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Article

Mechanisms for SU5416 as a radiosensitizer of endothelial cells

  • Authors:
    • Eun Ho Kim
    • Mi-Sook Kim
    • Youn Kyoung Jeong
    • Ilsung Cho
    • Seung Hoon You
    • Sung Ho Cho
    • Hanna Lee
    • Won-Gyun Jung
    • Hag Dong Kim
    • Joon Kim
  • View Affiliations / Copyright

    Affiliations: Division of Heavy Ion Clinical Research, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Republic of Korea, Research Center for Radiotherapy, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Republic of Korea, Laboratory of Biochemistry, Division of Life Sciences, Korea University, Seoul 136-701, Republic of Korea
  • Pages: 1440-1450
    |
    Published online on: August 21, 2015
       https://doi.org/10.3892/ijo.2015.3127
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Abstract

Endothelial cells (ECs), that comprise the tumor vasculature, are critical targets for anticancer radiotherapy. The aim of this work was to study the mechanism by which SU5416, a known anti-angiogenesis inhibitor, modifies the radiation responses of human vascular ECs. Two human endothelial cell lines (HUVEC and 2H11) were treated with SU5416 alone, radiation alone, or a combination of both. In vitro tests were performed using colony forming assays, FACS analysis, western blotting, immunohistochemistry, migration assay, invasion assays and endothelial tube formation assays. The combination of radiation and SU5416 significantly inhibited cell survival, the repair of radiation-induced DNA damage, and induced apoptosis. It also caused cell cycle arrest, inhibited cell migration and invasion, and suppressed angiogenesis. In this study, our results first provide a scientific rationale to combine SU5416 with radiotherapy to target ECs and suggest its clinical application in combination cancer treatment with radiotherapy.
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1 

Jubb AM, Pham TQ, Hanby AM, Frantz GD, Peale FV, Wu TD, Koeppen HW and Hillan KJ: Expression of vascular endothelial growth factor, hypoxia inducible factor 1α, and carbonic anhydrase IX in human tumours. J Clin Pathol. 57:504–512. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Garcia-Barros M, Paris F, Cordon-Cardo C, Lyden D, Rafii S, Haimovitz-Friedman A, Fuks Z and Kolesnick R: Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science. 300:1155–1159. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Huber PE, Bischof M, Jenne J, Heiland S, Peschke P, Saffrich R, Gröne HJ, Debus J, Lipson KE and Abdollahi A: Trimodal cancer treatment: Beneficial effects of combined antiangiogenesis, radiation, and chemotherapy. Cancer Res. 65:3643–3655. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Poggi MM, Coleman CN and Mitchell JB: Sensitizers and protectors of radiation and chemotherapy. Curr Probl Cancer. 25:334–411. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Chan LW and Camphausen K: Angiogenic tumor markers, anti-angiogenic agents and radiation therapy. Expert Rev Anticancer Ther. 3:357–366. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Wachsberger P, Burd R and Dicker AP: Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: Exploring mechanisms of interaction. Clin Cancer Res. 9:1957–1971. 2003.PubMed/NCBI

7 

Gorski DH, Beckett MA, Jaskowiak NT, Calvin DP, Mauceri HJ, Salloum RM, Seetharam S, Koons A, Hari DM, Kufe DW, et al: Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res. 59:3374–3378. 1999.PubMed/NCBI

8 

Lee CG, Heijn M, di Tomaso E, Griffon-Etienne G, Ancukiewicz M, Koike C, Park KR, Ferrara N, Jain RK, Suit HD, et al: Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res. 60:5565–5570. 2000.PubMed/NCBI

9 

Geng L, Donnelly E, McMahon G, Lin PC, Sierra-Rivera E, Oshinka H and Hallahan DE: Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy. Cancer Res. 61:2413–2419. 2001.PubMed/NCBI

10 

Fong TA, Shawver LK, Sun L, Tang C, App H, Powell TJ, Kim YH, Schreck R, Wang X, Risau W, et al: SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res. 59:99–106. 1999.PubMed/NCBI

11 

Mendel DB, Laird AD, Smolich BD, Blake RA, Liang C, Hannah AL, Shaheen RM, Ellis LM, Weitman S, Shawver LK, et al: Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent. Anticancer Drug Des. 15:29–41. 2000.PubMed/NCBI

