Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
October-2015 Volume 47 Issue 4

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2015 Volume 47 Issue 4

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Impact of Helicobacter pylori on the growth of hepatic orthotopic graft tumors in mice

  • Authors:
    • Junwei Wang
    • Xiaoqian Wang
    • Nanhong Tang
    • Yanling Chen
    • Feifei She
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China, Department of Hepatobiliary Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China
  • Pages: 1416-1428
    |
    Published online on: July 28, 2015
       https://doi.org/10.3892/ijo.2015.3107
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Helicobacter pylori is a well-known causative organism of chronic gastric diseases and has been found in many hepatic carcinoma samples. To explore the expression of apoptosis-related proteins and carcinoma development in H. pylori-infected livers, we utilized BALB/cAnSlac mice to establish an H. pylori-infected model by oral inoculation and orthotopic grafts of hepatic tumors by H22 cells, respectively. We found that H. pylori colonies could not be cultured from all liver and tumor samples. However, its 16S rRNA was detectable in 85.3% of livers and 66.7% of tumors in the infected mice. Inflammatory cells were observed and thinly distributed in the lobule portions of the liver, and H. pylori mainly existed in the infected hepatic sinusoids and the necrotic areas of the infected tumors. No significant difference was found in liver to body weight ratio between the infected and uninfected. Moreover, the pathological tumor difference was unremarkable between the two. The proliferating cell nuclear antigen (PCNA) and Bcl-2-associated X protein (Bax) expression in the infected tumors was significantly higher and lower, respectively, than those of the uninfected tumors. However, no significant difference in Bcl-2 (B-cell lymphoma 2) expression existed. The results indicate that H. pylori found in the livers which were infected by H. pylori oral inoculation could contribute to the infiltration of inflammatory cells in livers. Although H. pylori has no significant impact on the liver to body weight ratio or tumor Bcl-2 expression, it may upregulate PCNA expression and downregulate Bax expression, respectively. All our findings show that H. pylori may promote proliferation and inhibit apoptosis of tumor cells.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Rybicka M, Nakonieczna J, Stalke P and Bielawski KP: Host response to the presence of Helicobacter spp. DNA in the liver of patients with chronic liver diseases. Pol J Microbiol. 60:175–178. 2011.PubMed/NCBI

2 

Schistosomes, liver flukes and Helicobacter pylori. In: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans; Lyon. 7–14 June 1994; IARC monographs on the evaluation of carcinogenic risks to humans. World Health Organization, International Agency for Research on Cancer; 61. pp. 1–241. 1994

3 

Wedi B and Kapp A: Helicobacter pylori infection in skin diseases: a critical appraisal. Am J Clin Dermatol. 3:273–282. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Pellicano R, Menard A, Rizzetto M and Megraud F: Helicobacter species and liver diseases: association or causation? Lancet Infect Dis. 8:254–260. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Farsak B, Yildirir A, Akyön Y, Pinar A, Oç M, Böke E, Kes S and Tokgözoğlu L: Detection of Chlamydia pneumoniae and Helicobacter pylori DNA in human atherosclerotic plaques by PCR. J Clin Microbiol. 38:4408–4411. 2000.PubMed/NCBI

6 

Ameriso SF, Fridman EA, Leiguarda RC and Sevlever GE: Detection of Helicobacter pylori in human carotid atheroscle-rotic plaques. Stroke. 32:385–391. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Danesh J, Koreth J, Youngman L, Collins R, Arnold JR, Balarajan Y, McGee J and Roskell D: Is Helicobacter pylori a factor in coronary atherosclerosis? J Clin Microbiol. 37:16511999.PubMed/NCBI

