., Kagawa, Y., Kato, T., Osawa, H., Nishimura, J., Ikenaga, M., Murata, K., Uemura, M., Okuzaki, D., Takemasa, I., Mizushima, T., Yamamoto, H., Doki, Y., Mori, M."Circulating miR-103 and miR-720 as novel serum biomarkers for patients with colorectal cancer". International Journal of Oncology 47.3 (2015): 1097-1102.
Chicago
Nonaka, R., Miyake, Y., Hata, T., Kagawa, Y., Kato, T., Osawa, H., Nishimura, J., Ikenaga, M., Murata, K., Uemura, M., Okuzaki, D., Takemasa, I., Mizushima, T., Yamamoto, H., Doki, Y., Mori, M."Circulating miR-103 and miR-720 as novel serum biomarkers for patients with colorectal cancer". International Journal of Oncology 47, no. 3 (2015): 1097-1102. https://doi.org/10.3892/ijo.2015.3064
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