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Article

Chondromodulin-1 functions as a tumor suppressor in gastric adenocarcinoma

  • Authors:
    • Pengfei Zhang
    • Ying Wang
    • Po Xu
    • Shiyuan Song
    • Xiaojuan Zhu
    • Zhenguo Shi
    • Shegan Gao
    • Xiaoshan Feng
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China, Department of Urology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China
  • Pages: 941-950
    |
    Published online on: July 13, 2015
       https://doi.org/10.3892/ijo.2015.3081
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Abstract

Chondromodulin-1 (ChM1) is a cartilage-specific glycoprotein that stimulates the growth of chondrocytes and inhibits the tube formation of endothelial cells. Endogenously, ChM1 is expressed in the cartilage and is an anti-angiogenic factor. ChM1 has been reported to suppress the proliferation of multiple human tumor cells in an anchorage-independent manner. However, the role of ChM1 in carcinogenesis of gastric cancer remains unknown. By quantitative RT-PCR and western blotting we examined the expression of ChM1 in gastric cancer tissue and normal gastric tissue. In vitro we investigated the functional and mechanistic roles of ChM1 in the inhibition of gastric cancer cell aggressiveness. We observed that ChM1 expression was remarkably downregulated in gastric cancer cell lines compared with the immortal normal gastric epithelial cell line GES-1. Importantly, ChM1 was frequently downregulated in gastric cancer tissue compared with normal gastric tissue. Low ChM1 mRNA expression was associated with higher clinical stages, higher lymph node metastasis, and poorer prognosis of patients. Functional assays in vitro showed that ectopic expression of ChM1 was able to inhibit gastric tumor cell proliferation by arresting the cell cycle. Overall, our findings indicate that ChM1 is a potential tumor suppressor in gastric cancer, suggesting that it may be useful as a biomarker for the treatment and prognosis of gastric cancer.
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1 

Compare D, Rocco A and Nardone G: Risk factors in gastric cancer. Eur Rev Med Pharmacol Sci. 14:302–308. 2010.PubMed/NCBI

2 

Brenner H, Rothenbacher D and Arndt V: Epidemiology of stomach cancer. Cancer Epidemiology. Springer; pp. 467–477. 2009, View Article : Google Scholar

3 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Wu WK, Cho CH, Lee CW, Fan D, Wu K, Yu J and Sung JJ: Dysregulation of cellular signaling in gastric cancer. Cancer Lett. 295:144–153. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Fan D, Zhang X, Chen X, Mou Z, Hu J, Zhou S, Ding J and Wu K: Bird's-eye view on gastric cancer research of the past 25 years. J Gastroenterol Hepatol. 20:360–365. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Kuzuhara T, Suganuma M, Kurusu M and Fujiki H: Helicobacter pylori-secreting protein Tipα is a potent inducer of chemokine gene expressions in stomach cancer cells. J Cancer Res Clin Oncol. 133:287–296. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Suzuki H, Yamamoto E, Nojima M, Kai M, Yamano HO, Yoshikawa K, Kimura T, Kudo T, Harada E, Sugai T, et al: Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect. Carcinogenesis. 31:2066–2073. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Qiao F, Zhang K, Gong P, Wang L, Hu J, Lu S and Fan H: Decreased miR-30b-5p expression by DNMT1 methylation regulation involved in gastric cancer metastasis. Mol Biol Rep. 41:5693–5700. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Wei Q, Zhou W, Wang W, Gao B, Wang L, Cao J and Liu ZP: Tumor-suppressive functions of leucine zipper transcription factor-like 1. Cancer Res. 70:2942–2950. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Yanagihara I, Yamagata M, Sakai N, Shukunami C, Kurahashi H, Yamazaki M, Michigami T, Hiraki Y and Ozono K: Genomic organization of the human chondromodulin-1 gene containing a promoter region that confers the expression of reporter gene in chondrogenic ATDC5 cells. J Bone Miner Res. 15:421–429. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Zhou H, Kepa JK, Siegel D, Miura S, Hiraki Y and Ross D: Benzene metabolite hydroquinone up-regulates chondromodulin-I and inhibits tube formation in human bone marrow endothelial cells. Mol Pharmacol. 76:579–587. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Tsai A-C, Pan S-L, Sun H-L, Wang CY, Peng CY, Wang SW, Chang YL, Kuo SC, Lee KH and Teng CM: CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation. J Biol Chem. 285:5497–5506. 2010. View Article : Google Scholar :

