Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
September-2015 Volume 47 Issue 3

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2015 Volume 47 Issue 3

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture

  • Authors:
    • J. M. Wierzbicka
    • A. Binek
    • T. Ahrends
    • J. D. Nowacka
    • A. Szydłowska
    • Ł. Turczyk
    • T. Wąsiewicz
    • P. M. Wierzbicki
    • R. Sądej
    • R. C. Tuckey
    • A. T. Slominski
    • J. Chybicki
    • K. Adrych
    • Z. Kmieć
    • M. A. Żmijewski
  • View Affiliations / Copyright

    Affiliations: Department of Histology, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland, Students Scientific Association BIO‑MED, Intercollegiate Faculty of Biotechnology of the University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland, Department of Molecular Enzymology, Intercollegiate Faculty of Biotechnology of the University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland, School of Chemistry and Biochemistry, The University of Western Australia, Crawley WA, Australia, Department of Dermatology, University of Alabama Birmingham, VA Medical Center, Birmingham, AL 35294, USA, Department of General Surgery, Hospital Ministry Internal Affairs, 80104 Gdańsk, Poland, Department of Hepatology and Gastroenterology, Faculty of Medicine, Medical University of Gdańsk, 80210 Gdańsk, Poland
  • Pages: 1084-1096
    |
    Published online on: July 17, 2015
       https://doi.org/10.3892/ijo.2015.3088
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Colorectal cancer (CRC) is an emerging global problem with the rapid increase in its incidence being associated with an unhealthy lifestyle. Epidemiological studies have shown that decreased levels of vitamin D3 significantly increases the risk of CRC. Furthermore, negative effects of vitamin D3 deficiency can be compensated by appropriate supplementation. Vitamin D3 was shown to inhibit growth and induce differentiation of cancer cells, however, excessive vitamin D3 intake leads to hypercalcemia. Thus, development of efficient vitamin D3 analogues with limited impact on calcium homeostasis is an important scientific and clinically relevant task. The aims of the present study were to compare the antiproliferative potential of classic vitamin D3 metabolites (1α,25(OH)2D3 and 25(OH)D3) with selected low calcemic analogues (calcipotriol and 20(OH)D3) on CRC cell lines and to investigate the expression of vitamin D-related genes in CRC cell lines and clinical samples. Vitamin D3 analogues exerted anti-proliferative effects on all CRC cell lines tested. Calcipotriol proved to be as potent as 1α,25(OH)2D3 and had more efficacy than 20-hydroxyvitamin D3. In addition, the analogs tested effectively inhibited the formation of colonies in Matrigel. The expression of genes involved in 1α,25(OH)2D3 signaling and metabolism varied in cell lines analysed, which explains in part their different sensitivities to the various analogues. In CRC biopsies, there was decreased VDR expression in tumor samples in comparison to the surgical margin and healthy colon samples (p<0.01). The present study indicates that vitamin D3 analogues which have low calcemic activity, such as calcipotriol or 20(OH)D3, are very promising candidates for CRC therapy. Moreover, expression profiling of vitamin D-related genes is likely to be a powerful tool in the planning of anticancer therapy. Decreased levels of VDR and increased CYP24A1 expression in clinical samples underline the importance of deregulation of vitamin D pathways in the development of CRC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar

2 

López-Gómez M, Malmierca E, de Górgolas M and Casado E: Cancer in developing countries: The next most preventable pandemic. The global problem of cancer. Crit Rev Oncol Hematol. 88:117–122. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Wolpin BM and Mayer RJ: Systemic treatment of colorectal cancer. Gastroenterology. 134:1296–1310. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Johnston PG and Kaye S: Capecitabine: A novel agent for the treatment of solid tumors. Anticancer Drugs. 12:639–646. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Liu G, Hu X and Chakrabarty S: Vitamin D mediates its action in human colon carcinoma cells in a calcium-sensing receptor-dependent manner: Downregulates malignant cell behavior and the expression of thymidylate synthase and survivin and promotes cellular sensitivity to 5-FU. Int J Cancer. 126:631–639. 2010. View Article : Google Scholar

