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Article

Myricetin inhibits proliferation of cisplatin-resistant cancer cells through a p53-dependent apoptotic pathway

  • Authors:
    • Haizhi Huang
    • Allen Y. Chen
    • Xingqian Ye
    • Bingyun Li
    • Yon Rojanasakul
    • Gary O. Rankin
    • Yi Charlie Chen
  • View Affiliations / Copyright

    Affiliations: College of Science, Technology and Mathematics, Alderson Broaddus University, Philippi, WV 26416, USA, Department of Pharmaceutical Science, West Virginia University, Morgantown, WV 26506, USA, College of Biosystems Engineering and Food Science, Fuli Institute of Food Science, Zhejiang University, Hangzhou, Zhejiang 310027, P.R. China, Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, WV 26506, USA, Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA
  • Pages: 1494-1502
    |
    Published online on: August 25, 2015
       https://doi.org/10.3892/ijo.2015.3133
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Abstract

Cisplatin is a commonly used drug for cancer treatment by crosslinking DNA, leading to apoptosis of cancer cells, resistance to cisplatin treatment often occurs, leading to relapse. Therefore, there is a need for the development of more effective treatment strategies that can overcome chemoresistance. Myricetin is a flavonoid from fruits and vegetables, showing anticancer activity in various cancer cells. In this study, we found myricetin exhibited greater cytotoxicity than cisplatin in two cisplatin-resistant ovarian cancer cell lines, OVCAR-3 and A2780/CP70, and it was less cytotoxic to the normal ovarian cell line IOSE-364. Myricetin selectively induced apoptosis in both cisplatin-resistant cancer cell lines, but did not induce apoptosis in the normal ovarian cell line. It induced both Bcl-2 family-dependent intrinsic and DR5 dependent extrinsic apoptosis in OVCAR-3 cells. P53, a multifunctional tumor suppressor, regulated apoptosis in OVCAR-3 cells through a Bcl-2 family protein-dependent pathway. Myricetin did not induce cell cycle arrest in either ovarian cancer cell line. Because of its potency and selectivity against cisplatin-resistant cancer cells, myricetin could potentially be used to overcome cancer chemoresistance against platinum-based therapy.
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View References

1 

Stordal B and Davey M: Understanding cisplatin resistance using cellular models. IUBMB Life. 59:696–699. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Loehrer PJ and Einhorn LH: Drugs five years later. Cisplatin Ann Intern Med. 100:704–713. 1984. View Article : Google Scholar

3 

Milosavljevic N, Duranton C, Djerbi N, Puech PH, Gounon P, Lagadic-Gossmann D, Dimanche-Boitrel MT, Rauch C, Tauc M, Counillon L, et al: Nongenomic effects of cisplatin: Acute inhibition of mechanosensitive transporters and channels without actin remodeling. Cancer Res. 70:7514–7522. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Windsor RE, Strauss SJ, Kallis C, Wood NE and Whelan JS: Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma: A pilot study. Cancer. 118:1856–1867. 2012. View Article : Google Scholar

5 

Levi JA, Aroney RS and Dalley DN: Haemolytic anaemia after cisplatin treatment. Br Med J (Clin Res Ed). 282:2003–2004. 1981. View Article : Google Scholar

6 

Hall MD, Okabe M, Shen DW, Liang XJ and Gottesman MM: The role of cellular accumulation in determining sensitivity to platinum-based chemotherapy. Annu Rev Pharmacol Toxicol. 48:495–535. 2008. View Article : Google Scholar

7 

Champeris Tsaniras S, Kanellakis N, Symeonidou IE, Nikolopoulou P, Lygerou Z and Taraviras S: Licensing of DNA replication, cancer, pluripotency and differentiation: An interlinked world? Semin Cell Dev Biol. 30:174–180. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Buolamwini JK: Cell cycle molecular targets in novel anticancer drug discovery. Curr Pharm Des. 6:379–392. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Diaz-Moralli S, Tarrado-Castellarnau M, Miranda A and Cascante M: Targeting cell cycle regulation in cancer therapy. Pharmacol Ther. 138:255–271. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Brunelle JK and Letai A: Control of mitochondrial apoptosis by the Bcl-2 family. J Cell Sci. 122:437–441. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Gates MA, Vitonis AF, Tworoger SS, Rosner B, Titus-Ernstoff L, Hankinson SE and Cramer DW: Flavonoid intake and ovarian cancer risk in a population-based case-control study. Int J Cancer. 124:1918–1925. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Ong KC and Khoo HE: Biological effects of myricetin. Gen Pharmacol. 29:121–126. 1997. View Article : Google Scholar : PubMed/NCBI

