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Article

Livin modulates the apoptotic effects of vesicular stomatotitis virus in lung adenocarcinoma

  • Authors:
    • Gui-Hong Liu
    • Wei-Lin Wang
    • Chun Wang
    • Chang-Lin Li
    • Xiao-Long Zhang
    • Qiu Li
    • Zhen-Yu Ding
  • View Affiliations / Copyright

    Affiliations: Division of Thoracic Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, P.R. China, Department of Oncology, Chengdu First People's Hospital, Chengdu 610041, P.R. China, Division of Endocrinology and Metabolism, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, P.R. China, Division of Abdominal Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, P.R. China
  • Pages: 1775-1782
    |
    Published online on: September 24, 2015
       https://doi.org/10.3892/ijo.2015.3183
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Abstract

Vesicular stomatitis virus (VSV) has shown promise in cancer treatment. However, it achieved limited effects against lung cancer. Lung cancer has intrinsic mechanisms that render resistance to VSV. In this study, we attempted to explore the expression of the anti-apoptotic factor Livin in lung adenocarcinoma and its possible relationship to VSV vulnerability. We found VSV induced apoptosis in a time- and dose-dependent manner, with the concomitant change in the expression of Livin. We elevated the expression of Livin both transiently and stably, and the cells became insensitive to VSV treatment. We further found the BIR domain of Livin was mainly responsible for its modulation effects. This finding suggested a possible interaction with the second mitochondria-derived activator of caspase (SMAC). The knock-down of SMAC also inhibited apoptosis by VSV. The relationship was confirmed by the co-immunoprecipitation. Finally, we knocked down the endogenous Livin, and the knock-down sensitized cells to VSV treatment. Our results suggested the important role of Livin and its partner molecule in the process of VSV treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Liu G, Wang W, Wang C, Li C, Zhang X, Li Q and Ding Z: Livin modulates the apoptotic effects of vesicular stomatotitis virus in lung adenocarcinoma. Int J Oncol 47: 1775-1782, 2015.
APA
Liu, G., Wang, W., Wang, C., Li, C., Zhang, X., Li, Q., & Ding, Z. (2015). Livin modulates the apoptotic effects of vesicular stomatotitis virus in lung adenocarcinoma. International Journal of Oncology, 47, 1775-1782. https://doi.org/10.3892/ijo.2015.3183
MLA
Liu, G., Wang, W., Wang, C., Li, C., Zhang, X., Li, Q., Ding, Z."Livin modulates the apoptotic effects of vesicular stomatotitis virus in lung adenocarcinoma". International Journal of Oncology 47.5 (2015): 1775-1782.
Chicago
Liu, G., Wang, W., Wang, C., Li, C., Zhang, X., Li, Q., Ding, Z."Livin modulates the apoptotic effects of vesicular stomatotitis virus in lung adenocarcinoma". International Journal of Oncology 47, no. 5 (2015): 1775-1782. https://doi.org/10.3892/ijo.2015.3183
Copy and paste a formatted citation
x
Spandidos Publications style
Liu G, Wang W, Wang C, Li C, Zhang X, Li Q and Ding Z: Livin modulates the apoptotic effects of vesicular stomatotitis virus in lung adenocarcinoma. Int J Oncol 47: 1775-1782, 2015.
APA
Liu, G., Wang, W., Wang, C., Li, C., Zhang, X., Li, Q., & Ding, Z. (2015). Livin modulates the apoptotic effects of vesicular stomatotitis virus in lung adenocarcinoma. International Journal of Oncology, 47, 1775-1782. https://doi.org/10.3892/ijo.2015.3183
MLA
Liu, G., Wang, W., Wang, C., Li, C., Zhang, X., Li, Q., Ding, Z."Livin modulates the apoptotic effects of vesicular stomatotitis virus in lung adenocarcinoma". International Journal of Oncology 47.5 (2015): 1775-1782.
Chicago
Liu, G., Wang, W., Wang, C., Li, C., Zhang, X., Li, Q., Ding, Z."Livin modulates the apoptotic effects of vesicular stomatotitis virus in lung adenocarcinoma". International Journal of Oncology 47, no. 5 (2015): 1775-1782. https://doi.org/10.3892/ijo.2015.3183
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