Open Access

Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling

  • Authors:
    • Yuefeng Du
    • Qingzhi Long
    • Lin Zhang
    • Ying Shi
    • Xioagang Liu
    • Xudong Li
    • Bin Guan
    • Yanchao Tian
    • Xinyang Wang
    • Lei Li
    • Dalin He
  • View Affiliations

  • Published online on: October 13, 2015     https://doi.org/10.3892/ijo.2015.3202
  • Pages: 2064-2072
  • Copyright: © Du et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer-associated fibroblasts (CAFs) are key determinants in the malignant progression of cancer, supporting tumorigenesis and metastasis. CAFs also mediate epithelial to mesenchymal transition (EMT) in tumor cells and their achievement of stem cell traits. Curcumin has recently been found to possess anticancer activities via its effect on a variety of biological pathways involved in cancer progression. In this study, we found that CAFs could induce prostate cancer cell EMT and invasion through a monoamine oxidase A (MAOA)/mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1α (HIF-1α) signaling pathway, which exploits reactive oxygen species (ROS) to drive a migratory and aggressive phenotype of prostate carcinoma cells. Moreover, CAFs was able to increase CXC chemokine receptor 4 (CXCR4) and interleukin-6 (IL-6) receptor expression in prostate cancer cells. However, curcumin abrogated CAF-induced invasion and EMT, and inhibited ROS production and CXCR4 and IL-6 receptor expression in prostate cancer cells through inhibiting MAOA/mTOR/HIF-1α signaling, thereby supporting the therapeutic effect of curcumin in prostate cancer.
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December-2015
Volume 47 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Du Y, Long Q, Zhang L, Shi Y, Liu X, Li X, Guan B, Tian Y, Wang X, Li L, Li L, et al: Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling. Int J Oncol 47: 2064-2072, 2015
APA
Du, Y., Long, Q., Zhang, L., Shi, Y., Liu, X., Li, X. ... He, D. (2015). Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling. International Journal of Oncology, 47, 2064-2072. https://doi.org/10.3892/ijo.2015.3202
MLA
Du, Y., Long, Q., Zhang, L., Shi, Y., Liu, X., Li, X., Guan, B., Tian, Y., Wang, X., Li, L., He, D."Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling". International Journal of Oncology 47.6 (2015): 2064-2072.
Chicago
Du, Y., Long, Q., Zhang, L., Shi, Y., Liu, X., Li, X., Guan, B., Tian, Y., Wang, X., Li, L., He, D."Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling". International Journal of Oncology 47, no. 6 (2015): 2064-2072. https://doi.org/10.3892/ijo.2015.3202