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Review

TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review)

  • Authors:
    • Werner Hoffmann
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    Affiliations: Institute of Molecular Biology and Medicinal Chemistry, Otto-von-Guericke-University Magdeburg, D-39120 Magdeburg, Germany
  • Pages: 806-816
    |
    Published online on: July 17, 2015
       https://doi.org/10.3892/ijo.2015.3090
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Abstract

The peptide TFF2 (formerly ‘spasmolytic polypeptide’), a member of the trefoil factor family (TFF) containing two TFF domains, is mainly expressed together with the mucin MUC6 in the gastric epithelium and duodenal Brunner's glands. Pathologically, TFF2 expression is observed ectopically during stone diseases, chronic inflammatory conditions and in several metaplastic and neoplastic epithelia; most prominent being the ‘spasmolytic polypeptide-expressing metaplasia’ (SPEM), which is an established gastric precancerous lesion. TFF2 plays a critical role in maintaining gastric mucosal integrity and appears to restrain tumorigenesis in the stomach. Recently, porcine TFF2 has been shown to interact with the gastric mucin MUC6 and thus stabilize the gastric mucus barrier. On the one hand, TFF2 binds to MUC6 via non-covalent lectin interactions with the glycotope GlcNAcα1→4Galβ1→R. On the other hand, TFF2 is probably also covalently bound to MUC6 via disulfide bridges. Thus, implications for the complex multimeric assembly, cross-linking, and packaging of MUC6 as well as the rheology of gastric mucus are discussed in detail in this review. Furthermore, TFF2 is also expressed in minor amounts in the immune and nervous systems. Thus, similar to galectins, its lectin activity would perfectly enable TFF2 to form multivalent complexes and cross-linked lattices with a plethora of transmembrane glycoproteins and thus modulate different signal transduction processes. This could explain the multiple and diverse biological effects of TFF2 [e.g., motogenic, (anti)apoptotic, and angiogenic effects]. Finally, a function during fertilization is also possible for TFF domains because they occur as shuffled modules in certain zona pellucida proteins.
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1 

Laine L, Takeuchi K and Tarnawski A: Gastric mucosal defense and cytoprotection: Bench to bedside. Gastroenterology. 135:41–60. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Thornton DJ, Rousseau K and McGuckin MA: Structure and function of the polymeric mucins in airways mucus. Annu Rev Physiol. 70:459–486. 2008. View Article : Google Scholar

3 

Senapati S, Sharma P, Bafna S, Roy HK and Batra SK: The MUC gene family: Their role in the diagnosis and prognosis of gastric cancer. Histol Histopathol. 23:1541–1552. 2008.PubMed/NCBI

4 

Kjellev S: The trefoil factor family - small peptides with multiple functionalities. Cell Mol Life Sci. 66:1350–1369. 2009. View Article : Google Scholar

5 

Hoffmann W: TFF peptides. Handbook of Biologically Active Peptides. 2nd edition. Kastin A: Elsevier; San Diego: pp. 1338–1345. 2013, View Article : Google Scholar

6 

Thim L: Trefoil peptides: From structure to function. Cell Mol Life Sci. 53:888–903. 1997. View Article : Google Scholar

7 

Wright NA, Hoffmann W, Otto WR, Rio MC and Thim L: Rolling in the clover: Trefoil factor family (TFF)-domain peptides, cell migration and cancer. FEBS Lett. 408:121–123. 1997. View Article : Google Scholar : PubMed/NCBI

8 

Thim L: A new family of growth factor-like peptides. ‘Trefoil' disulphide loop structures as a common feature in breast cancer associated peptide (pS2), pancreatic spasmolytic polypeptide (PSP), and frog skin peptides (spasmolysins). FEBS Lett. 250:85–90. 1989. View Article : Google Scholar : PubMed/NCBI

9 

Gajhede M, Petersen TN, Henriksen A, Petersen JFW, Dauter Z, Wilson KS and Thim L: Pancreatic spasmolytic polypeptide: First three-dimensional structure of a member of the mammalian trefoil family of peptides. Structure. 1:253–262. 1993. View Article : Google Scholar : PubMed/NCBI

10 

Hanisch FG, Ragge H, Kalinski T, Meyer F, Kalbacher H and Hoffmann W: Human gastric TFF2 peptide contains an N-linked fucosylated N,N'-diacetyllactosediamine (LacdiNAc) oligosaccharide. Glycobiology. 23:2–11. 2013. View Article : Google Scholar

11 

Petersen TN, Henriksen A and Gajhede M: Structure of porcine pancreatic spasmolytic polypeptide at 1.95 A resolution. Acta Crystallogr D Biol Crystallogr. 52:730–737. 1996. View Article : Google Scholar : PubMed/NCBI

12 

Stürmer R, Müller S, Hanisch FG and Hoffmann W: Porcine gastric TFF2 is a mucus constituent and differs from pancreatic TFF2. Cell Physiol Biochem. 33:895–904. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Tomasetto C, Rio MC, Gautier C, Wolf C, Hareuveni M, Chambon P and Lathe R: hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma. EMBO J. 9:407–414. 1990.PubMed/NCBI

