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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Article

Metastasis suppressor 1 expression in human ovarian cancer: The impact on cellular migration and metastasis

Corrigendum in: /10.3892/ijo.2025.5770
  • Authors:
    • Rong Liu
    • Tracey A. Martin
    • Nicola J. Jordan
    • Fiona Ruge
    • Lin Ye
    • Wen G. Jiang
  • View Affiliations / Copyright

    Affiliations: Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, CF14 4XN, UK
  • Pages: 1429-1439
    |
    Published online on: August 13, 2015
       https://doi.org/10.3892/ijo.2015.3121
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Abstract

Metastasis suppressor 1 (MTSS1) is a potential metastasis suppressor gene involved in the regulation of cytoskeleton dynamics and subsequently in cell motility. MTSS1 expression is frequently reduced in a variety of cancer cells and tissues and this loss may account for increased invasive traits in cancer cells. The present study aimed to assess the role of MTSS1 in epithelial ovarian cancer (EOC) cells. Expression of MTSS1 in human ovarian cells was assessed at both the mRNA and protein levels using reverse transcription-PCR (RT-PCR) and immunohistochemistry, respectively. Full-length MTSS1 cDNA expression vector was used to generate MTSS1 overexpressing cells. The effect of MTSS1 overexpression on cellular functions was examined in EOC cells using a variety of in vitro assays. MTSS1 expression was observed both in ovarian cancer tissues and EOC cells. Over-expression of MTSS1 protein reduced the growth, invasion, adhesion and migration of EOC cell lines in vitro. The present study revealed that MTSS1 plays an essential inhibitory role in the development and progression of ovarian cancers. MTSS1 overexpression is intimately related to migration and metastasis, suggesting that MTSS1 is a potential prognostic marker and therapeutic molecular target in human ovarian cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Liu R, Martin TA, Jordan NJ, Ruge F, Ye L and Jiang WG: Metastasis suppressor 1 expression in human ovarian cancer: The impact on cellular migration and metastasis Corrigendum in /10.3892/ijo.2025.5770. Int J Oncol 47: 1429-1439, 2015.
APA
Liu, R., Martin, T.A., Jordan, N.J., Ruge, F., Ye, L., & Jiang, W.G. (2015). Metastasis suppressor 1 expression in human ovarian cancer: The impact on cellular migration and metastasis Corrigendum in /10.3892/ijo.2025.5770. International Journal of Oncology, 47, 1429-1439. https://doi.org/10.3892/ijo.2015.3121
MLA
Liu, R., Martin, T. A., Jordan, N. J., Ruge, F., Ye, L., Jiang, W. G."Metastasis suppressor 1 expression in human ovarian cancer: The impact on cellular migration and metastasis Corrigendum in /10.3892/ijo.2025.5770". International Journal of Oncology 47.4 (2015): 1429-1439.
Chicago
Liu, R., Martin, T. A., Jordan, N. J., Ruge, F., Ye, L., Jiang, W. G."Metastasis suppressor 1 expression in human ovarian cancer: The impact on cellular migration and metastasis Corrigendum in /10.3892/ijo.2025.5770". International Journal of Oncology 47, no. 4 (2015): 1429-1439. https://doi.org/10.3892/ijo.2015.3121
Copy and paste a formatted citation
x
Spandidos Publications style
Liu R, Martin TA, Jordan NJ, Ruge F, Ye L and Jiang WG: Metastasis suppressor 1 expression in human ovarian cancer: The impact on cellular migration and metastasis Corrigendum in /10.3892/ijo.2025.5770. Int J Oncol 47: 1429-1439, 2015.
APA
Liu, R., Martin, T.A., Jordan, N.J., Ruge, F., Ye, L., & Jiang, W.G. (2015). Metastasis suppressor 1 expression in human ovarian cancer: The impact on cellular migration and metastasis Corrigendum in /10.3892/ijo.2025.5770. International Journal of Oncology, 47, 1429-1439. https://doi.org/10.3892/ijo.2015.3121
MLA
Liu, R., Martin, T. A., Jordan, N. J., Ruge, F., Ye, L., Jiang, W. G."Metastasis suppressor 1 expression in human ovarian cancer: The impact on cellular migration and metastasis Corrigendum in /10.3892/ijo.2025.5770". International Journal of Oncology 47.4 (2015): 1429-1439.
Chicago
Liu, R., Martin, T. A., Jordan, N. J., Ruge, F., Ye, L., Jiang, W. G."Metastasis suppressor 1 expression in human ovarian cancer: The impact on cellular migration and metastasis Corrigendum in /10.3892/ijo.2025.5770". International Journal of Oncology 47, no. 4 (2015): 1429-1439. https://doi.org/10.3892/ijo.2015.3121
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