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Involvement of cyclic-nucleotide response element-binding family members in the radiation response of Ramos B lymphoma cells

  • Authors:
    • Chiara Di Nisio
    • Silvia Sancilio
    • Viviana Di Giacomo
    • Monica Rapino
    • Laura Sancillo
    • Domenico Genovesi
    • Alessandro Di Siena
    • Rosa Alba Rana
    • Amelia Cataldi
    • Roberta Di Pietro
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, G. d'Annunzio University, I-66100 Chieti, Italy, Molecular Genetics Institute CNR, I-27100 Pavia, Italy, Department of Medicine and Ageing Sciences, G. d'Annunzio University, I-66100 Chieti, Italy, Institute of Oncologic Radiotherapy, G. d'Annunzio University, I-66100 Chieti, Italy, Sanitary Physics Unit, SS. Annunziata Hospital, I-66100 Chieti, Italy
    Copyright: © Di Nisio et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 28-36
    |
    Published online on: November 9, 2015
       https://doi.org/10.3892/ijo.2015.3238
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Abstract

The aim of the present study was to investigate the role of Cyclic-nucleotide Response Element-Binding (CREB) family members and related nuclear transcription factors in the radiation response of human B lymphoma cell lines (Daudi and Ramos). Unlike the more radiosensitive Daudi cells, Ramos cells demonstrated only a moderate increase in early apoptosis after 3-5 Gy irradiation doses, which was detected with Annexin V/PI staining. Moreover, a significant and dose-dependent G2/M phase accumulation was observed in the same cell line at 24 h after both ionizing radiation (IR) doses. Western blot analysis showed an early increase in CREB protein expression that was still present at 3 h and more evident after 3 Gy IR in Ramos cells, along with the dose-dependent upregulation of p53 and NF-κB. These findings were consistent with real-time RT-PCR analysis that showed an early- and dose-dependent upregulation of NFKB1, IKBKB and XIAP gene expression. Unexpectedly, pre-treatment with SN50 did not increase cell death, but cell viability. Taken together, these findings let us hypothesise that the early induction and activation of NF-κB1 in Ramos cells could mediate necrotic cell death and be linked to other molecules belonging to CREB family and involved in the cell cycle regulation.
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1 

Di Pietro R, Falcieri E, Centurione L, Centurione MA, Mazzotti G and Rana R: Ultrastructural patterns of cell damage and death following gamma radiation exposure of murine erythroleukemia cells. Scanning Microsc. 8:667–673. 1994.PubMed/NCBI

2 

Di Pietro R, Centurione L, Santavenere E, Centurione MA, Sanità Di Toppi G, Zamai L and Rana R: Ionizing radiation-induced apoptosis and DNA repair in murine erythroleukemia cells. Scanning Microsc. 10:253–259. 1996.PubMed/NCBI

3 

Suzuki K and Yamashita S: Low-dose radiation exposure and carcinogenesis. Jpn J Clin Oncol. 42:563–568. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Miscia S, Di Baldassarre A, Alba Rana R, Di Pietro R and Cataldi A: Engagement of DNA polymerases during apoptosis. Cell Prolif. 30:325–340. 1997. View Article : Google Scholar : PubMed/NCBI

5 

Cataldi A, Zauli G, Di Pietro R, Castorina S and Rana RA: Involvement of the pathway PI-3-kinase/AKT 1 in the establishment of the survival response to ionising radiation. Cell Signal. 13:1–7. 2001.

6 

Cataldi A, di Giacomo V, Rapino M, Genovesi D and Rana RA: Cyclic nucleotide response element binding protein (CREB) activation promotes survival signal in human K562 erythroleukemia cells exposed to ionising radiation/etoposide combined treatment. J Radiat Res (Tokyo). 47:113–120. 2006. View Article : Google Scholar

7 

Cataldi A, Di Giacomo V, Rapino M, Zara S and Rana RA: Ionizing radiation induces apoptotic signal through protein kinase Cdelta (delta) and survival signal through Akt and cyclic-nucleotide response element-binding protein (CREB) in Jurkat T cells. Biol Bull. 217:202–212. 2009.PubMed/NCBI