14 

Rasmussen TN, Raaberg L, Poulsen SS, Thim L and Holst JJ: Immunohistochemical localization of pancreatic spasmolytic polypeptide (PSP) in the pig. Histochemistry. 98:113–119. 1992. View Article : Google Scholar : PubMed/NCBI

15 

Hanby AM, Poulsom R, Singh S, Elia G, Jeffery RE and Wright NA: Spasmolytic polypeptide is a major antral peptide: Distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach. Gastroenterology. 105:1110–1116. 1993.PubMed/NCBI

16 

Hanby AM, Poulsom R, Elia G, Singh S, Longcroft JM and Wright NA: The expression of the trefoil peptides pS2 and human spasmolytic polypeptide (hSP) in ‘gastric metaplasia' of the proximal duodenum: Implications for the nature of ‘gastric metaplasia'. J Pathol. 169:355–360. 1993. View Article : Google Scholar : PubMed/NCBI

17 

Poulsom R: Trefoil peptides. Baillieres Clin Gastroenterol. 10:113–134. 1996. View Article : Google Scholar : PubMed/NCBI

18 

Ota H, Hayama M, Momose M, El-Zimaity HMT, Matsuda K, Sano K, Maruta F, Okumura N and Katsuyama T: Co-localization of TFF2 with gland mucous cell mucin in gastric mucous cells and in extracellular mucous gel adherent to normal and damaged gastric mucosa. Histochem Cell Biol. 126:617–625. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Kouznetsova I, Kalinski T, Meyer F and Hoffmann W: Self-renewal of the human gastric epithelium: New insights from expression profiling using laser microdissection. Mol Biosyst. 7:1105–1112. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Quante M, Marrache F, Goldenring JR and Wang TC: TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa. Gastroenterology. 139:2018–2027.e2012. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Jeffrey GP, Oates PS, Wang TC, Babyatsky MW and Brand SJ: Spasmolytic polypeptide: A trefoil peptide secreted by rat gastric mucous cells. Gastroenterology. 106:336–345. 1994.PubMed/NCBI

22 

Semple JI, Newton JL, Westley BR and May FE: Dramatic diurnal variation in the concentration of the human trefoil peptide TFF2 in gastric juice. Gut. 48:648–655. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Kouznetsova I, Gerlach KL, Zahl C and Hoffmann W: Expression analysis of human salivary glands by laser microdissection: Differences between submandibular and labial glands. Cell Physiol Biochem. 26:375–382. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Cook GA, Familari M, Thim L and Giraud AS: The trefoil peptides TFF2 and TFF3 are expressed in rat lymphoid tissues and participate in the immune response. FEBS Lett. 456:155–159. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Kurt-Jones EA, Cao L, Sandor F, Rogers AB, Whary MT, Nambiar PR, Cerny A, Bowen G, Yan J, Takaishi S, et al: Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses. Infect Immun. 75:471–480. 2007. View Article : Google Scholar :

26 

Hinz M, Schwegler H, Chwieralski CE, Laube G, Linke R, Pohle W and Hoffmann W: Trefoil factor family (TFF) expression in the mouse brain and pituitary: Changes in the developing cerebellum. Peptides. 25:827–832. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Wong WM, Playford RJ and Wright NA: Peptide gene expression in gastrointestinal mucosal ulceration: Ordered sequence or redundancy? Gut. 46:286–292. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Poulsom R and Wright NA: Trefoil peptides: A newly recognized family of epithelial mucin-associated molecules. Am J Physiol. 265:G205–G213. 1993.PubMed/NCBI

29 

Wright NA: Aspects of the biology of regeneration and repair in the human gastrointestinal tract. Philos Trans R Soc Lond B Biol Sci. 353:925–933. 1998. View Article : Google Scholar : PubMed/NCBI

30 

Longman RJ, Thomas MG and Poulsom R: Trefoil peptides and surgical disease. Br J Surg. 86:740–748. 1999. View Article : Google Scholar : PubMed/NCBI

31 

Hoffmann W and Jagla W: Cell type specific expression of secretory TFF peptides: Colocalization with mucins and synthesis in the brain. Int Rev Cytol. 213:147–181. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Schmidt PH, Lee JR, Joshi V, Playford RJ, Poulsom R, Wright NA and Goldenring JR: Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma. Lab Invest. 79:639–646. 1999.PubMed/NCBI

33 

Nam KT, Lee HJ, Sousa JF, Weis VG, O'Neal RL, Finke PE, Romero-Gallo J, Shi G, Mills JC, Peek RM Jr, et al: Mature chief cells are cryptic progenitors for metaplasia in the stomach. Gastroenterology. 139:2028–2037.e9. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Goldenring JR, Nam KT, Wang TC, Mills JC and Wright NA: Spasmolytic polypeptide-expressing metaplasia and intestinal metaplasia: time for reevaluation of metaplasias and the origins of gastric cancer. Gastroenterology. 138:2207–2210. 2210.e22012010. View Article : Google Scholar : PubMed/NCBI