13 

Ross JA and Kasum CM: Dietary flavonoids: Bioavailability, metabolic effects, and safety. Annu Rev Nutr. 22:19–34. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Basli A, Soulet S, Chaher N, Mérillon JM, Chibane M, Monti JP and Richard T: Wine polyphenols: Potential agents in neuro-protection. Oxid Med Cell Longev. 2012:8057622012. View Article : Google Scholar

15 

Zhang XH, Chen SY, Tang L, Shen YZ, Luo L, Xu CW, Liu Q and Li D: Myricetin induces apoptosis in HepG2 cells through Akt/p70S6K/bad signaling and mitochondrial apoptotic pathway. Anticancer Agents Med Chem. 13:1575–1581. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Phillips PA, Sangwan V, Borja-Cacho D, Dudeja V, Vickers SM and Saluja AK: Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathway. Cancer Lett. 308:181–188. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Zang W, Wang T, Wang Y, Li M, Xuan X, Ma Y, Du Y, Liu K, Dong Z and Zhao G: Myricetin exerts anti-proliferative, anti-invasive, and pro-apoptotic effects on esophageal carcinoma EC9706 and KYSE30 cells via RSK2. Tumour Biol. 35:12583–12592. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Kim ME, Ha TK, Yoon JH and Lee JS: Myricetin induces cell death of human colon cancer cells via BAX/BCL2-dependent pathway. Anticancer Res. 34:701–706. 2014.PubMed/NCBI

19 

Li B, Gao Y, Rankin GO, Rojanasakul Y, Cutler SJ, Tu Y and Chen YC: Chaetoglobosin K induces apoptosis and G2 cell cycle arrest through p53-dependent pathway in cisplatin-resistant ovarian cancer cells. Cancer Lett. 356:418–433. 2015. View Article : Google Scholar

20 

Darcy KM, Brady WE, McBroom JW, Bell JG, Young RC, McGuire WP, Linnoila RI, Hendricks D, Bonome T and Farley JH; Gynecologic Oncology Group. Associations between p53 overexpression and multiple measures of clinical outcome in high-risk, early stage or suboptimally-resected, advanced stage epithelial ovarian cancers A Gynecologic Oncology Group study. Gynecol Oncol. 111:487–495. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Yang YI, Kim JH, Lee KT and Choi JH: Costunolide induces apoptosis in platinum-resistant human ovarian cancer cells by generating reactive oxygen species. Gynecol Oncol. 123:588–596. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Wilson TR, Johnston PG and Longley DB: Anti-apoptotic mechanisms of drug resistance in cancer. Curr Cancer Drug Targets. 9:307–319. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Liu T, Hannafon B, Gill L, Kelly W and Benbrook D: Flex-Hets differentially induce apoptosis in cancer over normal cells by directly targeting mitochondria. Mol Cancer Ther. 6:1814–1822. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Ozören N and El-Deiry WS: Cell surface death receptor signaling in normal and cancer cells. Semin Cancer Biol. 13:135–147. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Maggioni D, Nicolini G, Rigolio R, Biffi L, Pignataro L, Gaini R and Garavello W: Myricetin and naringenin inhibit human squamous cell carcinoma proliferation and migration in vitro. Nutr Cancer. 66:1257–1267. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Shiomi K, Kuriyama I, Yoshida H and Mizushina Y: Inhibitory effects of myricetin on mammalian DNA polymerase, topoisomerase and human cancer cell proliferation. Food Chem. 139:910–918. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Kong D, Ma S, Liang B, Yi H, Zhao Y, Xin R, Cui L, Jia L and Liu X and Liu X: The different regulatory effects of p53 status on multidrug resistance are determined by autophagy in ovarian cancer cells. Biomed Pharmacother. 66:271–278. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Hollstein M, Sidransky D, Vogelstein B and Harris CC: p53 mutations in human cancers. Science. 253:49–53. 1991. View Article : Google Scholar : PubMed/NCBI

29 

Kuo YC, Kuo PL, Hsu YL, Cho CY and Lin CC: Ellipticine induces apoptosis through p53-dependent pathway in human hepatocellular carcinoma HepG2 cells. Life Sci. 78:2550–2557. 2006. View Article : Google Scholar