6 

Milczarek M, Psurski M, Kutner A and Wietrzyk J: Vitamin D analogs enhance the anticancer activity of 5-fluorouracil in an in vivo mouse colon cancer model. BMC Cancer. 13:2942013. View Article : Google Scholar : PubMed/NCBI

7 

Holick MF, Frommer JE, McNeill SC, Richtand NM, Henley JW and Potts JT Jr: Photometabolism of 7-dehydrocholesterol to previtamin D3 in skin. Biochem Biophys Res Commun. 76:107–114. 1977. View Article : Google Scholar : PubMed/NCBI

8 

Holick MF, DeLuca HF and Avioli LV: Isolation and identification of 25-hydroxycholecalciferol from human plasma. Arch Intern Med. 129:56–61. 1972. View Article : Google Scholar : PubMed/NCBI

9 

Holick MF, Schnoes HK, DeLuca HF, Gray RW, Boyle IT and Suda T: Isolation and identification of 24,25-dihydroxycholecalciferol, a metabolite of vitamin D made in the kidney. Biochemistry. 11:4251–4255. 1972. View Article : Google Scholar : PubMed/NCBI

10 

Holick MF, Schnoes HK, DeLuca HF, Suda T and Cousins RJ: Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestine. Biochemistry. 10:2799–2804. 1971. View Article : Google Scholar : PubMed/NCBI

11 

Hewison M, Zehnder D, Chakraverty R and Adams JS: Vitamin D and barrier function: A novel role for extra-renal 1 alpha-hydroxylase. Mol Cell Endocrinol. 215:31–38. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Tieu EW, Tang EKY, Tuckey RC and Adams JS: Kinetic analysis of human CYP24A1 metabolism of vitamin D via the C24-oxidation pathway. FEBS J. 281:3280–3296. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Haussler MR, Whitfield GK, Haussler CA, Hsieh JC, Thompson PD, Selznick SH, Dominguez CE and Jurutka PW: The nuclear vitamin D receptor: Biological and molecular regulatory properties revealed. J Bone Miner Res. 13:325–349. 1998. View Article : Google Scholar : PubMed/NCBI

14 

Slominski A, Zjawiony J, Wortsman J, Semak I, Stewart J, Pisarchik A, Sweatman T, Marcos J, Dunbar C and Tuckey RC: A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin. Eur J Biochem. 271:4178–4188. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Slominski A, Semak I, Zjawiony J, Wortsman J, Li W, Szczesniewski A and Tuckey RC: The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism. FEBS J. 272:4080–4090. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Guryev O, Carvalho RA, Usanov S, Gilep A and Estabrook RW: A pathway for the metabolism of vitamin D3: Unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1). Proc Natl Acad Sci USA. 100:14754–14759. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Slominski A, Semak I, Wortsman J, Zjawiony J, Li W, Zbytek B and Tuckey RC: An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2. FEBS J. 273:2891–2901. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Slominski AT, Li W, Kim TK, Semak I, Wang J, Zjawiony JK and Tuckey RC: Novel activities of CYP11A1 and their potential physiological significance. J Steroid Biochem Mol Biol. 151:25–37. 2015. View Article : Google Scholar

19 

Slominski AT, Kim TK, Shehabi HZ, Semak I, Tang EK, Nguyen MN, Benson HA, Korik E, Janjetovic Z, Chen J, et al: In vivo evidence for a novel pathway of vitamin D3 metabolism initiated by P450scc and modified by CYP27B1. FASEB J. 26:3901–3915. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Slominski AT, Kim TK, Shehabi HZ, Tang EK, Benson HA, Semak I, Lin Z, Yates CR, Wang J, Li W, et al: In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland. Mol Cell Endocrinol. 383:181–192. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Slominski AT, Janjetovic Z, Kim TK, Wasilewski P, Rosas S, Hanna S, Sayre RM, Dowdy JC, Li W and Tuckey RC: Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation. J Steroid Biochem Mol Biol. 148:52–63. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Slominski AT, Kim TK, Li W, Yi AK, Postlethwaite A and Tuckey RC: The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions. J Steroid Biochem Mol Biol. 144:28–39. 2014. View Article : Google Scholar

