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Article

Sedanolide induces autophagy through the PI3K, p53 and NF-κB signaling pathways in human liver cancer cells

  • Authors:
    • Shu-Ling Hsieh
    • Chi-Tsai Chen
    • Jyh-Jye Wang
    • Yu-Hao Kuo
    • Chien-Chun Li
    • Lan-Chi Hsieh
    • Chih-Chung Wu
  • View Affiliations / Copyright

    Affiliations: Department of Seafood Sciences, National Kaohsiung Marine University, Kaohsiung 81143, Taiwan, R.O.C., Department of Restaurant and Hospitality Management, Chung Hwa University of Medical Technology, Tainan 71703, Taiwan, R.O.C., Department of Nutrition and Health Science, Fooyin University, Kaohsiung 83111, Taiwan, R.O.C., School of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan, R.O.C., Department of Dietetics Kaohsiung Municipal United Hospital, Kaohsiung 80457, Taiwan, R.O.C., Department of Nutrition and Health Sciences, Chang Jung Christian University, Tainan 71101, Taiwan, R.O.C.
  • Pages: 2240-2246
    |
    Published online on: October 15, 2015
       https://doi.org/10.3892/ijo.2015.3206
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Abstract

Sedanolide (SN), a phthalide-like compound from celery seed oil, possesses antioxidant effects. However, the effect of SN on cell death in human liver cancer cells has yet to be determined. In this study, cell viability determination, monodansylcadaverine (MDC) fluorescent staining and immunoblot analysis were performed to determine autophagy induction and autophagy-induced protein expression changes via molecular examination after human liver cancer (J5) cells were treated with SN. Our studies demonstrate that SN suppressed J5 cell viability by inducing autophagy. Phosphoinositide 3-kinase (PI3K)-I, mammalian target of rapamycin (mTOR) and Akt protein levels decreased, whereas PI3K-III, LC3-II and Beclin-1 protein levels increased following SN treatment in J5 cells. In addition, SN treatment upregulated nuclear p53 and damage-regulated autophagy modulator (DRAM) and downregulated cytosolic p53 and Tp53-induced glycolysis and apoptosis regulator (TIGAR) expression in J5 cells. Furthermore, the cytosolic phosphorylation of inhibitor of kappa B (IκB) and nuclear p65 and the DNA-binding activity of NF-κB increased after SN treatment. These results suggest that SN induces J5 cell autophagy by regulating PI3K, p53 and NF-κB autophagy-associated signaling pathways in J5 cells.
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View References

1 

Ferenci P, Fried M, Labrecque D, Bruix J, Sherman M, Omata M, Heathcote J, Piratsivuth T, Kew M, Otegbayo JA, et al; World Gastroenterology Organisation Guidelines and Publications Committee. World Gastroenterology Organisation Guideline. Hepatocellular carcinoma (HCC): A global perspective. J Gastrointestin Liver Dis. 19:311–317. 2010.PubMed/NCBI

2 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, Rosen J, Eskelinen EL, Mizushima N, Ohsumi Y, et al: Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest. 112:1809–1820. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Gozuacik D and Kimchi A: Autophagy as a cell death and tumor suppressor mechanism. Oncogene. 23:2891–2906. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Ding WX, Ni HM, Gao W, Chen X, Kang JH, Stolz DB, Liu J and Yin XM: Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy. Mol Cancer Ther. 8:2036–2045. 2009. View Article : Google Scholar : PubMed/NCBI