35 

Playford RJ: Peptides and gastrointestinal mucosal integrity. Gut. 37:595–597. 1995. View Article : Google Scholar : PubMed/NCBI

36 

Poulsen SS, Kissow H, Hare K, Hartmann B and Thim L: Luminal and parenteral TFF2 and TFF3 dimer and monomer in two models of experimental colitis in the rat. Regul Pept. 126:163–171. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Vandenbroucke K, Hans W, Van Huysse J, Neirynck S, Demetter P, Remaut E, Rottiers P and Steidler L: Active delivery of trefoil factors by genetically modified Lactococcus lactis prevents and heals acute colitis in mice. Gastroenterology. 127:502–513. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Graness A, Chwieralski CE, Reinhold D, Thim L and Hoffmann W: Protein kinase C and ERK activation are required for TFF-peptide-stimulated bronchial epithelial cell migration and tumor necrosis factor-α-induced interleukin-6 (IL-6) and IL-8 secretion. J Biol Chem. 277:18440–18446. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Chwieralski CE, Schnurra I, Thim L and Hoffmann W: Epidermal growth factor and trefoil factor family 2 synergistically trigger chemotaxis on BEAS-2B cells via different signaling cascades. Am J Respir Cell Mol Biol. 31:528–537. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Dubeykovskaya Z, Dubeykovskiy A, Solal-Cohen J and Wang TC: Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines. J Biol Chem. 284:3650–3662. 2009. View Article : Google Scholar :

41 

Hoffmann W: Trefoil factor family (TFF) peptides and chemokine receptors: A promising relationship. J Med Chem. 52:6505–6510. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Thim L and Mørtz E: Isolation and characterization of putative trefoil peptide receptors. Regul Pept. 90:61–68. 2000. View Article : Google Scholar : PubMed/NCBI

43 

Poulsen SS, Thulesen J, Nexø E and Thim L: Distribution and metabolism of intravenously administered trefoil factor 2/porcine spasmolytic polypeptide in the rat. Gut. 43:240–247. 1998. View Article : Google Scholar

44 

Fox JG, Rogers AB, Whary MT, Ge Z, Ohtani M, Jones EK and Wang TC: Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2−/− C57BL6 × Sv129 Helicobacter pylori-infected mice. Am J Pathol. 171:1520–1528. 2007. View Article : Google Scholar : PubMed/NCBI

45 

Xue L, Aihara E, Podolsky DK, Wang TC and Montrose MH: In vivo action of trefoil factor 2 (TFF2) to speed gastric repair is independent of cyclooxygenase. Gut. 59:1184–1191. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Baus-Loncar M, Schmid J, Lalani N, Rosewell I, Goodlad RA, Stamp GWH, Blin N and Kayademir T: Trefoil factor 2 (TFF2) deficiency in murine digestive tract influences the immune system. Cell Physiol Biochem. 16:31–42. 2005. View Article : Google Scholar : PubMed/NCBI

47 

Shah AA, Mihalj M, Ratkay I, Lubka-Pathak M, Balogh P, Klingel K, Bohn E, Blin N and Baus-Loncar M: Increased susceptibility to Yersinia enterocolitica infection of Tff2 deficient mice. Cell Physiol Biochem. 30:853–862. 2012. View Article : Google Scholar : PubMed/NCBI

48 

McBerry C, Egan CE, Rani R, Yang Y, Wu D, Boespflug N, Boon L, Butcher B, Mirpuri J, Hogan SP, et al: Trefoil factor 2 negatively regulates type 1 immunity against Toxoplasma gondii. J Immunol. 189:3078–3084. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Allen A: Gastrointestinal mucus. Section 6: The gastrointestinal system. Handbook of physiology. III. Schultz SG: Am Physiol Soc; Bethesda, MD: pp. 359–382. 1989

50 

Allen A and Flemström G: Gastroduodenal mucus bicarbonate barrier: Protection against acid and pepsin. Am J Physiol Cell Physiol. 288:C1–C19. 2005. View Article : Google Scholar

51 

De Bolós C, Garrido M and Real FX: MUC6 apomucin shows a distinct normal tissue distribution that correlates with Lewis antigen expression in the human stomach. Gastroenterology. 109:723–734. 1995. View Article : Google Scholar : PubMed/NCBI

52 

Nordman H, Davies JR, Lindell G, de Bolós C, Real F and Carlstedt I: Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution. Biochem J. 364:191–200. 2002. View Article : Google Scholar : PubMed/NCBI

53 

Hoffmann W: Self-renewal of the gastric epithelium from stem and progenitor cells. Front Biosci (Schol Ed). 5:720–731. 2013. View Article : Google Scholar

54 

Sawaguchi A, Ishihara K, Kawano Ji J, Oinuma T, Hotta K and Suganuma T: Fluid dynamics of the excretory flow of zymogenic and mucin contents in rat gastric gland processed by high-pressure freezing/freeze substitution. J Histochem Cytochem. 50:223–234. 2002. View Article : Google Scholar : PubMed/NCBI

