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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October-2015 Volume 47 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

miR-873 acts as a novel sensitizer of glioma cells to cisplatin by targeting Bcl-2

  • Authors:
    • Xiong Chen
    • Yingying Zhang
    • Yingying Shi
    • Haiwei Lian
    • Huilin Tu
    • Song Han
    • Biwen Peng
    • Wanhong Liu
    • Xiaohua He
  • View Affiliations / Copyright

    Affiliations: School of Basic Medical Sciences, Wuhan University, Wuhan 430071, P.R. China, Department of Neurosurgery, Wuhan University Renmin Hospital, Wuhan 430071, P.R. China
  • Pages: 1603-1611
    |
    Published online on: August 31, 2015
       https://doi.org/10.3892/ijo.2015.3143
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Abstract

Treatment with cisplatin, a chemotherapeutic agent commonly used in glioma patients, often results in chemoresistance. Increasing evidence has shown that microRNAs (miRNAs) are implicated in the drug resistance of gliomas. However, the function of miR‑873 in cisplatin resistance of gliomas remains unknown. In this study, we found that many miRNAs, including miR‑873, are differentially expressed in cisplatin-resistant glioma cells compared to wild-type glioma cells. Moreover, cisplatin reduced the expression of miR‑873 in a time-dependent manner. Overexpression of miR‑873 decreased the cell proliferation, migration and invasion while increased apoptosis of cisplatin-resistant glioma cells and sensitized the cells to cisplatin-induced cell growth arrest and apoptosis. Furthermore, miR‑873 was downregulated while Bcl-2 was upregulated in the tissues of twelve high-grade glioma patients compared to seven normal brain tissues, and the miR‑873 level was negatively correlated with the Bcl-2 protein level. A luciferase reporter assay further confirmed that Bcl-2 was a direct target of miR‑873, and miR‑873 decreased the level of the Bcl-2 protein in cisplatin-resistant glioma cells. Notably, re-expression of Bcl-2 attenuated the function of miR‑873 in cisplatin-resistant glioma cells and the sensitivity of the cells to cisplatin. Taken together, these data suggest that miR‑873 might be a potential marker for cisplatin resistance and a promising sensitizer in cisplatin treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Chen X, Zhang Y, Shi Y, Lian H, Tu H, Han S, Peng B, Liu W and He X: miR-873 acts as a novel sensitizer of glioma cells to cisplatin by targeting Bcl-2. Int J Oncol 47: 1603-1611, 2015.
APA
Chen, X., Zhang, Y., Shi, Y., Lian, H., Tu, H., Han, S. ... He, X. (2015). miR-873 acts as a novel sensitizer of glioma cells to cisplatin by targeting Bcl-2. International Journal of Oncology, 47, 1603-1611. https://doi.org/10.3892/ijo.2015.3143
MLA
Chen, X., Zhang, Y., Shi, Y., Lian, H., Tu, H., Han, S., Peng, B., Liu, W., He, X."miR-873 acts as a novel sensitizer of glioma cells to cisplatin by targeting Bcl-2". International Journal of Oncology 47.4 (2015): 1603-1611.
Chicago
Chen, X., Zhang, Y., Shi, Y., Lian, H., Tu, H., Han, S., Peng, B., Liu, W., He, X."miR-873 acts as a novel sensitizer of glioma cells to cisplatin by targeting Bcl-2". International Journal of Oncology 47, no. 4 (2015): 1603-1611. https://doi.org/10.3892/ijo.2015.3143
Copy and paste a formatted citation
x
Spandidos Publications style
Chen X, Zhang Y, Shi Y, Lian H, Tu H, Han S, Peng B, Liu W and He X: miR-873 acts as a novel sensitizer of glioma cells to cisplatin by targeting Bcl-2. Int J Oncol 47: 1603-1611, 2015.
APA
Chen, X., Zhang, Y., Shi, Y., Lian, H., Tu, H., Han, S. ... He, X. (2015). miR-873 acts as a novel sensitizer of glioma cells to cisplatin by targeting Bcl-2. International Journal of Oncology, 47, 1603-1611. https://doi.org/10.3892/ijo.2015.3143
MLA
Chen, X., Zhang, Y., Shi, Y., Lian, H., Tu, H., Han, S., Peng, B., Liu, W., He, X."miR-873 acts as a novel sensitizer of glioma cells to cisplatin by targeting Bcl-2". International Journal of Oncology 47.4 (2015): 1603-1611.
Chicago
Chen, X., Zhang, Y., Shi, Y., Lian, H., Tu, H., Han, S., Peng, B., Liu, W., He, X."miR-873 acts as a novel sensitizer of glioma cells to cisplatin by targeting Bcl-2". International Journal of Oncology 47, no. 4 (2015): 1603-1611. https://doi.org/10.3892/ijo.2015.3143
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