6 

White E and DiPaola RS: The double-edged sword of autophagy modulation in cancer. Clin Cancer Res. 15:5308–5316. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Mizushima N: The pleiotropic role of autophagy: From protein metabolism to bactericide. Cell Death Differ. 12(Suppl 2): 1535–1541. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Engelman JA, Luo J and Cantley LC: The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet. 7:606–619. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Bader AG, Kang S, Zhao L and Vogt PK: Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer. 5:921–929. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Vivanco I and Sawyers CL: The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer. 2:489–501. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Klionsky DJ and Emr SD: Autophagy as a regulated pathway of cellular degradation. Science. 290:1717–1721. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Arico S, Petiot A, Bauvy C, Dubbelhuis PF, Meijer AJ, Codogno P and Ogier-Denis E: The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem. 276:35243–35246. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Brazil DP and Hemmings BA: Ten years of protein kinase B signalling: A hard Akt to follow. Trends Biochem Sci. 26:657–664. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Kondapaka SB, Singh SS, Dasmahapatra GP, Sausville EA and Roy KK: Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation. Mol Cancer Ther. 2:1093–1103. 2003.PubMed/NCBI

15 

Sui X, Jin L, Huang X, Geng S, He C and Hu X: p53 signaling and autophagy in cancer: A revolutionary strategy could be developed for cancer treatment. Autophagy. 7:565–571. 2011. View Article : Google Scholar

16 

Feng Z, Zhang H, Levine AJ and Jin S: The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci USA. 102:8204–8209. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Trocoli A and Djavaheri-Mergny M: The complex interplay between autophagy and NF-κB signaling pathways in cancer cells. Am J Cancer Res. 1:629–649. 2011.

18 

Criollo A, Chereau F, Malik SA, Niso-Santano M, Mariño G, Galluzzi L, Maiuri MC, Baud V and Kroemer G: Autophagy is required for the activation of NFκB. Cell Cycle. 11:194–199. 2012. View Article : Google Scholar

19 

Comb WC, Cogswell P, Sitcheran R and Baldwin AS: IKK-dependent, NF-κB-independent control of autophagic gene expression. Oncogene. 30:1727–1732. 2011. View Article : Google Scholar

20 

Kang R, Zeh HJ, Lotze MT and Tang D: The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ. 18:571–580. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Zheng GQ, Kenney PM, Zhang J and Lam LK: Chemoprevention of benzo[a]pyrene-induced forestomach cancer in mice by natural phthalides from celery seed oil. Nutr Cancer. 19:77–86. 1993. View Article : Google Scholar

22 

Woods JA, Jewell C and O'Brien NM: Sedanolide, a natural phthalide from celery seed oil: Effect on hydrogen peroxide and tert-butyl hydroperoxide-induced toxicity in HepG2 and CaCo-2 human cell lines. In Vitr Mol Toxicol. 14:233–240. 2001. View Article : Google Scholar

23 

Sowbhagya HB: Chemistry, technology, and nutraceutical functions of celery (Apium graveolens L.): An overview. Crit Rev Food Sci Nutr. 54:389–398. 2014. View Article : Google Scholar

24 

Momin RA and Nair MG: Antioxidant, cyclooxygenase and topoisomerase inhibitory compounds from Apium graveolens Linn. seeds. Phytomedicine. 9:312–318. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Denizot F and Lang R: Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods. 89:271–277. 1986. View Article : Google Scholar : PubMed/NCBI

26 

Itoh T, Ohguchi K, Nozawa Y and Akao Y: Intracellular glutathione regulates sesquiterpene lactone-induced conversion of autophagy to apoptosis in human leukemia HL60 cells. Anticancer Res. 29:1449–1457. 2009.PubMed/NCBI

27 

Lowry OH, Rosebrough NJ, Farr AL and Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem. 193:265–275. 1951.PubMed/NCBI

28 

Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:680–685. 1970. View Article : Google Scholar : PubMed/NCBI

29 

Towbin H, Staehelin T and Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc Natl Acad Sci USA. 76:4350–4354. 1979. View Article : Google Scholar : PubMed/NCBI

30 

Gold HJ and Wilson CW III: The volatile flavor substances of celery. J Food Sci. 28:484–488. 1963. View Article : Google Scholar

31 

Amaravadi RK, Lippincott-Schwartz J, Yin XM, Weiss WA, Takebe N, Timmer W, DiPaola RS, Lotze MT and White E: Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res. 17:654–666. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Ogata A, Yanagie H, Ishikawa E, Morishita Y, Mitsui S, Yamashita A, Hasumi K, Takamoto S, Yamase T and Eriguchi M: Antitumour effect of polyoxomolybdates: Induction of apoptotic cell death and autophagy in in vitro and in vivo models. Br J Cancer. 98:399–409. 2008. View Article : Google Scholar