8 

Nilsson I, Lindgren S, Eriksson S and Wadstrom T: Serum antibodies to Helicobacter hepaticus and Helicobacter pylori in patients with chronic liver disease. Gut. 46:410–414. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Pellicano R, Leone N, Berrutti M, Cutufia MA, Fiorentino M, Rizzetto M and Ponzetto A: Helicobacter pylori seroprevalence in hepatitis C virus positive patients with cirrhosis. J Hepatol. 33:648–650. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Ponzetto A, Pellicano R, Leone N, Berrutti M, Turrini F and Rizzetto M: Helicobacter pylori seroprevalence in cirrhotic patients with hepatitis B virus infection. Neth J Med. 56:206–210. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Ponzetto A, Pellicano R, Leone N, Cutufia MA, Turrini F, Grigioni WF, D'Errico A, Mortimer P, Rizzetto M and Silengo L: Helicobacter infection and cirrhosis in hepatitis C virus carriage: is it an innocent bystander or a troublemaker? Med Hypotheses. 54:275–277. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Queiroz DM, Rocha AM, Rocha GA, Cinque SM, Oliveira AG, Godoy A and Tanno H: Association between Helicobacter pylori infection and cirrhosis in patients with chronic hepatitis C virus. Dig Dis Sci. 51:370–373. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Avenaud P, Marais A, Monteiro L, Le Bail B, Bioulac Sage P, Balabaud C and Mégraud F: Detection of Helicobacter species in the liver of patients with and without primary liver carcinoma. Cancer. 89:1431–1439. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Xuan SY, Li N, Qiang X, Zhou RR, Shi YX and Jiang WJ: Helicobacter infection in hepatocellular carcinoma tissue. World J Gastroenterol. 12:2335–2340. 2006.PubMed/NCBI

15 

Farazi PA and DePinho RA: Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer. 6:674–687. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar

17 

Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Iwatsuki S, Starzl TE, Sheahan DG, Yokoyama I, Demetris AJ, Todo S, Tzakis AG, Van Thiel DH, Carr B, Selby R, et al: Hepatic resection versus transplantation for hepatocellular carcinoma. Ann Surg. 214:221–228; discussion 228–229. 1991. View Article : Google Scholar : PubMed/NCBI

19 

McPeake JR, O'Grady JG, Zaman S, Portmann B, Wight DG, Tan KC, Calne RY and Williams R: Liver transplantation for primary hepatocellular carcinoma: tumor size and number determine outcome. J Hepatol. 18:226–234. 1993. View Article : Google Scholar : PubMed/NCBI

20 

Kensler TW, Roebuck BD, Wogan GN and Groopman JD: Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology. Toxicol Sci. 120(Suppl 1): S28–S48. 2011. View Article : Google Scholar :

21 

Chuang SC, La Vecchia C and Boffetta P: Liver cancer: Descriptive epidemiology and risk factors other than HBV and HCV infection. Cancer Lett. 286:9–14. 2009. View Article : Google Scholar

22 

Arzumanyan A, Reis HM and Feitelson MA: Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma. Nat Rev Cancer. 13:123–135. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Goo MJ, Ki MR, Lee HR, Yang HJ, Yuan DW, Hong IH, Park JK, Hong KS, Han JY, Hwang OK, et al: Helicobacter pylori promotes hepatic fibrosis in the animal model. Lab Invest. 89:1291–1303. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Ito K, Nakamura M, Toda G, Negishi M, Torii A and Ohno T: Potential role of Helicobacter pylori in hepatocarcinogenesis. Int J Mol Med. 13:221–227. 2004.PubMed/NCBI

25 

Ito K, Yamaoka Y, Ota H, El-Zimaity H and Graham DY: Adherence, internalization, and persistence of Helicobacter pylori in hepatocytes. Dig Dis Sci. 53:2541–2549. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Zhang Y, Fan XG, Huang YK, Chen R and Dai H: Helicobacter pylori enhances cyclin D1, PCNA expression in HepG2 cell line. Zhonghua Gan Zang Bing Za Zhi. 12:695–696. 2004.(In Chinese). PubMed/NCBI

27 

Chen R, Fan XG, Huang Y, Li N and Chen CH: In vitro cytotoxicity of Helicobacter pylori on hepatocarcinoma HepG2 cells. Ai Zheng. 23:44–49. 2004.(In Chinese). PubMed/NCBI

28 

Karita M, Li Q, Cantero D and Okita K: Establishment of a small animal model for human Helicobacter pylori infection using germ-free mouse. Am J Gastroenterol. 89:208–213. 1994.PubMed/NCBI

