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International Journal of Oncology
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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Epigenetic regulation of IQGAP2 promotes ovarian cancer progression via activating Wnt/β-catenin signaling

  • Authors:
    • Zhuo Deng
    • Lijie Wang
    • Huilian Hou
    • Jiancheng Zhou
    • Xu Li
  • View Affiliations / Copyright

    Affiliations: Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710061, P.R. China, Department of Pathology, The First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710061, P.R. China, Department of Urology, Shaanxi Provincal People's Hospital, Xi'an 710068, P.R. China
  • Pages: 153-160
    |
    Published online on: November 4, 2015
       https://doi.org/10.3892/ijo.2015.3228
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Abstract

Ovarian cancer is the most lethal gynecologic malignancy and most cases are diagnosed at an advanced stage with metastases; however, the molecular events supporting ovarian cancer development and progression remain poorly understood. In this study, by analysis of the genome-scale DNA methylation profiles of 8 healthy ovaries, 89 ovarian cancers and the corresponding 4 normal ovaries from The Cancer Genome Atlas, we unveiled the abnormalities in gene methylation of ovarian cancers, and found that IQGAP2 one of the most frequently altered genes, was significantly hypermethylated in ovarian cancer. There was an inverse correlation between IQGAP2 DNA methylation and mRNA expression, and IQGAP2 expression was downregulated in ovarian cancer. Further survival analysis indicated that decreased IQGAP2 was associated with a worse progression-free survival of patient with ovarian cancer, and biological function studies demonstrated that IQGAP2 inhibited ovarian cancer cell epithelial-mesenchymal transition, migration and invasion via suppression of Wnt-induced β-catenin nuclear translocation and transcriptional activity. Thus, these data identified IQGAP2 as a novel tumor suppressor for ovarian cancer to inhibit cell invasion through regulating Wnt/β-catenin signaling, and provided a new biomarker and potential therapeutic strategy for this disease.
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Copy and paste a formatted citation
Spandidos Publications style
Deng Z, Wang L, Hou H, Zhou J and Li X: Epigenetic regulation of IQGAP2 promotes ovarian cancer progression via activating Wnt/β-catenin signaling. Int J Oncol 48: 153-160, 2016.
APA
Deng, Z., Wang, L., Hou, H., Zhou, J., & Li, X. (2016). Epigenetic regulation of IQGAP2 promotes ovarian cancer progression via activating Wnt/β-catenin signaling. International Journal of Oncology, 48, 153-160. https://doi.org/10.3892/ijo.2015.3228
MLA
Deng, Z., Wang, L., Hou, H., Zhou, J., Li, X."Epigenetic regulation of IQGAP2 promotes ovarian cancer progression via activating Wnt/β-catenin signaling". International Journal of Oncology 48.1 (2016): 153-160.
Chicago
Deng, Z., Wang, L., Hou, H., Zhou, J., Li, X."Epigenetic regulation of IQGAP2 promotes ovarian cancer progression via activating Wnt/β-catenin signaling". International Journal of Oncology 48, no. 1 (2016): 153-160. https://doi.org/10.3892/ijo.2015.3228
Copy and paste a formatted citation
x
Spandidos Publications style
Deng Z, Wang L, Hou H, Zhou J and Li X: Epigenetic regulation of IQGAP2 promotes ovarian cancer progression via activating Wnt/β-catenin signaling. Int J Oncol 48: 153-160, 2016.
APA
Deng, Z., Wang, L., Hou, H., Zhou, J., & Li, X. (2016). Epigenetic regulation of IQGAP2 promotes ovarian cancer progression via activating Wnt/β-catenin signaling. International Journal of Oncology, 48, 153-160. https://doi.org/10.3892/ijo.2015.3228
MLA
Deng, Z., Wang, L., Hou, H., Zhou, J., Li, X."Epigenetic regulation of IQGAP2 promotes ovarian cancer progression via activating Wnt/β-catenin signaling". International Journal of Oncology 48.1 (2016): 153-160.
Chicago
Deng, Z., Wang, L., Hou, H., Zhou, J., Li, X."Epigenetic regulation of IQGAP2 promotes ovarian cancer progression via activating Wnt/β-catenin signaling". International Journal of Oncology 48, no. 1 (2016): 153-160. https://doi.org/10.3892/ijo.2015.3228
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