|
1
|
Ottaviani G and Jaffe N: The epidemiology
of osteosarcoma. Cancer Treat Res. 152:3–13. 2009. View Article : Google Scholar
|
|
2
|
Wardelmann E, Chemnitz JM and Wendtner CM:
Targeted therapy of soft tissue sarcomas. Onkologie. 35(Suppl 1):
21–27. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Arslan MA, Kutuk O and Basaga H: Protein
kinases as drug targets in cancer. Curr Cancer Drug Targets.
6:623–634. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Hay N and Sonenberg N: Upstream and
downstream of mTOR. Genes Dev. 18:1926–1945. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Gridelli C, Maione P and Rossi A: The
potential role of mTOR inhibitors in non-small cell lung cancer.
Oncologist. 13:139–147. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Mita MM and Tolcher AW: The role of mTOR
inhibitors for treatment of sarcomas. Curr Oncol Rep. 9:316–322.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Kim KW, Mutter RW, Cao C, Albert JM,
Freeman M, Hallahan DE and Lu B: Autophagy for cancer therapy
through inhibition of pro-apoptotic proteins and mammalian target
of rapamycin signaling. J Biol Chem. 281:36883–36890. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Hung JY, Hsu YL, Li CT, Ko YC, Ni WC,
Huang MS and Kuo PL: 6-Shogaol, an active constituent of dietary
ginger, induces autophagy by inhibiting the AKT/mTOR pathway in
human non-small cell lung cancer A549 cells. J Agric Food Chem.
57:9809–9816. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Tan ML, Ooi JP, Ismail N, Moad AI and
Muhammad TS: Programmed cell death pathways and current antitumor
targets. Pharm Res. 26:1547–1560. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Laplante M and Sabatini DM: mTOR signaling
in growth control and disease. Cell. 149:274–293. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Zoncu R, Efeyan A and Sabatini DM: mTOR:
From growth signal integration to cancer, diabetes and ageing. Nat
Rev Mol Cell Biol. 12:21–35. 2011. View
Article : Google Scholar
|
|
12
|
Beauchamp EM and Platanias LC: The
evolution of the TOR pathway and its role in cancer. Oncogene.
32:3923–3932. 2013. View Article : Google Scholar
|
|
13
|
Gozuacik D and Kimchi A: Autophagy as a
cell death and tumor suppressor mechanism. Oncogene. 23:2891–2906.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Roca H, Varsos Z and Pienta KJ: CCL2
protects prostate cancer PC3 cells from autophagic death via
phosphatidylinositol 3-kinase/AKT-dependent survivin up-regulation.
J Biol Chem. 283:25057–25073. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Rami A and Kögel D: Apoptosis meets
autophagy-like cell death in the ischemic penumbra: Two sides of
the same coin? Autophagy. 4:422–426. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Kondo Y, Kanzawa T, Sawaya R and Kondo S:
The role of autophagy in cancer development and response to
therapy. Nat Rev Cancer. 5:726–734. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Liu D, Yang Y, Liu Q and Wang J:
Inhibition of autophagy by 3-MA potentiates cisplatin-induced
apoptosis in esophageal squamous cell carcinoma cells. Med Oncol.
28:105–111. 2011. View Article : Google Scholar
|
|
18
|
Kanematsu S, Uehara N, Miki H, Yoshizawa
K, Kawanaka A, Yuri T and Tsubura A: Autophagy inhibition enhances
sulforaphane-induced apoptosis in human breast cancer cells.
Anticancer Res. 30:3381–3390. 2010.PubMed/NCBI
|
|
19
|
Ren Y, Huang F, Liu Y, Yang Y, Jiang Q and
Xu C: Autophagy inhibition through PI3K/Akt increases apoptosis by
sodium selenite in NB4 cells. BMB Rep. 42:599–604. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Liu J, Xia H, Kim M, Xu L, Li Y, Zhang L,
Cai Y, Norberg HV, Zhang T, Furuya T, et al: Beclin1 controls the
levels of p53 by regulating the deubiquitination activity of USP10
and USP13. Cell. 147:223–234. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Pankiv S, Clausen TH, Lamark T, Brech A,
Bruun JA, Outzen H, Øvervatn A, Bjørkøy G and Johansen T:
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of
ubiquitinated protein aggregates by autophagy. J Biol Chem.
282:24131–24145. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Kim MS, Kuehn HS, Metcalfe DD and
Gilfillan AM: Activation and function of the mTORC1 pathway in mast
cells. J Immunol. 180:4586–4595. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Klionsky DJ and Emr SD: Autophagy as a
regulated pathway of cellular degradation. Science. 290:1717–1721.
2000. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Meijer AJ and Codogno P: Regulation and
role of autophagy in mammalian cells. Int J Biochem Cell Biol.
36:2445–2462. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Mori M, Hitora T, Nakamura O, Yamagami Y,
Horie R, Nishimura H and Yamamoto T: Hsp90 inhibitor induces
autophagy and apoptosis in osteosarcoma cells. Int J Oncol.
46:47–54. 2015.
|
|
26
|
Liang X, Tang J, Liang Y, Jin R and Cai X:
Suppression of autophagy by chloroquine sensitizes
5-fluorouracil-mediated cell death in gallbladder carcinoma cells.
Cell Biosci. 4:102014. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Liu B, Cheng Y, Zhang B, Bian HJ and Bao
JK: Polygonatum cyrtonema lectin induces apoptosis and autophagy in
human melanoma A375 cells through a mitochondria-mediated
ROS-p38-p53 pathway. Cancer Lett. 275:54–60. 2009. View Article : Google Scholar
|
|
28
|
Wang Q, Chen Z, Diao X and Huang S:
Induction of autophagy-dependent apoptosis by the survivin
suppressant YM155 in prostate cancer cells. Cancer Lett. 302:29–36.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Nakamura O, Hitora T, Yamagami Y, Mori M,
Nishimura H, Horie R, Yamaguchi K and Yamamoto T: The combination
of rapamycin and MAPK inhibitors enhances the growth inhibitory
effect on Nara-H cells. Int J Mol Med. 33:1491–1497.
2014.PubMed/NCBI
|
|
30
|
Correa RJ, Valdes YR, Peart TM, Fazio EN,
Bertrand M, McGee J, Préfontaine M, Sugimoto A, DiMattia GE and
Shepherd TG: Combination of AKT inhibition with autophagy blockade
effectively reduces ascites-derived ovarian cancer cell viability.
Carcinogenesis. 35:1951–1961. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Nishikawa T, Tsuno NH, Okaji Y, Shuno Y,
Sasaki K, Hongo K, Sunami E, Kitayama J, Takahashi K and Nagawa H:
Inhibition of autophagy potentiates sulforaphane-induced apoptosis
in human colon cancer cells. Ann Surg Oncol. 17:592–602. 2010.
View Article : Google Scholar
|
|
32
|
Nakamura O, Hitora T, Akisue T, Kawamoto
T, Yamagami Y and Yamamoto T: Inhibition of induced autophagy
increases apoptosis of Nara-H cells. Int J Oncol. 39:1545–1552.
2011.PubMed/NCBI
|