12 

Peterson AC, Swiger S, Stadler WM, Medved M, Karczmar G and Gajewski TF: Phase II study of the Flk-1 tyrosine kinase inhibitor SU5416 in advanced melanoma. Clin Cancer Res. 10:4048–4054. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Bäckman U, Svensson A and Christofferson R: Importance of vascular endothelial growth factor A in the progression of experimental neuroblastoma. Angiogenesis. 5:267–274. 2002. View Article : Google Scholar

14 

Timke C, Zieher H, Roth A, Hauser K, Lipson KE, Weber KJ, Debus J, Abdollahi A and Huber PE: Combination of vascular endothelial growth factor receptor/platelet-derived growth factor receptor inhibition markedly improves radiation tumor therapy. Clin Cancer Res. 14:2210–2219. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Abdollahi A, Lipson KE, Han X, Krempien R, Trinh T, Weber KJ, Hahnfeldt P, Hlatky L, Debus J, Howlett AR, et al: SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro. Cancer Res. 63:3755–3763. 2003.PubMed/NCBI

16 

Wachsberger PR, Burd R, Marero N, Daskalakis C, Ryan A, McCue P and Dicker AP: Effect of the tumor vascular-damaging agent, ZD6126, on the radioresponse of U87 glioblastoma. Clin Cancer Res. 11:835–842. 2005.PubMed/NCBI

17 

Ning S, Laird D, Cherrington JM and Knox SJ: The antiangiogenic agents SU5416 and SU6668 increase the antitumor effects of fractionated irradiation. Radiat Res. 157:45–51. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Griffin RJ, Williams BW, Wild R, Cherrington JM, Park H and Song CW: Simultaneous inhibition of the receptor kinase activity of vascular endothelial, fibroblast, and platelet-derived growth factors suppresses tumor growth and enhances tumor radiation response. Cancer Res. 62:1702–1706. 2002.PubMed/NCBI

19 

Lu B, Geng L, Musiek A, Tan J, Cao C, Donnelly E, McMahon G, Choy H and Hallahan DE: Broad spectrum receptor tyrosine kinase inhibitor, SU6668, sensitizes radiation via targeting survival pathway of vascular endothelium. Int J Radiat Oncol Biol Phys. 58:844–850. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Zips D, Eicheler W, Geyer P, Hessel F, Dörfler A, Thames HD, Haberey M and Baumann M: Enhanced susceptibility of irradiated tumor vessels to vascular endothelial growth factor receptor tyrosine kinase inhibition. Cancer Res. 65:5374–5379. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Edwards E, Geng L, Tan J, Onishko H, Donnelly E and Hallahan DE: Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation. Cancer Res. 62:4671–4677. 2002.PubMed/NCBI

22 

Schueneman AJ, Himmelfarb E, Geng L, Tan J, Donnelly E, Mendel D, McMahon G and Hallahan DE: SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models. Cancer Res. 63:4009–4016. 2003.PubMed/NCBI

23 

Krystal GW, Honsawek S, Kiewlich D, Liang C, Vasile S, Sun L, McMahon G and Lipson KE: Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung cancer cells. Cancer Res. 61:3660–3668. 2001.PubMed/NCBI

24 

Kumar P, Benedict R, Urzua F, Fischbach C, Mooney D and Polverini P: Combination treatment significantly enhances the efficacy of antitumor therapy by preferentially targeting angiogenesis. Lab Invest. 85:756–767. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Lea DE: Actions of Radiations on Living Cells. 2nd edition. Cambridge University Press; New York, NY: 1955

26 

Tang D, Wu D, Hirao A, Lahti JM, Liu L, Mazza B, Kidd VJ, Mak TW and Ingram AJ: ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J Biol Chem. 277:12710–12717. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Yang J, Yu Y and Duerksen-Hughes PJ: Protein kinases and their involvement in the cellular responses to genotoxic stress. Mutat Res. 543:31–58. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Kabakov AE, Makarova YM and Malyutina YV: Radio-sensitization of human vascular endothelial cells through HSP90 inhibition with 17-N-allilamino-17-demethoxygeldanamycin. Int J Radiat Oncol Biol Phys. 71:858–865. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Tan J and Hallahan DE: Growth factor-independent activation of protein kinase B contributes to the inherent resistance of vascular endothelium to radiation-induced apoptotic response. Cancer Res. 63:7663–7667. 2003.PubMed/NCBI

30 

Cherrington JM, Strawn LM and Shawver LK: New paradigms for the treatment of cancer: The role of anti-angiogenesis agents. Adv Cancer Res. 79:1–38. 2000. View Article : Google Scholar : PubMed/NCBI

31 

Fontanini G, De Laurentiis M, Vignati S, Chinè S, Lucchi M, Silvestri V, Mussi A, De Placido S, Tortora G, Bianco AR, et al: Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I–IIIA non-small-cell lung cancer: Amphiregulin and microvessel count are independent prognostic indicators of survival. Clin Cancer Res. 4:241–249. 1998.PubMed/NCBI

32 

Kawaguchi T, Yamamoto S, Kudoh S, Goto K, Wakasa K and Sakurai M: Tumor angiogenesis as a major prognostic factor in stage I lung adenocarcinoma. Anticancer Res. 17:3743–3746. 1997.

