Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
November-2015 Volume 47 Issue 5

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2015 Volume 47 Issue 5

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

A quantitative proteomics study on olfactomedin 4 in the development of gastric cancer

  • Authors:
    • Xiaoping Ran
    • Xiaoming Xu
    • Yixuan Yang
    • Sha She
    • Min Yang
    • Shiying Li
    • Hong Peng
    • Xiangchun Ding
    • Huaidong Hu
    • Peng Hu
    • Dazhi Zhang
    • Hong Ren
    • Ligang Wu
    • Weiqun Zeng
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China, Department of Infectious Diseases, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China, Department of Oncological Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China
  • Pages: 1932-1944
    |
    Published online on: September 16, 2015
       https://doi.org/10.3892/ijo.2015.3168
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Gastric cancer (GC) is now one of the most common malignancies with a relatively high incidence and high mortality rate. The prognosis is closely related to the degree of tumor metastasis. The mechanism of metastasis is still unclear. Proteomics analysis is a powerful tool to study and evaluate protein expression in tumor tissues. In the present study, we collected 15 gastric cancer and adjacent normal gastric tissues and used the isobaric tags for relative and absolute quantitation (iTRAQ) method to identify differentially expressed proteins. A total of 134 proteins were differentially expressed between the cancerous and non-cancerous samples. Azurocidin 1 (AZU1), CPVL, olfactomedin 4 (OLFM4) and Villin 1 (VIL1) were upregulated and confirmed by western blot analysis, real-time quantitative PCR and immunohistochemical analyses. These results were in accordance with iTRAQ. Furthermore, silencing the OLFM4 expression suppressed the migration, invasion and proliferation of the GC cells in vitro. The present study represents a successful application of the iTRAQ method in analyzing the expression levels of thousands of proteins. Overexpression of OLFM4 in gastric cancer may induce the development of gastric cancer. Overall, suppression of OLFM4 expression may be a promising strategy in the development of novel cancer therapeutic drugs.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Loomis D, Huang W and Chen G: The International Agency for Research on Cancer (IARC) evaluation of the carcinogenicity of outdoor air pollution: Focus on China. Chin J Cancer. 33:189–196. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Takeno S, Noguchi T, Kikuchi R, Sato T, Uchida Y and Yokoyama S: Analysis of the survival period in resectable stage IV gastric cancer. Ann Surg Oncol. 8:215–221. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Klose J and Kobalz U: Two-dimensional electrophoresis of proteins: An updated protocol and implications for a functional analysis of the genome. Electrophoresis. 16:1034–1059. 1995. View Article : Google Scholar : PubMed/NCBI

4 

Görg A, Obermaier C, Boguth G, Harder A, Scheibe B, Wildgruber R and Weiss W: The current state of two-dimensional electrophoresis with immobilized pH gradients. Electrophoresis. 21:1037–1053. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Ross PL, Huang YN, Marchese JN, Williamson B, Parker K, Hattan S, Khainovski N, Pillai S, Dey S, Daniels S, et al: Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents. Mol Cell Proteomics. 3:1154–1169. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Gygi SP, Rist B, Gerber SA, Turecek F, Gelb MH and Aebersold R: Quantitative analysis of complex protein mixtures using isotope-coded affinity tags. Nat Biotechnol. 17:994–999. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Mirgorodskaya OA, Kozmin YP, Titov MI, Körner R, Sönksen CP and Roepstorff P: Quantitation of peptides and proteins by matrix-assisted laser desorption/ionization mass spectrometry using (18)O-labeled internal standards. Rapid Commun Mass Spectrom. 14:1226–1232. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Ong SE, Blagoev B, Kratchmarova I, Kristensen DB, Steen H, Pandey A and Mann M: Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics. 1:376–386. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Wang LN, Tong SW, Hu HD, Ye F, Li SL, Ren H, Zhang DZ, Xiang R and Yang YX: Quantitative proteome analysis of ovarian cancer tissues using a iTRAQ approach. J Cell Biochem. 113:3762–3772. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Yang Y, Toy W, Choong LY, Hou P, Ashktorab H, Smoot DT, Yeoh KG and Lim YP: Discovery of SLC3A2 cell membrane protein as a potential gastric cancer biomarker: Implications in molecular imaging. J Proteome Res. 11:5736–5747. 2012.PubMed/NCBI