23 

Slominski A, Janjetovic Z, Tuckey RC, Nguyen MN, Bhattacharya KG, Wang J, Li W, Jiao Y, Gu W, Brown M, et al: 20S-hydroxyvitamin D3, noncalcemic product of CYP11A1 action on vitamin D3, exhibits potent antifibrogenic activity in vivo. J Clin Endocrinol Metab. 98:E298–E303. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Slominski AT, Kim TK, Chen J, Nguyen MN, Li W, Yates CR, Sweatman T, Janjetovic Z and Tuckey RC: Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes. Int J Biochem Cell Biol. 44:2003–2018. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Slominski AT, Kim TK, Janjetovic Z, Tuckey RC, Bieniek R, Yue J, Li W, Chen J, Nguyen MN, Tang EK, et al: 20-Hydroxyvitamin D2 is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells. Am J Physiol Cell Physiol. 300:C526–C541. 2011. View Article : Google Scholar :

26 

Slominski AT, Janjetovic Z, Fuller BE, Zmijewski MA, Tuckey RC, Nguyen MN, Sweatman T, Li W, Zjawiony J, Miller D, et al: Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity. PLoS One. 5:e99072010. View Article : Google Scholar : PubMed/NCBI

27 

Slominski AT, Kim TK, Takeda Y, Janjetovic Z, Brozyna AA, Skobowiat C, Wang J, Postlethwaite A, Li W, Tuckey RC, et al: RORα and RORγ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy-and 20,23-dihydroxyvitamin D. FASEB J. 28:2775–2789. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Zbytek B, Janjetovic Z, Tuckey RC, Zmijewski MA, Sweatman TW, Jones E, Nguyen MN and Slominski AT: 20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation. J Invest Dermatol. 128:2271–2280. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Slominski AT, Janjetovic Z, Kim TK, Wright AC, Grese LN, Riney SJ, Nguyen MN and Tuckey RC: Novel vitamin D hydroxy-derivatives inhibit melanoma growth and show differential effects on normal melanocytes. Anticancer Res. 32:3733–3742. 2012.PubMed/NCBI

30 

Janjetovic Z, Brozyna AA, Tuckey RC, Kim TK, Nguyen MN, Jozwicki W, Pfeffer SR, Pfeffer LM and Slominski AT: High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives. Br J Cancer. 105:1874–1884. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Wang J, Slominski A, Tuckey RC, Janjetovic Z, Kulkarni A, Chen J, Postlethwaite AE, Miller D and Li W: 20-hydroxyvitamin D3 inhibits proliferation of cancer cells with high efficacy while being non-toxic. Anticancer Res. 32:739–746. 2012.PubMed/NCBI

32 

Holick MF: Vitamin D and bone health. J Nutr. 126(Suppl): 1159S–1164S. 1996.PubMed/NCBI

33 

Hayes CE, Nashold FE, Spach KM and Pedersen LB: The immunological functions of the vitamin D endocrine system. Cell Mol Biol (Noisy-le-grand). 49:277–300. 2003.

34 

Pálmer HG, Sánchez-Carbayo M, Ordóñez-Morán P, Larriba MJ, Cordón-Cardó C and Muñoz A: Genetic signatures of differentiation induced by 1alpha,25-dihydroxyvitamin D3 in human colon cancer cells. Cancer Res. 63:7799–7806. 2003.