13 

Wang S-W, Pan S-L, Huang Y-C, Guh JH, Chiang PC, Huang DY, Kuo SC, Lee KH and Teng CM: CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. Mol Cancer Ther. 7:350–360. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Hsu SC, Yang JS, Kuo CL, Lo C, Lin JP, Hsia TC, Lin JJ, Lai KC, Kuo HM, Huang LJ, et al: Novel quinolone CHM-1 induces apoptosis and inhibits metastasis in a human osterogenic sarcoma cell line. J Orthop Res. 27:1637–1644. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Patra D and Sandell LJ: Antiangiogenic and anticancer molecules in cartilage. Expert Rev Mol Med. 14:e102012. View Article : Google Scholar : PubMed/NCBI

16 

Steck E, Bertram H, Abel R, Chen B, Winter A and Richter W: Induction of intervertebral disc-like cells from adult mesenchymal stem cells. Stem Cells. 23:403–411. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Pirker R, Pereira JR, von Pawel J, Krzakowski M, Ramlau R, Park K, de Marinis F, Eberhardt WE, Paz-Ares L, Störkel S, et al: EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: Analysis of data from the phase 3 FLEX study. Lancet Oncol. 13:33–42. 2012. View Article : Google Scholar

18 

Dalby B, Cates S, Harris A, Ohki EC, Tilkins ML, Price PJ and Ciccarone VC: Advanced transfection with Lipofectamine 2000 reagent: Primary neurons, siRNA, and high-throughput applications. Methods. 33:95–103. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Zhu C, Jung S, Luo S, Meng F, Zhu X, Park TG and Zhong Z: Co-delivery of siRNA and paclitaxel into cancer cells by biodegradable cationic micelles based on PDMAEMA-PCL-PDMAEMA triblock copolymers. Biomaterials. 31:2408–2416. 2010. View Article : Google Scholar

20 

Ziyan W, Shuhua Y, Xiufang W and Xiaoyun L: MicroRNA-21 is involved in osteosarcoma cell invasion and migration. Med Oncol. 28:1469–1474. 2011. View Article : Google Scholar

21 

Mera H, Kawashima H, Yoshizawa T, Ishibashi O, Ali MM, Hayami T, Kitahara H, Yamagiwa H, Kondo N, Ogose A, et al: Chondromodulin-1 directly suppresses growth of human cancer cells. BMC Cancer. 9:1662009. View Article : Google Scholar : PubMed/NCBI

22 

Callow MG, Clairvoyant F, Zhu S, Schryver B, Whyte DB, Bischoff JR, Jallal B and Smeal T: Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines. J Biol Chem. 277:550–558. 2002. View Article : Google Scholar

23 

Schwartz MA and Assoian RK: Integrins and cell proliferation: Regulation of cyclin-dependent kinases via cytoplasmic signaling pathways. J Cell Sci. 114:2553–2560. 2001.PubMed/NCBI

24 

Schwartz MA and Ginsberg MH: Networks and crosstalk: Integrin signalling spreads. Nat Cell Biol. 4:E65–E68. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Hayami T, Shukunami C, Mitsui K, Endo N, Tokunaga K, Kondo J, Takahashi HE and Hiraki Y: Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo. FEBS Lett. 458:436–440. 1999. View Article : Google Scholar : PubMed/NCBI

26 

Sachdev SW, Dietz UH, Oshima Y, Lang MR, Knapik EW, Hiraki Y and Shukunami C: Sequence analysis of zebrafish chondromodulin-1 and expression profile in the notochord and chondrogenic regions during cartilage morphogenesis. Mech Dev. 105:157–162. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Klinger P, Surmann-Schmitt C, Brem M, Swoboda B, Distler JH, Carl HD, von der Mark K, Hennig FF and Gelse K: Chondromodulin 1 stabilizes the chondrocyte phenotype and inhibits endochondral ossification of porcine cartilage repair tissue. Arthritis Rheum. 63:2721–2731. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Chen K-F, Tai W-T, Chu P-Y, et al: STAT3 mediates regorafenib-induced apoptosis in hepatocellular carcinoma. Clin Cancer Res. 20:5768–5776. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Fujii M, Furumatsu T, Yokoyama Y, Kanazawa T, Kajiki Y, Abe N and Ozaki T: Chondromodulin-I derived from the inner meniscus prevents endothelial cell proliferation. J Orthop Res. 31:538–543. 2013. View Article : Google Scholar

30 

Shukunami C and Hiraki Y: Role of cartilage-derived anti-angiogenic factor, chondromodulin-I, during endochondral bone formation. Osteoarthritis Cartilage. 9(Suppl A): S91–S101. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Fang W, Friis TE, Long X and Xiao Y: Expression of chondromodulin-1 in the temporomandibular joint condylar cartilage and disc. J Oral Pathol Med. 39:356–360. 2010.