8 

Miura Y: Oxidative stress, radiation-adaptive responses, and aging. J Radiat Res (Tokyo). 45:357–372. 2004. View Article : Google Scholar

9 

Di Pietro R, Fang H, Fields K, Miller S, Flora M, Petricoin EC, Dveksler G, Rana RA and Grimley PM: Peroxiredoxin genes are not induced in myeloid leukemia cells exposed to ionizing radiation. Int J Immunopathol Pharmacol. 19:517–524. 2006.PubMed/NCBI

10 

Shaywitz AJ and Greenberg ME: CREB: A stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem. 68:821–861. 1999. View Article : Google Scholar

11 

Shi Y, Venkataraman SL, Dodson GE, Mabb AM, LeBlanc S and Tibbetts RS: Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress. Proc Natl Acad Sci USA. 101:5898–5903. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Zhang X, Odom DT, Koo SH, Conkright MD, Canettieri G, Best J, Chen H, Jenner R, Herbolsheimer E, Jacobsen E, et al: Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci USA. 102:4459–4464. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Di Pietro R, di Giacomo V, Caravatta L, Sancilio S, Rana RA and Cataldi A: Cyclic nucleotide response element binding (CREB) protein activation is involved in K562 erythroleukemia cells differentiation. J Cell Biochem. 100:1070–1079. 2007. View Article : Google Scholar

14 

Cho EC, Mitton B and Sakamoto KM: CREB and leukemogenesis. Crit Rev Oncog. 16:37–46. 2011. View Article : Google Scholar : PubMed/NCBI

15 

D'Auria F and Di Pietro R: Role of CREB protein family members in human haematological malignancies. Cancer Treatment/Book 2. Gali-Muhtasib H: InTech; Rijeka, Croatia: pp. 201–226. 2013

16 

Deng X, Elzey BD, Poulson JM, Morrison WB, Ko SC, Hahn NM, Ratliff TL and Hu CD: Ionizing radiation induces neuroendocrine differentiation of prostate cancer cells in vitro, in vivo and in prostate cancer patients. Am J Cancer Res. 1:834–844. 2011.PubMed/NCBI

17 

Klein G, Giovanella B, Westman A, Stehlin JS and Mumford D: An EBV-genome-negative cell line established from an American Burkitt lymphoma; receptor characteristics. EBV infectibility and permanent conversion into EBV-positive sublines by in vitro infection. Intervirology. 5:319–334. 1975.PubMed/NCBI

18 

Skvortsova I, Popper BA, Skvortsov S, Saurer M, Auer T, Moser R, Kamleitner H, Zwierzina H and Lukas P: Pretreatment with rituximab enhances radiosensitivity of non-Hodgkin's lymphoma cells. J Radiat Res (Tokyo). 46:241–248. 2005. View Article : Google Scholar

19 

Sancilio S, Grill V and Di Pietro R: A combined approach with rituximab plus anti-TRAIL-R agonistic antibodies for the treatment of haematological malignancies. Curr Pharm Des. 14:2085–2099. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Impicciatore G, Sancilio S, Miscia S and Di Pietro R: Nutlins and ionizing radiation in cancer therapy. Curr Pharm Des. 16:1427–1442. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Camus S, Higgins M, Lane DP and Lain S: Differences in the ubiquitination of p53 by Mdm2 and the HPV protein E6. FEBS Lett. 536:220–224. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Ben-Bassat H, Goldblum N, Mitrani S, Klein G and Johansson B: Concanavalin A receptors on the surface membrane of lymphocytes from patients with African Burkitt's lymphoma and lymphoma cell lines. Int J Cancer. 17:448–454. 1976. View Article : Google Scholar : PubMed/NCBI

23 

Sancilio S, Di Giacomo V, Quaglietta AM, Iacone A, Angelucci D, Tatasciore U, Rana RA, Cataldi A, Zauli G and Di Pietro R: TRAIL promotes a pro-survival signal in erythropoietin-deprived human erythroblasts through the activation of an NF-kB/IkBalpha pathway. J Biol Regul Homeost Agents. 25:375–386. 2011.PubMed/NCBI