29 

Thalmaier U, Lehn N, Pfeffer K, Stolte M, Vieth M and Schneider-Brachert W: Role of tumor necrosis factor alpha in Helicobacter pylori gastritis in tumor necrosis factor receptor 1-deficient mice. Infect Immun. 70:3149–3155. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Algood HM, Allen SS, Washington MK, Peek RM Jr, Miller GG and Cover TL: Regulation of gastric B cell recruitment is dependent on IL-17 receptor A signaling in a model of chronic bacterial infection. J Immunol. 183:5837–5846. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Maurer KJ, Ihrig MM, Rogers AB, Ng V, Bouchard G, Leonard MR, Carey MC and Fox JG: Identification of cholelithogenic enterohepatic Helicobacter species and their role in murine cholesterol gallstone formation. Gastroenterology. 128:1023–1033. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Lee CW, Rickman B, Rogers AB, Muthupalani S, Takaishi S, Yang P, Wang TC and Fox JG: Combination of sulindac and antimicrobial eradication of Helicobacter pylori prevents progression of gastric cancer in hypergastrinemic INS-GAS mice. Cancer Res. 69:8166–8174. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Yao X, Hu JF, Daniels M, Yien H, Lu H, Sharan H, Zhou X, Zeng Z, Li T, Yang Y, et al: A novel orthotopic tumor model to study growth factors and oncogenes in hepatocarcinogenesis. Clin Cancer Res. 9:2719–2726. 2003.PubMed/NCBI

34 

Aprahamian M, Bour G, Akladios CY, Fylaktakidou K, Greferath R, Soler L, Marescaux J, Egly JM, Lehn JM and Nicolau C: Myo-InositolTrisPyroPhosphate treatment leads to HIF-1α suppression and eradication of early hepatoma tumors in rats. Chem Biochem. 12:777–783. 2011.

35 

Fox JG, Dewhirst FE, Shen Z, Feng Y, Taylor NS, Paster BJ, Ericson RL, Lau CN, Correa P, Araya JC, et al: Hepatic Helicobacter species identified in bile and gallbladder tissue from Chileans with chronic cholecystitis. Gastroenterology. 114:755–763. 1998. View Article : Google Scholar : PubMed/NCBI

36 

Leone N, Pellicano R, Brunello F, Cutufia MA, Berrutti M, Fagoonee S, Rizzetto M and Ponzetto A: Helicobacter pylori seroprevalence in patients with cirrhosis of the liver and hepatocellular carcinoma. Cancer Detect Prev. 27:494–497. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Ponzetto A, Pellicano R, Redaelli A, Rizzetto M and Roffi L: Helicobacter pylori infection in patients with hepatitis C Virus positive chronic liver diseases. New Microbiol. 26:321–328. 2003.PubMed/NCBI

38 

Spinzi G, Pellicano R, Minoli G, Terreni N, Cutufia MA, Fagoonee S, Rizzetto M and Ponzetto A: Helicobacter pylori seroprevalence in hepatitis C virus positive patients with cirrhosis. The Como cross-sectional study. Panminerva Med. 43:85–87. 2001.PubMed/NCBI

39 

Fan XG, Zou YY, Wu AH, Li TG, Hu GL and Zhang Z: Seroprevalence of Helicobacter pylori infection in patients with hepatitis B. Br J Biomed Sci. 55:176–178. 1998.

40 

Zhang S, Bao Y and Zu MH: Research of relationship between Hp infection and HCC. Chin J Clin Oncol. 45–48. 2004.

