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Article

Cyanidin induces apoptosis and differentiation in prostate cancer cells

  • Authors:
    • Valeria Sorrenti
    • Luca Vanella
    • Rosaria Acquaviva
    • Venera Cardile
    • Salvatore Giofrè
    • Claudia Di Giacomo
  • View Affiliations / Copyright

    Affiliations: Department of Drug Science, Biochemistry Section, University of Catania, I-95125 Catania, Italy, Department of Bio-Medical Sciences, Physiology Section, University of Catania, I-95125 Catania, Italy, Department of ‘Scienze del Farmaco e Prodotti per la Salute’, University of Messina, I-98168 Messina, Italy
  • Pages: 1303-1310
    |
    Published online on: August 24, 2015
       https://doi.org/10.3892/ijo.2015.3130
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Abstract

Several natural antioxidants, including anthocyanins, have been reported to have chemotherapeutic activity in vivo and in vitro. The aim of the present study was to delineate the anti-proliferative activity and the cytodifferentiation properties mediated by cyanidin-3-O-β-glucopyranoside (C3G) treatment in the DU145 and LnCap human prostatic cancer cell lines. C3G produced anti-proliferative effects through activation of caspase-3 and induction of p21 protein expression. The reduced cell viability was associated with a clear increase of DNA fragmentation in both cell lines after C3G treatment. Since LnCap and DU145 exhibited differences in sensitivity to C3G treatment, the redox state of these cells was further investigated by estimating the levels of ROS and GSH. C3G antioxidant activity was confirmed only in DU145 cell line. Treatment with C3G increased the levels of tumor suppressor P75NGFR, indicating a possible role of C3G in the acquisition of a normal-like cell phenotype. Results reported in the present study demonstrate that C3G, the most abundant anthocyanin in diet, may represent a new approach and highly effective strategy in reducing carcinogenesis. C3G may be considered a new therapeutic agent with both anti-proliferative and pro-differentiation properties.
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1 

Ferlay J, Parkin DM and Steliarova-Foucher E: Estimates of cancer incidence and mortality in Europe in 2008. Eur J Cancer. 46:765–781. 2010. View Article : Google Scholar : PubMed/NCBI

2 

American Cancer Society. Prostate Cancer Statistics. 2013, http://www.cancer.org. Accessed May 20, 2013

3 

American Society of Clinical Oncology Prostate Cancer Statistics. http://www.cancer.net/prostate. Accessed May 20, 2013

4 

Ito K: Prostate cancer in Asian men. Nat Rev Urol. 11:197–212. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Arnold JT and Isaacs JT: Mechanisms involved in the progression of androgen-independent prostate cancers: It is not only the cancer cell's fault. Endocr Relat Cancer. 9:61–73. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Chen J and Xu X: Diet, epigenetic, and cancer prevention. Adv Genet. 71:237–255. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Kang NJ, Shin SH, Lee HJ and Lee KW: Polyphenols as small molecular inhibitors of signaling cascades in carcinogenesis. Pharmacol Ther. 130:310–324. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Weng CJ and Yen GC: Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: Phenolic acids, monophenol, polyphenol, and their derivatives. Cancer Treat Rev. 38:76–87. 2012. View Article : Google Scholar

9 

Russo A, Piovano M, Lombardo L, Vanella L, Cardile V and Garbarino J: Pannarin inhibits cell growth and induces cell death in human prostate carcinoma DU-145 cells. Anticancer Drugs. 17:1163–1169. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Yim D, Singh RP, Agarwal C, Lee S, Chi H and Agarwal R: A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells. Cancer Res. 65:1035–1044. 2005.PubMed/NCBI

11 

Cardile V, Scifo C, Russo A, Falsaperla M, Morgia G, Motta M, Renis M, Imbriani E and Silvestre G: Involvement of HSP70 in resveratrol-induced apoptosis of human prostate cancer. Anticancer Res. 23C:4921–4926. 2003.

12 

Russo A, Berretta M, Cardile V, Lombardo L, Vanella L, Troncoso N, Garbarino J, Ignazio B and Li Volti G: Pharmacological induction of heme oxygenase-1 reduces KB cell viability: Role of carbon monoxide. J Carcinog & Mutagen. 2014, http://dx.doi.org/10.4172/2157-2518.S8-009. Accessed April 16, 2014

13 

Waxman S: Differentiation therapy in acute myelogenous leukemia (non-APL). Leukemia. 14:491–496. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Vanella L, Barbagallo I, Acquaviva R, Di Giacomo C, Cardile V, Abraham NG and Sorrenti V: Ellagic acid: Cytodifferentiating and antiproliferative effects in human prostatic cancer cell lines. Curr Pharm Des. 19:2728–2736. 2013. View Article : Google Scholar

15 

Breitman T, Collins SJ and Keene B: Terminal differentiation of human promyelocytic leukemic cells in promyelocytic leukemic cells in primary culture response to retinoic acid. Blood. 57:1000–1004. 1981.PubMed/NCBI