24 

Caravatta L, Sancilio S, di Giacomo V, Rana R, Cataldi A and Di Pietro R and Di Pietro R: PI3-K/Akt-dependent activation of cAMP-response element-binding (CREB) protein in Jurkat T leukemia cells treated with TRAIL. J Cell Physiol. 214:192–200. 2008. View Article : Google Scholar

25 

Campbell BA, Connors JM, Gascoyne RD, Morris WJ, Pickles T and Sehn LH: Limited-stage diffuse large B-cell lymphoma treated with abbreviated systemic therapy and consolidation radiotherapy: Involved-field versus involved-node radiotherapy. Cancer. 118:4156–4165. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Zauli G, Sancilio S, Cataldi A, Sabatini N, Bosco D and Di Pietro R: PI-3K/Akt and NF-kappaB/IkappaBalpha pathways are activated in Jurkat T cells in response to TRAIL treatment. J Cell Physiol. 202:900–911. 2005. View Article : Google Scholar

27 

Sabatini N, Di Pietro R, Rapino M, Sancilio S, Comani S and Cataldi A: PI-3-kinase/NF-kappaB mediated response of Jurkat T leukemic cells to two different chemotherapeutic drugs, etoposide and TRAIL. J Cell Biochem. 93:301–311. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Dolcet X, Llobet D, Pallares J and Matias-Guiu X: NF-κB in development and progression of human cancer. Virchows Arch. 446:475–482. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Papazisis KT, Zambouli D, Kimoundri OT, Papadakis ES, Vala V, Geromichalos GD, Voyatzi S, Markala D, Destouni E, Boutis L, et al: Protein tyrosine kinase inhibitor, genistein, enhances apoptosis and cell cycle arrest in K562 cells treated with gamma-irradiation. Cancer Lett. 160:107–113. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Cataldi A, Rapino M, Centurione L, Sabatini N, Grifone G, Garaci F and Rana R: NF-kappaB activation plays an anti-apoptotic role in human leukemic K562 cells exposed to ionizing radiation. J Cell Biochem. 89:956–963. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Pajonk F, Pajonk K and McBride WH: Inhibition of NF-kappaB, clonogenicity, and radiosensitivity of human cancer cells. J Natl Cancer Inst. 91:1956–1960. 1999. View Article : Google Scholar : PubMed/NCBI

32 

Winters ZE, Ongkeko WM, Harris AL and Norbury CJ: p53 regulates Cdc2 independently of inhibitory phosphorylation to reinforce radiation-induced G2 arrest in human cells. Oncogene. 17:673–684. 1998. View Article : Google Scholar : PubMed/NCBI

33 

Sabatini N, Di Giacomo V, Rapino M, Rana R, Garaci G and Cataldi A: JNK/p53 mediated cell death response in K562 exposed to etoposide-ionizing radiation combined treatment. J Cell Biochem. 95:611–619. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Wuerzberger-Davis SM, Chang PY, Berchtold C and Miyamoto S: Enhanced G2-M arrest by nuclear factor-{kappa}B-dependent p21waf1/cip1 induction. Mol Cancer Res. 3:345–353. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Eleuterio E, Di Giuseppe F, Sulpizio M, di Giacomo V, Rapino M, Cataldi A, Di Ilio C and Angelucci S: Proteome analysis of X-ray irradiated human erythroleukemia cells. Biochim Biophys Acta. 1784:611–620. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Jin P, Gu Y and Morgan DO: Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells. J Cell Biol. 134:963–970. 1996. View Article : Google Scholar : PubMed/NCBI

37 

Pardo FS, Su M and Borek C: Cyclin D1 induced apoptosis maintains the integrity of the G1/S checkpoint following ionizing radiation irradiation. Somat Cell Mol Genet. 22:135–144. 1996. View Article : Google Scholar : PubMed/NCBI

38 

Cheng L, Li L, Qiao X, Liu J and Yao X: Functional characterization of the promoter of human kinetochore protein HEC1: Novel link between regulation of the cell cycle protein and CREB family transcription factors. Biochim Biophys Acta. 1769:593–602. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Mayr B and Montminy M: Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol. 2:599–609. 2001. View Article : Google Scholar : PubMed/NCBI