41 

Huang Y, Fan XG, Wang ZM, Zhou JH, Tian XF and Li N: Identification of helicobacter species in human liver samples from patients with primary hepatocellular carcinoma. J Clin Pathol. 57:1273–1277. 2004. View Article : Google Scholar : PubMed/NCBI

42 

Pellicano R, Mazzaferro V, Grigioni WF, Cutufia MA, Fagoonee S, Silengo L, Rizzetto M and Ponzetto A: Helicobacter species sequences in liver samples from patients with and without hepatocellular carcinoma. World J Gastroenterol. 10:598–601. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Leelawat K, Suksumek N, Leelawat S and Lek-Uthai U: Detection of VacA gene specific for Helicobactor pylori in hepatocellular carcinoma and cholangiocarcinoma specimens of Thai patients. Southeast Asian J Trop Med Public Health. 38:881–885. 2007.PubMed/NCBI

44 

de Magalhaes Queiroz DM and Santos A: Isolation of a Helicobacter strain from the human liver. Gastroenterology. 121:1023–1024. 2001. View Article : Google Scholar : PubMed/NCBI

45 

Matsukura N, Yokomuro S, Yamada S, Tajiri T, Sundo T, Hadama T, Kamiya S, Naito Z and Fox JG: Association between Helicobacter bilis in bile and biliary tract malignancies: H. bilis in bile from Japanese and Thai patients with benign and malignant diseases in the biliary tract. Jpn J Cancer Res. 93:842–847. 2002. View Article : Google Scholar : PubMed/NCBI

46 

García A, Feng Y, Parry NM, McCabe A, Mobley MW, Lertpiriyapong K, Whary MT and Fox JG: Helicobacter pylori infection does not promote hepatocellular cancer in a transgenic mouse model of hepatitis C virus pathogenesis. Gut Microbes. 4:577–590. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Rocha M, Avenaud P, Menard A, Le Bail B, Balabaud C, Bioulac-Sage P, de Magalhães Queiroz DM and Mégraud F: Association of Helicobacter species with hepatitis C cirrhosis with or without hepatocellular carcinoma. Gut. 54:396–401. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Hanninen ML: Sensitivity of Helicobacter pylori to different bile salts. Eur J Clin Microbiol Infect Disy. 10:515–518. 1991. View Article : Google Scholar

49 

Caldwell MT, McDermott M, Jazrawi S, O'Dowd G, Byrne PJ, Walsh TN, Hourihane DO and Hennessy TP: Helicobacter pylori infection increases following cholecystectomy. Ir J Med Sci. 164:52–55. 1995. View Article : Google Scholar : PubMed/NCBI

50 

Kawaguchi M, Saito T, Ohno H, Midorikawa S, Sanji T, Handa Y, Morita S, Yoshida H, Tsurui M, Misaka R, et al: Bacteria closely resembling Helicobacter pylori detected immunohistologically and genetically in resected gallbladder mucosa. J Gastroenterol. 31:294–298. 1996. View Article : Google Scholar : PubMed/NCBI

51 

Guyton JE and Hall AC: Textbook of Medical Physiology. Saunders Elsevier; Philadelphia, PA: 2011

52 

Kelly SM, Pitcher MC, Farmery SM and Gibson GR: Isolation of Helicobacter pylori from feces of patients with dyspepsia in the United Kingdom. Gastroenterology. 107:1671–1674. 1994.PubMed/NCBI

53 

Thomas JE, Gibson GR, Darboe MK, Dale A and Weaver LT: Isolation of Helicobacter pylori from human faeces. Lancet. 340:1194–1195. 1992. View Article : Google Scholar : PubMed/NCBI

54 

Narikawa S, Kawai S, Aoshima H, Kawamata O, Kawaguchi R, Hikiji K, Kato M, Iino S and Mizushima Y: Comparison of the nucleic acids of helical and coccoid forms of Helicobacter pylori. Clin Diagn Lab Immunol. 4:285–290. 1997.PubMed/NCBI

55 

Dore MP, Realdi G, Mura D, Graham DY and Sepulveda AR: Helicobacter infection in patients with HCV-related chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Dig Dis Sci. 47:1638–1643. 2002. View Article : Google Scholar : PubMed/NCBI

56 

Silva LD, Rocha AM, Rocha GA, de Moura SB, Rocha MM, Dani R, de Melo FF, Guerra JB, de Castro LP, Mendes GS, et al: The presence of Helicobacter pylori in the liver depends on the Th1, Th17 and Treg cytokine profile of the patient. Mem Inst Oswaldo Cruz. 106:748–754. 2011. View Article : Google Scholar : PubMed/NCBI