11 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−ΔΔC(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

12 

Ho J, Kong JW, Choong LY, Loh MC, Toy W, Chong PK, Wong CH, Wong CY, Shah N and Lim YP: Novel breast cancer metastasis-associated proteins. J Proteome Res. 8:583–594. 2009. View Article : Google Scholar

13 

Gan CS, Chong PK, Pham TK and Wright PC: Technical, experimental, and biological variations in isobaric tags for relative and absolute quantitation (iTRAQ). J Proteome Res. 6:821–827. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Chen Y, Choong LY, Lin Q, Philp R, Wong CH, Ang BK, Tan YL, Loh MC, Hew CL, Shah N, et al: Differential expression of novel tyrosine kinase substrates during breast cancer development. Mol Cell Proteomics. 6:2072–2087. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Chong PK, Lee H, Zhou J, Liu SC, Loh MC, So JB, Lim KH, Yeoh KG and Lim YP: Reduced plasma APOA1 level is associated with gastric tumor growth in MKN45 mouse xenograft model. J Proteomics. 73:1632–1640. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Pierce A, Unwin RD, Evans CA, Griffiths S, Carney L, Zhang L, Jaworska E, Lee CF, Blinco D, Okoniewski MJ, et al: Eight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases. Mol Cell Proteomics. 7:853–863. 2008. View Article : Google Scholar

17 

Zhou C, Simpson KL, Lancashire LJ, Walker MJ, Dawson MJ, Unwin RD, Rembielak A, Price P, West C, Dive C, et al: Statistical considerations of optimal study design for human plasma proteomics and biomarker discovery. J Proteome Res. 11:2103–2113. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Chong PK, Lee H, Loh MC, Choong LY, Lin Q, So JB, Lim KH, Soo RA, Yong WP, Chan SP, et al: Upregulation of plasma C9 protein in gastric cancer patients. Proteomics. 10:3210–3221. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Lim S, Choong LY, Kuan CP, Yunhao C and Lim YP: Regulation of macrophage inhibitory factor (MIF) by epidermal growth factor receptor (EGFR) in the MCF10AT model of breast cancer progression. J Proteome Res. 8:4062–4076. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Yang Y, Lim SK, Choong LY, Lee H, Chen Y, Chong PK, Ashktorab H, Wang TT, Salto-Tellez M, Yeoh KG, et al: Cathepsin S mediates gastric cancer cell migration and invasion via a putative network of metastasis-associated proteins. J Proteome Res. 9:4767–4778. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Choong LY, Lim S, Chong PK, Wong CY, Shah N and Lim YP: Proteome-wide profiling of the MCF10AT breast cancer progression model. PLoS One. 5:e110302010. View Article : Google Scholar : PubMed/NCBI

22 

Xie TX, Wei D, Liu M, Gao AC, Ali-Osman F, Sawaya R and Huang S: Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene. 23:3550–3560. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Yu H, Pardoll D and Jove R: STATs in cancer inflammation and immunity: A leading role for STAT3. Nat Rev Cancer. 9:798–809. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Huang Y, Yang M, Yang H and Zeng Z: Upregulation of the GRIM-19 gene suppresses invasion and metastasis of human gastric cancer SGC-7901 cell line. Exp Cell Res. 316:2061–2070. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Li C, Yan M, Chen J, Xiang M, Zhu ZG, Yin HR and Lin YZ: Survival benefit of non-curative gastrectomy for gastric cancer patients with synchronous distant metastasis. J Gastrointest Surg. 14:282–288. 2010. View Article : Google Scholar

26 

Yu L, Wang L and Chen S: Olfactomedin 4, a novel marker for the differentiation and progression of gastrointestinal cancers. Neoplasma. 58:9–13. 2011. View Article : Google Scholar