55 

Byrd JC, Yan P, Sternberg L, Yunker CK, Scheiman JM and Bresalier RS: Aberrant expression of gland-type gastric mucin in the surface epithelium of Helicobacter pylori-infected patients. Gastroenterology. 113:455–464. 1997. View Article : Google Scholar : PubMed/NCBI

56 

Ishihara K, Kurihara M, Goso Y, Urata T, Ota H, Katsuyama T and Hotta K: Peripheral α-linked N-acetylglucosamine on the carbohydrate moiety of mucin derived from mammalian gastric gland mucous cells: Epitope recognized by a newly characterized monoclonal antibody. Biochem J. 318:409–416. 1996. View Article : Google Scholar

57 

Nakayama J, Yeh JC, Misra AK, Ito S, Katsuyama T and Fukuda M: Expression cloning of a human α1, 4-N-acetylglucosaminyl-transferase that forms GlcNAα1→4Galβ→R, a glycan specifically expressed in the gastric gland mucous cell-type mucin. Proc Natl Acad Sci USA. 96:8991–8996. 1999. View Article : Google Scholar

58 

Karasawa F, Shiota A, Goso Y, Kobayashi M, Sato Y, Masumoto J, Fujiwara M, Yokosawa S, Muraki T, Miyagawa S, et al: Essential role of gastric gland mucin in preventing gastric cancer in mice. J Clin Invest. 122:923–934. 2012. View Article : Google Scholar : PubMed/NCBI

59 

Yang DH, Tsuyama S, Hotta K, Katsuyama T and Murata F: Expression of N-acetylglucosamine residues in developing rat fundic gland cells. Histochem J. 32:187–193. 2000. View Article : Google Scholar : PubMed/NCBI

60 

Nakayama J, Katsuyama T and Fukuda M: Recent progress in paradoxical concanavalin A staining. Acta Histochem Cytochem. 33:153–157. 2000. View Article : Google Scholar

61 

Skoog EC, Sjöling Å, Navabi N, Holgersson J, Lundin SB and Lindén SK: Human gastric mucins differently regulate Helicobacter pylori proliferation, gene expression and interactions with host cells. PLoS One. 7:e363782012. View Article : Google Scholar : PubMed/NCBI

62 

Shimizu T, Akamatsu T, Sugiyama A, Ota H and Katsuyama T: Helicobacter pylori and the surface mucous gel layer of the human stomach. Helicobacter. 1:207–218. 1996. View Article : Google Scholar : PubMed/NCBI

63 

Van den Brink GR, Tytgat KM, Van der Hulst RW, Van der Loos CM, Einerhand AWC, Büller HA and Dekker J: H. pylori colocalises with MUC5AC in the human stomach. Gut. 46:601–607. 2000. View Article : Google Scholar : PubMed/NCBI

64 

Hidaka E, Ota H, Hidaka H, Hayama M, Matsuzawa K, Akamatsu T, Nakayama J and Katsuyama T: Helicobacter pylori and two ultrastructurally distinct layers of gastric mucous cell mucins in the surface mucous gel layer. Gut. 49:474–480. 2001. View Article : Google Scholar : PubMed/NCBI

65 

Kawakubo M, Ito Y, Okimura Y, Kobayashi M, Sakura K, Kasama S, Fukuda MN, Fukuda M, Katsuyama T and Nakayama J: Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection. Science. 305:1003–1006. 2004. View Article : Google Scholar : PubMed/NCBI

66 

Jonckheere N and Van Seuningen I: The membrane-bound mucins: From cell signalling to transcriptional regulation and expression in epithelial cancers. Biochimie. 92:1–11. 2010. View Article : Google Scholar

67 

McGuckin MA, Lindén SK, Sutton P and Florin TH: Mucin dynamics and enteric pathogens. Nat Rev Microbiol. 9:265–278. 2011. View Article : Google Scholar : PubMed/NCBI

68 

Phillipson M, Johansson ME, Henriksnäs J, Petersson J, Gendler SJ, Sandler S, Persson AEG, Hansson GC and Holm L: The gastric mucus layers: Constituents and regulation of accumulation. Am J Physiol Gastrointest Liver Physiol. 295:G806–G812. 2008. View Article : Google Scholar : PubMed/NCBI

69 

Williams SJ, Wreschner DH, Tran M, Eyre HJ, Sutherland GR and McGuckin MA: Muc13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells. J Biol Chem. 276:18327–18336. 2001. View Article : Google Scholar : PubMed/NCBI

70 

Menheniott TR, Kurklu B and Giraud AS: Gastrokines: Stomach-specific proteins with putative homeostatic and tumor suppressor roles. Am J Physiol Gastrointest Liver Physiol. 304:G109–G121. 2013. View Article : Google Scholar

71 

Kang W, Nielsen O, Fenger C, Madsen J, Hansen S, Tornoe I, Eggleton P, Reid KBM and Holmskov U: The scavenger receptor, cysteine-rich domain-containing molecule gp-340 is differentially regulated in epithelial cell lines by phorbol ester. Clin Exp Immunol. 130:449–458. 2002. View Article : Google Scholar : PubMed/NCBI