35 

Shabahang M, Buras RR, Davoodi F, Schumaker LM, Nauta RJ and Evans SR: 1,25-Dihydroxyvitamin D3 receptor as a marker of human colon carcinoma cell line differentiation and growth inhibition. Cancer Res. 53:3712–3718. 1993.PubMed/NCBI

36 

Leyssens C, Verlinden L and Verstuyf A: The future of vitamin D analogs. Front Physiol. 5:1222014. View Article : Google Scholar : PubMed/NCBI

37 

Hansen CM, Hamberg KJ, Binderup E and Binderup L: Seocalcitol (EB 1089): A vitamin D analogue of anti-cancer potential. Background, design, synthesis, pre-clinical and clinical evaluation. Curr Pharm Des. 6:803–828. 2000. View Article : Google Scholar : PubMed/NCBI

38 

Slominski AT and Carlson JA: Melanoma resistance: A bright future for academicians and a challenge for patient advocates. Mayo Clin Proc. 89:429–433. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Bikle DD: Vitamin D: An ancient hormone. Exp Dermatol. 20:7–13. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Brown AJ, Dusso A and Slatopolsky E: Vitamin D. Am J Physiol. 277:F157–F175. 1999.PubMed/NCBI

41 

Ebert R, Schütze N, Adamski J and Jakob F: Vitamin D signaling is modulated on multiple levels in health and disease. Mol Cell Endocrinol. 248:149–159. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Whitfield GK, Jurutka PW, Haussler CA, Hsieh JC, Barthel TK, Jacobs ET, Encinas Dominguez C, Thatcher ML and Haussler MR: Nuclear vitamin D receptor: structure-function, molecular control of gene transcription, and novel bioactions. Vitamin D. 2nd edition. Feldman D, Pike JW and Glorieux FH: Elsevier Academic Press; Oxford: pp. 219–261. 2005, View Article : Google Scholar

43 

Khanal R and Nemere I: Membrane receptors for vitamin D metabolites. Crit Rev Eukaryot Gene Expr. 17:31–47. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Bouvier M: Accessory proteins and the assembly of human class I MHC molecules: A molecular and structural perspective. Mol Immunol. 39:697–706. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Eufemi M, Coppari S, Altieri F, Grillo C, Ferraro A and Turano C: ERp57 is present in STAT3-DNA complexes. Biochem Biophys Res Commun. 323:1306–1312. 2004. View Article : Google Scholar : PubMed/NCBI

46 

Ozkan B, Hatun S and Bereket A: Vitamin D intoxication. Turk J Pediatr. 54:93–98. 2012.PubMed/NCBI

47 

Wierzbicka J, Piotrowska A and Żmijewski MA: The renaissance of vitamin D. Acta Biochim Pol. 61:679–686. 2014.

48 

Wierzbicki PM, Adrych K, Kartanowicz D, Stanislawowski M, Kowalczyk A, Godlewski J, Skwierz-Bogdanska I, Celinski K, Gach T, Kulig J, et al: Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation. World J Gastroenterol. 19:4363–4373. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Wierzbicki PM, Klacz J, Rybarczyk A, Slebioda T, Stanislawowski M, Wronska A, Kowalczyk A, Matuszewski M and Kmiec Z: Identification of a suitable qPCR reference gene in metastatic clear cell renal cell carcinoma. Tumour Biol. 35:12473–12487. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Ren S, Nguyen L, Wu S, Encinas C, Adams JS and Hewison M: Alternative splicing of vitamin D-24-hydroxylase: A novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis. J Biol Chem. 280:20604–20611. 2005. View Article : Google Scholar : PubMed/NCBI

51 

Binderup L: Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: Effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol Toxicol. 72:240–244. 1993. View Article : Google Scholar : PubMed/NCBI

52 

Ieta K, Tanaka F, Haraguchi N, Kita Y, Sakashita H, Mimori K, Matsumoto T, Inoue H, Kuwano H and Mori M: Biological and genetic characteristics of tumor-initiating cells in colon cancer. Ann Surg Oncol. 15:638–648. 2008. View Article : Google Scholar