40 

Magné N, Toillon RA, Bottero V, Didelot C, Houtte PV, Gérard JP and Peyron JF: NF-kappaB modulation and ionizing radiation: Mechanisms and future directions for cancer treatment. Cancer Lett. 231:158–168. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Beier F, Lee RJ, Taylor AC, Pestell RG and LuValle P: Identification of the cyclin D1 gene as a target of activating transcription factor 2 in chondrocytes. Proc Natl Acad Sci USA. 96:1433–1438. 1999. View Article : Google Scholar : PubMed/NCBI

42 

Lau E and Ronai ZA: ATF2 - at the crossroad of nuclear and cytosolic functions. J Cell Sci. 125:2815–2824. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Kozakai N, Kikuchi E, Hasegawa M, Suzuki E, Ide H, Miyajima A, Horiguchi Y, Nakashima J, Umezawa K, Shigematsu N, et al: Enhancement of radiosensitivity by a unique novel NF-κB inhibitor, DHMEQ, in prostate cancer. Br J Cancer. 107:652–657. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Di Nisio C, Sancilio S, Di Giacomo V, Rapino M, Sancillo L, Genovesi D, Di Siena A, Rana RA, Cataldi A, Di Pietro R, Di Pietro R, et al: Involvement of cyclic-nucleotide response element-binding family members in the radiation response of Ramos B lymphoma cells. Int J Oncol 48: 28-36, 2016.
APA
Di Nisio, C., Sancilio, S., Di Giacomo, V., Rapino, M., Sancillo, L., Genovesi, D. ... Di Pietro, R. (2016). Involvement of cyclic-nucleotide response element-binding family members in the radiation response of Ramos B lymphoma cells. International Journal of Oncology, 48, 28-36. https://doi.org/10.3892/ijo.2015.3238
MLA
Di Nisio, C., Sancilio, S., Di Giacomo, V., Rapino, M., Sancillo, L., Genovesi, D., Di Siena, A., Rana, R. A., Cataldi, A., Di Pietro, R."Involvement of cyclic-nucleotide response element-binding family members in the radiation response of Ramos B lymphoma cells". International Journal of Oncology 48.1 (2016): 28-36.
Chicago
Di Nisio, C., Sancilio, S., Di Giacomo, V., Rapino, M., Sancillo, L., Genovesi, D., Di Siena, A., Rana, R. A., Cataldi, A., Di Pietro, R."Involvement of cyclic-nucleotide response element-binding family members in the radiation response of Ramos B lymphoma cells". International Journal of Oncology 48, no. 1 (2016): 28-36. https://doi.org/10.3892/ijo.2015.3238
Copy and paste a formatted citation
x
Spandidos Publications style
Di Nisio C, Sancilio S, Di Giacomo V, Rapino M, Sancillo L, Genovesi D, Di Siena A, Rana RA, Cataldi A, Di Pietro R, Di Pietro R, et al: Involvement of cyclic-nucleotide response element-binding family members in the radiation response of Ramos B lymphoma cells. Int J Oncol 48: 28-36, 2016.
APA
Di Nisio, C., Sancilio, S., Di Giacomo, V., Rapino, M., Sancillo, L., Genovesi, D. ... Di Pietro, R. (2016). Involvement of cyclic-nucleotide response element-binding family members in the radiation response of Ramos B lymphoma cells. International Journal of Oncology, 48, 28-36. https://doi.org/10.3892/ijo.2015.3238
MLA
Di Nisio, C., Sancilio, S., Di Giacomo, V., Rapino, M., Sancillo, L., Genovesi, D., Di Siena, A., Rana, R. A., Cataldi, A., Di Pietro, R."Involvement of cyclic-nucleotide response element-binding family members in the radiation response of Ramos B lymphoma cells". International Journal of Oncology 48.1 (2016): 28-36.
Chicago
Di Nisio, C., Sancilio, S., Di Giacomo, V., Rapino, M., Sancillo, L., Genovesi, D., Di Siena, A., Rana, R. A., Cataldi, A., Di Pietro, R."Involvement of cyclic-nucleotide response element-binding family members in the radiation response of Ramos B lymphoma cells". International Journal of Oncology 48, no. 1 (2016): 28-36. https://doi.org/10.3892/ijo.2015.3238
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