72 

Nio-Kobayashi J, Takahashi-Iwanaga H and Iwanaga T: Immuno-histochemical localization of six galectin subtypes in the mouse digestive tract. J Histochem Cytochem. 57:41–50. 2009. View Article : Google Scholar :

73 

O'Neil DA, Cole SP, Martin-Porter E, Housley MP, Liu L, Ganz T and Kagnoff MF: Regulation of human β-defensins by gastric epithelial cells in response to infection with Helicobacter pylori or stimulation with interleukin-1. Infect Immun. 68:5412–5415. 2000. View Article : Google Scholar : PubMed/NCBI

74 

Hase K, Murakami M, Iimura M, Cole SP, Horibe Y, Ohtake T, Obonyo M, Gallo RL, Eckmann L and Kagnoff MF: Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori. Gastroenterology. 125:1613–1625. 2003. View Article : Google Scholar

75 

Aloulou A and Carrière F: Gastric lipase: An extremophilic interfacial enzyme with medical applications. Cell Mol Life Sci. 65:851–854. 2008. View Article : Google Scholar : PubMed/NCBI

76 

Mauch F, Bode G, Ditschuneit H and Malfertheiner P: Demonstration of a phospholipid-rich zone in the human gastric epithelium damaged by Helicobacter pylori. Gastroenterology. 105:1698–1704. 1993.PubMed/NCBI

77 

Lichtenberger LM: The hydrophobic barrier properties of gastrointestinal mucus. Annu Rev Physiol. 57:565–583. 1995. View Article : Google Scholar : PubMed/NCBI

78 

Taylor C, Allen A, Dettmar PW and Pearson JP: The gel matrix of gastric mucus is maintained by a complex interplay of transient and nontransient associations. Biomacromolecules. 4:922–927. 2003. View Article : Google Scholar : PubMed/NCBI

79 

Atuma C, Strugala V, Allen A and Holm L: The adherent gastrointestinal mucus gel layer: Thickness and physical state in vivo. Am J Physiol Gastrointest Liver Physiol. 280:G922–G929. 2001.PubMed/NCBI

80 

Ermund A, Schütte A, Johansson ME, Gustafsson JK and Hansson GC: Studies of mucus in mouse stomach, small intestine, and colon. I Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches. Am J Physiol Gastrointest Liver Physiol. 305:G341–G347. 2013. View Article : Google Scholar : PubMed/NCBI

81 

Ota H and Katsuyama T: Alternating laminated array of two types of mucin in the human gastric surface mucous layer. Histochem J. 24:86–92. 1992. View Article : Google Scholar : PubMed/NCBI

82 

Ho SB, Takamura K, Anway R, Shekels LL, Toribara NW and Ota H: The adherent gastric mucous layer is composed of alternating layers of MUC5AC and MUC6 mucin proteins. Dig Dis Sci. 49:1598–1606. 2004. View Article : Google Scholar : PubMed/NCBI

83 

Hanisch FG, Chai W, Rosankiewicz JR, Lawson AM, Stoll MS and Feizi T: Core-typing of O-linked glycans from human gastric mucins. Lack of evidence for the occurrence of the core sequence Gal1-6GalNAc. Eur J Biochem. 217:645–655. 1993. View Article : Google Scholar : PubMed/NCBI

84 

Phillipson M, Atuma C, Henriksnäs J and Holm L: The importance of mucus layers and bicarbonate transport in preservation of gastric juxtamucosal pH. Am J Physiol Gastrointest Liver Physiol. 282:G211–G219. 2002. View Article : Google Scholar : PubMed/NCBI

85 

Schreiber S and Scheid P: Gastric mucus of the guinea pig: Proton carrier and diffusion barrier. Am J Physiol. 272:G63–G70. 1997.PubMed/NCBI

86 

Johansson M, Synnerstad I and Holm L: Acid transport through channels in the mucous layer of rat stomach. Gastroenterology. 119:1297–1304. 2000. View Article : Google Scholar : PubMed/NCBI

87 

Kouznetsova I, Laubinger W, Kalbacher H, Kalinski T, Meyer F, Roessner A and Hoffmann W: Biosynthesis of gastrokine-2 in the human gastric mucosa: Restricted spatial expression along the antral gland axis and differential interaction with TFF1, TFF2 and mucins. Cell Physiol Biochem. 20:899–908. 2007. View Article : Google Scholar : PubMed/NCBI

88 

Hanisch FG, Bonar D, Schloerer N and Schroten H: Human trefoil factor 2 is a lectin that binds α-GlcNAc-capped mucin glycans with antibiotic activity against Helicobacter pylori. J Biol Chem. 289:27363–27375. 2014. View Article : Google Scholar : PubMed/NCBI

89 

Rossez Y, Maes E, Lefebvre Darroman T, Gosset P, Ecobichon C, Joncquel Chevalier Curt M, Boneca IG, Michalski J-C and Robbe-Masselot C: Almost all human gastric mucin O-glycans harbor blood group A, B or H antigens and are potential binding sites for Helicobacter pylori. Glycobiology. 22:1193–1206. 2012. View Article : Google Scholar : PubMed/NCBI