57 

Boonyanugomol W, Chomvarin C, Sripa B, Bhudhisawasdi V, Khuntikeo N, Hahnvajanawong C and Chamsuwan A: Helicobacter pylori in Thai patients with cholangiocarcinoma and its association with biliary inflammation and proliferation. HPB (Oxford). 14:177–184. 2012. View Article : Google Scholar

58 

Myung SJ, Kim MH, Shim KN, Kim YS, Kim EO, Kim HJ, Park ET, Yoo KS, Lim BC, Seo DW, et al: Detection of Helicobacter pylori DNA in human biliary tree and its association with hepatolithiasis. Dig Dis Sci. 45:1405–1412. 2000. View Article : Google Scholar : PubMed/NCBI

59 

Chen W, Li D, Cannan RJ and Stubbs RS: Common presence of Helicobacter DNA in the gallbladder of patients with gallstone diseases and controls. Dig Liver Dis. 35:237–243. 2003. View Article : Google Scholar : PubMed/NCBI

60 

Silva CP, Pereira-Lima JC, Oliveira AG, Guerra JB, Marques DL, Sarmanho L, Cabral MM and Queiroz DM: Association of the presence of Helicobacter in gallbladder tissue with cholelithiasis and cholecystitis. J Clin Microbiol. 41:5615–5618. 2003. View Article : Google Scholar : PubMed/NCBI

61 

Maurer KJ, Rogers AB, Ge Z, Wiese AJ, Carey MC and Fox JG: Helicobacter pylori and cholesterol gallstone formation in C57L/J mice: A prospective study. Am J Physiol Gastrointest Liver Physiol. 290:G175–G182. 2006. View Article : Google Scholar

62 

Abayli B, Colakoglu S, Serin M, Erdogan S, Isiksal YF, Tuncer I, Koksal F and Demiryurek H: Helicobacter pylori in the etiology of cholesterol gallstones. J Clin Gastroenterol. 39:134–137. 2005.PubMed/NCBI

63 

Kowalski M, Rees W, Konturek PC, Grove R, Scheffold T, Meixner H, Brunec M, Franz N, Konturek JW, Pieniazek P, et al: Detection of Helicobacter pylori specific DNA in human atheromatous coronary arteries and its association to prior myocardial infarction and unstable angina. Dig Liver Dis. 34:398–402. 2002. View Article : Google Scholar : PubMed/NCBI

64 

Kusters JG, Gerrits MM, Van Strijp JA and Vandenbroucke-Grauls CM: Coccoid forms of Helicobacter pylori are the morphologic manifestation of cell death. Infect Immun. 65:3672–3679. 1997.PubMed/NCBI

65 

Andersen LP, Dorland A, Karacan H, Colding H, Nilsson HO, Wadström T and Blom J: Possible clinical importance of the transformation of Helicobacter pylori into coccoid forms. Scand J Gastroenterol. 35:897–903. 2000. View Article : Google Scholar : PubMed/NCBI

66 

Tian XF, Fan XG, Fu CY, Huang Y and Zhu C: Experimental study on the pathological effect of Helicobacter pylori on liver tissues. Zhonghua Gan Zang Bing Za Zhi. 13:780–783. 2005.(In Chinese). PubMed/NCBI

67 

Egelkrout EM, Mariconti L, Settlage SB, Cella R, Robertson D and Hanley-Bowdoin L: Two E2F elements regulate the proliferating cell nuclear antigen promoter differently during leaf development. Plant Cell. 14:3225–3236. 2002. View Article : Google Scholar : PubMed/NCBI

68 

Essers J, Theil AF, Baldeyron C, van Cappellen WA, Houtsmuller AB, Kanaar R and Vermeulen W: Nuclear dynamics of PCNA in DNA replication and repair. Mol Cell Biol. 25:9350–9359. 2005. View Article : Google Scholar : PubMed/NCBI

69 

Shivji KK, Kenny MK and Wood RD: Proliferating cell nuclear antigen is required for DNA excision repair. Cell. 69:367–374. 1992. View Article : Google Scholar : PubMed/NCBI

