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Article

Expression profile of parkin isoforms in human gliomas

  • Authors:
    • Grazia Maugeri
    • Agata Grazia D'Amico
    • Gaetano Magro
    • Lucia Salvatorelli
    • Giuseppe M.V. Barbagallo
    • Salvatore Saccone
    • Filippo Drago
    • Sebastiano Cavallaro
    • Velia D'Agata
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Sciences and Biotechnology, Section of Anatomy and Histology, University of Catania, Catania, Italy, G.F. Ingrassia Department, Anatomic Pathology, University of Catania, Catania, Italy, Neurosurgery Department, Policlinico ‘G. Rodolico’ University Hospital, Catania, Italy, Department of Biological, Geological and Environmental Sciences, Section of Animal Biology, University of Catania, Catania, Italy, Department of Biomedical Sciences and Biotechnology, Section of Pharmacology and Biochemistry, University of Catania, Catania, Italy, Functional Genomics Center, Institute of Neurological Sciences, Italian National Research Council, Catania, Italy
  • Pages: 1282-1292
    |
    Published online on: July 24, 2015
       https://doi.org/10.3892/ijo.2015.3105
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Abstract

Mutations of parkin gene are not restricted to familial forms of Parkinsonism but they also occur in a wide variety of malignancies including gliomas. Parkin over­expression reduces glioma cells proliferation and analysis of its expression is predictive for the survival outcome of patients with glioma. To date have been identified 21 parkin alternative splice variants. However, most of the studies have focused their attention exclusively on full-length protein. In the present study, the expression profile of parkin isoforms in different grades of astrocytomas was analyzed for the first time, in order to evaluate their involvement in this malignancy. Furthermore, to investigate their role in cellular processes, their expression in three glioblastoma cell lines was analyzed following treatment with the proteasome inhibitor MG132, or induction of mitophagy with CCCP, or after serum deprivation. Results suggested that H20, H1 and H5 isoforms are always expressed in tumors both in vivo and in vitro models. Therefore, these isoforms might be used as specific biomarkers to develop a prognostic tool for brain tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Maugeri G, D'Amico AG, Magro G, Salvatorelli L, Barbagallo GM, Saccone S, Drago F, Cavallaro S and D'Agata V: Expression profile of parkin isoforms in human gliomas. Int J Oncol 47: 1282-1292, 2015.
APA
Maugeri, G., D'Amico, A.G., Magro, G., Salvatorelli, L., Barbagallo, G.M., Saccone, S. ... D'Agata, V. (2015). Expression profile of parkin isoforms in human gliomas. International Journal of Oncology, 47, 1282-1292. https://doi.org/10.3892/ijo.2015.3105
MLA
Maugeri, G., D'Amico, A. G., Magro, G., Salvatorelli, L., Barbagallo, G. M., Saccone, S., Drago, F., Cavallaro, S., D'Agata, V."Expression profile of parkin isoforms in human gliomas". International Journal of Oncology 47.4 (2015): 1282-1292.
Chicago
Maugeri, G., D'Amico, A. G., Magro, G., Salvatorelli, L., Barbagallo, G. M., Saccone, S., Drago, F., Cavallaro, S., D'Agata, V."Expression profile of parkin isoforms in human gliomas". International Journal of Oncology 47, no. 4 (2015): 1282-1292. https://doi.org/10.3892/ijo.2015.3105
Copy and paste a formatted citation
x
Spandidos Publications style
Maugeri G, D'Amico AG, Magro G, Salvatorelli L, Barbagallo GM, Saccone S, Drago F, Cavallaro S and D'Agata V: Expression profile of parkin isoforms in human gliomas. Int J Oncol 47: 1282-1292, 2015.
APA
Maugeri, G., D'Amico, A.G., Magro, G., Salvatorelli, L., Barbagallo, G.M., Saccone, S. ... D'Agata, V. (2015). Expression profile of parkin isoforms in human gliomas. International Journal of Oncology, 47, 1282-1292. https://doi.org/10.3892/ijo.2015.3105
MLA
Maugeri, G., D'Amico, A. G., Magro, G., Salvatorelli, L., Barbagallo, G. M., Saccone, S., Drago, F., Cavallaro, S., D'Agata, V."Expression profile of parkin isoforms in human gliomas". International Journal of Oncology 47.4 (2015): 1282-1292.
Chicago
Maugeri, G., D'Amico, A. G., Magro, G., Salvatorelli, L., Barbagallo, G. M., Saccone, S., Drago, F., Cavallaro, S., D'Agata, V."Expression profile of parkin isoforms in human gliomas". International Journal of Oncology 47, no. 4 (2015): 1282-1292. https://doi.org/10.3892/ijo.2015.3105
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