90 

Van Halbeek H, Gerwig GJ, Vliegenthart JF, Smits HL, Van Kerkhof PJ and Kramer MF: Terminal α(1→4)-linked N-acetylglucosamine: A characteristic constituent of duodenal-gland mucous glycoproteins in rat and pig. A high-resolution 1H-NMR study. Biochim Biophys Acta. 747:107–116. 1983. View Article : Google Scholar : PubMed/NCBI

91 

Gabius HJ: Ca2+: mastermind and active player for lectin activity (including a gallery of lectin folds). The Sugar Code: Fundamentals of Glycosciences. Gabius HJ: Wiley-VCH; Weinheim: pp. 269–278. 2009

92 

Westley BR, Griffin SM and May FE: Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C. Biochemistry. 44:7967–7975. 2005. View Article : Google Scholar : PubMed/NCBI

93 

Albert TK, Laubinger W, Müller S, Hanisch F-G, Kalinski T, Meyer F and Hoffmann W: Human intestinal TFF3 forms disulfide-linked heteromers with the mucus-associated FCGBP protein and is released by hydrogen sulfide. J Proteome Res. 9:3108–3117. 2010. View Article : Google Scholar : PubMed/NCBI

94 

Otto WR, Rao J, Cox HM, Kotzian E, Lee CY, Goodlad RA, Lane A, Gorman M, Freemont PA, Hansen HF, et al: Effects of pancreatic spasmolytic polypeptide (PSP) on epithelial cell function. Eur J Biochem. 235:64–72. 1996. View Article : Google Scholar : PubMed/NCBI

95 

Rousseau K, Byrne C, Kim YS, Gum JR, Swallow DM and Toribara NW: The complete genomic organization of the human MUC6 and MUC2 mucin genes. Genomics. 83:936–939. 2004. View Article : Google Scholar : PubMed/NCBI

96 

Bäckström M, Ambort D, Thomsson E, Johansson ME and Hansson GC: Increased understanding of the biochemistry and biosynthesis of MUC2 and other gel-forming mucins through the recombinant expression of their protein domains. Mol Biotechnol. 54:250–256. 2013. View Article : Google Scholar : PubMed/NCBI

97 

Joba W and Hoffmann W: Similarities of integumentary mucin B.1 from Xenopus laevis and prepro-von Willebrand factor at their amino-terminal regions. J Biol Chem. 272:1805–1810. 1997. View Article : Google Scholar : PubMed/NCBI

98 

Leir SH and Harris A: MUC6 mucin expression inhibits tumor cell invasion. Exp Cell Res. 317:2408–2419. 2011. View Article : Google Scholar : PubMed/NCBI

99 

Purvis AR, Gross J, Dang LT, Huang R-H, Kapadia M, Townsend RR and Sadler JE: Two Cys residues essential for von Willebrand factor multimer assembly in the Golgi. Proc Natl Acad Sci USA. 104:15647–15652. 2007. View Article : Google Scholar : PubMed/NCBI

100 

Springer TA: von Willebrand factor, Jedi knight of the bloodstream. Blood. 124:1412–1425. 2014. View Article : Google Scholar : PubMed/NCBI

101 

Purvis AR and Sadler JE: A covalent oxidoreductase intermediate in propeptide-dependent von Willebrand factor multimerization. J Biol Chem. 279:49982–49988. 2004. View Article : Google Scholar : PubMed/NCBI

102 

Godl K, Johansson ME, Lidell ME, Mörgelin M, Karlsson H, Olson FJ, Gum JR Jr, Kim YS and Hansson GC: The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment. J Biol Chem. 277:47248–47256. 2002. View Article : Google Scholar : PubMed/NCBI

103 

Perez-Vilar J and Hill RL: Identification of the half-cystine residues in porcine submaxillary mucin critical for multimerization through the D-domains. Roles of the CGLCG motif in the D1- and D3-domains. J Biol Chem. 273:34527–34534. 1998. View Article : Google Scholar : PubMed/NCBI

104 

Hoffmann W, Jagla W and Wiede A: Molecular medicine of TFF-peptides: From gut to brain. Histol Histopathol. 16:319–334. 2001.PubMed/NCBI

105 

Toribara NW, Ho SB, Gum E, Gum JR Jr, Lau P and Kim YS: The carboxyl-terminal sequence of the human secretory mucin, MUC6. Analysis of the primary amino acid sequence. J Biol Chem. 272:16398–16403. 1997. View Article : Google Scholar : PubMed/NCBI

106 

Zhou YF and Springer TA: Highly reinforced structure of a C-terminal dimerization domain in von Willebrand factor. Blood. 123:1785–1793. 2014. View Article : Google Scholar : PubMed/NCBI

107 

Perez-Vilar J and Hill RL: The carboxyl-terminal 90 residues of porcine submaxillary mucin are sufficient for forming disulfide-bonded dimers. J Biol Chem. 273:6982–6988. 1998. View Article : Google Scholar : PubMed/NCBI