53 

Tuohimaa P, Wang JH, Khan S, Kuuslahti M, Qian K, Manninen T, Auvinen P, Vihinen M and Lou YR: Gene expression profiles in human and mouse primary cells provide new insights into the differential actions of vitamin D3 metabolites. PLoS One. 8:e753382013. View Article : Google Scholar : PubMed/NCBI

54 

Benton G, Arnaoutova I, George J, Kleinman HK and Koblinski J: Matrigel: From discovery and ECM mimicry to assays and models for cancer research. Adv Drug Deliv Rev. 79–80:3–18. 2014. View Article : Google Scholar

55 

Evans SR, Schwartz AM, Shchepotin EI, Uskokovic M and Shchepotin IB: Growth inhibitory effects of 1,25-dihydroxyvitamin D3 and its synthetic analogue, 1α,25-dihydroxy-16-ene-23yne-26,27-hexafluoro-19-nor-cholecalcifero l (Ro 25-6760), on a human colon cancer xenograft. Clin Cancer Res. 4:2869–2876. 1998.PubMed/NCBI

56 

Cross HS, Bises G, Lechner D, Manhardt T and Kállay E: The Vitamin D endocrine system of the gut - its possible role in colorectal cancer prevention. J Steroid Biochem Mol Biol. 97:121–128. 2005. View Article : Google Scholar : PubMed/NCBI

57 

Milczarek M, Filip-Psurska B, Swiętnicki W, Kutner A and Wietrzyk J: Vitamin D analogs combined with 5-fluorouracil in human HT-29 colon cancer treatment. Oncol Rep. 32:491–504. 2014.PubMed/NCBI

58 

Milczarek M, Rosinska S, Psurski M, Maciejewska M, Kutner A and Wietrzyk J: Combined colonic cancer treatment with vitamin D analogs and irinotecan or oxaliplatin. Anticancer Res. 33:433–444. 2013.PubMed/NCBI

59 

Tanaka Y, Bush KK, Klauck TM and Higgins PJ: Enhancement of butyrate-induced differentiation of HT-29 human colon carcinoma cells by 1,25-dihydroxyvitamin D3. Biochem Pharmacol. 38:3859–3865. 1989. View Article : Google Scholar : PubMed/NCBI

60 

Cross HS, Farsoudi KH and Peterlik M: Growth inhibition of human colon adenocarcinoma-derived Caco-2 cells by 1,25-dihydroxyvitamin D3 and two synthetic analogs: Relation to in vitro hypercalcemic potential. Naunyn Schmiedebergs Arch Pharmacol. 347:105–110. 1993. View Article : Google Scholar : PubMed/NCBI

61 

Höbaus J, Fetahu IS, Khorchide M, Manhardt T and Kallay E: Epigenetic regulation of the 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1) in colon cancer cells. J Steroid Biochem Mol Biol. 136:296–299. 2013. View Article : Google Scholar

62 

Mordan-McCombs S, Valrance M, Zinser G, Tenniswood M and Welsh J: Calcium, vitamin D and the vitamin D receptor: Impact on prostate and breast cancer in preclinical models. Nutr Rev. 65:S131–S133. 2007. View Article : Google Scholar : PubMed/NCBI

63 

Peleg S and Nguyen CV: The importance of nuclear import in protection of the vitamin D receptor from polyubiquitination and proteasome-mediated degradation. J Cell Biochem. 110:926–934. 2010. View Article : Google Scholar : PubMed/NCBI

64 

Zgaga L, Theodoratou E, Farrington SM, Din FV, Ooi LY, Glodzik D, Johnston S, Tenesa A, Campbell H and Dunlop MG: Plasma vitamin D concentration influences survival outcome after a diagnosis of colorectal cancer. J Clin Oncol. 32:2430–2439. 2014. View Article : Google Scholar : PubMed/NCBI

65 

Köstner K, Denzer N, Müller CS, Klein R, Tilgen W and Reichrath J: The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: A review of the literature. Anticancer Res. 29:3511–3536. 2009.PubMed/NCBI

