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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Review

Epithelial-mesenchymal transition and drug resistance in breast cancer (Review)

  • Authors:
    • Jing Huang
    • Hongzhong Li
    • Guosheng Ren
  • View Affiliations / Copyright

    Affiliations: Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China
  • Pages: 840-848
    |
    Published online on: July 16, 2015
       https://doi.org/10.3892/ijo.2015.3084
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Abstract

Breast cancer is the leading cause of cancer death in women worldwide. Insensitivity of tumor cells to drug therapies is an essential reason arousing such high mortality. Epithelial-mesenchymal transition (EMT) is defined by the loss of epithelial characteristics and the acquisition of a mesenchymal phenotype. It is well known that EMT plays an important role in breast cancer progression. Recently, mounting evidence has demonstrated involvement of EMT in antagonizing chemotherapy in breast cancer. Here, we discuss the biological significance and clinical implications of these findings, with an emphasis on novel approaches that effectively target EMT to increase the efficacy of anticancer therapies.
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Copy and paste a formatted citation
Spandidos Publications style
Huang J, Li H and Ren G: Epithelial-mesenchymal transition and drug resistance in breast cancer (Review). Int J Oncol 47: 840-848, 2015.
APA
Huang, J., Li, H., & Ren, G. (2015). Epithelial-mesenchymal transition and drug resistance in breast cancer (Review). International Journal of Oncology, 47, 840-848. https://doi.org/10.3892/ijo.2015.3084
MLA
Huang, J., Li, H., Ren, G."Epithelial-mesenchymal transition and drug resistance in breast cancer (Review)". International Journal of Oncology 47.3 (2015): 840-848.
Chicago
Huang, J., Li, H., Ren, G."Epithelial-mesenchymal transition and drug resistance in breast cancer (Review)". International Journal of Oncology 47, no. 3 (2015): 840-848. https://doi.org/10.3892/ijo.2015.3084
Copy and paste a formatted citation
x
Spandidos Publications style
Huang J, Li H and Ren G: Epithelial-mesenchymal transition and drug resistance in breast cancer (Review). Int J Oncol 47: 840-848, 2015.
APA
Huang, J., Li, H., & Ren, G. (2015). Epithelial-mesenchymal transition and drug resistance in breast cancer (Review). International Journal of Oncology, 47, 840-848. https://doi.org/10.3892/ijo.2015.3084
MLA
Huang, J., Li, H., Ren, G."Epithelial-mesenchymal transition and drug resistance in breast cancer (Review)". International Journal of Oncology 47.3 (2015): 840-848.
Chicago
Huang, J., Li, H., Ren, G."Epithelial-mesenchymal transition and drug resistance in breast cancer (Review)". International Journal of Oncology 47, no. 3 (2015): 840-848. https://doi.org/10.3892/ijo.2015.3084
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