IL-8, a novel messenger to cross-link inflammation and tumor EMT via autocrine and paracrine pathways (Review)

  • Authors:
    • Xinxin Long
    • Yingnan Ye
    • Lijie Zhang
    • Pengpeng Liu
    • Wenwen Yu
    • Feng Wei
    • Xiubao Ren
    • Jinpu Yu
  • View Affiliations

  • Published online on: November 6, 2015     https://doi.org/10.3892/ijo.2015.3234
  • Pages: 5-12
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The epithelial-mesenchymal transition (EMT) is a process through which epithelial cells trans-differentiate and acquire an aggressive mesenchymal phenotype. In tumor cells, EMT is a vital step of tumor progression and metastasis. Amid the increasing interest in tumor EMT, only a few studies focused on the soluble mediators secreted by tumor cells passing through this phenotypic switch. In this review, we focus on the essential role of interleukin-8 (IL-8) signaling for the acquisition and maintenance of tumor EMT via direct and indirect mechanisms. Besides the autocrine loop between IL-8 and tumor cells that have gone through EMT, IL-8 could potentiate adjacent epithelial tumor cells into a mesenchymal phenotype via a paracrine mode. Moreover, understanding the role of IL-8 in EMT will provide insight into the pathogenesis of tumor progression and may facilitate the development of an effective strategy for the prevention and treatment of metastatic cancer.
View Figures
View References

Related Articles

Journal Cover

January-2016
Volume 48 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Long X, Ye Y, Zhang L, Liu P, Yu W, Wei F, Ren X and Yu J: IL-8, a novel messenger to cross-link inflammation and tumor EMT via autocrine and paracrine pathways (Review). Int J Oncol 48: 5-12, 2016
APA
Long, X., Ye, Y., Zhang, L., Liu, P., Yu, W., Wei, F. ... Yu, J. (2016). IL-8, a novel messenger to cross-link inflammation and tumor EMT via autocrine and paracrine pathways (Review). International Journal of Oncology, 48, 5-12. https://doi.org/10.3892/ijo.2015.3234
MLA
Long, X., Ye, Y., Zhang, L., Liu, P., Yu, W., Wei, F., Ren, X., Yu, J."IL-8, a novel messenger to cross-link inflammation and tumor EMT via autocrine and paracrine pathways (Review)". International Journal of Oncology 48.1 (2016): 5-12.
Chicago
Long, X., Ye, Y., Zhang, L., Liu, P., Yu, W., Wei, F., Ren, X., Yu, J."IL-8, a novel messenger to cross-link inflammation and tumor EMT via autocrine and paracrine pathways (Review)". International Journal of Oncology 48, no. 1 (2016): 5-12. https://doi.org/10.3892/ijo.2015.3234