32 

Takeda K, Clausen BE, Kaisho T, Tsujimura T, Terada N, Förster I and Akira S: Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity. 10:39–49. 1999. View Article : Google Scholar : PubMed/NCBI

33 

Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H, Eckmann L, et al: IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell. 15:103–113. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Corvinus FM, Orth C, Moriggl R, Tsareva SA, Wagner S, Pfitzner EB, Baus D, Kaufmann R, Huber LA, Zatloukal K, et al: Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth. Neoplasia. 7:545–555. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Sherry MM, Reeves A, Wu JK and Cochran BH: STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem Cells. 27:2383–2392. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Gao Q, Wolfgang MJ, Neschen S, Morino K, Horvath TL, Shulman GI and Fu XY: Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci USA. 101:4661–4666. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Aggarwal BB, Sethi G, Ahn KS, Sandur SK, Pandey MK, Kunnumakkara AB, Sung B and Ichikawa H: Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: Modern target but ancient solution. Ann NY Acad Sci. 1091:151–169. 2006. View Article : Google Scholar

38 

Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R and Sebti SM: Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 63:1270–1279. 2003.PubMed/NCBI

39 

Chen T, Wang LH and Farrar WL: Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells. Cancer Res. 60:2132–2135. 2000.PubMed/NCBI

40 

Aggarwal BB, Kunnumakkara AB, Harikumar KB, Gupta SR, Tharakan ST, Koca C, Dey S and Sung B: Signal transducer and activator of transcription-3, inflammation, and cancer: How intimate is the relationship? Ann NY Acad Sci. 1171:59–76. 2009. View Article : Google Scholar : PubMed/NCBI

41 

De Simone V, Franzè E, Ronchetti G, Colantoni A, Fantini MC, Di Fusco D, Sica GS, Sileri P, MacDonald TT, Pallone F, et al: Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-κB to promote colorectal cancer cell growth. Oncogene 2014. Sep 1–2014.(Epub ahead of print). View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhang P, Wang Y, Xu P, Song S, Zhu X, Shi Z, Gao S and Feng X: Chondromodulin-1 functions as a tumor suppressor in gastric adenocarcinoma. Int J Oncol 47: 941-950, 2015.
APA
Zhang, P., Wang, Y., Xu, P., Song, S., Zhu, X., Shi, Z. ... Feng, X. (2015). Chondromodulin-1 functions as a tumor suppressor in gastric adenocarcinoma. International Journal of Oncology, 47, 941-950. https://doi.org/10.3892/ijo.2015.3081
MLA
Zhang, P., Wang, Y., Xu, P., Song, S., Zhu, X., Shi, Z., Gao, S., Feng, X."Chondromodulin-1 functions as a tumor suppressor in gastric adenocarcinoma". International Journal of Oncology 47.3 (2015): 941-950.
Chicago
Zhang, P., Wang, Y., Xu, P., Song, S., Zhu, X., Shi, Z., Gao, S., Feng, X."Chondromodulin-1 functions as a tumor suppressor in gastric adenocarcinoma". International Journal of Oncology 47, no. 3 (2015): 941-950. https://doi.org/10.3892/ijo.2015.3081
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang P, Wang Y, Xu P, Song S, Zhu X, Shi Z, Gao S and Feng X: Chondromodulin-1 functions as a tumor suppressor in gastric adenocarcinoma. Int J Oncol 47: 941-950, 2015.
APA
Zhang, P., Wang, Y., Xu, P., Song, S., Zhu, X., Shi, Z. ... Feng, X. (2015). Chondromodulin-1 functions as a tumor suppressor in gastric adenocarcinoma. International Journal of Oncology, 47, 941-950. https://doi.org/10.3892/ijo.2015.3081
MLA
Zhang, P., Wang, Y., Xu, P., Song, S., Zhu, X., Shi, Z., Gao, S., Feng, X."Chondromodulin-1 functions as a tumor suppressor in gastric adenocarcinoma". International Journal of Oncology 47.3 (2015): 941-950.
Chicago
Zhang, P., Wang, Y., Xu, P., Song, S., Zhu, X., Shi, Z., Gao, S., Feng, X."Chondromodulin-1 functions as a tumor suppressor in gastric adenocarcinoma". International Journal of Oncology 47, no. 3 (2015): 941-950. https://doi.org/10.3892/ijo.2015.3081
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