27 

Zeng LC, Han ZG and Ma WJ: Elucidation of subfamily segregation and intramolecular coevolution of the olfactomedin-like proteins by comprehensive phylogenetic analysis and gene expression pattern assessment. FEBS Lett. 579:5443–5453. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Tomarev SI and Nakaya N: Olfactomedin domain-containing proteins: Possible mechanisms of action and functions in normal development and pathology. Mol Neurobiol. 40:122–138. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Liu W, Zhu J, Cao L and Rodgers GP: Expression of hGC-1 is correlated with differentiation of gastric carcinoma. Histopathology. 51:157–165. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Besson D1, Pavageau AH, Valo I, Bourreau A, Bélanger A, Eymerit-Morin C, Moulière A, Chassevent A, Boisdron-Celle M, Morel A, et al: A quantitative proteomic approach of the different stages of colorectal cancer establishes OLFM4 as a new nonmetastatic tumor marker. Mol Cell Proteomics. 10:M111.0097122011. View Article : Google Scholar : PubMed/NCBI

31 

Kobayashi D, Koshida S, Moriai R, Tsuji N and Watanabe N: Olfactomedin 4 promotes S-phase transition in proliferation of pancreatic cancer cells. Cancer Sci. 98:334–340. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Koshida S, Kobayashi D, Moriai R, Tsuji N and Watanabe N: Specific overexpression of OLFM4(GW112/HGC-1) mRNA in colon, breast and lung cancer tissues detected using quantitative analysis. Cancer Sci. 98:315–320. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Marimuthu A, Chavan S, Sathe G, Sahasrabuddhe NA, Srikanth SM, Renuse S, Ahmad S, Radhakrishnan A, Barbhuiya MA, Kumar RV, et al: Identification of head and neck squamous cell carcinoma biomarker candidates through proteomic analysis of cancer cell secretome. Biochim Biophys Acta. 1834:2308–2316. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Zhang X, Huang Q, Yang Z, Li Y and Li CY: GW112, a novel antiapoptotic protein that promotes tumor growth. Cancer Res. 64:2474–2481. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Liu W, Chen L, Zhu J and Rodgers GP: The glycoprotein hGC-1 binds to cadherin and lectins. Exp Cell Res. 312:1785–1797. 2006. View Article : Google Scholar : PubMed/NCBI

36 

van der Flier LG, Haegebarth A, Stange DE, van de Wetering M and Clevers H: OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. Gastroenterology. 137:15–17. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Yoon S, Woo SU, Kang JH, Kim K, Shin HJ, Gwak HS, Park S and Chwae YJ: NF-κB and STAT3 cooperatively induce IL6 in starved cancer cells. Oncogene. 31:3467–3481. 2012. View Article : Google Scholar

38 

Rousseau-Merck MF, Simon-Chazottes D, Arpin M, Pringault E, Louvard D, Guénet JL and Berger R: Localization of the villin gene on human chromosome 2q35-q36 and on mouse chromosome 1. Hum Genet. 78:130–133. 1988. View Article : Google Scholar : PubMed/NCBI

39 

Yokota E, Tominaga M, Mabuchi I, Tsuji Y, Staiger CJ, Oiwa K and Shimmen T: Plant villin, lily P-135-ABP, possesses G-actin binding activity and accelerates the polymerization and depolymerization of actin in a Ca2+-sensitive manner. Plant Cell Physiol. 46:1690–1703. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Osborn M, Mazzoleni G, Santini D, Marrano D, Martinelli G and Weber K: Villin, intestinal brush border hydrolases and keratin polypeptides in intestinal metaplasia and gastric cancer; an immunohistologic study emphasizing the different degrees of intestinal and gastric differentiation in signet ring cell carcinomas. Virchows Arch A Pathol Anat Histopathol. 413:303–312. 1988. View Article : Google Scholar : PubMed/NCBI

