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International Journal of Oncology
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Article

A comparative study on the effect of docetaxel-albumin nanoparticles and docetaxel-loaded PEG-albumin nanoparticles against non-small cell lung cancer

  • Authors:
    • Guangming Jin
    • Mingji Jin
    • Xuezhe Yin
    • Zhehu Jin
    • Liqing Chen
    • Zhonggao Gao
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Bioactive Substance and Functions of Natural Medicines, Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P.R. China, Yanbian University Hospital, Yanji, Jilin 133000, P.R. China
  • Pages: 1945-1953
    |
    Published online on: September 18, 2015
       https://doi.org/10.3892/ijo.2015.3174
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Abstract

The present study mainly compared the effect of docetaxel-albumin nanoparticles (DANPs) and docetaxel-loaded PEG-albumin nanoparticles (PEG-DANPs) against non-small cell lung cancer (NSCLC). We made systematic assessments on these three drugs against NSCLC both in vitro and in vivo. With the purpose of eliminating side-effects of the commercial formulation (Tween-80) and prolonging the blood circulation time, we used emulsion-evaporation cross-link method to prepare DANPs and PEG-DANPs. The DANPs had an average particle size of 163.4±3.76 nm, a zeta potential of -19.4±0.18 mV, a polydispersity index of 0.143±0.03, a drug loading of 8.71±0.98%, and an encapsulation efficiency of 93.58±0.86%; the average particle size of PEG-DANPs is 169.19±2.36 nm, zeta potential is -18.2±0.21 mV, with a polydispersity index of 1.56±0.05, a drug loading of 8.72±1.05% and an encapsulation efficiency of 95.4±5.5%. PEG-DANPs showed a dose- and time-dependent efficacy in cytotoxicity studies in vitro; the hemolysis test indicated that PEG-DANPs had less hemocytolysis than Aisu® and DANPs; in addition, a more prolonged circulation time and sustained in vitro release behavior were observed in the PEG-DANPs compared with Aisu® and DANPs; the cellular uptake test in vitro demonstrated that PEG-DANPs could be absorbed easier into the nucleus; furthermore, the tumor growth of NSCLC-bearing nude mice in vivo was reduced the most by PEG-DANPs. In conclusion, the PEG-DANPs have the lowest side-effects, the highest antitumor activity with the longest blood circulation time of the three drugs, and it will provide an alternative to patients with NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Jin G, Jin M, Yin X, Jin Z, Chen L and Gao Z: A comparative study on the effect of docetaxel-albumin nanoparticles and docetaxel-loaded PEG-albumin nanoparticles against non-small cell lung cancer. Int J Oncol 47: 1945-1953, 2015.
APA
Jin, G., Jin, M., Yin, X., Jin, Z., Chen, L., & Gao, Z. (2015). A comparative study on the effect of docetaxel-albumin nanoparticles and docetaxel-loaded PEG-albumin nanoparticles against non-small cell lung cancer. International Journal of Oncology, 47, 1945-1953. https://doi.org/10.3892/ijo.2015.3174
MLA
Jin, G., Jin, M., Yin, X., Jin, Z., Chen, L., Gao, Z."A comparative study on the effect of docetaxel-albumin nanoparticles and docetaxel-loaded PEG-albumin nanoparticles against non-small cell lung cancer". International Journal of Oncology 47.5 (2015): 1945-1953.
Chicago
Jin, G., Jin, M., Yin, X., Jin, Z., Chen, L., Gao, Z."A comparative study on the effect of docetaxel-albumin nanoparticles and docetaxel-loaded PEG-albumin nanoparticles against non-small cell lung cancer". International Journal of Oncology 47, no. 5 (2015): 1945-1953. https://doi.org/10.3892/ijo.2015.3174
Copy and paste a formatted citation
x
Spandidos Publications style
Jin G, Jin M, Yin X, Jin Z, Chen L and Gao Z: A comparative study on the effect of docetaxel-albumin nanoparticles and docetaxel-loaded PEG-albumin nanoparticles against non-small cell lung cancer. Int J Oncol 47: 1945-1953, 2015.
APA
Jin, G., Jin, M., Yin, X., Jin, Z., Chen, L., & Gao, Z. (2015). A comparative study on the effect of docetaxel-albumin nanoparticles and docetaxel-loaded PEG-albumin nanoparticles against non-small cell lung cancer. International Journal of Oncology, 47, 1945-1953. https://doi.org/10.3892/ijo.2015.3174
MLA
Jin, G., Jin, M., Yin, X., Jin, Z., Chen, L., Gao, Z."A comparative study on the effect of docetaxel-albumin nanoparticles and docetaxel-loaded PEG-albumin nanoparticles against non-small cell lung cancer". International Journal of Oncology 47.5 (2015): 1945-1953.
Chicago
Jin, G., Jin, M., Yin, X., Jin, Z., Chen, L., Gao, Z."A comparative study on the effect of docetaxel-albumin nanoparticles and docetaxel-loaded PEG-albumin nanoparticles against non-small cell lung cancer". International Journal of Oncology 47, no. 5 (2015): 1945-1953. https://doi.org/10.3892/ijo.2015.3174
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