70 

Leonardi E, Girlando S, Serio G, Mauri FA, Perrone G, Scampini S, Dalla Palma P and Barbareschi M: PCNA and Ki67 expression in breast carcinoma: correlations with clinical and biological variables. J Clin Pathol. 45:416–419. 1992. View Article : Google Scholar : PubMed/NCBI

71 

Kobayashi I, Matsuo K, Ishibashi Y, Kanda S and Sakai H: The proliferative activity in dysplasia and carcinoma in situ of the uterine cervix analyzed by proliferating cell nuclear antigen immunostaining and silver-binding argyrophilic nucleolar organizer region staining. Hum Pathol. 25:198–202. 1994. View Article : Google Scholar : PubMed/NCBI

72 

Allegranza A, Girlando S, Arrigoni GL, Veronese S, Mauri FA, Gambacorta M, Pollo B, Dalla Palma P and Barbareschi M: Proliferating cell nuclear antigen expression in central nervous system neoplasms. Virchows Arch A Pathol Anat Histopathol. 419:417–423. 1991. View Article : Google Scholar : PubMed/NCBI

73 

Tsai ST and Jin YT: Proliferating cell nuclear antigen (PCNA) expression in oral squamous cell carcinomas. J Oral Pathol Med. 24:313–315. 1995. View Article : Google Scholar : PubMed/NCBI

74 

Willett CG1, Warland G, Hagan MP, Daly WJ, Coen J, Shellito PC and Compton CC: Tumor proliferation in rectal cancer following preoperative irradiation. J Clin Oncol. 13:1417–1424. 1995.PubMed/NCBI

75 

Prosperi E: Multiple roles of the proliferating cell nuclear antigen: DNA replication, repair and cell cycle control. Prog Cell Cycle Res. 3:193–210. 1997. View Article : Google Scholar : PubMed/NCBI

76 

Moldovan GL, Pfander B and Jentsch S: PCNA, the maestro of the replication fork. Cell. 129:665–679. 2007. View Article : Google Scholar : PubMed/NCBI

77 

Wang SC, Nakajima Y, Yu YL, Xia W, Chen CT, Yang CC, McIntush EW, Li LY, Hawke DH, Kobayashi R and Hung MC: Tyrosine phosphorylation controls PCNA function through protein stability. Nat Cell Biol. 8:1359–1368. 2006. View Article : Google Scholar : PubMed/NCBI

78 

Pal HC1, Sharma S, Strickland LR, Agarwal J, Athar M, Elmets CA and Afaq F: Delphinidin reduces cell proliferation and induces apoptosis of non-small-cell lung cancer cells by targeting EGFR/VEGFR2 signaling pathways. PLoS One. 8:e772702013. View Article : Google Scholar : PubMed/NCBI

79 

Aziz MH, Wheeler DL, Bhamb B and Verma AK: Protein kinase C delta overexpressing transgenic mice are resistant to chemically but not to UV radiation-induced development of squamous cell carcinomas: A possible link to specific cytokines and cyclo-oxygenase-2. Cancer Res. 66:713–722. 2006. View Article : Google Scholar : PubMed/NCBI

80 

Ojeh N, Hiilesvuo K, Warri A, Salmivirta M, Henttinen T and Maatta A: Ectopic expression of syndecan-1 in basal epidermis affects keratinocyte proliferation and wound re-epithelialization. J Invest Dermatol. 128:26–34. 2008. View Article : Google Scholar

81 

Tian XF, Fan XG, Huang Y, Zhang Y and Zhu C: Expression of cyclin D1 proliferating cell nuclear antigen in liver of C57BL/6 mice infected with Helicobacter pylori. World Chin J Digestol. 14:1341–1345. 2006.