33 

Toi M, Hoshina S, Takayanagi T and Tominaga T: Association of vascular endothelial growth factor expression with tumor angiogenesis and with early relapse in primary breast cancer. Jpn J Cancer Res. 85:1045–1049. 1994. View Article : Google Scholar : PubMed/NCBI

34 

Gasparini G and Harris AL: Clinical importance of the determination of tumor angiogenesis in breast carcinoma: Much more than a new prognostic tool. J Clin Oncol. 13:765–782. 1995.PubMed/NCBI

35 

Dickinson AJ, Fox SB, Persad RA, Hollyer J, Sibley GN and Harris AL: Quantification of angiogenesis as an independent predictor of prognosis in invasive bladder carcinomas. Br J Urol. 74:762–766. 1994. View Article : Google Scholar : PubMed/NCBI

36 

Takahashi Y, Kitadai Y, Bucana CD, Cleary KR and Ellis LM: Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res. 55:3964–3968. 1995.PubMed/NCBI

37 

Williams JK, Carlson GW, Cohen C, Derose PB, Hunter S and Jurkiewicz MJ: Tumor angiogenesis as a prognostic factor in oral cavity tumors. Am J Surg. 168:373–380. 1994. View Article : Google Scholar : PubMed/NCBI

38 

Ferrara N: Molecular and biological properties of vascular endothelial growth factor. J Mol Med Berl. 77:527–543. 1999. View Article : Google Scholar : PubMed/NCBI

39 

Boehm-Viswanathan T: Is angiogenesis inhibition the Holy Grail of cancer therapy? Curr Opin Oncol. 12:89–94. 2000. View Article : Google Scholar : PubMed/NCBI

40 

Brieger J, Kattwinkel J, Berres M, Gosepath J and Mann WJ: Impact of vascular endothelial growth factor release on radiation resistance. Oncol Rep. 18:1597–1601. 2007.PubMed/NCBI

41 

Jain RK, Duda DG, Clark JW and Loeffler JS: Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol. 3:24–40. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Chapman JD and Gillespie CJ: Radiation-induced events and their time-scale in mammalian cells. Adv Radiat Biol. 9:143–198. 1981. View Article : Google Scholar

43 

Rogakou EP, Pilch DR, Orr AH, Ivanova VS and Bonner WM: DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem. 273:5858–5868. 1998. View Article : Google Scholar : PubMed/NCBI

44 

Bonner WM, Redon CE, Dickey JS, Nakamura AJ, Sedelnikova OA, Solier S and Pommier Y: GammaH2AX and cancer. Nat Rev Cancer. 8:957–967. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Bourton EC, Plowman PN, Smith D, Arlett CF and Parris CN: Prolonged expression of the γ-H2AX DNA repair biomarker correlates with excess acute and chronic toxicity from radio-therapy treatment. Int J Cancer. 129:2928–2934. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Itokawa T, Nokihara H, Nishioka Y, Sone S, Iwamoto Y, Yamada Y, Cherrington J, McMahon G, Shibuya M, Kuwano M, et al: Antiangiogenic effect by SU5416 is partly attributable to inhibition of Flt-1 receptor signaling. Mol Cancer Ther. 1:295–302. 2002.PubMed/NCBI

47 

Peña LA, Fuks Z and Kolesnick RN: Radiation-induced apoptosis of endothelial cells in the murine central nervous system: Protection by fibroblast growth factor and sphingomyelinase deficiency. Cancer Res. 60:321–327. 2000.PubMed/NCBI

48 

Kumar P, Miller AI and Polverini PJ: p38 MAPK mediates gamma-irradiation-induced endothelial cell apoptosis, and vascular endothelial growth factor protects endothelial cells through the phosphoinositide 3-kinase-Akt-Bcl-2 pathway. J Biol Chem. 279:43352–43360. 2004. View Article : Google Scholar : PubMed/NCBI