66 

Laczmanska I, Laczmanski L, Bebenek M, Karpinski P, Czemarmazowicz H, Ramsey D, Milewicz A and Sasiadek MM: Vitamin D receptor gene polymorphisms in relation to the risk of colorectal cancer in the Polish population. Tumour Biol. 35:12397–12401. 2014. View Article : Google Scholar : PubMed/NCBI

67 

Vandewalle B, Adenis A, Hornez L, Revillion F and Lefebvre J: 1,25-dihydroxyvitamin D3 receptors in normal and malignant human colorectal tissues. Cancer Lett. 86:67–73. 1994. View Article : Google Scholar : PubMed/NCBI

68 

Brożyna AA, Jozwicki W, Janjetovic Z and Slominski AT: Expression of vitamin D receptor decreases during progression of pigmented skin lesions. Hum Pathol. 42:618–631. 2011. View Article : Google Scholar

69 

Brożyna AA, Jóźwicki W and Slominski AT: Decreased VDR expression in cutaneous melanomas as marker of tumor progression: New data and analyses. Anticancer Res. 34:2735–2743. 2014.

70 

Reichrath J, Rech M, Moeini M, Meese E, Tilgen W and Seifert M: In vitro comparison of the vitamin D endocrine system in 1,25(OH)2D3-responsive and -resistant melanoma cells. Cancer Biol Ther. 6:48–55. 2007. View Article : Google Scholar

71 

Albertson DG, Ylstra B, Segraves R, Collins C, Dairkee SH, Kowbel D, Kuo WL, Gray JW and Pinkel D: Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene. Nat Genet. 25:144–146. 2000. View Article : Google Scholar : PubMed/NCBI

72 

Brożyna AA, Jochymski C, Janjetovic Z, Jóźwicki W, Tuckey RC and Slominski AT: CYP24A1 expression inversely correlates with melanoma progression: Clinic-pathological studies. Int J Mol Sci. 15:19000–19017. 2014. View Article : Google Scholar

73 

Flanagan JN, Young MV, Persons KS, Wang L, Mathieu JS, Whitlatch LW, Holick MF and Chen TC: Vitamin D metabolism in human prostate cells: Implications for prostate cancer chemoprevention by vitamin D. Anticancer Res. 26:2567–2572. 2006.PubMed/NCBI

74 

Zehnder D, Bland R, Williams MC, McNinch RW, Howie AJ, Stewart PM and Hewison M: Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase. J Clin Endocrinol Metab. 86:888–894. 2001.PubMed/NCBI

75 

Cross HS, Bareis P, Hofer H, Bischof MG, Bajna E, Kriwanek S, Bonner E and Peterlik M: 25-Hydroxyvitamin D3-1alpha-hydroxylase and vitamin D receptor gene expression in human colonic mucosa is elevated during early cancerogenesis. Steroids. 66:287–292. 2001. View Article : Google Scholar : PubMed/NCBI

76 

Bareis P, Bises G, Bischof MG, Cross HS and Peterlik M: 25-hydroxy-vitamin d metabolism in human colon cancer cells during tumor progression. Biochem Biophys Res Commun. 285:1012–1017. 2001. View Article : Google Scholar : PubMed/NCBI

77 

Bises G, Kállay E, Weiland T, Wrba F, Wenzl E, Bonner E, Kriwanek S, Obrist P and Cross HS: 25-hydroxyvitamin D3-1alpha-hydroxylase expression in normal and malignant human colon. J Histochem Cytochem. 52:985–989. 2004. View Article : Google Scholar : PubMed/NCBI

78 

Brożyna AA, Jóźwicki W, Jochymski C and Slominski AT: Decreased expression of CYP27B1 correlates with the increased aggressiveness of ovarian carcinomas. Oncol Rep. 33:599–606. 2015.

