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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Glucose starvation induces mutation and lineage-dependent adaptive responses in a large collection of cancer cell lines

  • Authors:
    • Ningning He
    • Nayoung Kim
    • Euna Jeong
    • Yiling Lu
    • Gordon B. Mills
    • Sukjoon Yoon
  • View Affiliations / Copyright

    Affiliations: Center for Advanced Bioinformatics and Systems Medicine, Department of Biological Sciences, Sookmyung Women's University, Seoul 140-742, Republic of Korea, Systems Biology, University of Texas, M.D. Anderson Cancer Center, Houston, TX 77054, USA
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 67-72
    |
    Published online on: November 11, 2015
       https://doi.org/10.3892/ijo.2015.3242
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Abstract

Tolerance of glucose deprivation is an important factor for cancer proliferation, survival, migration and progression. To systematically understand adaptive responses under glucose starvation in cancers, we analyzed reverse phase protein array (RPPA) data of 115 protein antibodies across a panel of approximately 170 heterogeneous cancer cell lines, cultured under normal and low glucose conditions. In general, glucose starvation broadly altered levels of many of the proteins and phosphoproteins assessed across the cell lines. Many mTOR pathway components were selectively sensitive to glucose stress, although the change in their levels still varied greatly across the cell line set. Furthermore, lineage- and genotype-based classification of cancer cell lines revealed mutation-specific variation of protein expression and phosphorylation in response to glucose starvation. Decreased AKT phosphorylation (S473) was significantly associated with PTEN mutation under glucose starvation conditions in lung cancer cell lines. The present study (see TCPAportal.org for data resource) provides insight into adaptive responses to glucose deprivation under diverse cellular contexts.
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Copy and paste a formatted citation
Spandidos Publications style
He N, Kim N, Jeong E, Lu Y, Mills GB and Yoon S: Glucose starvation induces mutation and lineage-dependent adaptive responses in a large collection of cancer cell lines. Int J Oncol 48: 67-72, 2016.
APA
He, N., Kim, N., Jeong, E., Lu, Y., Mills, G.B., & Yoon, S. (2016). Glucose starvation induces mutation and lineage-dependent adaptive responses in a large collection of cancer cell lines. International Journal of Oncology, 48, 67-72. https://doi.org/10.3892/ijo.2015.3242
MLA
He, N., Kim, N., Jeong, E., Lu, Y., Mills, G. B., Yoon, S."Glucose starvation induces mutation and lineage-dependent adaptive responses in a large collection of cancer cell lines". International Journal of Oncology 48.1 (2016): 67-72.
Chicago
He, N., Kim, N., Jeong, E., Lu, Y., Mills, G. B., Yoon, S."Glucose starvation induces mutation and lineage-dependent adaptive responses in a large collection of cancer cell lines". International Journal of Oncology 48, no. 1 (2016): 67-72. https://doi.org/10.3892/ijo.2015.3242
Copy and paste a formatted citation
x
Spandidos Publications style
He N, Kim N, Jeong E, Lu Y, Mills GB and Yoon S: Glucose starvation induces mutation and lineage-dependent adaptive responses in a large collection of cancer cell lines. Int J Oncol 48: 67-72, 2016.
APA
He, N., Kim, N., Jeong, E., Lu, Y., Mills, G.B., & Yoon, S. (2016). Glucose starvation induces mutation and lineage-dependent adaptive responses in a large collection of cancer cell lines. International Journal of Oncology, 48, 67-72. https://doi.org/10.3892/ijo.2015.3242
MLA
He, N., Kim, N., Jeong, E., Lu, Y., Mills, G. B., Yoon, S."Glucose starvation induces mutation and lineage-dependent adaptive responses in a large collection of cancer cell lines". International Journal of Oncology 48.1 (2016): 67-72.
Chicago
He, N., Kim, N., Jeong, E., Lu, Y., Mills, G. B., Yoon, S."Glucose starvation induces mutation and lineage-dependent adaptive responses in a large collection of cancer cell lines". International Journal of Oncology 48, no. 1 (2016): 67-72. https://doi.org/10.3892/ijo.2015.3242
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