49 

Datta SR, Brunet A and Greenberg ME: Cellular survival: A play in three Akts. Genes Dev. 13:2905–2927. 1999. View Article : Google Scholar : PubMed/NCBI

50 

Dangi S, Cha H and Shapiro P: Requirement for phosphatidylinositol-3 kinase activity during progression through S-phase and entry into mitosis. Cell Signal. 15:667–675. 2003. View Article : Google Scholar : PubMed/NCBI

51 

Kandel ES, Skeen J, Majewski N, Di Cristofano A, Pandolfi PP, Feliciano CS, Gartel A and Hay N: Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage. Mol Cell Biol. 22:7831–7841. 2002. View Article : Google Scholar : PubMed/NCBI

52 

Davies SP, Reddy H, Caivano M and Cohen P: Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 351:95–105. 2000. View Article : Google Scholar : PubMed/NCBI

53 

Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, Chen C, Zhang X, Vincent P, McHugh M, et al: BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 64:7099–7109. 2004. View Article : Google Scholar : PubMed/NCBI

54 

Roberts PJ and Der CJ: Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene. 26:3291–3310. 2007. View Article : Google Scholar : PubMed/NCBI

55 

Figueroa C, Tarras S, Taylor J and Vojtek AB: Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex. J Biol Chem. 278:47922–47927. 2003. View Article : Google Scholar : PubMed/NCBI

56 

Shonai T, Adachi M, Sakata K, Takekawa M, Endo T, Imai K and Hareyama M: MEK/ERK pathway protects ionizing radiation-induced loss of mitochondrial membrane potential and cell death in lymphocytic leukemia cells. Cell Death Differ. 9:963–971. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim EH, Kim M, Jeong YK, Cho I, You SH, Cho SH, Lee H, Jung W, Kim HD, Kim J, Kim J, et al: Mechanisms for SU5416 as a radiosensitizer of endothelial cells. Int J Oncol 47: 1440-1450, 2015.
APA
Kim, E.H., Kim, M., Jeong, Y.K., Cho, I., You, S.H., Cho, S.H. ... Kim, J. (2015). Mechanisms for SU5416 as a radiosensitizer of endothelial cells. International Journal of Oncology, 47, 1440-1450. https://doi.org/10.3892/ijo.2015.3127
MLA
Kim, E. H., Kim, M., Jeong, Y. K., Cho, I., You, S. H., Cho, S. H., Lee, H., Jung, W., Kim, H. D., Kim, J."Mechanisms for SU5416 as a radiosensitizer of endothelial cells". International Journal of Oncology 47.4 (2015): 1440-1450.
Chicago
Kim, E. H., Kim, M., Jeong, Y. K., Cho, I., You, S. H., Cho, S. H., Lee, H., Jung, W., Kim, H. D., Kim, J."Mechanisms for SU5416 as a radiosensitizer of endothelial cells". International Journal of Oncology 47, no. 4 (2015): 1440-1450. https://doi.org/10.3892/ijo.2015.3127
Copy and paste a formatted citation
x
Spandidos Publications style
Kim EH, Kim M, Jeong YK, Cho I, You SH, Cho SH, Lee H, Jung W, Kim HD, Kim J, Kim J, et al: Mechanisms for SU5416 as a radiosensitizer of endothelial cells. Int J Oncol 47: 1440-1450, 2015.
APA
Kim, E.H., Kim, M., Jeong, Y.K., Cho, I., You, S.H., Cho, S.H. ... Kim, J. (2015). Mechanisms for SU5416 as a radiosensitizer of endothelial cells. International Journal of Oncology, 47, 1440-1450. https://doi.org/10.3892/ijo.2015.3127
MLA
Kim, E. H., Kim, M., Jeong, Y. K., Cho, I., You, S. H., Cho, S. H., Lee, H., Jung, W., Kim, H. D., Kim, J."Mechanisms for SU5416 as a radiosensitizer of endothelial cells". International Journal of Oncology 47.4 (2015): 1440-1450.
Chicago
Kim, E. H., Kim, M., Jeong, Y. K., Cho, I., You, S. H., Cho, S. H., Lee, H., Jung, W., Kim, H. D., Kim, J."Mechanisms for SU5416 as a radiosensitizer of endothelial cells". International Journal of Oncology 47, no. 4 (2015): 1440-1450. https://doi.org/10.3892/ijo.2015.3127
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