79 

Brożyna AA, Jóźwicki W, Janjetovic Z and Slominski AT: Expression of the vitamin D-activating enzyme 1α-hydroxylase (CYP27B1) decreases during melanoma progression. Hum Pathol. 44:374–387. 2013. View Article : Google Scholar

80 

Brown AJ and Slatopolsky E: Vitamin D analogs: Therapeutic applications and mechanisms for selectivity. Mol Aspects Med. 29:433–452. 2008. View Article : Google Scholar : PubMed/NCBI

81 

Kim TK, Wang J, Janjetovic Z, Chen J, Tuckey RC, Nguyen MN, Tang EK, Miller D, Li W and Slominski AT: Correlation between secosteroid-induced vitamin D receptor activity in melanoma cells and computer-modeled receptor binding strength. Mol Cell Endocrinol. 361:143–152. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wierzbicka JM, Binek A, Ahrends T, Nowacka JD, Szydłowska A, Turczyk Ł, Wąsiewicz T, Wierzbicki PM, Sądej R, Tuckey RC, Tuckey RC, et al: Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture. Int J Oncol 47: 1084-1096, 2015.
APA
Wierzbicka, J.M., Binek, A., Ahrends, T., Nowacka, J.D., Szydłowska, A., Turczyk, Ł. ... Żmijewski, M.A. (2015). Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture. International Journal of Oncology, 47, 1084-1096. https://doi.org/10.3892/ijo.2015.3088
MLA
Wierzbicka, J. M., Binek, A., Ahrends, T., Nowacka, J. D., Szydłowska, A., Turczyk, Ł., Wąsiewicz, T., Wierzbicki, P. M., Sądej, R., Tuckey, R. C., Slominski, A. T., Chybicki, J., Adrych, K., Kmieć, Z., Żmijewski, M. A."Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture". International Journal of Oncology 47.3 (2015): 1084-1096.
Chicago
Wierzbicka, J. M., Binek, A., Ahrends, T., Nowacka, J. D., Szydłowska, A., Turczyk, Ł., Wąsiewicz, T., Wierzbicki, P. M., Sądej, R., Tuckey, R. C., Slominski, A. T., Chybicki, J., Adrych, K., Kmieć, Z., Żmijewski, M. A."Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture". International Journal of Oncology 47, no. 3 (2015): 1084-1096. https://doi.org/10.3892/ijo.2015.3088
Copy and paste a formatted citation
x
Spandidos Publications style
Wierzbicka JM, Binek A, Ahrends T, Nowacka JD, Szydłowska A, Turczyk Ł, Wąsiewicz T, Wierzbicki PM, Sądej R, Tuckey RC, Tuckey RC, et al: Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture. Int J Oncol 47: 1084-1096, 2015.
APA
Wierzbicka, J.M., Binek, A., Ahrends, T., Nowacka, J.D., Szydłowska, A., Turczyk, Ł. ... Żmijewski, M.A. (2015). Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture. International Journal of Oncology, 47, 1084-1096. https://doi.org/10.3892/ijo.2015.3088
MLA
Wierzbicka, J. M., Binek, A., Ahrends, T., Nowacka, J. D., Szydłowska, A., Turczyk, Ł., Wąsiewicz, T., Wierzbicki, P. M., Sądej, R., Tuckey, R. C., Slominski, A. T., Chybicki, J., Adrych, K., Kmieć, Z., Żmijewski, M. A."Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture". International Journal of Oncology 47.3 (2015): 1084-1096.
Chicago
Wierzbicka, J. M., Binek, A., Ahrends, T., Nowacka, J. D., Szydłowska, A., Turczyk, Ł., Wąsiewicz, T., Wierzbicki, P. M., Sądej, R., Tuckey, R. C., Slominski, A. T., Chybicki, J., Adrych, K., Kmieć, Z., Żmijewski, M. A."Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture". International Journal of Oncology 47, no. 3 (2015): 1084-1096. https://doi.org/10.3892/ijo.2015.3088
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team