82 

Zhang Y, Fan XG, Chen R, Xiao ZQ, Feng XP, Tian XF and Chen ZH: Comparative proteome analysis of untreated and Helicobacter pylori-treated HepG2. World J Gastroenterol. 11:3485–3489. 2005. View Article : Google Scholar : PubMed/NCBI

83 

Komatsu K1, Miyashita T, Hang H, Hopkins KM, Zheng W, Cuddeback S, Yamada M, Lieberman HB and Wang HG: Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-xL and promotes apoptosis. Nat Cell Biol. 2:1–6. 2000.PubMed/NCBI

84 

Lin B, Kolluri SK, Lin F, Liu W, Han YH, Cao X, Dawson MI, Reed JC and Zhang XK: Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell. 116:527–540. 2004. View Article : Google Scholar : PubMed/NCBI

85 

Hoetelmans RW: Nuclear partners of Bcl-2: Bax and PML. DNA Cell Biol. 23:351–354. 2004. View Article : Google Scholar : PubMed/NCBI

86 

Oltvai ZN, Milliman CL and Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 74:609–619. 1993. View Article : Google Scholar : PubMed/NCBI

87 

Tsujimoto Y, Finger LR, Yunis J, Nowell PC and Croce CM: Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science. 226:1097–1099. 1984. View Article : Google Scholar : PubMed/NCBI

88 

Cleary ML, Smith SD and Sklar J: Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell. 47:19–28. 1986. View Article : Google Scholar : PubMed/NCBI

89 

Yang LJ, Cao XT and Yu LZ: Bcl-2 and Bax in apoptosis of tumor cells. Chin J Cancer Biother. 10:232–234. 2003.

90 

Yin XM, Oltvai ZN and Korsmeyer SJ: BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature. 369:321–323. 1994. View Article : Google Scholar : PubMed/NCBI

91 

Yang E and Korsmeyer SJ: Molecular thanatopsis: a discourse on the BCL2 family and cell death. Blood. 88:386–401. 1996.PubMed/NCBI

92 

Yang E, Zha J, Jockel J, Boise LH, Thompson CB and Korsmeyer SJ: Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell. 80:285–291. 1995. View Article : Google Scholar : PubMed/NCBI

93 

Cotran RS, Kumar V and Collins T: Robbins Pathologic Basis of Disease. 6th edition. W.B Saunders Company; Philadelphia, PA: 1998

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang J, Wang X, Tang N, Chen Y and She F: Impact of Helicobacter pylori on the growth of hepatic orthotopic graft tumors in mice. Int J Oncol 47: 1416-1428, 2015.
APA
Wang, J., Wang, X., Tang, N., Chen, Y., & She, F. (2015). Impact of Helicobacter pylori on the growth of hepatic orthotopic graft tumors in mice. International Journal of Oncology, 47, 1416-1428. https://doi.org/10.3892/ijo.2015.3107
MLA
Wang, J., Wang, X., Tang, N., Chen, Y., She, F."Impact of Helicobacter pylori on the growth of hepatic orthotopic graft tumors in mice". International Journal of Oncology 47.4 (2015): 1416-1428.
Chicago
Wang, J., Wang, X., Tang, N., Chen, Y., She, F."Impact of Helicobacter pylori on the growth of hepatic orthotopic graft tumors in mice". International Journal of Oncology 47, no. 4 (2015): 1416-1428. https://doi.org/10.3892/ijo.2015.3107
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Wang X, Tang N, Chen Y and She F: Impact of Helicobacter pylori on the growth of hepatic orthotopic graft tumors in mice. Int J Oncol 47: 1416-1428, 2015.
APA
Wang, J., Wang, X., Tang, N., Chen, Y., & She, F. (2015). Impact of Helicobacter pylori on the growth of hepatic orthotopic graft tumors in mice. International Journal of Oncology, 47, 1416-1428. https://doi.org/10.3892/ijo.2015.3107
MLA
Wang, J., Wang, X., Tang, N., Chen, Y., She, F."Impact of Helicobacter pylori on the growth of hepatic orthotopic graft tumors in mice". International Journal of Oncology 47.4 (2015): 1416-1428.
Chicago
Wang, J., Wang, X., Tang, N., Chen, Y., She, F."Impact of Helicobacter pylori on the growth of hepatic orthotopic graft tumors in mice". International Journal of Oncology 47, no. 4 (2015): 1416-1428. https://doi.org/10.3892/ijo.2015.3107
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team