108 

Perez-Vilar J and Mabolo R: Gel-forming mucins. Notions from in vitro studies. Histol Histopathol. 22:455–464. 2007.PubMed/NCBI

109 

Park SW, Zhen G, Verhaeghe C, Nakagami Y, Nguyenvu LT, Barczak AJ, Killeen N and Erle DJ: The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. Proc Natl Acad Sci USA. 106:6950–6955. 2009. View Article : Google Scholar : PubMed/NCBI

110 

Adler KB, Tuvim MJ and Dickey BF: Regulated mucin secretion from airway epithelial cells. Front Endocrinol. 4:article 129. 2013. View Article : Google Scholar

111 

Kaser A, Adolph TE and Blumberg RS: The unfolded protein response and gastrointestinal disease. Semin Immunopathol. 35:307–319. 2013. View Article : Google Scholar : PubMed/NCBI

112 

Gupta A, Wodziak D, Tun M, Bouley DM and Lowe AW: Loss of anterior gradient 2 (Agr2) expression results in hyperplasia and defective lineage maturation in the murine stomach. J Biol Chem. 288:4321–4333. 2013. View Article : Google Scholar :

113 

Mayadas TN and Wagner DD: Vicinal cysteines in the prosequence play a role in von Willebrand factor multimer assembly. Proc Natl Acad Sci USA. 89:3531–3535. 1992. View Article : Google Scholar : PubMed/NCBI

114 

Huang RH, Wang Y, Roth R, Yu X, Purvis AR, Heuser JE, Egelman EH and Sadler JE: Assembly of Weibel-Palade body-like tubules from N-terminal domains of von Willebrand factor. Proc Natl Acad Sci USA. 105:482–487. 2008. View Article : Google Scholar : PubMed/NCBI

115 

Ambort D, Johansson ME, Gustafsson JK, Nilsson HE, Ermund A, Johansson BR, Koeck PJB, Hebert H and Hansson GC: Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin. Proc Natl Acad Sci USA. 109:5645–5650. 2012. View Article : Google Scholar : PubMed/NCBI

116 

Perez-Vilar J, Eckhardt AE, DeLuca A and Hill RL: Porcine submaxillary mucin forms disulfide-linked multimers through its amino-terminal D-domains. J Biol Chem. 273:14442–14449. 1998. View Article : Google Scholar : PubMed/NCBI

117 

Dang LT, Purvis AR, Huang RH, Westfield LA and Sadler JE: Phylogenetic and functional analysis of histidine residues essential for pH-dependent multimerization of von Willebrand factor. J Biol Chem. 286:25763–25769. 2011. View Article : Google Scholar : PubMed/NCBI

118 

Chin WC, Quesada I, Nguyen T and Verdugo P: Oscillations of pH inside the secretory granule control the gain of Ca2+ release for signal transduction in goblet cell exocytosis. Novartis Found Symp. 248:132–141; discussion 141–149, 277–282. 2002. View Article : Google Scholar

119 

Dickson EJ, Duman JG, Moody MW, Chen L and Hille B: Orai-STIM-mediated Ca2+ release from secretory granules revealed by a targeted Ca2+ and pH probe. Proc Natl Acad Sci USA. 109:E3539–E3548. 2012. View Article : Google Scholar

120 

Borges R, Domínguez N, Estévez-Herrera J, Pereda D and Machado JD: Vesicular Ca2+ mediates granule motion and exocytosis. Cell Calcium. 51:338–341. 2012. View Article : Google Scholar : PubMed/NCBI

121 

Perez-Vilar J, Olsen JC, Chua M and Boucher RC: pH-dependent intraluminal organization of mucin granules in live human mucous/goblet cells. J Biol Chem. 280:16868–16881. 2005. View Article : Google Scholar : PubMed/NCBI

122 

Perez-Vilar J: Mucin granule intraluminal organization. Am J Respir Cell Mol Biol. 36:183–190. 2007. View Article : Google Scholar

123 

Verdugo P: Mucin exocytosis. Am Rev Respir Dis. 144:S33–S37. 1991. View Article : Google Scholar : PubMed/NCBI

124 

Verdugo P: Supramolecular dynamics of mucus. Cold Spring Harb Perspect Med. 2:22012. View Article : Google Scholar

125 

Chen EY, Yang N, Quinton PM and Chin W-C: A new role for bicarbonate in mucus formation. Am J Physiol Lung Cell Mol Physiol. 299:L542–L549. 2010. View Article : Google Scholar : PubMed/NCBI

126 

Thim L, Madsen F and Poulsen SS: Effect of trefoil factors on the viscoelastic properties of mucus gels. Eur J Clin Invest. 32:519–527. 2002. View Article : Google Scholar : PubMed/NCBI

127 

Bansil R, Celli JP, Hardcastle JM and Turner BS: The influence of mucus microstructure and rheology in Helicobacter pylori infection. Front Immunol. 4:3102013. View Article : Google Scholar : PubMed/NCBI

