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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January-2016 Volume 48 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

NF-κB signaling plays irreplaceable roles in cisplatin-induced bladder cancer chemoresistance and tumor progression

  • Authors:
    • Yi Sun
    • Zhenfeng Guan
    • Liang Liang
    • Yongyi Cheng
    • Jiancheng Zhou
    • Jing Li
    • Yonggang Xu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Shaanxi Provincial People's Hospital, Xi'an, P.R. China
  • Pages: 225-234
    |
    Published online on: November 20, 2015
       https://doi.org/10.3892/ijo.2015.3256
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Abstract

Bladder cancer (BCa) is the most vital urogenital malignant disease worldwide, bringing huge economic and social burden every year. Clinically, BCa is subdivided into superficial type and invasive type according to clinic-pathology, accompanied with different strategy of therapy. Number of reports indicate that 10-30% of superficial BCa will inevitable progress into invasive type, manifesting enhanced malignant behavior compared to original invasive type. Regardless of the original being an original invasive type or invasive type that progressed from superficial type of BCa, chemotherapy (including adjuvant or neo-adjuvant chemotherapy) in line with radiotherapy is the final regimen for BCa patients. Previous reports pointed out the high efficiency of cisplatin-containing chemotherapeutic regimen for BCa patients, leading to wide use of this regimen in BCa therapeutics. However, cisplatin-resistance inevitably appear, resulting in the failure of the BCa chemotherapy, the mechanism of which is still unknown. In the present study, parental BCa cell lines T24/J82 were used to obtain stable-cisplatin-resistance cell lines T24R/J82R, which showed enhanced capacity of malignancy, tumorigenesis and drug resistance, accompanied by elevated expression of EMT markers. The further mechanism investigation suggested that prolonged time of cisplatin-treatment contributed to the activation of the NF-κB signal, resulting in the upregulation of EMT markers, the maintenance of stem cell marker and the elevated expression of ABCB1. Thus, our study provides us a new view of the role of NF-κB signaling in BCa therapeutics.
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Copy and paste a formatted citation
Spandidos Publications style
Sun Y, Guan Z, Liang L, Cheng Y, Zhou J, Li J and Xu Y: NF-κB signaling plays irreplaceable roles in cisplatin-induced bladder cancer chemoresistance and tumor progression. Int J Oncol 48: 225-234, 2016.
APA
Sun, Y., Guan, Z., Liang, L., Cheng, Y., Zhou, J., Li, J., & Xu, Y. (2016). NF-κB signaling plays irreplaceable roles in cisplatin-induced bladder cancer chemoresistance and tumor progression. International Journal of Oncology, 48, 225-234. https://doi.org/10.3892/ijo.2015.3256
MLA
Sun, Y., Guan, Z., Liang, L., Cheng, Y., Zhou, J., Li, J., Xu, Y."NF-κB signaling plays irreplaceable roles in cisplatin-induced bladder cancer chemoresistance and tumor progression". International Journal of Oncology 48.1 (2016): 225-234.
Chicago
Sun, Y., Guan, Z., Liang, L., Cheng, Y., Zhou, J., Li, J., Xu, Y."NF-κB signaling plays irreplaceable roles in cisplatin-induced bladder cancer chemoresistance and tumor progression". International Journal of Oncology 48, no. 1 (2016): 225-234. https://doi.org/10.3892/ijo.2015.3256
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Y, Guan Z, Liang L, Cheng Y, Zhou J, Li J and Xu Y: NF-κB signaling plays irreplaceable roles in cisplatin-induced bladder cancer chemoresistance and tumor progression. Int J Oncol 48: 225-234, 2016.
APA
Sun, Y., Guan, Z., Liang, L., Cheng, Y., Zhou, J., Li, J., & Xu, Y. (2016). NF-κB signaling plays irreplaceable roles in cisplatin-induced bladder cancer chemoresistance and tumor progression. International Journal of Oncology, 48, 225-234. https://doi.org/10.3892/ijo.2015.3256
MLA
Sun, Y., Guan, Z., Liang, L., Cheng, Y., Zhou, J., Li, J., Xu, Y."NF-κB signaling plays irreplaceable roles in cisplatin-induced bladder cancer chemoresistance and tumor progression". International Journal of Oncology 48.1 (2016): 225-234.
Chicago
Sun, Y., Guan, Z., Liang, L., Cheng, Y., Zhou, J., Li, J., Xu, Y."NF-κB signaling plays irreplaceable roles in cisplatin-induced bladder cancer chemoresistance and tumor progression". International Journal of Oncology 48, no. 1 (2016): 225-234. https://doi.org/10.3892/ijo.2015.3256
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