16 

Ohno R, Asou N and Ohnishi K: Treatment of acute promyelocytic leukemia: Strategy toward further increase of cure rate. Leukemia. 17:1454–1463. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Vanella L, Di Giacomo C, Acquaviva R, Barbagallo I, Cardile V, Kim DH, Abraham NG and Sorrenti V: Apoptotic markers in a prostate cancer cell line: Effect of ellagic acid. Oncol Rep. 30:2804–2810. 2013.PubMed/NCBI

18 

Vanella L, Di Giacomo C, Acquaviva R, Barbagallo I, Li Volti G, Cardile V, Abraham NG and Sorrenti V: Effects of ellagic Acid on angiogenic factors in prostate cancer cells. Cancers (Basel). 5:726–738. 2013. View Article : Google Scholar

19 

Wang H, Race EJ and Shrikhande AJ: Characterization of antho-cyanins in grape juices by ion trap liquid chromatography-mass spectrometry. J Agric Food Chem. 51:1839–1844. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Seeram NP, Cichewicz RH, Chandra A and Nair MG: Cyclooxygenase inhibitory and antioxidant compounds from crabapple fruits. J Agric Food Chem. 51:1948–1951. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Amorini AM, Fazzina G, Lazzarino G, Tavazzi B, Di Pierro D, Santucci R, Sinibaldi F, Galvano F and Galvano G: Activity and mechanism of the antioxidant properties of cyanidin-3-O-beta-glucopyranoside. Free Radic Res. 35:953–966. 2001. View Article : Google Scholar

22 

Lee HS: Characterization of major anthocyanins and the color of red-fleshed Budd Blood orange (Citrus sinensis). J Agric Food Chem. 50:1243–1246. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Matsumoto H, Inaba H, Kishi M, Tominaga S, Hirayama M and Tsuda T: Orally administered delphinidin 3-rutinoside and cyanidin 3-rutinoside are directly absorbed in rats and humans and appear in the blood as the intact forms. J Agric Food Chem. 49:1546–1551. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Tsuda T, Horio F and Osawa T: Absorption and metabolism of cyanidin 3-O-beta-D-glucoside in rats. FEBS Lett. 449:179–182. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Ichikawa H, Ichiyanagi T, Xu B, Yoshii Y, Nakajima M and Konishi T: Antioxidant activity of anthocyanin extract from purple black rice. J Med Food. 4:211–218. 2001. View Article : Google Scholar

26 

Kähkönen MP and Heinonen M: Antioxidant activity of antho-cyanins and their aglycons. J Agric Food Chem. 51:628–633. 2003. View Article : Google Scholar

27 

Briviba K, Abrahamse SL, Pool-Zobel BL and Rechkemmer G: Neurotensin-and EGF-induced metabolic activation of colon carcinoma cells is diminished by dietary flavonoid cyanidin but not by its glycosides. Nutr Cancer. 41:172–179. 2001. View Article : Google Scholar

28 

Hagiwara A, Miyashita K, Nakanishi T, Sano M, Tamano S, Kadota T, Koda T, Nakamura M, Imaida K, Ito N, et al: Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine. Cancer Lett. 171:17–25. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Fimognari C, Berti F, Nüsse M, Cantelli-Forti G and Hrelia P: Induction of apoptosis in two human leukemia cell lines as well as differentiation in human promyelocytic cells by cyanidin-3-O-beta-glucopyranoside. Biochem Pharmacol. 67:2047–2056. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Serafino A, Sinibaldi-Vallebona P, Lazzarino G, Tavazzi B, Rasi G, Pierimarchi P, Andreola F, Moroni G, Galvano G, Galvano F, et al: Differentiation of human melanoma cells induced by cyanidin-3-O-β-glucopyranoside. FASEB J. 18:1940–1942. 2004.PubMed/NCBI

31 

Traverso N, Ricciarelli R, Nitti M, Marengo B, Furfaro AL, Pronzato MA, Marinari UM and Domenicotti C: Role of glutathione in cancer progression and chemoresistance. Oxid Med Cell Longev. 2013:9729132013. View Article : Google Scholar : PubMed/NCBI

32 

Vanella L, Di Giacomo C, Acquaviva R, Santangelo R, Cardile V, Barbagallo I, Abraham NG and Sorrenti V: The DDAH/NOS pathway in human prostatic cancer cell lines: Antiangiogenic effect of L-NAME. Int J Oncol. 39:1303–1310. 2011.PubMed/NCBI

33 

Sigala S, Tognazzi N, Rizzetti MC, Faraoni I, Missale C, Bonmassar E and Spano P: Nerve growth factor induces the re-expression of functional androgen receptors and p75(NGFR) in the androgen-insensitive prostate cancer cell line DU145. Eur J Endocrinol. 147:407–415. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:248–254. 1976. View Article : Google Scholar : PubMed/NCBI

35 

Acquaviva R, Di Giacomo C, Sorrenti V, Galvano F, Santangelo R, Cardile V, Gangia S, D'Orazio N, Abraham NG and Vanella L: Antiproliferative effect of oleuropein in prostate cell lines. Int J Oncol. 41:31–38. 2012.PubMed/NCBI

