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Review Open Access

Pemetrexed clinical studies in performance status 2 patients with non-small cell lung cancer (Review)

  • Authors:
    • Ralph Zinner
    • Carla Visseren-Grul
    • David R. Spigel
    • Coleman Obasaju
  • View Affiliations / Copyright

    Affiliations: Departments of Investigational Cancer Therapeutics, and Thoracic/Head and Neck Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA, EU Lead, Late Phase Development, Lilly Oncology, Lilly Nederland B.V., 3991 RA Houten, The Netherlands, Sarah Cannon Research Institute, Nashville, TN 37203, USA, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Copyright: © Zinner et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 13-27
    |
    Published online on: October 29, 2015
       https://doi.org/10.3892/ijo.2015.3219
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Abstract

Because poor performance status (PS) is an independent prognostic factor in non-small cell lung cancer (NSCLC), PS scores are widely used by oncologists to make treatment decisions. Advanced NSCLC patients with an Eastern Cooperative Oncology Group PS of 2 have poor prognoses and are frequently excluded from clinical trials. This article reviews the efficacy and safety of pemetrexed in this patient group. We identified English-language literature (through March 2015) involving completed and ongoing studies through searches of PubMed, meeting abstracts, ClinicalTrials.gov and the European Clinical Trials Register; search terms included ‘pemetrexed,’ ‘NSCLC’ and ‘PS2’. Only studies reporting ≥1 subset analysis of PS2 patients receiving pemetrexed were chosen. Our search identified a total of ten pemetrexed studies in PS2 patients. Eight studies included only chemonaive patients, one study included both chemonaive patients and patients with one prior chemotherapy regimen and one study included only patients with one prior regimen. In subset analyses in these studies, PS2 patients had worse outcomes than PS0-1 patients regardless of treatment. In a phase 3 study, chemonaive advanced NSCLC patients with PS2 receiving pemetrexed‑carboplatin versus pemetrexed experienced improved overall survival [hazard ratio (HR)=0.62; P=0.001], progression-free survival (HR=0.46; P<0.001) and response (P=0.032). This review confirms the poorer outcomes in PS2 vs. PS0-1 patients. Although it is not an approved combination therapy, in clinical studies, PS2 patients treated with pemetrexed plus carboplatin as first-line therapy had improved response rates and survival. Additional research on PS2 patients is needed.
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Copy and paste a formatted citation
Spandidos Publications style
Zinner R, Visseren-Grul C, Spigel DR and Obasaju C: Pemetrexed clinical studies in performance status 2 patients with non-small cell lung cancer (Review). Int J Oncol 48: 13-27, 2016.
APA
Zinner, R., Visseren-Grul, C., Spigel, D.R., & Obasaju, C. (2016). Pemetrexed clinical studies in performance status 2 patients with non-small cell lung cancer (Review). International Journal of Oncology, 48, 13-27. https://doi.org/10.3892/ijo.2015.3219
MLA
Zinner, R., Visseren-Grul, C., Spigel, D. R., Obasaju, C."Pemetrexed clinical studies in performance status 2 patients with non-small cell lung cancer (Review)". International Journal of Oncology 48.1 (2016): 13-27.
Chicago
Zinner, R., Visseren-Grul, C., Spigel, D. R., Obasaju, C."Pemetrexed clinical studies in performance status 2 patients with non-small cell lung cancer (Review)". International Journal of Oncology 48, no. 1 (2016): 13-27. https://doi.org/10.3892/ijo.2015.3219
Copy and paste a formatted citation
x
Spandidos Publications style
Zinner R, Visseren-Grul C, Spigel DR and Obasaju C: Pemetrexed clinical studies in performance status 2 patients with non-small cell lung cancer (Review). Int J Oncol 48: 13-27, 2016.
APA
Zinner, R., Visseren-Grul, C., Spigel, D.R., & Obasaju, C. (2016). Pemetrexed clinical studies in performance status 2 patients with non-small cell lung cancer (Review). International Journal of Oncology, 48, 13-27. https://doi.org/10.3892/ijo.2015.3219
MLA
Zinner, R., Visseren-Grul, C., Spigel, D. R., Obasaju, C."Pemetrexed clinical studies in performance status 2 patients with non-small cell lung cancer (Review)". International Journal of Oncology 48.1 (2016): 13-27.
Chicago
Zinner, R., Visseren-Grul, C., Spigel, D. R., Obasaju, C."Pemetrexed clinical studies in performance status 2 patients with non-small cell lung cancer (Review)". International Journal of Oncology 48, no. 1 (2016): 13-27. https://doi.org/10.3892/ijo.2015.3219
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