41 

Robine S, Huet C, Moll R, Sahuquillo-Merino C, Coudrier E, Zweibaum A and Louvard D: Can villin be used to identify malignant and undifferentiated normal digestive epithelial cells? Proc Natl Acad Sci USA. 82:8488–8492. 1985. View Article : Google Scholar : PubMed/NCBI

42 

Xieraili M, Yasen M, Mogushi K, Obulhasim G, Mayinuer A, Aihara A, Tanaka S, Mizushima H, Tanaka H and Arii S: Villin 1 is a predictive factor for the recurrence of high serum alpha-fetoprotein-associated hepatocellular carcinoma after hepatectomy. Cancer Sci. 103:1493–1501. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Pereira HA, Shafer WM, Pohl J, Martin LE and Spitznagel JK: CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity. J Clin Invest. 85:1468–1476. 1990. View Article : Google Scholar : PubMed/NCBI

44 

Raff JW: Centrosomes and cancer: Lessons from a TACC. Trends Cell Biol. 12:222–225. 2002. View Article : Google Scholar : PubMed/NCBI

45 

Mahoney JA, Ntolosi B, DaSilva RP, Gordon S and McKnight AJ: Cloning and characterization of CPVL, a novel serine carboxypeptidase, from human macrophages. Genomics. 72:243–251. 2001. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ran X, Xu X, Yang Y, She S, Yang M, Li S, Peng H, Ding X, Hu H, Hu P, Hu P, et al: A quantitative proteomics study on olfactomedin 4 in the development of gastric cancer. Int J Oncol 47: 1932-1944, 2015.
APA
Ran, X., Xu, X., Yang, Y., She, S., Yang, M., Li, S. ... Zeng, W. (2015). A quantitative proteomics study on olfactomedin 4 in the development of gastric cancer. International Journal of Oncology, 47, 1932-1944. https://doi.org/10.3892/ijo.2015.3168
MLA
Ran, X., Xu, X., Yang, Y., She, S., Yang, M., Li, S., Peng, H., Ding, X., Hu, H., Hu, P., Zhang, D., Ren, H., Wu, L., Zeng, W."A quantitative proteomics study on olfactomedin 4 in the development of gastric cancer". International Journal of Oncology 47.5 (2015): 1932-1944.
Chicago
Ran, X., Xu, X., Yang, Y., She, S., Yang, M., Li, S., Peng, H., Ding, X., Hu, H., Hu, P., Zhang, D., Ren, H., Wu, L., Zeng, W."A quantitative proteomics study on olfactomedin 4 in the development of gastric cancer". International Journal of Oncology 47, no. 5 (2015): 1932-1944. https://doi.org/10.3892/ijo.2015.3168
Copy and paste a formatted citation
x
Spandidos Publications style
Ran X, Xu X, Yang Y, She S, Yang M, Li S, Peng H, Ding X, Hu H, Hu P, Hu P, et al: A quantitative proteomics study on olfactomedin 4 in the development of gastric cancer. Int J Oncol 47: 1932-1944, 2015.
APA
Ran, X., Xu, X., Yang, Y., She, S., Yang, M., Li, S. ... Zeng, W. (2015). A quantitative proteomics study on olfactomedin 4 in the development of gastric cancer. International Journal of Oncology, 47, 1932-1944. https://doi.org/10.3892/ijo.2015.3168
MLA
Ran, X., Xu, X., Yang, Y., She, S., Yang, M., Li, S., Peng, H., Ding, X., Hu, H., Hu, P., Zhang, D., Ren, H., Wu, L., Zeng, W."A quantitative proteomics study on olfactomedin 4 in the development of gastric cancer". International Journal of Oncology 47.5 (2015): 1932-1944.
Chicago
Ran, X., Xu, X., Yang, Y., She, S., Yang, M., Li, S., Peng, H., Ding, X., Hu, H., Hu, P., Zhang, D., Ren, H., Wu, L., Zeng, W."A quantitative proteomics study on olfactomedin 4 in the development of gastric cancer". International Journal of Oncology 47, no. 5 (2015): 1932-1944. https://doi.org/10.3892/ijo.2015.3168
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team