36 

Romeo R, Giofrè SV, Garozzo A, Bisignano B, Corsaro A and Chiacchio MA: Synthesis and biological evaluation of furopyrimidine N,O-nucleosides. Bioorg Med Chem. 21:5688–5693. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Romeo R, Giofrè SV, Carnovale C, Campisi A, Parenti R, Bandini L and Chiacchio MA: Synthesis and biological evaluation of 3-hydroxymethyl-5-(1H-1,2,3-triazol) isoxazolidines. Bioorg Med Chem. 21:7929–7937. 2013. View Article : Google Scholar

38 

Calabrese V, Cornelius C, Trovato A, Cavallaro M, Mancuso C, Di Rienzo L, Condorelli D, De Lorenzo A and Calabrese EJ: The hormetic role of dietary antioxidants in free radical-related diseases. Curr Pharm Des. 16:877–883. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Renis M, Calandra L, Scifo C, Tomasello B, Cardile V, Vanella L, Bei R, La Fauci L and Galvano F: Response of cell cycle/stress-related protein expression and DNA damage upon treatment of CaCo2 cells with anthocyanins. Br J Nutr. 100:27–35. 2008. View Article : Google Scholar

40 

Alimirah F, Chen J, Basrawala Z, Xin H and Choubey D: DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: Implications for the androgen receptor functions and regulation. FEBS Lett. 580:2294–2300. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Litvinov IV, Antony L, Dalrymple SL, Becker R, Cheng L and Isaacs JT: PC3, but not DU145, human prostate cancer cells retain the coregulators required for tumor suppressor ability of androgen receptor. Prostate. 66:1329–1338. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Hagiwara Y, Kasukabe T, Kaneko Y, Niitsu N and Okabe-Kado J: Ellagic acid, a natural polyphenolic compound, induces apoptosis and potentiates retinoic acid-induced differentiation of human leukemia HL-60 cells. Int J Hematol. 92:136–143. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Yang Z, Chen H, Huo L, Yang Z, Bai Y, Fan X, Ni B, Fang L, Hu J, Peng J, et al: Epigenetic inactivation and tumor-suppressor behavior of NGFR in human colorectal cancer. Mol Cancer Res. 13:107–119. 2015. View Article : Google Scholar

44 

Panayiotidis M: Reactive oxygen species (ROS) in multistage carcinogenesis. Cancer Lett. 266:3–5. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Meister A: Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy. Pharmacol Ther. 51:155–194. 1991. View Article : Google Scholar : PubMed/NCBI

46 

Shaw JP and Chou IN: Elevation of intracellular glutathione content associated with mitogenic stimulation of quiescent fibroblasts. J Cell Physiol. 129:193–198. 1986. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sorrenti V, Vanella L, Acquaviva R, Cardile V, Giofrè S and Di Giacomo C: Cyanidin induces apoptosis and differentiation in prostate cancer cells. Int J Oncol 47: 1303-1310, 2015.
APA
Sorrenti, V., Vanella, L., Acquaviva, R., Cardile, V., Giofrè, S., & Di Giacomo, C. (2015). Cyanidin induces apoptosis and differentiation in prostate cancer cells. International Journal of Oncology, 47, 1303-1310. https://doi.org/10.3892/ijo.2015.3130
MLA
Sorrenti, V., Vanella, L., Acquaviva, R., Cardile, V., Giofrè, S., Di Giacomo, C."Cyanidin induces apoptosis and differentiation in prostate cancer cells". International Journal of Oncology 47.4 (2015): 1303-1310.
Chicago
Sorrenti, V., Vanella, L., Acquaviva, R., Cardile, V., Giofrè, S., Di Giacomo, C."Cyanidin induces apoptosis and differentiation in prostate cancer cells". International Journal of Oncology 47, no. 4 (2015): 1303-1310. https://doi.org/10.3892/ijo.2015.3130
Copy and paste a formatted citation
x
Spandidos Publications style
Sorrenti V, Vanella L, Acquaviva R, Cardile V, Giofrè S and Di Giacomo C: Cyanidin induces apoptosis and differentiation in prostate cancer cells. Int J Oncol 47: 1303-1310, 2015.
APA
Sorrenti, V., Vanella, L., Acquaviva, R., Cardile, V., Giofrè, S., & Di Giacomo, C. (2015). Cyanidin induces apoptosis and differentiation in prostate cancer cells. International Journal of Oncology, 47, 1303-1310. https://doi.org/10.3892/ijo.2015.3130
MLA
Sorrenti, V., Vanella, L., Acquaviva, R., Cardile, V., Giofrè, S., Di Giacomo, C."Cyanidin induces apoptosis and differentiation in prostate cancer cells". International Journal of Oncology 47.4 (2015): 1303-1310.
Chicago
Sorrenti, V., Vanella, L., Acquaviva, R., Cardile, V., Giofrè, S., Di Giacomo, C."Cyanidin induces apoptosis and differentiation in prostate cancer cells". International Journal of Oncology 47, no. 4 (2015): 1303-1310. https://doi.org/10.3892/ijo.2015.3130
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