33 

Bommareddy A, Hahm ER, Xiao D, Powolny AA, Fisher AL, Jiang Y and Singh SV: Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells. Cancer Res. 69:3704–3712. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Chen YJ, Huang WP, Yang YC, Lin CP, Chen SH, Hsu ML, Tseng YJ, Shieh HR, Chen YY and Lee JJ: Platonin induces autophagy-associated cell death in human leukemia cells. Autophagy. 5:173–183. 2009. View Article : Google Scholar

35 

Amaravadi RK, Yu D, Lum JJ, Bui T, Christophorou MA, Evan GI, Thomas-Tikhonenko A and Thompson CB: Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest. 117:326–336. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Fleming A, Noda T, Yoshimori T and Rubinsztein DC: Chemical modulators of autophagy as biological probes and potential therapeutics. Nat Chem Biol. 7:9–17. 2011. View Article : Google Scholar

37 

Uhlig JW, Chang A and Jen JJ: Effect of phthalides on celery flavor. J Food Sci. 52:658–660. 1987. View Article : Google Scholar

38 

Zhang X, Xiao H, Xu Q, Li X, Wang J and Liang X: Characterization of phthalides in Ligusticum chuanxiong by liquid chromatographic-atmospheric pressure chemical ionization-mass spectrometry. J Chromatogr Sci. 41:428–433. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Kan WL, Cho CH, Rudd JA and Lin G: Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells. J Ethnopharmacol. 120:36–43. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Yang ZR, Liu M, Peng XL, Lei XF, Zhang JX and Dong WG: Noscapine induces mitochondria-mediated apoptosis in human colon cancer cells in vivo and in vitro. Biochem Biophys Res Commun. 421:627–633. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Chen C and Yang RL: A phthalide derivative isolated from endophytic fungi Pestalotiopsis photiniae induces G1 cell cycle arrest and apoptosis in human HeLa cells. Braz J Med Biol Res. 46:643–649. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Liu P, Cheng H, Roberts TM and Zhao JJ: Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 8:627–644. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Backer JM: The regulation and function of Class III PI3Ks: Novel roles for Vps34. Biochem J. 410:1–17. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Meijer AJ and Codogno P: Regulation and role of autophagy in mammalian cells. Int J Biochem Cell Biol. 36:2445–2462. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Shinojima N, Yokoyama T, Kondo Y and Kondo S: Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy. Autophagy. 3:635–637. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Pyo JO, Nah J and Jung YK: Molecules and their functions in autophagy. Exp Mol Med. 44:73–80. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Georgakis GV and Younes A: From Rapa Nui to rapamycin: Targeting PI3K/Akt/mTOR for cancer therapy. Expert Rev Anticancer Ther. 6:131–140. 2006. View Article : Google Scholar

48 

Saiki S, Sasazawa Y, Imamichi Y, Kawajiri S, Fujimaki T, Tanida I, Kobayashi H, Sato F, Sato S, Ishikawa K, et al: Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/ mTOR/p70S6K inhibition. Autophagy. 7:176–187. 2011. View Article : Google Scholar :

49 

Wang K, Liu R, Li J, Mao J, Lei Y, Wu J, Zeng J, Zhang T, Wu H, Chen L, et al: Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling. Autophagy. 7:966–978. 2011. View Article : Google Scholar : PubMed/NCBI

50 

Murray-Zmijewski F, Slee EA and Lu X: A complex barcode underlies the heterogeneous response of p53 to stress. Nat Rev Mol Cell Biol. 9:702–712. 2008. View Article : Google Scholar : PubMed/NCBI

51 

Zilfou JT and Lowe SW: Tumor suppressive functions of p53. Cold Spring Harb Perspect Biol. 1:a0018832009. View Article : Google Scholar :