30 

Basu A and Haldar S: The relationship between BcI2, Bax and p53: Consequences for cell cycle progression and cell death. Mol Hum Reprod. 4:1099–1109. 1998. View Article : Google Scholar

31 

Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P and Moll UM: p53 has a direct apoptogenic role at the mitochondria. Mol Cell. 11:577–590. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Guan YQ, Li Z, Yang A, Huang Z, Zheng Z, Zhang L, Li L and Liu JM: Cell cycle arrest and apoptosis of OVCAR-3 and MCF-7 cells induced by co-immobilized TNF-α plus IFN-γ on polystyrene and the role of p53 activation. Biomaterials. 33:6162–6171. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Ho JS, Ma W, Mao DY and Benchimol S: p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest. Mol Cell Biol. 25:7423–7431. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Hermeking H and Eick D: Mediation of c-Myc-induced apoptosis by p53. Science. 265:2091–2093. 1994. View Article : Google Scholar : PubMed/NCBI

35 

Gartel AL and Radhakrishnan SK: Lost in transcription: p21 repression, mechanisms, and consequences. Cancer Res. 65:3980–3985. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Zhang XH, Zou ZQ, Xu CW, Shen YZ and Li D: Myricetin induces G2/M phase arrest in HepG2 cells by inhibiting the activity of the cyclin B/Cdc2 complex. Mol Med Rep. 4:273–277. 2011.PubMed/NCBI

37 

Piccolo MT and Crispi S: The dual role played by p21 may influence the apoptotic or anti-apoptotic fate in cancer. J Cancer Res Updates. 1:189–202. 2012.

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Copy and paste a formatted citation
Spandidos Publications style
Huang H, Chen AY, Ye X, Li B, Rojanasakul Y, Rankin GO and Chen YC: Myricetin inhibits proliferation of cisplatin-resistant cancer cells through a p53-dependent apoptotic pathway. Int J Oncol 47: 1494-1502, 2015.
APA
Huang, H., Chen, A.Y., Ye, X., Li, B., Rojanasakul, Y., Rankin, G.O., & Chen, Y.C. (2015). Myricetin inhibits proliferation of cisplatin-resistant cancer cells through a p53-dependent apoptotic pathway. International Journal of Oncology, 47, 1494-1502. https://doi.org/10.3892/ijo.2015.3133
MLA
Huang, H., Chen, A. Y., Ye, X., Li, B., Rojanasakul, Y., Rankin, G. O., Chen, Y. C."Myricetin inhibits proliferation of cisplatin-resistant cancer cells through a p53-dependent apoptotic pathway". International Journal of Oncology 47.4 (2015): 1494-1502.
Chicago
Huang, H., Chen, A. Y., Ye, X., Li, B., Rojanasakul, Y., Rankin, G. O., Chen, Y. C."Myricetin inhibits proliferation of cisplatin-resistant cancer cells through a p53-dependent apoptotic pathway". International Journal of Oncology 47, no. 4 (2015): 1494-1502. https://doi.org/10.3892/ijo.2015.3133
Copy and paste a formatted citation
x
Spandidos Publications style
Huang H, Chen AY, Ye X, Li B, Rojanasakul Y, Rankin GO and Chen YC: Myricetin inhibits proliferation of cisplatin-resistant cancer cells through a p53-dependent apoptotic pathway. Int J Oncol 47: 1494-1502, 2015.
APA
Huang, H., Chen, A.Y., Ye, X., Li, B., Rojanasakul, Y., Rankin, G.O., & Chen, Y.C. (2015). Myricetin inhibits proliferation of cisplatin-resistant cancer cells through a p53-dependent apoptotic pathway. International Journal of Oncology, 47, 1494-1502. https://doi.org/10.3892/ijo.2015.3133
MLA
Huang, H., Chen, A. Y., Ye, X., Li, B., Rojanasakul, Y., Rankin, G. O., Chen, Y. C."Myricetin inhibits proliferation of cisplatin-resistant cancer cells through a p53-dependent apoptotic pathway". International Journal of Oncology 47.4 (2015): 1494-1502.
Chicago
Huang, H., Chen, A. Y., Ye, X., Li, B., Rojanasakul, Y., Rankin, G. O., Chen, Y. C."Myricetin inhibits proliferation of cisplatin-resistant cancer cells through a p53-dependent apoptotic pathway". International Journal of Oncology 47, no. 4 (2015): 1494-1502. https://doi.org/10.3892/ijo.2015.3133
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