128 

Kjellev S, Nexø E, Thim L and Poulsen SS: Systemically administered trefoil factors are secreted into the gastric lumen and increase the viscosity of gastric contents. Br J Pharmacol. 149:92–99. 2006. View Article : Google Scholar : PubMed/NCBI

129 

Tanaka S, Podolsky DK, Engel E, Guth PH and Kaunitz JD: Human spasmolytic polypeptide decreases proton permeation through gastric mucus in vivo and in vitro. Am J Physiol. 272:G1473–G1480. 1997.PubMed/NCBI

130 

Jagla W, Wiede A, Kölle S and Hoffmann W: Differential expression of the TFF-peptides xP1 and xP4 in the gastrointestinal tract of Xenopus laevis. Cell Tissue Res. 291:13–18. 1998. View Article : Google Scholar : PubMed/NCBI

131 

Botzler C, Oertel M, Hinz M and Hoffmann W: Structure of the Xenopus laevis TFF-gene xP4.1, differentially expressed to its duplicated homolog xP4.2. Biochim Biophys Acta. 1489:345–353. 1999. View Article : Google Scholar

132 

Crouzier T, Beckwitt CH and Ribbeck K: Mucin multilayers assembled through sugar-lectin interactions. Biomacromolecules. 13:3401–3408. 2012. View Article : Google Scholar : PubMed/NCBI

133 

Peterson AJ, Menheniott TR, O'Connor L, Walduck AK, Fox JG, Kawakami K, Minamoto T, Ong EK, Wang TC, Judd LM, et al: Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans. Gastroenterology. 139:2005–2017. 2010. View Article : Google Scholar : PubMed/NCBI

134 

Yang I, Nell S and Suerbaum S: Survival in hostile territory: The microbiota of the stomach. FEMS Microbiol Rev. 37:736–761. 2013. View Article : Google Scholar : PubMed/NCBI

135 

Paulsen FP, Schaudig U, Fabian A, Ehrich D and Sel S: TFF peptides and mucins are major components of dacryoliths. Graefes Arch Clin Exp Ophthalmol. 244:1160–1170. 2006. View Article : Google Scholar : PubMed/NCBI

136 

Rinnert M, Hinz M, Buhtz P, Reiher F, Lessel W and Hoffmann W: Synthesis and localization of trefoil factor family (TFF) peptides in the human urinary tract and TFF2 excretion into the urine. Cell Tissue Res. 339:639–647. 2010. View Article : Google Scholar : PubMed/NCBI

137 

Reeves EP, Ali T, Leonard P, Hearty S, O'Kennedy R, May FEB, Westley BR, Josenhans C, Rust M, Suerbaum S, et al: Helicobacter pylori lipopolysaccharide interacts with TFF1 in a pH-dependent manner. Gastroenterology. 135:2043–2054. 2054.e2041–2042. 2008. View Article : Google Scholar : PubMed/NCBI

138 

Hoffmann W and Hauser F: Biosynthesis of frog skin mucins: Cysteine-rich shuffled modules, polydispersities and genetic polymorphism. Comp Biochem Physiol B. 105:465–472. 1993.PubMed/NCBI

139 

De Giorgio MR, Yoshioka M, Riedl I, Moreault O, Cherizol R-G, Shah AA, Blin N, Richard D and St-Amand J: Trefoil factor family member 2 (Tff2) KO mice are protected from high-fat diet-induced obesity. Obesity. 21:1389–1395. 2013. View Article : Google Scholar : PubMed/NCBI

140 

Sacchettini JC, Baum LG and Brewer CF: Multivalent protein-carbohydrate interactions. A new paradigm for supermolecular assembly and signal transduction. Biochemistry. 40:3009–3015. 2001. View Article : Google Scholar : PubMed/NCBI

141 

Rabinovich GA, Toscano MA, Jackson SS and Vasta GR: Functions of cell surface galectin-glycoprotein lattices. Curr Opin Struct Biol. 17:513–520. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hoffmann W: TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review). Int J Oncol 47: 806-816, 2015.
APA
Hoffmann, W. (2015). TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review). International Journal of Oncology, 47, 806-816. https://doi.org/10.3892/ijo.2015.3090
MLA
Hoffmann, W."TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review)". International Journal of Oncology 47.3 (2015): 806-816.
Chicago
Hoffmann, W."TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review)". International Journal of Oncology 47, no. 3 (2015): 806-816. https://doi.org/10.3892/ijo.2015.3090
Copy and paste a formatted citation
x
Spandidos Publications style
Hoffmann W: TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review). Int J Oncol 47: 806-816, 2015.
APA
Hoffmann, W. (2015). TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review). International Journal of Oncology, 47, 806-816. https://doi.org/10.3892/ijo.2015.3090
MLA
Hoffmann, W."TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review)". International Journal of Oncology 47.3 (2015): 806-816.
Chicago
Hoffmann, W."TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review)". International Journal of Oncology 47, no. 3 (2015): 806-816. https://doi.org/10.3892/ijo.2015.3090
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