52 

Maiuri MC, Galluzzi L, Morselli E, Kepp O, Malik SA and Kroemer G: Autophagy regulation by p53. Curr Opin Cell Biol. 22:181–185. 2010. View Article : Google Scholar : PubMed/NCBI

53 

Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, Bartrons R, Gottlieb E and Vousden KH: TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell. 126:107–120. 2006. View Article : Google Scholar : PubMed/NCBI

54 

Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, Harrison PR, Gasco M, Garrone O, Crook T and Ryan KM: DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell. 126:121–134. 2006. View Article : Google Scholar : PubMed/NCBI

55 

Bensaad K, Cheung EC and Vousden KH: Modulation of intracellular ROS levels by TIGAR controls autophagy. EMBO J. 28:3015–3026. 2009. View Article : Google Scholar : PubMed/NCBI

56 

Mohammadpour R, Safarian S, Sheibani N, Norouzi S and Razazan A: Death inducing and cytoprotective autophagy in T-47D cells by two common antibacterial drugs: Sulphathiazole and sulphacetamide. Cell Biol Int. 37:348–358. 2013. View Article : Google Scholar : PubMed/NCBI

57 

Pan ST, Qin Y, Zhou ZW, He ZX, Zhang X, Yang T, Yang YX, Wang D, Qiu JX and Zhou SF: Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells. Drug Des Devel Ther. 9:1601–1626. 2015.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hsieh S, Chen C, Wang J, Kuo Y, Li C, Hsieh L and Wu C: Sedanolide induces autophagy through the PI3K, p53 and NF-κB signaling pathways in human liver cancer cells. Int J Oncol 47: 2240-2246, 2015.
APA
Hsieh, S., Chen, C., Wang, J., Kuo, Y., Li, C., Hsieh, L., & Wu, C. (2015). Sedanolide induces autophagy through the PI3K, p53 and NF-κB signaling pathways in human liver cancer cells. International Journal of Oncology, 47, 2240-2246. https://doi.org/10.3892/ijo.2015.3206
MLA
Hsieh, S., Chen, C., Wang, J., Kuo, Y., Li, C., Hsieh, L., Wu, C."Sedanolide induces autophagy through the PI3K, p53 and NF-κB signaling pathways in human liver cancer cells". International Journal of Oncology 47.6 (2015): 2240-2246.
Chicago
Hsieh, S., Chen, C., Wang, J., Kuo, Y., Li, C., Hsieh, L., Wu, C."Sedanolide induces autophagy through the PI3K, p53 and NF-κB signaling pathways in human liver cancer cells". International Journal of Oncology 47, no. 6 (2015): 2240-2246. https://doi.org/10.3892/ijo.2015.3206
Copy and paste a formatted citation
x
Spandidos Publications style
Hsieh S, Chen C, Wang J, Kuo Y, Li C, Hsieh L and Wu C: Sedanolide induces autophagy through the PI3K, p53 and NF-κB signaling pathways in human liver cancer cells. Int J Oncol 47: 2240-2246, 2015.
APA
Hsieh, S., Chen, C., Wang, J., Kuo, Y., Li, C., Hsieh, L., & Wu, C. (2015). Sedanolide induces autophagy through the PI3K, p53 and NF-κB signaling pathways in human liver cancer cells. International Journal of Oncology, 47, 2240-2246. https://doi.org/10.3892/ijo.2015.3206
MLA
Hsieh, S., Chen, C., Wang, J., Kuo, Y., Li, C., Hsieh, L., Wu, C."Sedanolide induces autophagy through the PI3K, p53 and NF-κB signaling pathways in human liver cancer cells". International Journal of Oncology 47.6 (2015): 2240-2246.
Chicago
Hsieh, S., Chen, C., Wang, J., Kuo, Y., Li, C., Hsieh, L., Wu, C."Sedanolide induces autophagy through the PI3K, p53 and NF-κB signaling pathways in human liver cancer cells". International Journal of Oncology 47, no. 6 (2015): 2240-2246. https://doi.org/10.3892/ijo.2015.3206
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